{"id":"https://openalex.org/W1487701579","doi":"https://doi.org/10.1186/1471-2105-7-259","title":"The effects of multiple features of alternatively spliced exons on the K A /K S ratio test","display_name":"The effects of multiple features of alternatively spliced exons on the K A /K S ratio test","publication_year":2006,"publication_date":"2006-05-19","ids":{"openalex":"https://openalex.org/W1487701579","doi":"https://doi.org/10.1186/1471-2105-7-259","mag":"1487701579","pmid":"https://pubmed.ncbi.nlm.nih.gov/16709259"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-259","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-259","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-259","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-259","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054373289","display_name":"Feng\u2010Chi Chen","orcid":"https://orcid.org/0000-0002-1437-4420"},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]},{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Feng-Chi Chen","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, Academia Road, Nankang, Taipei 11529, Taiwan. fcchen@iis.sinica.edu.tw","Division of Biostatistics and Bioinformatics, National Health Research Institute, Miaoli County, Taiwan","Genomics Research Center, Academia Sinica, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, Academia Road, Nankang, Taipei 11529, Taiwan. fcchen@iis.sinica.edu.tw","institution_ids":["https://openalex.org/I4210087491"]},{"raw_affiliation_string":"Division of Biostatistics and Bioinformatics, National Health Research Institute, Miaoli County, Taiwan","institution_ids":["https://openalex.org/I165441096"]},{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210087491"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047988084","display_name":"Trees\u2010Juen Chuang","orcid":"https://orcid.org/0000-0002-9661-6672"},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Trees-Juen Chuang","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, Academia Road, Nankang, Taipei, 11529, Taiwan","Genomics Research Center, Academia Sinica, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, Academia Road, Nankang, Taipei, 11529, Taiwan","institution_ids":["https://openalex.org/I4210087491"]},{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210087491"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047988084"],"corresponding_institution_ids":["https://openalex.org/I4210087491"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.409,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.59947301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"7","issue":"1","first_page":"259","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.5928000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.5928000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.1509000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.06210000067949295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.9387174248695374},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.5537991523742676},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5341989398002625},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5199445486068726},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.49616917967796326},{"id":"https://openalex.org/keywords/tandem-exon-duplication","display_name":"Tandem exon duplication","score":0.49457404017448425},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4331853985786438},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3104161024093628},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.08405980467796326}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.9387174248695374},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5537991523742676},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5341989398002625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5199445486068726},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.49616917967796326},{"id":"https://openalex.org/C156446351","wikidata":"https://www.wikidata.org/wiki/Q7682435","display_name":"Tandem exon duplication","level":4,"score":0.49457404017448425},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4331853985786438},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3104161024093628},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.08405980467796326}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022821","descriptor_name":"RNA Splice Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022821","descriptor_name":"RNA Splice Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022821","descriptor_name":"RNA Splice Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-7-259","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-259","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-259","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16709259","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16709259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:235c616b0a8243f6a2b4d3a23f8e4821","is_oa":false,"landing_page_url":"https://doaj.org/article/235c616b0a8243f6a2b4d3a23f8e4821","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 259 (2006)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1526763","is_oa":true,"landing_page_url":"http://doi.org/10.1186/1471-2105-7-259","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-259","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-259","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-259","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G644030054","display_name":null,"funder_award_id":"NHRI-EX95","funder_id":"https://openalex.org/F4320322845","funder_display_name":"National Health Research Institutes"}],"funders":[{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"},{"id":"https://openalex.org/F4320322845","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1487701579.pdf","grobid_xml":"https://content.openalex.org/works/W1487701579.