{"id":"https://openalex.org/W1826153834","doi":"https://doi.org/10.1186/1471-2105-7-247","title":"Bayesian models for pooling microarray studies with multiple sources of replications","display_name":"Bayesian models for pooling microarray studies with multiple sources of replications","publication_year":2006,"publication_date":"2006-05-05","ids":{"openalex":"https://openalex.org/W1826153834","doi":"https://doi.org/10.1186/1471-2105-7-247","mag":"1826153834","pmid":"https://pubmed.ncbi.nlm.nih.gov/16677390"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-247","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-247","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-247","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-247","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057528476","display_name":"Erin M. Conlon","orcid":"https://orcid.org/0000-0002-3875-5316"},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erin M Conlon","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Massachusetts, Amherst, Massachusetts, USA. econlon@mathstat.umass.edu","Department of Mathematics & Statistics, University of Massachusetts, Amherst, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Massachusetts, Amherst, Massachusetts, USA. econlon@mathstat.umass.edu","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Department of Mathematics & Statistics, University of Massachusetts, Amherst, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080111960","display_name":"Joon Jin Song","orcid":"https://orcid.org/0000-0002-1385-4924"},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joon J Song","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Massachusetts, Amherst, Massachusetts, USA","Department of Mathematics & Statistics, University of Massachusetts, Amherst, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Massachusetts, Amherst, Massachusetts, USA","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Department of Mathematics & Statistics, University of Massachusetts, Amherst, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012820890","display_name":"Jun S. Liu","orcid":"https://orcid.org/0000-0002-4450-7239"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun S Liu","raw_affiliation_strings":["Department of Statistics, Harvard University, Cambridge, Massachusetts, USA","Dept of Statistics, Harvard University, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Harvard University, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Dept of Statistics, Harvard University, Cambridge, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057528476"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":2.2876,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.87080057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"247","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9472000002861023,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9472000002861023,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replicate","display_name":"Replicate","score":0.8165762424468994},{"id":"https://openalex.org/keywords/pooling","display_name":"Pooling","score":0.7824362516403198},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.7074493169784546},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.6713977456092834},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5538031458854675},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.5256713032722473},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5025708675384521},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4950615465641022},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.4941706955432892},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4181350767612457},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3849990963935852},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3846155107021332},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3211175203323364},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30079251527786255},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.29063332080841064},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.20475080609321594},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20157429575920105},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19655963778495789}],"concepts":[{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.8165762424468994},{"id":"https://openalex.org/C70437156","wikidata":"https://www.wikidata.org/wiki/Q7228652","display_name":"Pooling","level":2,"score":0.7824362516403198},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.7074493169784546},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.6713977456092834},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5538031458854675},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.5256713032722473},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5025708675384521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4950615465641022},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4941706955432892},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4181350767612457},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3849990963935852},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3846155107021332},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3211175203323364},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30079251527786255},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.29063332080841064},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20475080609321594},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20157429575920105},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19655963778495789}],"mesh":[{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1471-2105-7-247","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-247","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-247","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16677390","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16677390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:works.bepress.com:erin_conlon-1003","is_oa":true,"landing_page_url":"https://works.bepress.com/erin_conlon/2","pdf_url":"https://works.bepress.com/cgi/viewcontent.cgi?article=1003&context=erin_conlon","source":{"id":"https://openalex.org/S4306402240","display_name":"ScholarWorks@UMassAmherst (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Erin