{"id":"https://openalex.org/W1629279812","doi":"https://doi.org/10.1186/1471-2105-7-364","title":"Improving the quality of protein structure models by selecting from alignment alternatives","display_name":"Improving the quality of protein structure models by selecting from alignment alternatives","publication_year":2006,"publication_date":"2006-07-27","ids":{"openalex":"https://openalex.org/W1629279812","doi":"https://doi.org/10.1186/1471-2105-7-364","mag":"1629279812","pmid":"https://pubmed.ncbi.nlm.nih.gov/16872519"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-364","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-364","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-364","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-364","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102778617","display_name":"I. Sommer","orcid":"https://orcid.org/0000-0002-2682-5313"},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ingolf Sommer","raw_affiliation_strings":["Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Stuhlsatzenhausweg 85, D-66123 Saarbr\u00fccken, Germany. sommer@mpi-sb.mpg.de","Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Stuhlsatzenhausweg 85, D-66123 Saarbr\u00fccken, Germany. sommer@mpi-sb.mpg.de","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071924678","display_name":"Stefano Toppo","orcid":"https://orcid.org/0000-0002-0246-3119"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Toppo","raw_affiliation_strings":["Department of Biological Chemistry, University of Padova, via U. Bassi 58/b, 1-35121, Padova, Italy","Department of Biological Chemistry, University of Padova, Padova, (Italy)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Padova, via U. Bassi 58/b, 1-35121, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Department of Biological Chemistry, University of Padova, Padova, (Italy)","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082524584","display_name":"Oliver Sander","orcid":"https://orcid.org/0000-0003-1093-6374"},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Sander","raw_affiliation_strings":["Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Stuhlsatzenhausweg 85, D-66123, Saarbr\u00fccken, Germany","Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Stuhlsatzenhausweg 85, D-66123, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023556977","display_name":"Thomas Lengauer","orcid":"https://orcid.org/0000-0003-3801-2640"},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Lengauer","raw_affiliation_strings":["Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Stuhlsatzenhausweg 85, D-66123, Saarbr\u00fccken, Germany","Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Stuhlsatzenhausweg 85, D-66123, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max-Planck-lnstitute for Informatics, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066560665","display_name":"Silvio C. E. Tosatto","orcid":"https://orcid.org/0000-0003-4525-7793"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]}],"countries":["DE","IT"],"is_corresponding":false,"raw_author_name":"Silvio CE Tosatto","raw_affiliation_strings":["Department of Biology and CRIBI Biotechnology Centre University of Padova, V.le G. Colombo 3, I-35131, Padova, Italy","Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and CRIBI Biotechnology Centre University of Padova, V.le G. Colombo 3, I-35131, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society","institution_ids":["https://openalex.org/I149899117"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102778617"],"corresponding_institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210109712"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":1090,"currency":"EUR","value_usd":1175},"fwci":1.3987,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.78341853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"1","first_page":"364","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9104999899864197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9104999899864197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5877780914306641},{"id":"https://openalex.org/keywords/quality","display_name":"Quality (philosophy)","score":0.5486144423484802},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4961431920528412},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4928272068500519},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"Protein structure prediction","score":0.4565413296222687},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.35912424325942993},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3200330138206482},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.29349902272224426},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23501303791999817},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1392045021057129},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07328912615776062}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5877780914306641},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.5486144423484802},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4961431920528412},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4928272068500519},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.4565413296222687},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35912424325942993},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3200330138206482},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.29349902272224426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23501303791999817},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1392045021057129},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07328912615776062},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2105-7-364","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-364","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-364","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16872519","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16872519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a4b83b73bdfe41b8a31a9b550b939872","is_oa":true,"landing_page_url":"https://doaj.org/article/a4b83b73bdfe41b8a31a9b550b939872","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 