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1481835696","https://openalex.org/W1963793607","https://openalex.org/W1965991219","https://openalex.org/W1967618835","https://openalex.org/W1970774008","https://openalex.org/W1971158461","https://openalex.org/W1975972631","https://openalex.org/W2017304814","https://openalex.org/W2020112525","https://openalex.org/W2023648355","https://openalex.org/W2024147708","https://openalex.org/W2027699344","https://openalex.org/W2028279880","https://openalex.org/W2029760674","https://openalex.org/W2038921819","https://openalex.org/W2039140951","https://openalex.org/W2047495572","https://openalex.org/W2063318299","https://openalex.org/W2066622144","https://openalex.org/W2077199821","https://openalex.org/W2090335524","https://openalex.org/W2091448229","https://openalex.org/W2108462643","https://openalex.org/W2114858580","https://openalex.org/W2115011276","https://openalex.org/W2119195082","https://openalex.org/W2119247621","https://openalex.org/W2119632499","https://openalex.org/W2124288620","https://openalex.org/W2129682060","https://openalex.org/W2132332921","https://openalex.org/W2140150514","https://openalex.org/W2152873040","https://openalex.org/W2154270713","https://openalex.org/W2157567137","https://openalex.org/W2162293432","https://openalex.org/W2166336598","https://openalex.org/W2169685494"],"related_works":["https://openalex.org/W1539107620","https://openalex.org/W1984349060","https://openalex.org/W2014905760","https://openalex.org/W2151954452","https://openalex.org/W2147652847","https://openalex.org/W2520430930","https://openalex.org/W3045601368","https://openalex.org/W2019185025","https://openalex.org/W2951772693","https://openalex.org/W1986333984"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,295],"evolution":[2,36,324],"of":[3,9,22,25,37,65,81,139,208,216,227,303,314,343,346],"alternatively":[4],"spliced":[5],"exons":[6,14,142,152,357],"(ASEs)":[7],"is":[8,277,286],"primary":[10],"interest":[11],"because":[12],"these":[13,228],"are":[15,197,328],"suggested":[16,32],"to":[17,33,70,161,265,339],"be":[18,334,353,360],"a":[19,158,244,253],"major":[20],"source":[21],"functional":[23],"diversity":[24],"proteins.":[26],"Many":[27],"exon":[28,56,76,89,170,281],"features":[29,90,143,171,327],"have":[30,42,91,94,202,232,263],"been":[31],"affect":[34,136],"the":[35,45,66,79,82,109,120,137,145,163,186,213,240,266,278,287,309,317,337,341,363],"ASEs.":[38,209],"However,":[39,239],"previous":[40],"studies":[41],"relied":[43],"on":[44,205,236,257,308],"KA/KS":[46,83,146,310,364],"ratio":[47,84,147,311,365],"test":[48,85,148,166,206,237,258,292,312],"without":[49],"taking":[50],"into":[51,336],"consideration":[52],"information":[53,132],"sufficiency":[54,133],"(i.e.,":[55],"length":[57,192],">":[58,63],"75":[59],"bp,":[60],"cross-species":[61],"divergence":[62],"5%)":[64],"studied":[67],"exons,":[68],"leading":[69],"potentially":[71],"biased":[72],"interpretations.":[73],"Furthermore,":[74],"which":[75],"feature":[77,282],"dominates":[78],"results":[80,167,207,313],"and":[86,116,119,144,168,179,193,200,219,272],"whether":[87],"multiple":[88,306,326],"additive":[92,234,301],"effects":[93,235,302],"remained":[95],"unexplored.":[96],"RESULTS:":[97],"In":[98,210,348],"this":[99],"study,":[100],"we":[101,156],"collect":[102],"two":[103,229],"different":[104,246],"datasets":[105],"for":[106,185,362],"analysis":[107,345],"-":[108],"ASE":[110,187],"dataset":[111,122,242],"(which":[112,123],"includes":[113,124],"lineage-specific":[114],"ASEs":[115,261,271],"conserved":[117,126],"ASEs)":[118],"ACE":[121,241],"only":[125],"ASEs).":[127],"We":[128,189],"first":[129],"show":[130],"that":[131,191,249],"can":[134,298,319,332,358],"significantly":[135],"interpretation":[138],"relationship":[140,164],"between":[141,165],"results.":[149,238,259,293],"After":[150],"discarding":[151],"with":[153],"insufficient":[154],"information,":[155],"use":[157],"Boolean":[159],"method":[160,297,351],"analyze":[162,320],"four":[169],"(namely":[172],"length,":[173],"protein":[174,194,274],"domain":[175,195,275],"overlapping,":[176],"inclusion":[177,217,250],"level,":[178],"exonic":[180],"splicing":[181],"enhancer":[182],"(ESE)":[183],"frequency)":[184],"dataset.":[188],"demonstrate":[190],"overlapping":[196,276],"dominant":[198,280],"factors,":[199],"they":[201],"similar":[203],"impacts":[204,215],"addition,":[211,349],"despite":[212],"weak":[214],"level":[218,251],"ESE":[220,284],"motif":[221],"frequency":[222,285],"when":[223,355],"considered":[224],"individually,":[225],"combination":[226],"factors":[230,307,331],"still":[231],"minor":[233],"shows":[243],"slightly":[245],"result":[247],"in":[248,269,290,323],"has":[252],"marginally":[254],"significant":[255],"effect":[256],"Lineage-specific":[260],"may":[262,352],"contributed":[264],"difference.":[267],"Overall,":[268],"both":[270],"ACEs,":[273],"most":[279],"while":[283],"weakest":[288],"one":[289],"affecting":[291],"CONCLUSION:":[294],"proposed":[296],"easily":[299],"find":[300],"individual":[304],"or":[305],"exons.":[315,347],"Therefore,":[316],"system":[318,338],"complex":[321],"conditions":[322],"where":[325],"involved.":[329],"More":[330],"also":[333],"added":[335],"extend":[340],"scope":[342],"evolutionary":[344],"our":[350],"useful":[354],"orthologous":[356],"not":[359],"found":[361],"test.":[366]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
