{"id":"https://openalex.org/W1814100322","doi":"https://doi.org/10.1186/1471-2105-7-366","title":"bioNMF: a versatile tool for non-negative matrix factorization in biology","display_name":"bioNMF: a versatile tool for non-negative matrix factorization in biology","publication_year":2006,"publication_date":"2006-07-28","ids":{"openalex":"https://openalex.org/W1814100322","doi":"https://doi.org/10.1186/1471-2105-7-366","mag":"1814100322","pmid":"https://pubmed.ncbi.nlm.nih.gov/16875499"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-366","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-366","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-366","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-366","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072639458","display_name":"Alberto Pascual-Montano","orcid":null},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Alberto Pascual-Montano","raw_affiliation_strings":["Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, 28040, Spain. pascual@fis.ucm.es","Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, 28040, Spain. pascual@fis.ucm.es","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079394518","display_name":"Pedro Carmona\u2010S\u00e1ez","orcid":"https://orcid.org/0000-0002-6173-7255"},"institutions":[{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pedro Carmona-Saez","raw_affiliation_strings":["BioComputing Unit, National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, 28049, Spain","BioComputing Unit. National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioComputing Unit, National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, 28049, Spain","institution_ids":["https://openalex.org/I4210104776","https://openalex.org/I63634437"]},{"raw_affiliation_string":"BioComputing Unit. National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030602787","display_name":"M\u00f3nica Chagoyen","orcid":"https://orcid.org/0000-0001-6911-1591"},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Monica Chagoyen","raw_affiliation_strings":["BioComputing Unit, National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, 28049, Spain","Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, 28040, Spain","BioComputing Unit, National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, Spain","Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, , Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioComputing Unit, National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, 28049, Spain","institution_ids":["https://openalex.org/I4210104776","https://openalex.org/I63634437"]},{"raw_affiliation_string":"Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, 28040, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"BioComputing Unit, National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, , Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062402935","display_name":"Francisco Tirado","orcid":"https://orcid.org/0000-0003-0974-2687"},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Tirado","raw_affiliation_strings":["Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, 28040, Spain","Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, 28040, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Computer Architecture Department, Facultad de Ciencias F\u00edsicas, Universidad Complutense de Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046960969","display_name":"J.M. Carazo","orcid":"https://orcid.org/0000-0003-0788-8447"},"institutions":[{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose M Carazo","raw_affiliation_strings":["BioComputing Unit, National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, 28049, Spain","BioComputing Unit. National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioComputing Unit, National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, 28049, Spain","institution_ids":["https://openalex.org/I4210104776","https://openalex.org/I63634437"]},{"raw_affiliation_string":"BioComputing Unit. National Center of Biotechnology, Campus Universidad Aut\u00f3noma de Madrid, Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005237564","display_name":"Roberto D. Pascual\u2010Marqui","orcid":"https://orcid.org/0000-0002-5029-4065"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto D Pascual-Marqui","raw_affiliation_strings":["The KEY Institute for Brain-Mind Research, University Hospital of Psychiatry. Lenggstr. 31, CH-8029, Zurich, Switzerland","The KEY Institute for Brain-Mind Research, University Hospital of Psychiatry. Lenggstr. 31, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The KEY Institute for Brain-Mind Research, University Hospital of Psychiatry. Lenggstr. 31, CH-8029, Zurich, Switzerland","institution_ids":[]},{"raw_affiliation_string":"The KEY Institute for Brain-Mind Research, University Hospital of Psychiatry. Lenggstr. 31, Zurich, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5072639458"],"corresponding_institution_ids":["https://openalex.org/I121748325"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.0,"has_fulltext":true,"cited_by_count":90,"citation_normalized_percentile":{"value":0.90782235,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"366","last_page":"366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.03750000149011612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biclustering","display_name":"Biclustering","score":0.7507983446121216},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7175090909004211},{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"Non-negative matrix factorization","score":0.6961124539375305},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6188434362411499},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.6048400402069092},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.5838474035263062},{"id":"https://openalex.org/keywords/graphical-user-interface","display_name":"Graphical user interface","score":0.5739356279373169},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.5385364890098572},{"id":"https://openalex.org/keywords/interface","display_name":"Interface (matter)","score":0.49678900837898254},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.47029921412467957},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.37280553579330444},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3446807861328125},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3001708984375},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13664856553077698},{"id":"https://openalex.org/keywords/fuzzy-clustering","display_name":"Fuzzy clustering","score":0.12744557857513428}],"concepts":[{"id":"https://openalex.org/C144817290","wikidata":"https://www.wikidata.org/wiki/Q2976575","display_name":"Biclustering","level":5,"score":0.7507983446121216},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7175090909004211},{"id":"https://openalex.org/C152671427","wikidata":"https://www.wikidata.org/wiki/Q10843505","display_name":"Non-negative matrix factorization","level":4,"score":0.6961124539375305},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6188434362411499},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.6048400402069092},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.5838474035263062},{"id":"https://openalex.org/C37789001","wikidata":"https://www.wikidata.org/wiki/Q782543","display_name":"Graphical