364 (2006)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:314404","is_oa":false,"landing_page_url":"http://edoc.mpg.de/314404","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, v.7, 1-11 (2006)","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1579234","is_oa":true,"landing_page_url":"http://doi.org/10.1186/1471-2105-7-364","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_1328442","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-000F-2330-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.research.unipd.it:11577/2449295","is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/2449295","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-364","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-364","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-364","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1629279812.pdf","grobid_xml":"https://content.openalex.org/works/W1629279812.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1549656520","https://openalex.org/W1554935168","https://openalex.org/W1618905105","https://openalex.org/W1989777815","https://openalex.org/W1996051469","https://openalex.org/W2015403140","https://openalex.org/W2030028095","https://openalex.org/W2057447180","https://openalex.org/W2061033843","https://openalex.org/W2063597362","https://openalex.org/W2071486470","https://openalex.org/W2091809126","https://openalex.org/W2099075703","https://openalex.org/W2099667027","https://openalex.org/W2102533986","https://openalex.org/W2106154817","https://openalex.org/W2108376320","https://openalex.org/W2110483430","https://openalex.org/W2125725297","https://openalex.org/W2133657429","https://openalex.org/W2139270371","https://openalex.org/W2144357990","https://openalex.org/W2144574197","https://openalex.org/W2145358391","https://openalex.org/W2147667050","https://openalex.org/W2149478651","https://openalex.org/W2150434184","https://openalex.org/W2153635508","https://openalex.org/W2157938277","https://openalex.org/W2161151688","https://openalex.org/W2161776897","https://openalex.org/W2168508791","https://openalex.org/W3120421331","https://openalex.org/W3201413583"],"related_works":["https://openalex.org/W2415545834","https://openalex.org/W2069695727","https://openalex.org/W2118505788","https://openalex.org/W4254166511","https://openalex.org/W2150084125","https://openalex.org/W1542823905","https://openalex.org/W1490878237","https://openalex.org/W2990314835","https://openalex.org/W2131319730","https://openalex.org/W2059850119"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,187],"the":[2,16,46,69,85,123,132,136,140,147,178,200,222],"area":[3],"of":[4,11,18,48,62,73,118,122,210,224],"protein":[5,28,189],"structure":[6,29,190],"prediction,":[7],"recently":[8],"a":[9,37,51,60,115,151,162,197,208],"lot":[10],"effort":[12],"has":[13,111],"gone":[14],"into":[15],"development":[17],"Model":[19],"Quality":[20],"Assessment":[21],"Programs":[22],"(MQAPs).":[23],"MQAPs":[24],"distinguish":[25],"high":[26],"quality":[27,47,72,142,156,223],"models":[30,67,75,127],"from":[31],"inferior":[32],"models.":[33,49,226],"Here,":[34],"we":[35,58,205],"propose":[36],"new":[38],"method":[39,124],"to":[40,44,83,102,125,135,195],"use":[41],"an":[42,79],"MQAP":[43,80,97],"improve":[45,126,221],"With":[50],"given":[52],"target":[53],"sequence":[54],"and":[55,65,81,214],"template":[56],"structure,":[57],"construct":[59],"number":[61],"different":[63],"alignments":[64],"corresponding":[66],"for":[68,95,104],"sequence.":[70],"The":[71,109,120,171],"these":[74],"is":[76,93,157,176,184,193],"scored":[77],"with":[78,139,161],"used":[82],"choose":[84],"most":[86],"promising":[87],"model.":[88],"An":[89],"SVM-based":[90,148],"selection":[91],"scheme":[92],"suggested":[94],"combining":[96],"partial":[98],"potentials,":[99],"in":[100,154,174,182],"order":[101],"optimize":[103],"improved":[105],"model":[106,141,149,155,202,216],"selection.":[107],"RESULTS:":[108],"approach":[110],"been":[112],"tested":[113],"on":[114],"representative":[116],"set":[117],"proteins.":[119],"ability":[121],"was":[128],"validated":[129],"by":[130],"comparing":[131],"MQAP-selected":[133],"structures":[134,138],"native":[137],"evaluation":[143],"program":[144],"TM-score.":[145],"Using":[146],"selection,":[150],"significant":[152],"increase":[153,173,181],"obtained":[158],"(as":[159],"shown":[160],"Wilcoxon":[163],"signed":[164],"rank":[165],"test":[166],"yielding":[167],"p-values":[168],"below":[169],"10(-15)).":[170],"average":[172],"TMscore":[175],"0.016,":[177],"maximum":[179],"observed":[180],"TM-score":[183],"0.29.":[185],"CONCLUSION:":[186],"template-based":[188],"prediction":[191],"alignment":[192,212],"known":[194],"be":[196],"bottleneck":[198],"limiting":[199],"overall":[201],"quality.":[203],"Here":[204],"show":[206],"that":[207],"combination":[209],"systematic":[211],"variation":[213],"modern":[215],"scoring":[217],"functions":[218],"can":[219],"significantly":[220],"alignment-based":[225]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}