{"id":"https://openalex.org/W1525349614","doi":"https://doi.org/10.1186/1471-2105-7-494","title":"Time scale and dimension analysis of a budding yeast cell cycle model","display_name":"Time scale and dimension analysis of a budding yeast cell cycle model","publication_year":2006,"publication_date":"2006-11-09","ids":{"openalex":"https://openalex.org/W1525349614","doi":"https://doi.org/10.1186/1471-2105-7-494","mag":"1525349614","pmid":"https://pubmed.ncbi.nlm.nih.gov/17094799"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-494","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-494","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-494","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-494","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065324568","display_name":"Anna Lovrics","orcid":"https://orcid.org/0000-0001-5143-3816"},"institutions":[{"id":"https://openalex.org/I106118109","display_name":"E\u00f6tv\u00f6s Lor\u00e1nd University","ror":"https://ror.org/01jsq2704","country_code":"HU","type":"education","lineage":["https://openalex.org/I106118109"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Anna Lovrics","raw_affiliation_strings":["Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), P\u00e1zm\u00e1ny P, s\u00e9t\u00e1ny 1/A, H-1117 Budapest, Hungary. lovricsa@yahoo.com <lovricsa@yahoo.com>","Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), P\u00e1zm\u00e1ny P, s\u00e9t\u00e1ny 1/A, H-1117 Budapest, Hungary. lovricsa@yahoo.com <lovricsa@yahoo.com>","institution_ids":["https://openalex.org/I106118109"]},{"raw_affiliation_string":"Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), Budapest, Hungary","institution_ids":["https://openalex.org/I106118109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017814227","display_name":"Attila Csik\u00e1sz\u2010Nagy","orcid":"https://orcid.org/0000-0002-2919-5601"},"institutions":[{"id":"https://openalex.org/I29770179","display_name":"Budapest University of Technology and Economics","ror":"https://ror.org/02w42ss30","country_code":"HU","type":"education","lineage":["https://openalex.org/I29770179"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Attila Csik\u00e1sz-Nagy","raw_affiliation_strings":["Molecular Network Dynamics Research Group of the Hungarian Academy of Sciences and Budapest University of Technology and Economics, Gell\u00e9rt t\u00e9r 4, H-1521, Budapest, Hungary","Molecular Network Dynamics Research Group of the Hungarian Academy of Sciences and Budapest University of Technology and Economics, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Network Dynamics Research Group of the Hungarian Academy of Sciences and Budapest University of Technology and Economics, Gell\u00e9rt t\u00e9r 4, H-1521, Budapest, Hungary","institution_ids":["https://openalex.org/I29770179","https://openalex.org/I7597260"]},{"raw_affiliation_string":"Molecular Network Dynamics Research Group of the Hungarian Academy of Sciences and Budapest University of Technology and Economics, Budapest, Hungary","institution_ids":["https://openalex.org/I29770179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053818029","display_name":"Istv\u00e1n Gy. Zs\u00e9ly","orcid":"https://orcid.org/0000-0002-6512-670X"},"institutions":[{"id":"https://openalex.org/I106118109","display_name":"E\u00f6tv\u00f6s Lor\u00e1nd University","ror":"https://ror.org/01jsq2704","country_code":"HU","type":"education","lineage":["https://openalex.org/I106118109"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Istv\u00e1n Gy Zs\u00e9ly","raw_affiliation_strings":["Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), P\u00e1zm\u00e1ny P. s\u00e9t\u00e1ny 1/A, H-1117, Budapest, Hungary","Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), P\u00e1zm\u00e1ny P. s\u00e9t\u00e1ny 1/A, H-1117, Budapest, Hungary","institution_ids":["https://openalex.org/I106118109"]},{"raw_affiliation_string":"Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), Budapest, Hungary","institution_ids":["https://openalex.org/I106118109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018648223","display_name":"Judit Z\u00e1dor","orcid":"https://orcid.org/0000-0002-9123-8238"},"institutions":[{"id":"https://openalex.org/I106118109","display_name":"E\u00f6tv\u00f6s Lor\u00e1nd University","ror":"https://ror.org/01jsq2704","country_code":"HU","type":"education","lineage":["https://openalex.org/I106118109"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Judit Z\u00e1dor","raw_affiliation_strings":["Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), P\u00e1zm\u00e1ny P. s\u00e9t\u00e1ny 1/A, H-1117, Budapest, Hungary","Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), P\u00e1zm\u00e1ny P. s\u00e9t\u00e1ny 