{"id":"https://openalex.org/W1816116508","doi":"https://doi.org/10.1186/1471-2105-7-378","title":"Comprehensive quality control utilizing the prehybridization third-dye image leads to accurate gene expression measurements by cDNA microarrays","display_name":"Comprehensive quality control utilizing the prehybridization third-dye image leads to accurate gene expression measurements by cDNA microarrays","publication_year":2006,"publication_date":"2006-08-14","ids":{"openalex":"https://openalex.org/W1816116508","doi":"https://doi.org/10.1186/1471-2105-7-378","mag":"1816116508","pmid":"https://pubmed.ncbi.nlm.nih.gov/16907976"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-378","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-378","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-378","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-378","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102788743","display_name":"Xujing Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I126218986","display_name":"Children's Hospital of Wisconsin","ror":"https://ror.org/049cbmb74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126218986"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xujing Wang","raw_affiliation_strings":["The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. xujing@mcw.edu","The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. xujing@mcw.edu","institution_ids":["https://openalex.org/I126218986","https://openalex.org/I204308271"]},{"raw_affiliation_string":"The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I126218986","https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100537992","display_name":"Shuang Jia","orcid":"https://orcid.org/0009-0006-2253-382X"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I126218986","display_name":"Children's Hospital of Wisconsin","ror":"https://ror.org/049cbmb74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126218986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuang Jia","raw_affiliation_strings":["The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I126218986","https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091775208","display_name":"Lisa Meyer","orcid":null},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I126218986","display_name":"Children's Hospital of Wisconsin","ror":"https://ror.org/049cbmb74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126218986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Meyer","raw_affiliation_strings":["The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I126218986","https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057362560","display_name":"Bixia Xiang","orcid":null},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I126218986","display_name":"Children's Hospital of Wisconsin","ror":"https://ror.org/049cbmb74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126218986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bixia Xiang","raw_affiliation_strings":["The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I126218986","https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032051987","display_name":"Li-Yen Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li-Yen Chen","raw_affiliation_strings":["The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009577668","display_name":"Nan Jiang","orcid":"https://orcid.org/0000-0001-8460-3949"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nan Jiang","raw_affiliation_strings":["NimbleGen Systems Inc., 1 Science Court, Madison, WI, 53711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NimbleGen Systems Inc., 1 Science Court, Madison, WI, 53711, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056554686","display_name":"Carol Moreno","orcid":"https://orcid.org/0000-0003-3275-0271"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Moreno","raw_affiliation_strings":["The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070802128","display_name":"Howard J. Jacob","orcid":"https://orcid.org/0000-0002-1521-3055"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard J Jacob","raw_affiliation_strings":["The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019318755","display_name":"Soumitra Ghosh","orcid":"https://orcid.org/0000-0002-8376-8677"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I126218986","display_name":"Children's Hospital of Wisconsin","ror":"https://ror.org/049cbmb74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126218986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soumitra Ghosh","raw_affiliation_strings":["The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I126218986","https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034542132","display_name":"Martin J. Hessner","orcid":"https://orcid.org/0000-0001-9941-0314"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I126218986","display_name":"Children's Hospital of Wisconsin","ror":"https://ror.org/049cbmb74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126218986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin J Hessner","raw_affiliation_strings":["The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Human and Molecular Genetics Center, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA","institution_ids":["https://openalex.org/I126218986","https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5102788743"],"corresponding_institution_ids":["https://openalex.org/I126218986","https://openalex.org/I204308271"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.9542,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.71821844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"7","issue":"1","first_page":"378","last_page":"378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9433000087738037,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9433000087738037,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.8185741305351257},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.637300431728363},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.556544303894043},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.550557553768158},{"id":"https://openalex.org/keywords/gene-chip-analysis","display_name":"Gene chip analysis","score":0.5490541458129883},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5007429122924805},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4974530041217804},{"id":"https://openalex.org/keywords/microarray-databases","display_name":"Microarray databases","score":0.4911796748638153},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4431614875793457},{"id":"https://openalex.org/keywords/complementary-dna","display_name":"Complementary