{"id":"https://openalex.org/W2037001449","doi":"https://doi.org/10.1186/1471-2105-7-s5-s7","title":"Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris","display_name":"Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W2037001449","doi":"https://doi.org/10.1186/1471-2105-7-s5-s7","mag":"2037001449","pmid":"https://pubmed.ncbi.nlm.nih.gov/17254312"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-s5-s7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-s5-s7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-S5-S7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-S5-S7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108219528","display_name":"Joo Chuan Tong","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I3005327000","display_name":"Institute for Infocomm Research","ror":"https://ror.org/053rfa017","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3005327000","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Joo Chuan Tong","raw_affiliation_strings":["Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore. jctong@i2r.a-star.edu.sg","Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore","Institute for Infocomm Research, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore. jctong@i2r.a-star.edu.sg","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Institute for Infocomm Research, Singapore, Singapore","institution_ids":["https://openalex.org/I3005327000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108317608","display_name":"Tin Wee Tan","orcid":"https://orcid.org/0009-0008-7829-3647"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Tin Wee Tan","raw_affiliation_strings":["Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore","Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore , Singapore , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore , Singapore , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007075153","display_name":"Animesh A. Sinha","orcid":"https://orcid.org/0000-0003-3213-7813"},"institutions":[{"id":"https://openalex.org/I4210113003","display_name":"Physical Sciences (United States)","ror":"https://ror.org/021qvjc46","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113003"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Animesh A Sinha","raw_affiliation_strings":["Center for Investigative Dermatology, Division of Dermatology and Cutaneous Sciences, College of Human Medicine, Michigan State University, 4120 Biomedical and Physical Sciences Building, East Lansing, MI, 48824, USA","Center for Investigative Dermatology, Division of Dermatology and Cutaneous Sciences, College of Human Medicine, Michigan State University, East Lansing, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Investigative Dermatology, Division of Dermatology and Cutaneous Sciences, College of Human Medicine, Michigan State University, 4120 Biomedical and Physical Sciences Building, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513","https://openalex.org/I4210113003"]},{"raw_affiliation_string":"Center for Investigative Dermatology, Division of Dermatology and Cutaneous Sciences, College of Human Medicine, Michigan State University, East Lansing, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083278600","display_name":"Shoba Ranganathan","orcid":"https://orcid.org/0000-0002-8290-813X"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU","SG"],"is_corresponding":true,"raw_author_name":"Shoba Ranganathan","raw_affiliation_strings":["Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore","Department of Chemistry and Biomolecular Sciences & Biotechnology Research Institute, Macquarie University, Sydney, NSW, 2109, Australia","Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore","Department of Chemistry and Biomolecular Sciences & Biotechnology Research Institute, Macquarie University, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Chemistry and Biomolecular Sciences & Biotechnology Research Institute, Macquarie University, Sydney, NSW, 2109, Australia","institution_ids":["https://openalex.org/I99043593"]},{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Chemistry and Biomolecular Sciences & Biotechnology Research Institute, Macquarie University, Sydney, Australia","institution_ids":["https://openalex.org/I99043593"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5007075153","https://openalex.org/A5083278600"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210113003","https://openalex.org/I87216513","https://openalex.org/I99043593"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.1709,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.78978582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"7","issue":"S5","first_page":"S7","last_page":"S7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11730","display_name":"Autoimmune Bullous Skin Diseases","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11730","display_name":"Autoimmune Bullous Skin Diseases","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12438","display_name":"Urticaria and Related Conditions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pemphigus-vulgaris","display_name":"Pemphigus