{"id":"https://openalex.org/W1481552892","doi":"https://doi.org/10.1186/1471-2105-7-436","title":"ORENZA: a web resource for studying ORphan ENZyme activities","display_name":"ORENZA: a web resource for studying ORphan ENZyme activities","publication_year":2006,"publication_date":"2006-10-06","ids":{"openalex":"https://openalex.org/W1481552892","doi":"https://doi.org/10.1186/1471-2105-7-436","mag":"1481552892","pmid":"https://pubmed.ncbi.nlm.nih.gov/17026747"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-436","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-436","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-436","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-436","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043682944","display_name":"Olivier Lespinet","orcid":"https://orcid.org/0000-0002-4961-7461"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Olivier Lespinet","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique et Microbiologie, CNRS UMR 8621, Universit\u00e9 Paris-Sud, B\u00e2timent 400, 91405 Orsay Cedex, France. olivier.lespinet@igmors.u-psud.fr","Institut de G\u00e9n\u00e9tique et Microbiologie, CNRS UMR 8621, Universit\u00e9 Paris-Sud, Orsay cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et Microbiologie, CNRS UMR 8621, Universit\u00e9 Paris-Sud, B\u00e2timent 400, 91405 Orsay Cedex, France. olivier.lespinet@igmors.u-psud.fr","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et Microbiologie, CNRS UMR 8621, Universit\u00e9 Paris-Sud, Orsay cedex, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016732311","display_name":"Bernard Labedan","orcid":"https://orcid.org/0000-0002-6179-5279"},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Labedan","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique et Microbiologie, CNRS UMR 8621, Universit\u00e9 Paris-Sud, B\u00e2timent 400, 91405, Orsay Cedex, France","Institut de G\u00e9n\u00e9tique et Microbiologie, CNRS UMR 8621, Universit\u00e9 Paris-Sud, Orsay cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et Microbiologie, CNRS UMR 8621, Universit\u00e9 Paris-Sud, B\u00e2timent 400, 91405, Orsay Cedex, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et Microbiologie, CNRS UMR 8621, Universit\u00e9 Paris-Sud, Orsay cedex, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043682944"],"corresponding_institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.9255,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.84322262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"436","last_page":"436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.32109999656677246,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.32109999656677246,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.14920000731945038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.07919999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.5846359729766846},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.5203225612640381},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5070250034332275},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4684477150440216},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.41744473576545715},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3735867738723755},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.3335367441177368},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3068115711212158},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2848902940750122}],"concepts":[{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5846359729766846},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.5203225612640381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5070250034332275},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4684477150440216},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41744473576545715},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3735867738723755},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3335367441177368},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3068115711212158},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2848902940750122}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-7-436","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-436","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-436","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17026747","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17026747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:HAL:hal-00112674v1","is_oa":true,"landing_page_url":"https://hal.science/hal-00112674","pdf_url":"https://hal.science/hal-00112674v1/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 2006, 7, pp.436. &#x27E8;10.1186/1471-2105-7-436&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:HAL:hal-04011247v1","is_oa":false,"landing_page_url":"https://hal.science/hal-04011247","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 2006, 7 (1), pp.436. &#x27E8;10.1186/1471-2105-7-436&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:d6e308ca59a74617a4774dd93e585267","is_oa":true,"landing_page_url":"https://doaj.org/article/d6e308ca59a74617a4774dd93e585267","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 436 (2006)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1609188","is_oa":true,"landing_page_url":"http://doi.org/10.1186/1471-2105-7-436","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-436","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-436","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-436","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5600000023841858,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1481552892.pdf","grobid_xml":"https://content.openalex.org/works/W1481552892.