DNA","score":0.42917096614837646},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4285047650337219},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.41107600927352905},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.31311923265457153},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3053058385848999}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.8185741305351257},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.637300431728363},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.556544303894043},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.550557553768158},{"id":"https://openalex.org/C24361400","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Gene chip analysis","level":5,"score":0.5490541458129883},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5007429122924805},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4974530041217804},{"id":"https://openalex.org/C548314002","wikidata":"https://www.wikidata.org/wiki/Q6839218","display_name":"Microarray databases","level":5,"score":0.4911796748638153},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4431614875793457},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.42917096614837646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4285047650337219},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41107600927352905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31311923265457153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3053058385848999},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-7-378","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-378","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-378","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16907976","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16907976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:92d41c03a6364ba9ac616b119d71d18a","is_oa":false,"landing_page_url":"https://doaj.org/article/92d41c03a6364ba9ac616b119d71d18a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 378 (2006)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1563483","is_oa":true,"landing_page_url":"http://doi.org/10.1186/1471-2105-7-378","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-378","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-378","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-378","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","score":0.4699999988079071,"id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1816116508.pdf","grobid_xml":"https://content.openalex.org/works/W1816116508.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1498862674","https://openalex.org/W1586080684","https://openalex.org/W1603044149","https://openalex.org/W1801728064","https://openalex.org/W1857558819","https://openalex.org/W1960864427","https://openalex.org/W1961280822","https://openalex.org/W1964253326","https://openalex.org/W1967053372","https://openalex.org/W1986381857","https://openalex.org/W1992794281","https://openalex.org/W2002084557","https://openalex.org/W2017977879","https://openalex.org/W2025139597","https://openalex.org/W2038644720","https://openalex.org/W2059288813","https://openalex.org/W2067385113","https://openalex.org/W2085742009","https://openalex.org/W2096037842","https://openalex.org/W2098453858","https://openalex.org/W2100668965","https://openalex.org/W2101011196","https://openalex.org/W2108244474","https://openalex.org/W2117607208","https://openalex.org/W2125488056","https://openalex.org/W2127938920","https://openalex.org/W2135230352","https://openalex.org/W2139025111","https://openalex.org/W2141009231","https://openalex.org/W2147353173","https://openalex.org/W2154116661","https://openalex.org/W2164155888","https://openalex.org/W2167190345","https://openalex.org/W2168846334","https://openalex.org/W2170973713","https://openalex.org/W2416232867","https://openalex.org/W4232903880"],"related_works":["https://openalex.org/W170658859","https://openalex.org/W2151007749","https://openalex.org/W2051808073","https://openalex.org/W2160130936","https://openalex.org/W1996185163","https://openalex.org/W1547158732","https://openalex.org/W2081127504","https://openalex.org/W1594655861","https://openalex.org/W2490137852","https://openalex.org/W3023720143"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gene":[1],"expression":[2,121,198],"profiling":[3],"using":[4,124,203],"microarrays":[5],"has":[6],"become":[7],"an":[8],"important":[9],"genetic":[10],"tool.":[11],"Spotted":[12],"arrays":[13],"prepared":[14],"in":[15,64,85,136,162],"academic":[16],"labs":[17],"have":[18,44],"the":[19,105,130,141,163,182,204],"advantage":[20,63],"of":[21,74,98,107,134,181,184],"low":[22],"cost":[23],"and":[24,27,91,110,116,139,174,187],"high":[25],"design":[26],"content":[28],"flexibility,":[29],"but":[30],"are":[31],"often":[32],"limited":[33],"by":[34,143],"their":[35],"susceptibility":[36],"to":[37,81],"quality":[38,108],"control":[39,137],"(QC)":[40],"issues.":[41],"Previously,":[42],"we":[43,59],"reported":[45],"a":[46,178,189],"novel":[47],"3-color":[48],"microarray":[49,164,172,206],"technology":[50],"that":[51,71,194],"enabled":[52,177],"array":[53],"fabrication":[54],"QC.":[55,67,192],"In":[56,148],"this":[57],"report":[58],"further":[60],"investigated":[61],"its":[62],"spot-level":[65],"data":[66,89,126,185],"RESULTS:":[68],"We":[69,118],"found":[70],"inadequate":[72],"amount":[73],"bound":[75],"probes":[76],"available":[77],"for":[78],"hybridization":[79],"led":[80],"significant,":[82],"gene-specific":[83],"compression":[84,161],"ratio":[86],"measurements,":[87],"increased":[88],"variability,":[90],"printing":[92],"pin":[93],"dependent":[94],"heterogeneities.":[95],"The":[96],"impact":[97],"such":[99],"problems":[100],"can":[101,200],"be":[102,201],"captured":[103],"through":[104,113],"definition":[106],"scores,":[109],"efficiently":[111],"controlled":[112],"quality-dependent":[114],"filtering":[115],"normalization.":[117],"compared":[119],"gene":[120,197],"measurements":[122,142,165,199],"derived":[123],"our":[125],"processing":[127],"pipeline":[128],"with":[129,140,159],"known":[131],"input":[132],"ratios":[133],"spiked":[135],"clones,":[138],"quantitative":[144],"real":[145],"time":[146],"RT-PCR.":[147],"each":[149],"case,":[150],"highly":[151,195],"linear":[152],"relationships":[153],"(R2":[154],">":[155],"0.94)":[156],"were":[157],"observed,":[158],"modest":[160],"(correction":[166],"factor":[167],"<":[168],"1.17).":[169],"CONCLUSION:":[170],"Our":[171],"analytical":[173],"technical":[175],"advancements":[176],"better":[179],"dissection":[180],"sources":[183],"variability":[186],"hence":[188],"more":[190],"efficient":[191],"With":[193],"accurate":[196],"achieved":[202],"cDNA":[205],"technology.":[207]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