user interface","level":2,"score":0.5739356279373169},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.5385364890098572},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.49678900837898254},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.47029921412467957},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.37280553579330444},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3446807861328125},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3001708984375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13664856553077698},{"id":"https://openalex.org/C17212007","wikidata":"https://www.wikidata.org/wiki/Q5511111","display_name":"Fuzzy clustering","level":3,"score":0.12744557857513428},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C33704608","wikidata":"https://www.wikidata.org/wiki/Q5014717","display_name":"CURE data clustering algorithm","level":4,"score":0.0},{"id":"https://openalex.org/C129307140","wikidata":"https://www.wikidata.org/wiki/Q6795880","display_name":"Maximum bubble pressure method","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1471-2105-7-366","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-366","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-366","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16875499","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16875499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:doi:10.5167/uzh-24","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4406922384","display_name":"Open MIND","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:digital.csic.es:10261/17471","is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/17471","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:doaj.org/article:8090d9b6c2f4431d81a7581936f790be","is_oa":false,"landing_page_url":"https://doaj.org/article/8090d9b6c2f4431d81a7581936f790be","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 366 (2006)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:350654","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1550731","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1550731","is_oa":true,"landing_page_url":"http://doi.org/10.1186/1471-2105-7-366","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:www.ucm.es:36321","is_oa":false,"landing_page_url":"http://eprints.ucm.es/36321/1/tirado37libre%2BCC.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400298","display_name":"Library Open Repository (Universidad Complutense Madrid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121748325","host_organization_name":"Universidad Complutense de Madrid","host_organization_lineage":["https://openalex.org/I121748325"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-366","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-366","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-366","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325124","display_name":"CYTED Ciencia y Tecnolog\u00eda para el Desarrollo","ror":"https://ror.org/03myqtf56"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1814100322.pdf","grobid_xml":"https://content.openalex.org/works/W1814100322.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1538685017","https://openalex.org/W1548779692","https://openalex.org/W1902027874","https://openalex.org/W1977859620","https://openalex.org/W2006919923","https://openalex.org/W2041236924","https://openalex.org/W2064690543","https://openalex.org/W2092423825","https://openalex.org/W2096603500","https://openalex.org/W2097793061","https://openalex.org/W2109363337","https://openalex.org/W2113847750","https://openalex.org/W2125015667","https://openalex.org/W2125173990","https://openalex.org/W2125512776","https://openalex.org/W2135029798","https://openalex.org/W2136787567","https://openalex.org/W2136992683","https://openalex.org/W2144544802","https://openalex.org/W2144792853","https://openalex.org/W2146264532","https://openalex.org/W2146892804","https://openalex.org/W2146913572","https://openalex.org/W2147368249","https://openalex.org/W2152320972","https://openalex.org/W2158599626","https://openalex.org/W2163988673","https://openalex.org/W3143596294"],"related_works":["https://openalex.org/W2611629964","https://openalex.org/W2127243424","https://openalex.org/W2037504162","https://openalex.org/W4390394189","https://openalex.org/W2792706544","https://openalex.org/W1568451138","https://openalex.org/W2539013788","https://openalex.org/W2156699640","https://openalex.org/W2045265907","https://openalex.org/W2972997031"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,102],"the":[2,31,64,70,77,114,125,180,208,213],"Bioinformatics":[3],"field,":[4],"a":[5,107,164,188],"great":[6],"deal":[7],"of":[8,23,43,57,94,124,130,147,207],"interest":[9,65],"has":[10,46,73],"been":[11,47,74],"given":[12],"to":[13,20,50,89,121,168,217],"Non-negative":[14],"matrix":[15],"factorization":[16],"technique":[17,68],"(NMF),":[18],"due":[19],"its":[21,44],"capability":[22],"providing":[24],"new":[25,132,219],"insights":[26],"and":[27,41,59,109,137,150,175],"relevant":[28],"information":[29],"about":[30],"complex":[32],"latent":[33],"relationships":[34],"in":[35,97,117,171,177,212],"experimental":[36],"data":[37,95,182],"sets.":[38],"This":[39,134,224],"method,":[40],"some":[42,123],"variants,":[45],"successfully":[48],"applied":[49],"gene":[51,139,154],"expression,":[52],"sequence":[53,143],"analysis,":[54,144],"functional":[55],"characterization":[56],"genes":[58],"text":[60,145],"mining.":[61],"Even":[62],"if":[63],"on":[66],"this":[67,103,131,178,222],"by":[69],"bioinformatics":[71,214],"community":[72],"increased":[75],"during":[76],"last":[78],"few":[79],"years,":[80],"there":[81],"are":[82],"not":[83,194],"many":[84],"available":[85,228],"simple":[86],"standalone":[87,189],"tools":[88],"specifically":[90],"perform":[91],"these":[92],"types":[93],"analysis":[96,119,183],"an":[98,172],"integrated":[99],"environment.":[100],"RESULTS:":[101],"work":[104],"we":[105],"propose":[106],"versatile":[108,190],"user-friendly":[110,165],"tool":[111,225],"that":[112],"implements":[113],"NMF":[115],"methodology":[116],"different":[118],"contexts":[120],"support":[122,218],"most":[126,206],"important":[127],"reported":[128],"applications":[129,210],"methodology.":[133],"includes":[135],"clustering":[136],"biclustering":[138],"expression":[140],"data,":[141],"protein":[142],"mining":[146],"biomedical":[148],"literature":[149],"sample":[151],"classification":[152],"using":[153,221],"expression.":[155],"The":[156],"tool,":[157],"which":[158,192],"is":[159,187,226],"named":[160],"bioNMF,":[161],"also":[162],"contains":[163],"graphical":[166],"interface":[167],"explore":[169],"results":[170],"interactive":[173],"manner":[174],"facilitate":[176],"way":[179],"exploratory":[181],"process.":[184],"CONCLUSION:":[185],"bioNMF":[186],"application":[191],"does":[193],"require":[195],"any":[196],"special":[197],"installation":[198],"or":[199,216],"libraries.":[200],"It":[201],"can":[202],"be":[203],"used":[204],"for":[205],"multiple":[209],"proposed":[211],"field":[215],"research":[220],"method.":[223],"publicly":[227],"at":[229],"http://www.dacya.ucm.es/apascual/bioNMF.":[230]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}