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W217834111","https://openalex.org/W1700503930","https://openalex.org/W1982481323","https://openalex.org/W1995808589","https://openalex.org/W2096525273","https://openalex.org/W2101269636","https://openalex.org/W2104295259","https://openalex.org/W2111973517","https://openalex.org/W2119730342","https://openalex.org/W2132754077","https://openalex.org/W2141356165","https://openalex.org/W2142237411","https://openalex.org/W2144000913","https://openalex.org/W2161062388","https://openalex.org/W4230903726","https://openalex.org/W4245796391","https://openalex.org/W4253017488","https://openalex.org/W4301035320"],"related_works":["https://openalex.org/W2361861616","https://openalex.org/W2263699433","https://openalex.org/W2377979023","https://openalex.org/W2218034408","https://openalex.org/W2392921965","https://openalex.org/W2358755282","https://openalex.org/W2625833328","https://openalex.org/W1533177136","https://openalex.org/W2251519152","https://openalex.org/W4380994516"],"abstract_inverted_index":{"BACKGROUND:":[0],"Despite":[1],"the":[2,18,25,29,103,108,140,147,180,185,188,195,199,230,239,264,294,305],"current":[3],"availability":[4],"of":[5,8,10,17,28,32,55,67,95,119,124,143,184,198,211,236,247,284,287,296],"several":[6],"hundreds":[7],"thousands":[9],"amino":[11,43,217],"acid":[12,44,218],"sequences,":[13],"more":[14],"than":[15],"36%":[16],"enzyme":[19,115,161,213,232,298],"activities":[20,299],"(EC":[21],"numbers)":[22],"defined":[23,106,186],"by":[24,107,238,300],"Nomenclature":[26],"Committee":[27],"International":[30],"Union":[31],"Biochemistry":[33],"and":[34,58,123,130,205,271,286],"Molecular":[35],"Biology":[36],"(NC-IUBMB)":[37],"are":[38,128],"not":[39],"associated":[40,149],"with":[41,110,150,215],"any":[42],"sequence":[45,59,219,272],"in":[46,81,170,191,251,275],"major":[47],"public":[48,252,276],"databases.":[49,253],"This":[50,289],"wide":[51],"gap":[52,266],"separating":[53],"knowledge":[54],"biochemical":[56,182],"function":[57,268],"information":[60,101],"is":[61,71,174,220,256,290],"found":[62],"for":[63,167,179,245],"nearly":[64],"all":[65,120],"classes":[66],"enzymes.":[68,307],"Thus,":[69],"there":[70],"an":[72,160,212,216],"urgent":[73],"need":[74],"to":[75,83,99,138,154,176,226,261,292,304],"explore":[76],"these":[77],"sequence-less":[78],"EC":[79,104,121,126,144,158,249],"numbers,":[80],"order":[82],"progressively":[84,262],"close":[85],"this":[86],"gap.":[87],"DESCRIPTION:":[88],"We":[89],"designed":[90,260],"ORENZA,":[91],"a":[92,156,164,257],"PostgreSQL":[93],"database":[94],"ORphan":[96],"ENZyme":[97],"Activities,":[98],"collate":[100],"about":[102],"numbers":[105,122,127,145,250],"NC-IUBMB":[109],"specific":[111,157],"emphasis":[112],"on":[113],"orphan":[114,125,151,231,248,297],"activities.":[116,233],"Complete":[117],"lists":[118],"available":[129],"will":[131],"be":[132],"periodically":[133],"updated.":[134],"ORENZA":[135,178,255,278],"allows":[136],"one":[137],"browse":[139],"complete":[141],"list":[142],"or":[146,153,163],"subset":[148],"enzymes":[152],"query":[155],"number,":[159],"name":[162,166],"species":[165],"those":[168],"interested":[169],"particular":[171],"organisms.":[172],"It":[173],"possible":[175],"search":[177],"different":[181],"properties":[183],"enzymes,":[187],"metabolic":[189],"pathways":[190],"which":[192],"they":[193],"participate,":[194],"taxonomic":[196],"data":[197],"organisms":[200],"whose":[201],"genomes":[202],"encode":[203],"them,":[204],"many":[206],"other":[207],"features.":[208],"The":[209],"association":[210],"activity":[214],"clearly":[221],"underlined,":[222],"making":[223],"it":[224],"easy":[225],"identify":[227],"at":[228],"once":[229],"Interactive":[234],"publishing":[235],"suggestions":[237],"community":[240],"would":[241],"provide":[242],"expert":[243],"evidence":[244],"re-annotation":[246],"CONCLUSION:":[254],"Web":[258],"resource":[259],"bridge":[263],"unwanted":[265],"between":[267,282],"(enzyme":[269],"activities)":[270],"(dataset":[273],"present":[274],"databases).":[277],"should":[279],"increase":[280],"interactions":[281],"communities":[283],"biochemists":[285],"genomicists.":[288],"expected":[291],"reduce":[293],"number":[295],"allocating":[301],"gene":[302],"sequences":[303],"relevant":[306]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}