M. Conlon","raw_type":"text"},{"id":"pmh:oai:dash.harvard.edu:1/4454166","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:4454166","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.umass.edu:math_faculty_pubs-1308","is_oa":false,"landing_page_url":"https://scholarworks.umass.edu/math_faculty_pubs/309","pdf_url":null,"source":{"id":"https://openalex.org/S4306402057","display_name":"Scholarworks (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mathematics and Statistics Department Faculty Publication Series","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e247108392af4a49943f509a1006c0a1","is_oa":false,"landing_page_url":"https://doaj.org/article/e247108392af4a49943f509a1006c0a1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 247 (2006)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1534062","is_oa":true,"landing_page_url":"http://doi.org/10.1186/1471-2105-7-247","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:scholarworks.umass.edu:20.500.14394/34554","is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14394/34554","pdf_url":null,"source":{"id":"https://openalex.org/S4306402057","display_name":"Scholarworks (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-247","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-247","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-247","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2719944227","display_name":null,"funder_award_id":"R01 HG002518","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G774642654","display_name":null,"funder_award_id":"R01-HG02518-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G875445546","display_name":null,"funder_award_id":"R01-HG02518-01","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1826153834.pdf","grobid_xml":"https://content.openalex.org/works/W1826153834.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W55083422","https://openalex.org/W1544729927","https://openalex.org/W1551744077","https://openalex.org/W1792175597","https://openalex.org/W1800724332","https://openalex.org/W1971289666","https://openalex.org/W1973325935","https://openalex.org/W1995017987","https://openalex.org/W1999649023","https://openalex.org/W2005107355","https://openalex.org/W2038774163","https://openalex.org/W2041585923","https://openalex.org/W2047204673","https://openalex.org/W2054100651","https://openalex.org/W2060449515","https://openalex.org/W2062353821","https://openalex.org/W2063661220","https://openalex.org/W2063862573","https://openalex.org/W2067164993","https://openalex.org/W2067306349","https://openalex.org/W2069739265","https://openalex.org/W2074089196","https://openalex.org/W2079470188","https://openalex.org/W2089657469","https://openalex.org/W2099114361","https://openalex.org/W2100889355","https://openalex.org/W2105381419","https://openalex.org/W2105793531","https://openalex.org/W2108645007","https://openalex.org/W2110065044","https://openalex.org/W2113128520","https://openalex.org/W2116811581","https://openalex.org/W2117044793","https://openalex.org/W2117116259","https://openalex.org/W2124201592","https://openalex.org/W2134696273","https://openalex.org/W2141407136","https://openalex.org/W2144227498","https://openalex.org/W2152155643","https://openalex.org/W2153201655","https://openalex.org/W2156031219","https://openalex.org/W2156246479","https://openalex.org/W2157795344","https://openalex.org/W2158940923","https://openalex.org/W2170264612","https://openalex.org/W2170700353","https://openalex.org/W4243634040","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2467227750","https://openalex.org/W4293336298","https://openalex.org/W4300887971","https://openalex.org/W2178204436","https://openalex.org/W2143079975","https://openalex.org/W2032708737","https://openalex.org/W2026085942","https://openalex.org/W2333750400","https://openalex.org/W1986765826","https://openalex.org/W2076024021"],"abstract_inverted_index":{"BACKGROUND:":[0],"Biologists":[1],"often":[2,29],"conduct":[3],"multiple":[4,50,67,78,219],"but":[5,220],"different":[6],"cDNA":[7,63],"microarray":[8,64,223],"studies":[9,34,52,69,182,199,224,262],"that":[10,195,239,263],"all":[11],"target":[12,41],"the":[13,92,133,144,154,165,205,234],"same":[14,235],"biological":[15],"system":[16],"or":[17,268],"pathway.":[18],"Within":[19],"each":[20,188,240],"study,":[21],"replicate":[22,83],"slides":[23,84],"within":[24,85],"repeated":[25,86],"identical":[26,87,222],"experiments":[27],"are":[28],"produced.":[30],"Pooling":[31],"information":[32],"across":[33,66],"can":[35],"help":[36],"more":[37,159,174],"accurately":[38],"identify":[39,71,173],"true":[40,206],"genes.":[42,74],"Here,":[43],"we":[44,128,193],"introduce":[45,56],"a":[46,57,101,214,249,258],"method":[47,103,212],"to":[48,61,70,172],"integrate":[49],"independent":[51,68,122,181],"efficiently.":[53],"RESULTS:":[54],"We":[55,168,237,252],"Bayesian":[58,109,201],"hierarchical":[59],"model":[60,90,156],"pool":[62],"data":[65,190,231],"highly":[72],"expressed":[73,162,176],"Each":[75],"study":[76,241],"has":[77],"sources":[79,227],"of":[80,96,111,135,146,228,261],"variation,":[81],"i.e.":[82],"experiments.":[88],"Our":[89,211],"produces":[91],"gene-specific":[93],"posterior":[94],"probability":[95],"differential":[97],"expression,":[98],"which":[99],"provides":[100,108,213],"direct":[102],"for":[104,217,257],"ranking":[105],"genes,":[106],"and":[107,120,248],"estimates":[110,203],"false":[112],"discovery":[113],"rates":[114],"(FDR).":[115],"In":[116],"simulations":[117],"combining":[118,218],"two":[119,180,244],"five":[121],"studies,":[123],"with":[124,225,230],"fixed":[125,150],"FDR":[126,202],"levels,":[127],"observed":[129,194],"large":[130],"increases":[131],"in":[132,138,183,196],"number":[134,145,260],"discovered":[136],"genes":[137,148,163,177],"pooled":[139,155],"versus":[140],"individual":[141,166,189],"analyses.":[142],"When":[143],"output":[147],"is":[149],"(e.g.,":[151],"top":[152],"100),":[153],"found":[157],"appreciably":[158],"truly":[160],"differentially":[161,175],"than":[164,186],"studies.":[167],"were":[169],"also":[170],"able":[171],"from":[178,187,233],"pooling":[179],"Bacillus":[184],"subtilis":[185],"set.":[191],"Finally,":[192],"our":[197,200,254],"simulation":[198],"tracked":[204],"FDRs":[207],"very":[208],"well.":[209],"CONCLUSION:":[210],"cohesive":[215],"framework":[216],"not":[221],"several":[226],"replication,":[229],"produced":[232],"platform.":[236],"assume":[238],"contains":[242],"only":[243],"conditions:":[245],"an":[246],"experimental":[247],"control":[250],"sample.":[251],"demonstrated":[253],"model's":[255],"suitability":[256],"small":[259],"have":[264,269],"been":[265],"either":[266],"pre-scaled":[267],"no":[270],"outliers.":[271]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
