{"id":"https://openalex.org/W2100781199","doi":"https://doi.org/10.1186/1471-2105-7-s2-s20","title":"Gene Expression Profiles Distinguish the Carcinogenic Effects of Aristolochic Acid in Target (Kidney) and Non-target (Liver) Tissues in Rats","display_name":"Gene Expression Profiles Distinguish the Carcinogenic Effects of Aristolochic Acid in Target (Kidney) and Non-target (Liver) Tissues in Rats","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W2100781199","doi":"https://doi.org/10.1186/1471-2105-7-s2-s20","mag":"2100781199","pmid":"https://pubmed.ncbi.nlm.nih.gov/17118142"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-s2-s20","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-s2-s20","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-S2-S20","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-S2-S20","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108085976","display_name":"Tao Chen","orcid":"https://orcid.org/0009-0006-4934-1246"},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tao Chen","raw_affiliation_strings":["Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA. tao.chen@fda.hhs.gov","Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA. tao.chen@fda.hhs.gov","institution_ids":["https://openalex.org/I1304557061"]},{"raw_affiliation_string":"Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079261300","display_name":"Lei Guo","orcid":"https://orcid.org/0000-0002-0402-4152"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Guo","raw_affiliation_strings":["Division of Systems Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Systems Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100711298","display_name":"Lu Zhang","orcid":"https://orcid.org/0000-0002-1580-6774"},"institutions":[{"id":"https://openalex.org/I174947986","display_name":"Flex (United States)","ror":"https://ror.org/03q7jt003","country_code":"US","type":"company","lineage":["https://openalex.org/I174947986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Zhang","raw_affiliation_strings":["Molecular Biology SDS/Arrays Group, Applied BioSystems, Foster City, CA, 94404, USA","Solexa, Inc., Industrial Boulevard Hayward, 25861, CA, 94545, USA"],"affiliations":[{"raw_affiliation_string":"Molecular Biology SDS/Arrays Group, Applied BioSystems, Foster City, CA, 94404, USA","institution_ids":[]},{"raw_affiliation_string":"Solexa, Inc., Industrial Boulevard Hayward, 25861, CA, 94545, USA","institution_ids":["https://openalex.org/I174947986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041312244","display_name":"Leming Shi","orcid":"https://orcid.org/0000-0002-2981-4150"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leming Shi","raw_affiliation_strings":["Division of Systems Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Systems Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082869942","display_name":"Hong Fang","orcid":"https://orcid.org/0000-0002-4940-9662"},"institutions":[{"id":"https://openalex.org/I4210147108","display_name":"Hi-Z Technology (United States)","ror":"https://ror.org/03x8f0b85","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Fang","raw_affiliation_strings":["Z-Tech Corporation, 3900 NCTR Road, Jefferson, Arkansas, 72079, USA"],"affiliations":[{"raw_affiliation_string":"Z-Tech Corporation, 3900 NCTR Road, Jefferson, Arkansas, 72079, USA","institution_ids":["https://openalex.org/I4210147108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067123720","display_name":"Yongming Sun","orcid":"https://orcid.org/0000-0002-3398-4267"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongming Sun","raw_affiliation_strings":["Molecular Biology SDS/Arrays Group, Applied BioSystems, Foster City, CA, 94404, USA"],"affiliations":[{"raw_affiliation_string":"Molecular Biology SDS/Arrays Group, Applied BioSystems, Foster City, CA, 94404, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018882292","display_name":"James C. Fuscoe","orcid":null},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C Fuscoe","raw_affiliation_strings":["Division of Systems Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Systems Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006406931","display_name":"Nan Mei","orcid":"https://orcid.org/0000-0002-3501-9014"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Mei","raw_affiliation_strings":["Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5108085976"],"corresponding_institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":4.6329,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.94451354,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"S2","first_page":"S20","last_page":"S20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9796000123023987,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13079","display_name":"Heavy Metals in Plants","score":0.9757999777793884,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aristolochic-acid","display_name":"Aristolochic acid","score":0.8076679706573486},{"id":"https://openalex.org/keywords/kidney","display_name":"Kidney","score":0.6533403396606445},{"id":"https://openalex.org/keywords/carcinogen","display_name":"Carcinogen","score":0.6305607557296753},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.6231235861778259},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.6222532987594604},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6068099737167358},{"id":"https://openalex.org/keywords/toxicogenomics","display_name":"Toxicogenomics","score":0.5508933663368225},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"Kidney cancer","score":0.5294042825698853},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4986586570739746},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.48206382989883423},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.48010873794555664},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4611769914627075},{"id":"https://openalex.org/keywords/gene-chip-analysis","display_name":"Gene chip analysis","score":0.43272367119789124},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"Liver