{"id":"https://openalex.org/W1599936794","doi":"https://doi.org/10.1186/1471-2105-7-34","title":"A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks","display_name":"A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks","publication_year":2006,"publication_date":"2006-01-23","ids":{"openalex":"https://openalex.org/W1599936794","doi":"https://doi.org/10.1186/1471-2105-7-34","mag":"1599936794","pmid":"https://pubmed.ncbi.nlm.nih.gov/16430778"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-34","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-34","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-34","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-34","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052161376","display_name":"H. Conzelmann","orcid":null},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Holger Conzelmann","raw_affiliation_strings":["Institute for System Dynamics and Control Engineering, University of Stuttgart, Pfaffenwaldring 9, 70569 Stuttgart, Germany. Conzelmann@isr.uni-stuttgart.de","Institute for System Dynamics and Control Engineering, University of Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for System Dynamics and Control Engineering, University of Stuttgart, Pfaffenwaldring 9, 70569 Stuttgart, Germany. Conzelmann@isr.uni-stuttgart.de","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Institute for System Dynamics and Control Engineering, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005499510","display_name":"Julio S\u00e1ez-Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-8552-8976"},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julio Saez-Rodriguez","raw_affiliation_strings":["Max-Planck-lnstitute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106, Magdeburg, Germany","Max-Planck-lnstitute for Dynamics of Complex Technical Systems, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-lnstitute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]},{"raw_affiliation_string":"Max-Planck-lnstitute for Dynamics of Complex Technical Systems, Magdeburg, Germany","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050871083","display_name":"Thomas Sauter","orcid":"https://orcid.org/0000-0001-8225-2954"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Sauter","raw_affiliation_strings":["Institute for System Dynamics and Control Engineering, University of Stuttgart, Pfaffenwaldring 9, 70569, Stuttgart, Germany","Institute for System Dynamics and Control Engineering, University of Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for System Dynamics and Control Engineering, University of Stuttgart, Pfaffenwaldring 9, 70569, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Institute for System Dynamics and Control Engineering, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003776093","display_name":"Boris \u039d. Kholodenko","orcid":"https://orcid.org/0000-0002-9483-4975"},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boris N Kholodenko","raw_affiliation_strings":["Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA, 19107, USA","Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University Philadelphia USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA, 19107, USA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University Philadelphia USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105425269","display_name":"Ernst D Gilles","orcid":null},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ernst D Gilles","raw_affiliation_strings":["Institute for System Dynamics and Control Engineering, University of Stuttgart, Pfaffenwaldring 9, 70569, Stuttgart, Germany","Max-Planck-lnstitute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106, Magdeburg, Germany","Institute for System Dynamics and Control Engineering, University of Stuttgart, Stuttgart, Germany","Max-Planck-lnstitute for Dynamics of Complex Technical Systems, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for System Dynamics and Control Engineering, University of Stuttgart, Pfaffenwaldring 9, 70569, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Max-Planck-lnstitute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]},{"raw_affiliation_string":"Institute for System Dynamics and Control Engineering, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Max-Planck-lnstitute for Dynamics of Complex Technical Systems, Magdeburg, Germany","institution_ids":["https://openalex.org/I149899117"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5052161376"],"corresponding_institution_ids":["https://openalex.org/I100066346"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":4.2272,"has_fulltext":true,"cited_by_count":93,"citation_normalized_percentile":{"value":0.94553452,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"34","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.5081999897956848,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.5081999897956848,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.20010000467300415,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.561169445514679},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5473816394805908},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.5306443572044373},{"id":"https://openalex.org/keywords/combinatorial-explosion","display_name":"Combinatorial explosion","score":0.5035998225212097},{"id":"https://openalex.org/keywords/variety","display_name":"Variety (cybernetics)","score":0.4844055771827698},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4467742443084717},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3493213653564453},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3390595614910126},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.32902613282203674},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2037101686000824},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18227025866508484}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.561169445514679},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5473816394805908},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5306443572044373},{"id":"https://openalex.org/C115908005","wikidata":"https://www.wikidata.org/wiki/Q2668364","display_name":"Combinatorial