vulgaris","score":0.7408480048179626},{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.7113461494445801},{"id":"https://openalex.org/keywords/desmoglein-3","display_name":"Desmoglein 3","score":0.6770206093788147},{"id":"https://openalex.org/keywords/human-leukocyte-antigen","display_name":"Human leukocyte antigen","score":0.6096338033676147},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5099779367446899},{"id":"https://openalex.org/keywords/pemphigus","display_name":"Pemphigus","score":0.4644363820552826},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3804905116558075},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3757995367050171},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.3123294711112976},{"id":"https://openalex.org/keywords/autoantibody","display_name":"Autoantibody","score":0.131989985704422},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.08070814609527588}],"concepts":[{"id":"https://openalex.org/C2781313415","wikidata":"https://www.wikidata.org/wiki/Q3899001","display_name":"Pemphigus vulgaris","level":2,"score":0.7408480048179626},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.7113461494445801},{"id":"https://openalex.org/C2909223747","wikidata":"https://www.wikidata.org/wiki/Q3011469","display_name":"Desmoglein 3","level":4,"score":0.6770206093788147},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.6096338033676147},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5099779367446899},{"id":"https://openalex.org/C2781327288","wikidata":"https://www.wikidata.org/wiki/Q1483214","display_name":"Pemphigus","level":2,"score":0.4644363820552826},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3804905116558075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3757995367050171},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3123294711112976},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.131989985704422},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.08070814609527588}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010392","descriptor_name":"Pemphigus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010392","descriptor_name":"Pemphigus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010392","descriptor_name":"Pemphigus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015804","descriptor_name":"HLA-DR4 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015804","descriptor_name":"HLA-DR4 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015804","descriptor_name":"HLA-DR4 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015808","descriptor_name":"HLA-DR6 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015808","descriptor_name":"HLA-DR6 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015808","descriptor_name":"HLA-DR6 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051184","descriptor_name":"Desmoglein 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051184","descriptor_name":"Desmoglein 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051184","descriptor_name":"Desmoglein 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051184","descriptor_name":"Desmoglein 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051184","descriptor_name":"Desmoglein 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051184","descriptor_name":"Desmoglein 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D059811","descriptor_name":"HLA-DRB1 Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059811","descriptor_name":"HLA-DRB1 Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059811","descriptor_name":"HLA-DRB1 Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059866","descriptor_name":"HLA-DQ beta-Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059866","descriptor_name":"HLA-DQ beta-Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059866","descriptor_name":"HLA-DQ beta-Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-7-s5-s7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-s5-s7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-S5-S7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17254312","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17254312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/28639","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/28639","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:f1395e649bdb407cb2b6db7c392adbb6","is_oa":false,"landing_page_url":"https://doaj.org/article/f1395e649bdb407cb2b6db7c392adbb6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss Suppl 5, p S7 (2006)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1764484","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1764484","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-s5-s7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-s5-s7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-S5-S7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5400000214576721,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2037001449.pdf","grobid_xml":"https://content.openalex.org/works/W2037001449.