{"id":"https://openalex.org/W1663540166","doi":"https://doi.org/10.1186/1471-2105-7-81","title":"Transcriptomic response to differentiation induction","display_name":"Transcriptomic response to differentiation induction","publication_year":2006,"publication_date":"2006-02-17","ids":{"openalex":"https://openalex.org/W1663540166","doi":"https://doi.org/10.1186/1471-2105-7-81","mag":"1663540166","pmid":"https://pubmed.ncbi.nlm.nih.gov/16503971"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-81","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-81","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-81","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-81","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109057674","display_name":"GW Patton","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"GW Patton","raw_affiliation_strings":["Screening Technologies Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, MD 21702, USA. gpatton@ncifcrf.gov","Screening Technologies Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Screening Technologies Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, MD 21702, USA. gpatton@ncifcrf.gov","institution_ids":[]},{"raw_affiliation_string":"Screening Technologies Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088311319","display_name":"R. Scott Stephens","orcid":"https://orcid.org/0000-0002-5472-7577"},"institutions":[{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Stephens","raw_affiliation_strings":["Advanced Biomedical Computing Center, NCI-Frederick, Frederick, MD, 21702, USA","Advanced Biomedical Computing Center, NCI-Frederick, Frederick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Biomedical Computing Center, NCI-Frederick, Frederick, MD, 21702, USA","institution_ids":["https://openalex.org/I880747138"]},{"raw_affiliation_string":"Advanced Biomedical Computing Center, NCI-Frederick, Frederick, USA","institution_ids":["https://openalex.org/I880747138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078566855","display_name":"Igor A. Sidorov","orcid":"https://orcid.org/0000-0001-6519-4983"},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"IA Sidorov","raw_affiliation_strings":["Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, MD, 21702, USA","Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, MD, 21702, USA","institution_ids":["https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, USA","institution_ids":["https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101898790","display_name":"Xue Xiao","orcid":"https://orcid.org/0000-0002-0598-776X"},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X Xiao","raw_affiliation_strings":["Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, MD, 21702, USA","Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, MD, 21702, USA","institution_ids":["https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, USA","institution_ids":["https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085875110","display_name":"Richard A. Lempicki","orcid":"https://orcid.org/0000-0002-7059-409X"},"institutions":[{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RA Lempicki","raw_affiliation_strings":["SAIC-Frederick, Frederick, MD, 21702, USA","SAIC-Frederick, Frederick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAIC-Frederick, Frederick, MD, 21702, USA","institution_ids":["https://openalex.org/I880747138"]},{"raw_affiliation_string":"SAIC-Frederick, Frederick, USA","institution_ids":["https://openalex.org/I880747138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110316688","display_name":"DS Dimitrov","orcid":null},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DS Dimitrov","raw_affiliation_strings":["Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, MD, 21702, USA","Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, MD, 21702, USA","institution_ids":["https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Center for Cancer Research Nanobiology Program (CCRNP), Center for Cancer Research, NCI-Frederick, Frederick, USA","institution_ids":["https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049131822","display_name":"R H Shoemaker","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RH Shoemaker","raw_affiliation_strings":["Screening Technologies Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, MD, 21702, USA","Screening Technologies Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Screening Technologies Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, MD, 21702, USA","institution_ids":[]},{"raw_affiliation_string":"Screening Technologies Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064730807","display_name":"Gabriela Tudor","orcid":null},"institutions":[{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Tudor","raw_affiliation_strings":["SAIC-Frederick, Frederick, MD, 21702, USA","SAIC-Frederick, Frederick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAIC-Frederick, Frederick, MD, 21702, USA","institution_ids":["https://openalex.org/I880747138"]},{"raw_affiliation_string":"SAIC-Frederick, Frederick, USA","institution_ids":["https://openalex.org/I880747138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5109057674"],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.1364,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50332308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"1","first_page":"81","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.6995999813079834,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.6995999813079834,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.04450000077486038,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.770026683807373},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.701305091381073},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"Acute promyelocytic leukemia","score":0.6753580570220947},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"Retinoic