1/A, H-1117, Budapest, Hungary","institution_ids":["https://openalex.org/I106118109"]},{"raw_affiliation_string":"Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), Budapest, Hungary","institution_ids":["https://openalex.org/I106118109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026884101","display_name":"Tam\u00e1s Tur\u00e1nyi","orcid":"https://orcid.org/0000-0002-1461-165X"},"institutions":[{"id":"https://openalex.org/I106118109","display_name":"E\u00f6tv\u00f6s Lor\u00e1nd University","ror":"https://ror.org/01jsq2704","country_code":"HU","type":"education","lineage":["https://openalex.org/I106118109"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Tam\u00e1s Tur\u00e1nyi","raw_affiliation_strings":["Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), P\u00e1zm\u00e1ny P. s\u00e9t\u00e1ny 1/A, H-1117, Budapest, Hungary","Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), P\u00e1zm\u00e1ny P. s\u00e9t\u00e1ny 1/A, H-1117, Budapest, Hungary","institution_ids":["https://openalex.org/I106118109"]},{"raw_affiliation_string":"Laboratory for Chemical Kinetics, Institute of Chemistry, E\u00f6tv\u00f6s University (ELTE), Budapest, Hungary","institution_ids":["https://openalex.org/I106118109"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020843492","display_name":"B\u00e9la Nov\u00e1k","orcid":"https://orcid.org/0000-0002-6961-1366"},"institutions":[{"id":"https://openalex.org/I29770179","display_name":"Budapest University of Technology and Economics","ror":"https://ror.org/02w42ss30","country_code":"HU","type":"education","lineage":["https://openalex.org/I29770179"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"B\u00e9la Nov\u00e1k","raw_affiliation_strings":["Molecular Network Dynamics Research Group of the Hungarian Academy of Sciences and Budapest University of Technology and Economics, Gell\u00e9rt t\u00e9r 4, H-1521, Budapest, Hungary","Molecular Network Dynamics Research Group of the Hungarian Academy of Sciences and Budapest University of Technology and Economics, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Network Dynamics Research Group of the Hungarian Academy of Sciences and Budapest University of Technology and Economics, Gell\u00e9rt t\u00e9r 4, H-1521, Budapest, Hungary","institution_ids":["https://openalex.org/I29770179","https://openalex.org/I7597260"]},{"raw_affiliation_string":"Molecular Network Dynamics Research Group of the Hungarian Academy of Sciences and Budapest University of Technology and Economics, Budapest, Hungary","institution_ids":["https://openalex.org/I29770179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5026884101"],"corresponding_institution_ids":["https://openalex.org/I106118109"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.9545,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.71782745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"494","last_page":"494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8982999920845032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8982999920845032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.057999998331069946,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limit-cycle","display_name":"Limit cycle","score":0.630404531955719},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.5956413745880127},{"id":"https://openalex.org/keywords/steady-state","display_name":"Steady state (chemistry)","score":0.5845699310302734},{"id":"https://openalex.org/keywords/eigenvalues-and-eigenvectors","display_name":"Eigenvalues and eigenvectors","score":0.5028800368309021},{"id":"https://openalex.org/keywords/relaxation","display_name":"Relaxation (psychology)","score":0.4865957498550415},{"id":"https://openalex.org/keywords/mitosis","display_name":"Mitosis","score":0.4790709912776947},{"id":"https://openalex.org/keywords/hopf-bifurcation","display_name":"Hopf bifurcation","score":0.4756840467453003},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.4676133394241333},{"id":"https://openalex.org/keywords/cell-division","display_name":"Cell division","score":0.4344739615917206},{"id":"https://openalex.org/keywords/bifurcation","display_name":"Bifurcation","score":0.4204796850681305},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.4027068018913269},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3845522999763489},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3490966260433197},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29043224453926086},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.21933719515800476},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.19999998807907104},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.16843390464782715},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14425379037857056},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.13464361429214478},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.10802966356277466},{"id":"https://openalex.org/keywords/limit","display_name":"Limit (mathematics)","score":0.09988626837730408}],"concepts":[{"id":"https://openalex.org/C93357160","wikidata":"https://www.wikidata.org/wiki/Q1545916","display_name":"Limit cycle","level":3,"score":0.630404531955719},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5956413745880127},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.5845699310302734},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.5028800368309021},{"id":"https://openalex.org/C2776029896","wikidata":"https://www.wikidata.org/wiki/Q3935810","display_name":"Relaxation (psychology)","level":2,"score":0.4865957498550415},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.4790709912776947},{"id":"https://openalex.org/C172435161","wikidata":"https://www.wikidata.org/wiki/Q531126","display_name":"Hopf bifurcation","level":4,"score":0.4756840467453003},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.4676133394241333},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.4344739615917206},{"id":"https://openalex.org/C2781349735","wikidata":"https://www.wikidata.org/wiki/Q4904824","display_name":"Bifurcation","level":3,"score":0.4204796850681305},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4027068018913269},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3845522999763489},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3490966260433197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29043224453926086},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.21933719515800476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19999998807907104},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16843390464782715},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14425379037857056},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.13464361429214478},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.10802966356277466},{"id":"https://openalex.org/C151201525","wikidata":"https://www.wikidata.org/wiki/Q177239","display_name":"Limit (mathematics)","level":2,"score":0.09988626837730408},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013995","descriptor_name":"Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013995","descriptor_name":"Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013995","descriptor_name":"Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-7-494","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-494","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-494","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17094799","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17094799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:21e0327472c8402781d73a8117d570b8","is_oa":true,"landing_page_url":"https://doaj.org/article/21e0327472c8402781d73a8117d570b8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 494 (2006)","raw_type":"article"},{"id":"pmh:oai:edit.elte.hu:10831/92840","is_oa":true,"landing_page_url":"http://hdl.handle.net/10831/92840","pdf_url":null,"source":{"id":"https://openalex.org/S4306400126","display_name":"ELTE Digital Institutional Repository (EDIT) (E\u00f6tv\u00f6s Lor\u00e1nd University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I106118109","host_organization_name":"E\u00f6tv\u00f6s Lor\u00e1nd University","host_organization_lineage":["https://openalex.org/I106118109"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1660553","is_oa":true,"landing_page_url":"http://doi.org/10.1186/1471-2105-7-494","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-494","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-494","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-494","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1983594455","display_name":null,"funder_award_id":"T043770","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321994","display_name":"Hungarian Scientific Research Fund","ror":"https://ror.org/00v349e63"},{"id":"https://openalex.org/F4320326124","display_name":"E\u00f6tv\u00f6s Lor\u00e1nd Tudom\u00e1nyegyetem","ror":"https://ror.org/01jsq2704"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1525349614.pdf","grobid_xml":"https://content.openalex.org/works/W1525349614.