cancer","score":0.4231833219528198},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4052535891532898},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3767783045768738},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3221805989742279},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.28003939986228943},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.1831493377685547},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16040045022964478}],"concepts":[{"id":"https://openalex.org/C2780813843","wikidata":"https://www.wikidata.org/wiki/Q424210","display_name":"Aristolochic acid","level":2,"score":0.8076679706573486},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6533403396606445},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6305607557296753},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.6231235861778259},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.6222532987594604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6068099737167358},{"id":"https://openalex.org/C93231420","wikidata":"https://www.wikidata.org/wiki/Q841450","display_name":"Toxicogenomics","level":4,"score":0.5508933663368225},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.5294042825698853},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4986586570739746},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48206382989883423},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.48010873794555664},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4611769914627075},{"id":"https://openalex.org/C24361400","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Gene chip analysis","level":5,"score":0.43272367119789124},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4231833219528198},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4052535891532898},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3767783045768738},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3221805989742279},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.28003939986228943},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.1831493377685547},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16040045022964478}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001699","descriptor_name":"Biometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001699","descriptor_name":"Biometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001699","descriptor_name":"Biometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034341","descriptor_name":"Aristolochic Acids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D034341","descriptor_name":"Aristolochic Acids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D034341","descriptor_name":"Aristolochic Acids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-7-s2-s20","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-s2-s20","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-S2-S20","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17118142","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17118142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:1815137","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1683578","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1683578","is_oa":true,"landing_page_url":"http://doi.org/10.1186/1471-2105-7-S2-S20","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-s2-s20","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-s2-s20","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-S2-S20","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2100781199.pdf","grobid_xml":"https://content.openalex.org/works/W2100781199.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1527927437","https://openalex.org/W1533958480","https://openalex.org/W1591835648","https://openalex.org/W1976243031","https://openalex.org/W1980205917","https://openalex.org/W2000053786","https://openalex.org/W2006926854","https://openalex.org/W2018086514","https://openalex.org/W2021280906","https://openalex.org/W2029945609","https://openalex.org/W2037673603","https://openalex.org/W2041882751","https://openalex.org/W2043296545","https://openalex.org/W2044176859","https://openalex.org/W2059550141","https://openalex.org/W2061376602","https://openalex.org/W2063958246","https://openalex.org/W2064762827","https://openalex.org/W2073746032","https://openalex.org/W2084379569","https://openalex.org/W2087463240","https://openalex.org/W2090024127","https://openalex.org/W2095619460","https://openalex.org/W2098170884","https://openalex.org/W2099908383","https://openalex.org/W2118700885","https://openalex.org/W2120221084","https://openalex.org/W2123489566","https://openalex.org/W2126904926","https://openalex.org/W2147955536","https://openalex.org/W2157795344","https://openalex.org/W2162463986","https://openalex.org/W2169268001","https://openalex.org/W2396511922","https://openalex.org/W2397942177","https://openalex.org/W2403726559","https://openalex.org/W2462962645","https://openalex.org/W2599711791","https://openalex.org/W3142714722","https://openalex.org/W4294107304","https://openalex.org/W4300540094"],"related_works":["https://openalex.org/W1493577616","https://openalex.org/W4206229536","https://openalex.org/W2361310707","https://openalex.org/W2061516382","https://openalex.org/W2353370625","https://openalex.org/W4250247420","https://openalex.org/W1588440461","https://openalex.org/W2099536383","https://openalex.org/W615028171","https://openalex.org/W2269924708"],"abstract_inverted_index":{"Our":[0],"results":[1],"suggest":[2],"that":[3,14,37],"microarray":[4],"analysis":[5,15],"is":[6],"a":[7],"useful":[8],"tool":[9],"for":[10,59],"detecting":[11],"AA":[12,31],"exposure;":[13],"of":[16,30,40,65],"the":[17,23,60],"gene":[18],"expression":[19],"profiles":[20],"can":[21],"define":[22],"differential":[24],"responses":[25],"to":[26],"toxicity":[27,62],"and":[28,34,36,47,63],"carcinogenicity":[29,64],"from":[32],"kidney":[33],"liver;":[35],"significant":[38],"alteration":[39],"genes":[41],"associated":[42],"with":[43],"defense":[44],"response,":[45],"apoptosis":[46],"immune":[48],"response":[49],"in":[50,54],"kidney,":[51],"but":[52],"not":[53],"liver,":[55],"may":[56],"be":[57],"responsible":[58],"tissue-specific":[61],"AA.":[66]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}