{"id":"https://openalex.org/W2104854813","doi":"https://doi.org/10.1186/1471-2105-7-26","title":"Discovery of time-delayed gene regulatory networks based on temporal gene expression profiling","display_name":"Discovery of time-delayed gene regulatory networks based on temporal gene expression profiling","publication_year":2006,"publication_date":"2006-01-18","ids":{"openalex":"https://openalex.org/W2104854813","doi":"https://doi.org/10.1186/1471-2105-7-26","mag":"2104854813","pmid":"https://pubmed.ncbi.nlm.nih.gov/16420705"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-26","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-26","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-26","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100445596","display_name":"Xia Li","orcid":"https://orcid.org/0000-0002-9794-2648"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xia Li","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin 150086, PR China. lixia@ems.hrbmu.edu.cn","Biomedical Engineering Institute, Capital University of Medical Sciences, Beijing, PR China","Department of Bioinformatics, Harbin Medical University, Harbin, PR China","Department of Computer Science, Harbin Institute of Technology, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin 150086, PR China. lixia@ems.hrbmu.edu.cn","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Biomedical Engineering Institute, Capital University of Medical Sciences, Beijing, PR China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, PR China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089580482","display_name":"Shaoqi Rao","orcid":"https://orcid.org/0000-0001-7809-3700"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Shaoqi Rao","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","Departments of Cardiovascular Medicine and Molecular Cardiology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","Department of Bioinformatics, Harbin Medical University, Harbin, PR China","Departments of Cardiovascular Medicine and Molecular Cardiology, The Cleveland Clinic Foundation, Cleveland, USA","Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","institution_ids":["https://openalex.org/I36373038"]},{"raw_affiliation_string":"Departments of Cardiovascular Medicine and Molecular Cardiology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Departments of Cardiovascular Medicine and Molecular Cardiology, The Cleveland Clinic Foundation, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, USA","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041957721","display_name":"Wei Jiang","orcid":"https://orcid.org/0000-0003-1591-4721"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Jiang","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","Department of Bioinformatics, Harbin Medical University, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, PR China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064777784","display_name":"Chuanxing Li","orcid":"https://orcid.org/0000-0003-2189-5010"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuanxing Li","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","Department of Bioinformatics, Harbin Medical University, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, PR China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003301022","display_name":"Yun Xiao","orcid":"https://orcid.org/0000-0003-0785-3957"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Xiao","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","Department of Bioinformatics, Harbin Medical University, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, PR China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087055335","display_name":"Zheng Guo","orcid":"https://orcid.org/0000-0003-4466-6026"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Guo","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","Department of Computer Science, Harbin Institute of Technology, Harbin, 150080, PR China","Department of Bioinformatics, Harbin Medical University, Harbin, PR China","Department of Computer Science, Harbin Institute of Technology, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, 150080, PR China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, PR China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101750319","display_name":"Qingpu Zhang","orcid":"https://orcid.org/0000-0003-2113-9071"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingpu Zhang","raw_affiliation_strings":["Department of Computer Science, Harbin Institute of Technology, Harbin, 150080, PR China","Department of Computer Science, Harbin Institute of Technology, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, 150080, PR China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, PR China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443576","display_name":"Lihong Wang","orcid":"https://orcid.org/0000-0002-6715-2944"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lihong Wang","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","Department of Bioinformatics, Harbin Medical University, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, PR China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053805107","display_name":"Lei Du","orcid":"https://orcid.org/0000-0003-2245-7100"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Du","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","Department of Bioinformatics, Harbin Medical University, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, PR China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337051","display_name":"Jing Li","orcid":"https://orcid.org/0000-0003-1160-6959"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","Department of Bioinformatics, Harbin Medical University, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, PR China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360961","display_name":"Li Li","orcid":"https://orcid.org/0000-0001-5097-9972"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Li","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","Department of Bioinformatics, Harbin Medical University, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, PR China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, PR China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082458788","display_name":"Tianwen Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianwen Zhang","raw_affiliation_strings":["Department of Computer Science, Harbin Institute of Technology, Harbin, 150080, PR China","Department of Computer Science, Harbin Institute of Technology, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, 150080, PR China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, PR China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010515168","display_name":"Qing K. Wang","orcid":"https://orcid.org/0000-0002-5639-8519"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing K Wang","raw_affiliation_strings":["Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","Departments of Cardiovascular Medicine and Molecular Cardiology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, USA","Departments of Cardiovascular Medicine and Molecular Cardiology, The Cleveland Clinic Foundation, Cleveland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","institution_ids":["https://openalex.org/I36373038"]},{"raw_affiliation_string":"Departments of Cardiovascular Medicine and Molecular Cardiology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, USA","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Departments of Cardiovascular Medicine and Molecular Cardiology, The Cleveland Clinic Foundation, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5089580482","https://openalex.org/A5100445596"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I156144747","https://openalex.org/I183519381","https://openalex.org/I204983213","https://openalex.org/I36373038","https://openalex.org/I58956616"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.3767,"has_fulltext":true,"cited_by_count":84,"citation_normalized_percentile":{"value":0.92517523,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"26","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.11909999698400497,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.7091021537780762},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6809811592102051},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.5975966453552246},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.547179102897644},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5331662893295288},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.5313573479652405},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.531086802482605},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5308481454849243},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4826641380786896},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4600962996482849},{"id":"https://openalex.org/keywords/toolbox","display_name":"Toolbox","score":0.45250898599624634},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.43055975437164307},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.3603287935256958},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3553740978240967},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35419678688049316},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.34071117639541626}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.7091021537780762},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6809811592102051},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5975966453552246},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.547179102897644},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5331662893295288},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5313573479652405},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.531086802482605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5308481454849243},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4826641380786896},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4600962996482849},{"id":"https://openalex.org/C2777655017","wikidata":"https://www.wikidata.org/wiki/Q1501161","display_name":"Toolbox","level":2,"score":0.45250898599624634},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.43055975437164307},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3603287935256958},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3553740978240967},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35419678688049316},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.34071117639541626},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-7-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-26","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-26","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16420705","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16420705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:0bef95f00295463fb1e34f10e0333505","is_oa":true,"landing_page_url":"https://doaj.org/article/0bef95f00295463fb1e34f10e0333505","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 26 (2006)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1386718","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1386718","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-26","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-26","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1831064010","display_name":null,"funder_award_id":"P50 HL077101-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4243412236","display_name":null,"funder_award_id":"863 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4761465898","display_name":null,"funder_award_id":"P50 HL077101","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5464014682","display_name":null,"funder_award_id":"R01 HL066251","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G807070257","display_name":null,"funder_award_id":"211 Project","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8070914166","display_name":"\u57fa\u4e8e\u751f\u7269\u8c31\u7684\u590d\u6742\u75be\u75c5\u57fa\u56e0\u8bc6\u522b\u7cfb\u7edf\u878d\u5408\u5206\u6790\u65b9\u6cd5\u7814\u7a76","funder_award_id":"30571034","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8491678993","display_name":"\u590d\u6742\u75be\u75c5\u591a\u9776\u70b9\u53d1\u73b0\u53ca\u9776\u70b9\u95f4\u7f51\u7edc\u5173\u7cfb\u8bc6\u522b\u65b9\u6cd5\u7814\u7a76","funder_award_id":"30570424","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8774128957","display_name":null,"funder_award_id":"30370798","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320312270","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335773","display_name":"National High-tech Research and Development Program","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104854813.pdf","grobid_xml":"https://content.openalex.org/works/W2104854813.