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W568631482","https://openalex.org/W1490155859","https://openalex.org/W1549641435","https://openalex.org/W1635725730","https://openalex.org/W1771326673","https://openalex.org/W1966118161","https://openalex.org/W1966388921","https://openalex.org/W1971101243","https://openalex.org/W1984078422","https://openalex.org/W1985028250","https://openalex.org/W2003542620","https://openalex.org/W2007901622","https://openalex.org/W2027408247","https://openalex.org/W2029087609","https://openalex.org/W2029615301","https://openalex.org/W2034861886","https://openalex.org/W2038961612","https://openalex.org/W2040654352","https://openalex.org/W2041553413","https://openalex.org/W2047309488","https://openalex.org/W2050179219","https://openalex.org/W2055043387","https://openalex.org/W2058151034","https://openalex.org/W2058876253","https://openalex.org/W2059688181","https://openalex.org/W2061111040","https://openalex.org/W2061984168","https://openalex.org/W2065283382","https://openalex.org/W2072162021","https://openalex.org/W2078204120","https://openalex.org/W2080986404","https://openalex.org/W2081400647","https://openalex.org/W2083753580","https://openalex.org/W2089835279","https://openalex.org/W2094136265","https://openalex.org/W2094800200","https://openalex.org/W2095179395","https://openalex.org/W2098132847","https://openalex.org/W2099485004","https://openalex.org/W2100905754","https://openalex.org/W2105529422","https://openalex.org/W2114090652","https://openalex.org/W2115392836","https://openalex.org/W2115875627","https://openalex.org/W2122664553","https://openalex.org/W2130479394","https://openalex.org/W2134171839","https://openalex.org/W2152195464","https://openalex.org/W2166831581","https://openalex.org/W2171300323","https://openalex.org/W2171781500"],"related_works":["https://openalex.org/W2029583250","https://openalex.org/W2037517936","https://openalex.org/W2094136265","https://openalex.org/W4386760019","https://openalex.org/W2010623624","https://openalex.org/W3167916903","https://openalex.org/W1970015257","https://openalex.org/W2058712729","https://openalex.org/W4214872146","https://openalex.org/W4211077307"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pemphigus":[1],"vulgaris":[2],"(PV)":[3],"is":[4,12,33,55,103,219],"a":[5,43,73,191,240],"severe":[6],"autoimmune":[7,284],"blistering":[8],"skin":[9],"disorder":[10],"that":[11,159,174,260],"strongly":[13],"associated":[14],"with":[15,274],"major":[16],"histocompatibility":[17],"complex":[18],"class":[19],"II":[20],"alleles":[21],"DRB1*0402":[22,83,107,175,231],"and":[23,57,84,93,122,151,167,176,232,254,262,270],"DQB1*0503.":[24,85],"The":[25,86],"target":[26],"antigen":[27],"of":[28,45,60,65,79,148,155,206,216,225,239,244,282],"PV,":[29],"desmoglein":[30],"3":[31],"(Dsg3),":[32],"crucial":[34],"for":[35,76,105,163,194,276,279],"initiating":[36],"T-cell":[37,46,245],"response":[38],"in":[39,62,169,200,267],"early":[40],"disease.":[41,285],"Although":[42],"number":[44,54,243],"specificities":[47,181],"within":[48],"Dsg3":[49,149,250],"have":[50],"been":[51],"reported,":[52],"the":[53,58,63,77,145,153,195,204,214,220,237,248,268,280],"limited":[56],"role":[59],"T-cells":[61],"pathogenesis":[64],"PV":[66,264],"remains":[67],"poorly":[68],"understood.":[69],"We":[70,143],"report":[71,222],"here":[72],"structure-based":[74],"model":[75],"prediction":[78],"peptide":[80,98],"binding":[81,146,183,187],"to":[82,140],"scoring":[87],"functions":[88],"were":[89],"rigorously":[90],"trained,":[91],"tested":[92],"validated":[94],"using":[95],"experimentally":[96],"verified":[97],"sequences.":[99],"RESULTS:":[100],"High":[101],"predictivity":[102],"obtained":[104],"both":[106,164,228],"(r2":[108,124],"=":[109,112,116,119,125,128,132,135],"0.90,":[110],"s":[111,127],"1.20":[113,129],"kJ/mol,":[114,130],"q2":[115,131],"0.82,":[117],"s(press)":[118,134],"1.61":[120],"kJ/mol)":[121,137],"DQB1*0503":[123,177],"0.95,":[126],"0.75,":[133],"2.15":[136],"models,":[138],"compared":[139],"experimental":[141],"data.":[142],"investigated":[144],"patterns":[147],"peptides":[150,184],"illustrate":[152],"existence":[154,238],"multiple":[156],"immunodominant":[157],"epitopes":[158,246],"may":[160,178,265],"be":[161],"responsible":[162],"disease":[165],"initiation":[166],"propagation":[168],"PV.":[170,201,217],"Further":[171],"analysis":[172],"reveals":[173],"share":[179],"similar":[180],"by":[182],"at":[185],"different":[186],"registers,":[188],"thus":[189],"providing":[190],"molecular":[192],"mechanism":[193],"dual":[196],"HLA":[197],"association":[198],"observed":[199],"CONCLUSION:":[202],"Collectively,":[203],"results":[205,258],"this":[207,283],"study":[208],"provide":[209],"interesting":[210],"new":[211],"insights":[212],"into":[213],"pathology":[215],"This":[218],"first":[221],"illustrating":[223],"high-level":[224],"cross-reactivity":[226],"between":[227],"PV-implicated":[229],"alleles,":[230],"DQB1*0503,":[233],"as":[234,236],"well":[235],"potentially":[241],"large":[242],"throughout":[247],"entire":[249],"extracellular":[251],"domain":[252],"(ECD)":[253],"transmembrane":[255,271],"region.":[256],"Our":[257],"reveal":[259],"DR4":[261],"DR6":[263],"initiate":[266],"ECD":[269],"region":[272],"respectively,":[273],"implications":[275],"immunotherapeutic":[277],"strategies":[278],"treatment":[281]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}