acid","score":0.5559746623039246},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5499401688575745},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.444768488407135},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.42368248105049133},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.42177021503448486},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4204697012901306},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4180780053138733},{"id":"https://openalex.org/keywords/effector","display_name":"Effector","score":0.4136210083961487},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.4108458459377289},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3920665383338928},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.32590407133102417},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3050346374511719}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.770026683807373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.701305091381073},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.6753580570220947},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5559746623039246},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5499401688575745},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.444768488407135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42368248105049133},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.42177021503448486},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4204697012901306},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4180780053138733},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4136210083961487},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4108458459377289},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3920665383338928},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32590407133102417},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3050346374511719}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D042381","descriptor_name":"Granulocyte Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042381","descriptor_name":"Granulocyte Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042381","descriptor_name":"Granulocyte Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-7-81","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-81","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-81","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16503971","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16503971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:2baa7c60cc444066a7aef195fe55e2e2","is_oa":false,"landing_page_url":"https://doaj.org/article/2baa7c60cc444066a7aef195fe55e2e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 81 (2006)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1395336","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1395336","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-81","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-81","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-81","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1663540166.pdf"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W35862036","https://openalex.org/W1594655861","https://openalex.org/W1657438214","https://openalex.org/W1966063731","https://openalex.org/W1970156673","https://openalex.org/W1970300845","https://openalex.org/W1977355465","https://openalex.org/W1978005360","https://openalex.org/W1978443443","https://openalex.org/W1986457767","https://openalex.org/W2019037494","https://openalex.org/W2039396493","https://openalex.org/W2054383392","https://openalex.org/W2078280660","https://openalex.org/W2108638877","https://openalex.org/W2122683221","https://openalex.org/W2133034723","https://openalex.org/W2133764756","https://openalex.org/W2150926065","https://openalex.org/W2168341106","https://openalex.org/W2323865678","https://openalex.org/W2346125858","https://openalex.org/W2519703809","https://openalex.org/W2917140582","https://openalex.org/W4232816883"],"related_works":["https://openalex.org/W2334200141","https://openalex.org/W2412751271","https://openalex.org/W2023968523","https://openalex.org/W2353898132","https://openalex.org/W2017638479","https://openalex.org/W1986892844","https://openalex.org/W3023720143","https://openalex.org/W4310366902","https://openalex.org/W170658859","https://openalex.org/W2490137852"],"abstract_inverted_index":{"BACKGROUND:":[0],"Microarrays":[1],"used":[2],"for":[3,163,183,188,207,230,269],"gene":[4],"expression":[5,167],"studies":[6],"yield":[7,141],"large":[8],"amounts":[9],"of":[10,14,21,34,50,62,71,98,146,161,166,226,249,254],"data.":[11],"The":[12],"processing":[13],"such":[15,75],"data":[16,27,67],"typically":[17],"leads":[18],"to":[19,31,45,104,152,201,245,266,273],"lists":[20],"differentially-regulated":[22],"genes.":[23,37],"A":[24],"common":[25],"terminal":[26],"analysis":[28,43],"step":[29],"is":[30,220,244],"map":[32],"pathways":[33,49],"potentially":[35,147],"interrelated":[36],"METHODS:":[38],"We":[39,197],"applied":[40],"a":[41,84,94,210],"transcriptomics":[42],"tool":[44,179,206],"elucidate":[46],"the":[47,54,87,126,132,159,171,181,224,227,232,255],"underlying":[48],"leukocyte":[51],"maturation":[52,91,233],"at":[53,93],"genomic":[55,128,211],"level":[56],"in":[57,68,86,144,222],"an":[58],"established":[59],"cellular":[60],"model":[61],"leukemia":[63],"by":[64,83,192,215],"examining":[65],"time-course":[66],"two":[69],"subclones":[70],"U-937":[72],"cells.":[73],"Leukemias":[74],"as":[76,153],"Acute":[77],"Promyelocytic":[78],"Leukemia":[79],"(APL)":[80],"are":[81],"characterized":[82],"block":[85],"hematopoietic":[88],"stem":[89],"cell":[90],"program":[92],"point":[95],"when":[96],"expansion":[97],"clones":[99],"which":[100],"should":[101],"be":[102,246],"destined":[103],"mature":[105],"into":[106,112,170],"terminally-differentiated":[107],"effector":[108],"cells":[109,117],"get":[110],"locked":[111],"endless":[113],"proliferation":[114],"with":[115,121],"few":[116],"reaching":[118],"maturation.":[119],"Treatment":[120],"retinoic":[122,154],"acid,":[123],"depending":[124],"on":[125,209],"precise":[127],"abnormality,":[129],"often":[130],"releases":[131],"responsible":[133,229],"promyelocytes":[134],"from":[135],"this":[136,203],"blockade":[137],"but":[138],"clinically":[139],"can":[140],"adverse":[142],"sequellae":[143],"terms":[145],"lethal":[148],"side":[149],"effects,":[150],"referred":[151],"acid":[155],"syndrome.":[156],"RESULTS:":[157],"Briefly,":[158],"list":[160],"genes":[162,213,238],"temporal":[164],"patterns":[165],"was":[168],"pasted":[169],"ABCC":[172],"GRID":[173],"Promoter":[174],"TFSite":[175],"Comparison":[176],"Page":[177],"website":[178],"and":[180,235,257],"outputs":[182],"each":[184],"pattern":[185],"were":[186],"examined":[187],"possible":[189],"coordinated":[190],"regulation":[191],"shared":[193],"regelems":[194],"(regulatory":[195],"elements).":[196],"found":[198],"it":[199],"informative":[200],"use":[202],"novel":[204],"web":[205],"identifying,":[208],"scale,":[212],"regulated":[214],"drug":[216],"treatment.":[217],"CONCLUSION:":[218],"Improvement":[219],"needed":[221],"understanding":[223],"nature":[225],"mutations":[228],"controlling":[231],"process":[234],"how":[236],"these":[237],"regulate":[239],"downstream":[240],"effects":[241],"if":[242],"there":[243],"better":[247,262],"targeting":[248],"chemical":[250],"interventions.":[251],"Expanded":[252],"implementation":[253],"techniques":[256],"results":[258],"reported":[259],"here":[260],"may":[261],"direct":[263],"future":[264],"efforts":[265],"improve":[267],"treatment":[268],"diseases":[270],"not":[271],"restricted":[272],"APL.":[274]},"counts_by_year":[],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}