explosion","level":2,"score":0.5035998225212097},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.4844055771827698},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4467742443084717},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3493213653564453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3390595614910126},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.32902613282203674},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2037101686000824},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18227025866508484},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1186/1471-2105-7-34","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-34","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-34","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16430778","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16430778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:jdc.jefferson.edu:pacbfp-1003","is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/pacbfp/3","pdf_url":"https://jdc.jefferson.edu/pacbfp/3","source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Pathology, Anatomy, and Cell Biology Faculty Papers","raw_type":"article"},{"id":"pmh:oai:pure.mpg.de:item_1757302","is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0013-9AA4-6","pdf_url":"http://hdl.handle.net/11858/00-001M-0000-0013-9AA4-6","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:aafd96501c2b474499bcfa8e679b2531","is_oa":false,"landing_page_url":"https://doaj.org/article/aafd96501c2b474499bcfa8e679b2531","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 34 (2006)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:216324","is_oa":false,"landing_page_url":"http://edoc.mpg.de/216324","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Poster"},{"id":"pmh:oai:edoc.mpg.de:239966","is_oa":false,"landing_page_url":"http://edoc.mpg.de/239966","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, v.7 (2006)","raw_type":"Article"},{"id":"pmh:oai:opus4.hsfu:9045","is_oa":true,"landing_page_url":"https://opus.hs-furtwangen.de/frontdoor/index/index/docId/9045","pdf_url":null,"source":{"id":"https://openalex.org/S4377196512","display_name":"Repository of Futwangen University of Applied Sciences (Furtwangen University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I882953328","host_organization_name":"Furtwangen University","host_organization_lineage":["https://openalex.org/I882953328"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:orbilu.uni.lu:10993/803","is_oa":false,"landing_page_url":"https://orbilu.uni.lu/handle/10993/803","pdf_url":null,"source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 7, 34 (2006)","raw_type":"peer reviewed"},{"id":"pmh:oai:pubmedcentral.nih.gov:1413560","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1413560","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_1757534","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0013-9C51-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-34","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-34","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-34","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6600000262260437,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1599936794.pdf","grobid_xml":"https://content.openalex.org/works/W1599936794.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1485942758","https://openalex.org/W1693076983","https://openalex.org/W1987129107","https://openalex.org/W2001620484","https://openalex.org/W2007393641","https://openalex.org/W2022864842","https://openalex.org/W2028415754","https://openalex.org/W2030630541","https://openalex.org/W2034492556","https://openalex.org/W2038398800","https://openalex.org/W2044784465","https://openalex.org/W2047329119","https://openalex.org/W2067160012","https://openalex.org/W2068209123","https://openalex.org/W2071523020","https://openalex.org/W2071928210","https://openalex.org/W2075161553","https://openalex.org/W2112651905","https://openalex.org/W2113950027","https://openalex.org/W2121811364","https://openalex.org/W2133667940","https://openalex.org/W2134800568","https://openalex.org/W2138321569","https://openalex.org/W2139941949","https://openalex.org/W2145080853","https://openalex.org/W2153624566","https://openalex.org/W2163493106","https://openalex.org/W2165700291","https://openalex.org/W3160954918","https://openalex.org/W4211075026","https://openalex.org/W4243826908","https://openalex.org/W4254344576"],"related_works":["https://openalex.org/W2032233321","https://openalex.org/W3121970507","https://openalex.org/W2110028391","https://openalex.org/W54497855","https://openalex.org/W217960748","https://openalex.org/W3125814499","https://openalex.org/W2090827041","https://openalex.org/W2565703248","https://openalex.org/W187246281","https://openalex.org/W2143548620"],"abstract_inverted_index":{"BACKGROUND:":[0],"Receptors":[1],"and":[2,11,49,136,150],"scaffold":[3],"proteins":[4,135],"possess":[5],"a":[6,24,96,101,148],"number":[7,36,44],"of":[8,27,37,45,79,104,115,117,122,125,161],"distinct":[9],"domains":[10],"bind":[12],"multiple":[13],"partners.":[14],"A":[15],"common":[16],"problem":[17],"in":[18],"modeling":[19],"signaling":[20,80,105],"systems":[21],"arises":[22],"from":[23],"combinatorial":[25,59],"explosion":[26],"different":[28,46],"states":[29],"generated":[30],"by":[31,86],"feasible":[32],"molecular":[33],"species.":[34],"The":[35,91,128,144],"possible":[38],"species":[39],"grows":[40],"exponentially":[41],"with":[42],"the":[43,77,113,118,140,159],"docking":[47],"sites":[48],"can":[50,82],"easily":[51],"reach":[52],"several":[53],"millions.":[54],"Models":[55],"accounting":[56],"for":[57,63],"this":[58],"variety":[60],"become":[61],"impractical":[62],"many":[64],"applications.":[65],"RESULTS:":[66],"Our":[67],"results":[68],"show":[69],"that":[70],"under":[71],"realistic":[72],"assumptions":[73],"on":[74],"domain":[75],"interactions,":[76],"dynamics":[78,160],"pathways":[81],"be":[83],"exactly":[84],"described":[85,131],"reduced,":[87],"hierarchically":[88],"structured":[89],"models.":[90],"method":[92,129,146],"presented":[93,145],"here":[94],"provides":[95],"rigorous":[97],"way":[98],"to":[99,139,153],"model":[100,156],"large":[102],"class":[103],"networks":[106],"using":[107,132],"macro-states":[108],"(macroscopic":[109],"quantities":[110],"such":[111],"as":[112],"levels":[114],"occupancy":[116],"binding":[119],"domains)":[120],"instead":[121],"micro-states":[123],"(concentrations":[124],"individual":[126],"species).":[127],"is":[130,137,147],"generic":[133],"multidomain":[134],"applied":[138],"molecule":[141],"LAT.":[142],"CONCLUSION:":[143],"systematic":[149],"powerful":[151],"tool":[152],"derive":[154],"reduced":[155],"structures":[157],"describing":[158],"multiprotein":[162],"complex":[163],"formation":[164],"accurately.":[165]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-06-23T13:55:30.953635","created_date":"2025-10-10T00:00:00"}