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W71642687","https://openalex.org/W149894293","https://openalex.org/W1251130462","https://openalex.org/W1481919380","https://openalex.org/W1494248298","https://openalex.org/W1513501940","https://openalex.org/W1544851750","https://openalex.org/W1557900165","https://openalex.org/W1559547793","https://openalex.org/W1604959358","https://openalex.org/W1851004085","https://openalex.org/W1872619067","https://openalex.org/W1893505266","https://openalex.org/W1963142741","https://openalex.org/W1970783685","https://openalex.org/W1971141362","https://openalex.org/W1979213543","https://openalex.org/W1981114175","https://openalex.org/W1991040778","https://openalex.org/W2006668515","https://openalex.org/W2008107402","https://openalex.org/W2014141336","https://openalex.org/W2024893039","https://openalex.org/W2031407766","https://openalex.org/W2035141594","https://openalex.org/W2038012561","https://openalex.org/W2053961182","https://openalex.org/W2058487454","https://openalex.org/W2061280979","https://openalex.org/W2065458745","https://openalex.org/W2066599845","https://openalex.org/W2069115331","https://openalex.org/W2079829409","https://openalex.org/W2080540350","https://openalex.org/W2081933515","https://openalex.org/W2098509901","https://openalex.org/W2099333957","https://openalex.org/W2100603120","https://openalex.org/W2103453943","https://openalex.org/W2105712639","https://openalex.org/W2105902888","https://openalex.org/W2112821758","https://openalex.org/W2122123241","https://openalex.org/W2128150566","https://openalex.org/W2128506325","https://openalex.org/W2133401281","https://openalex.org/W2136605310","https://openalex.org/W2136988691","https://openalex.org/W2137989059","https://openalex.org/W2138073318","https://openalex.org/W2138973161","https://openalex.org/W2140827816","https://openalex.org/W2142460132","https://openalex.org/W2142634942","https://openalex.org/W2148636094","https://openalex.org/W2150114634","https://openalex.org/W2150630892","https://openalex.org/W2150926065","https://openalex.org/W2152071488","https://openalex.org/W2159482845","https://openalex.org/W2160091849","https://openalex.org/W2160533336","https://openalex.org/W2161477969","https://openalex.org/W2162601372","https://openalex.org/W2168459422","https://openalex.org/W2240246689","https://openalex.org/W2963086699","https://openalex.org/W4294216483","https://openalex.org/W4297440291","https://openalex.org/W4298851888","https://openalex.org/W6637460831"],"related_works":["https://openalex.org/W2020634034","https://openalex.org/W2156421048","https://openalex.org/W2135896045","https://openalex.org/W4388247109","https://openalex.org/W2092868481","https://openalex.org/W2884256268","https://openalex.org/W2171763327","https://openalex.org/W2511617859","https://openalex.org/W3108451992","https://openalex.org/W2055418365"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"is":[2,62],"one":[3],"of":[4,21,31,50,56,77,107,136,143,158,164,191,202,235,262,289],"the":[5,15,19,22,29,45,68,73,133,165,175,192,211,218,242,259,277,283],"ultimate":[6],"goals":[7],"for":[8,217,265],"modern":[9],"biological":[10],"research":[11],"to":[12,35,71,89,131,154,178,230,248,257,275,282],"fully":[13],"elucidate":[14],"intricate":[16],"interplays":[17],"and":[18,27,44,47,58,182,187,205,226,286],"regulations":[20,135,160,195,264,280],"molecular":[23],"determinants":[24],"that":[25,138,196,206],"propel":[26],"characterize":[28],"progression":[30],"versatile":[32],"life":[33],"phenomena,":[34],"name":[36],"a":[37,120,151,224,290],"few,":[38],"cell":[39,180,185,219,252,266],"cycling,":[40,267],"developmental":[41],"biology,":[42],"aging,":[43],"progressive":[46,287],"recurrent":[48],"pathogenesis":[49,288],"complex":[51,278,291],"diseases.":[52],"The":[53],"vast":[54],"amount":[55],"large-scale":[57],"genome-wide":[59],"time-resolved":[60],"data":[61,97],"becoming":[63],"increasing":[64],"available,":[65],"which":[66],"provides":[67],"golden":[69],"opportunity":[70],"unravel":[72],"challenging":[74],"reverse-engineering":[75],"problem":[76],"time-delayed":[78,168,194],"gene":[79,95,159,169,263,279],"regulatory":[80,91],"networks.":[81],"RESULTS:":[82],"In":[83,255],"particular,":[84],"this":[85,268],"methodological":[86],"paper":[87],"aims":[88],"reconstruct":[90],"networks":[92],"from":[93],"temporal":[94],"expression":[96,108,170],"by":[98,199,245],"using":[99],"delayed":[100],"correlations":[101],"between":[102,296],"genes,":[103],"i.e.,":[104],"pairwise":[105],"overlaps":[106],"levels":[109],"shifted":[110],"in":[111],"time":[112,144,156,260],"relative":[113],"each":[114],"other.":[115],"We":[116,172,222,238],"have":[117,173,188,239],"thus":[118],"developed":[119],"novel":[121],"model-free":[122,228],"computational":[123],"toolbox":[124,148],"termed":[125],"TdGRN":[126],"(Time-delayed":[127],"Gene":[128],"Regulatory":[129],"Network)":[130],"address":[132],"underlying":[134,193],"genes":[137],"can":[139,271],"span":[140],"any":[141],"unit(s)":[142],"intervals.":[145],"This":[146],"bioinformatics":[147],"has":[149],"provided":[150],"unified":[152,269],"approach":[153,229,270],"uncovering":[155,258],"trends":[157,234,261],"through":[161],"decision":[162],"analysis":[163],"newly":[166],"designed":[167],"matrix.":[171],"applied":[174],"proposed":[176,243],"method":[177],"yeast":[179],"cycling":[181,186,253],"human":[183],"HeLa":[184],"discovered":[189],"most":[190],"are":[197,207],"supported":[198],"multiple":[200],"lines":[201],"experimental":[203],"evidence":[204],"remarkably":[208],"consistent":[209],"with":[210],"current":[212],"knowledge":[213],"on":[214],"phase":[215],"characteristics":[216],"cyclings.":[220],"CONCLUSION:":[221],"established":[223],"usable":[225],"powerful":[227],"dissecting":[231],"high-order":[232],"dynamic":[233],"gene-gene":[236],"interactions.":[237],"carefully":[240],"validated":[241],"algorithm":[244],"applying":[246],"it":[247],"two":[249],"publicly":[250],"available":[251],"datasets.":[254],"addition":[256],"also":[272],"be":[273],"used":[274],"study":[276],"related":[281],"development,":[284],"aging":[285],"disease":[292],"where":[293],"potential":[294],"dependences":[295],"different":[297],"experiment":[298],"units":[299],"might":[300],"occurs.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}