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W55455380","https://openalex.org/W601716862","https://openalex.org/W1486453207","https://openalex.org/W1934183749","https://openalex.org/W1965556226","https://openalex.org/W1966113499","https://openalex.org/W1979434044","https://openalex.org/W1985205248","https://openalex.org/W2004008931","https://openalex.org/W2006682510","https://openalex.org/W2007269038","https://openalex.org/W2015038174","https://openalex.org/W2026362959","https://openalex.org/W2033141310","https://openalex.org/W2037009957","https://openalex.org/W2053806588","https://openalex.org/W2059665827","https://openalex.org/W2061064014","https://openalex.org/W2062319807","https://openalex.org/W2065949669","https://openalex.org/W2068681052","https://openalex.org/W2069076431","https://openalex.org/W2070005695","https://openalex.org/W2075408326","https://openalex.org/W2077278757","https://openalex.org/W2078300553","https://openalex.org/W2078477504","https://openalex.org/W2095571979","https://openalex.org/W2119194326","https://openalex.org/W2129260097","https://openalex.org/W2132936297","https://openalex.org/W2133401281","https://openalex.org/W2141906015","https://openalex.org/W2144702196","https://openalex.org/W2149694811","https://openalex.org/W2152293062","https://openalex.org/W2160256138","https://openalex.org/W2951797124","https://openalex.org/W4285719527","https://openalex.org/W4300200228"],"related_works":["https://openalex.org/W4291538016","https://openalex.org/W2950828455","https://openalex.org/W2183240581","https://openalex.org/W2089802397","https://openalex.org/W1973870711","https://openalex.org/W2040431513","https://openalex.org/W1994849878","https://openalex.org/W1990797765","https://openalex.org/W4280625606","https://openalex.org/W2912850042"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"progress":[2],"through":[3],"the":[4,36,62,90,111,119,122,131,134,139,144,147,151,153,168,203,208,216,220,239,243,265,292,333,337],"eukaryotic":[5],"cell":[6,65,82,114,135,154,169,188,314,323],"division":[7],"cycle":[8,18,66,136,155,170,189,324],"is":[9],"driven":[10,263],"by":[11,224,230,264,309,317],"an":[12,165],"underlying":[13,338],"molecular":[14,339],"regulatory":[15],"network.":[16,340],"Cell":[17],"progression":[19],"can":[20,156,183],"be":[21,157,184],"considered":[22],"as":[23,84],"a":[24,59,85,174,249,310,322,329],"series":[25],"of":[26,58,96,121,124,133,138,146,150,219,242,267,332],"irreversible":[27,187],"transitions":[28,104,190,301,335],"from":[29,198],"one":[30,78],"steady":[31,72,108,177,210,256,303],"state":[32,178,257],"to":[33,246,281],"another":[34],"in":[35,255,336],"correct":[37],"order.":[38],"Although":[39],"this":[40],"view":[41],"has":[42,50,67],"been":[43,52,279],"put":[44],"forward":[45],"some":[46],"time":[47],"ago,":[48],"it":[49],"not":[51,278,307],"quantitatively":[53],"proven":[54],"yet.":[55],"Bifurcation":[56],"analysis":[57,294],"model":[60,222,244],"for":[61,75,79,103,321],"budding":[63,112],"yeast":[64,113],"identified":[68],"only":[69],"two":[70,273],"different":[71,94,107],"states":[73,109,304],"(one":[74],"G1":[76],"and":[77,161,196,258],"mitosis)":[80],"using":[81,93],"mass":[83],"bifurcation":[86,293,311],"parameter.":[87],"By":[88,117],"analyzing":[89],"same":[91],"model,":[92,326],"methods":[95,287],"dynamical":[97,217,240,334],"systems":[98],"theory,":[99],"we":[100,128,327],"provide":[101,328],"evidence":[102],"among":[105],"several":[106],"during":[110,226,232],"cycle.":[115],"RESULTS:":[116],"calculating":[118],"eigenvalues":[120],"Jacobian":[123],"kinetic":[125,252],"differential":[126],"equations":[127],"have":[129,277],"determined":[130],"stability":[132],"trajectories":[137],"Chen":[140],"model.":[141],"Based":[142],"on":[143],"sign":[145],"real":[148],"part":[149],"eigenvalues,":[152],"divided":[158],"into":[159,194],"excitation":[160,166,181,227],"relaxation":[162,201,233,237],"periods.":[163,234],"During":[164,200],"period,":[167],"control":[171,204,284,325],"system":[172,205],"leaves":[173],"formerly":[175],"stable":[176],"and,":[179],"accordingly,":[180],"periods":[182,228],"associated":[185],"with":[186],"like":[191],"START,":[192],"entry":[193],"mitosis":[195],"exit":[197],"mitosis.":[199],"periods,":[202],"asymptotically":[206],"approaches":[207],"new":[209],"state.":[211],"We":[212,271],"also":[213],"show":[214],"that":[215,305],"dimension":[218,241],"Chen's":[221],"fluctuates":[223],"increasing":[225],"followed":[229],"decrease":[231],"In":[235],"each":[236],"period":[238,250],"drops":[245],"one,":[247],"indicating":[248],"where":[251],"processes":[253],"are":[254,262,288,306],"all":[259],"concentration":[260],"changes":[261],"increase":[266],"cytoplasmic":[268],"growth.":[269],"CONCLUSION:":[270],"apply":[272],"numerical":[274],"methods,":[275],"which":[276],"used":[280,295],"analyze":[282],"biological":[283],"systems.":[285],"These":[286],"more":[289],"sensitive":[290],"than":[291],"before":[296],"because":[297],"they":[298],"identify":[299],"those":[300],"between":[302],"controlled":[308],"parameter":[312],"(e.g.":[313],"mass).":[315],"Therefore":[316],"applying":[318],"these":[319],"tools":[320],"deeper":[330],"understanding":[331]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}