{"id":"https://openalex.org/W1814099126","doi":"https://doi.org/10.1186/1471-2105-7-177","title":"Identifying metabolic enzymes with multiple types of association evidence","display_name":"Identifying metabolic enzymes with multiple types of association evidence","publication_year":2006,"publication_date":"2006-03-29","ids":{"openalex":"https://openalex.org/W1814099126","doi":"https://doi.org/10.1186/1471-2105-7-177","mag":"1814099126","pmid":"https://pubmed.ncbi.nlm.nih.gov/16571130"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-177","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-177","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-177","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-177","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034449272","display_name":"Peter V. Kharchenko","orcid":"https://orcid.org/0000-0002-6036-5875"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter Kharchenko","raw_affiliation_strings":["Department of Genetics, New Research Building (NRB) Room 238, 77 Ave, Louis Pasteur, Harvard Medical School, Boston, MA 02115, USA. peter.kharchenko@post.harvard.edu","Department of Genetics, New Research Building (NRB) Room 238, Harvard Medical School, Boston, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, New Research Building (NRB) Room 238, 77 Ave, Louis Pasteur, Harvard Medical School, Boston, MA 02115, USA. peter.kharchenko@post.harvard.edu","institution_ids":["https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Genetics, New Research Building (NRB) Room 238, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089644877","display_name":"Haiyong Chen","orcid":"https://orcid.org/0000-0002-4889-2752"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lifeng Chen","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Biomedical Informatics, Columbia University, New York, USA"],"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biomedical Informatics, Columbia University, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072341135","display_name":"Yoav Freund","orcid":"https://orcid.org/0000-0002-3850-6184"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoav Freund","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Biomedical Informatics, Columbia University, 1150 St. Nicholas Ave., New York, NY 10032, USA and","Department of Computer Science and Engineering, University of California San Diego, 9500 Gilman Drive 0404, Room 4126, La Jolla, CA 92093, USA","Department of Computer Science & Engineering, University of California San Diego, La Jolla, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biomedical Informatics, Columbia University, 1150 St. Nicholas Ave., New York, NY 10032, USA and","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, University of California San Diego, 9500 Gilman Drive 0404, Room 4126, La Jolla, CA 92093, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Computer Science & Engineering, University of California San Diego, La Jolla, USA#TAB#","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008458536","display_name":"Dennis Vitkup","orcid":"https://orcid.org/0000-0003-4259-8162"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Vitkup","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Biomedical Informatics, Columbia University, 1150 St. Nicholas Ave., New York, NY 10032, USA and","Center for Computational Biology and Bioinformatics, Department of Biomedical Informatics, Columbia University, New York, USA"],"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biomedical Informatics, Columbia University, 1150 St. Nicholas Ave., New York, NY 10032, USA and","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biomedical Informatics, Columbia University, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103076360","display_name":"George M. Church","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210128845","display_name":"Louis Pasteur Center for Medical Research","ror":"https://ror.org/032t7yz93","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210128845"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"George M Church","raw_affiliation_strings":["Department of Genetics, New Research Building (NRB) Room 238, 77 Ave. Louis Pasteur, Harvard Medical School, Boston, MA 02115, USA,","Department of Genetics, New Research Building (NRB) Room 238, Harvard Medical School, Boston, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, New Research Building (NRB) Room 238, 77 Ave. Louis Pasteur, Harvard Medical School, Boston, MA 02115, USA,","institution_ids":["https://openalex.org/I4210128845"]},{"raw_affiliation_string":"Department of Genetics, New Research Building (NRB) Room 238, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5034449272"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210134579"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":5.8333,"has_fulltext":true,"cited_by_count":99,"citation_normalized_percentile":{"value":0.96884412,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"177","last_page":"177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7092020511627197},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.6513422727584839},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6284187436103821},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6199054718017578},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.538653552532196},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5294339656829834},{"id":"https://openalex.org/keywords/homology","display_name":"Homology (biology)","score":0.5224741697311401},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4266894459724426},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4192092716693878},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.19706690311431885}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7092020511627197},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.6513422727584839},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6284187436103821},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6199054718017578},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.538653552532196},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5294339656829834},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.5224741697311401},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4266894459724426},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4192092716693878},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19706690311431885}],"mesh":[{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1471-2105-7-177","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-177","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-177","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16571130","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16571130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:osti.gov:1626317","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1626317","pdf_url":"https://www.osti.gov/servlets/purl/1626317","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:dash.harvard.edu:1/10246868","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10246868","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:academiccommons.columbia.edu:10.7916/D8BV7F2P","is_oa":false,"landing_page_url":"https://doi.org/10.7916/D8BV7F2P","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:doaj.org/article:819f0c5cd3044c3a89d4d16fe5b10a46","is_oa":true,"landing_page_url":"https://doaj.org/article/819f0c5cd3044c3a89d4d16fe5b10a46","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 177 (2006)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1450304","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1450304","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"doi:10.7916/d8bv7f2p","is_oa":true,"landing_page_url":"https://doi.org/10.7916/d8bv7f2p","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-177","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-177","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-177","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320332815","display_name":"Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1814099126.pdf","grobid_xml":"https://content.openalex.org/works/W1814099126.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W591644047","https://openalex.org/W1553313034","https://openalex.org/W1566965859","https://openalex.org/W1603241183","https://openalex.org/W1650502025","https://openalex.org/W1881647329","https://openalex.org/W1966957642","https://openalex.org/W1974748393","https://openalex.org/W1975846642","https://openalex.org/W1987622597","https://openalex.org/W1987866119","https://openalex.org/W1987996359","https://openalex.org/W1988790447","https://openalex.org/W1991071802","https://openalex.org/W1995117714","https://openalex.org/W2000495354","https://openalex.org/W2000496641","https://openalex.org/W2022620641","https://openalex.org/W2022846158","https://openalex.org/W2030889455","https://openalex.org/W2034106962","https://openalex.org/W2037036397","https://openalex.org/W2041115444","https://openalex.org/W2046618236","https://openalex.org/W2053501576","https://openalex.org/W2055043387","https://openalex.org/W2057443273","https://openalex.org/W2057885377","https://openalex.org/W2065304353","https://openalex.org/W2072966557","https://openalex.org/W2079007492","https://openalex.org/W2079048673","https://openalex.org/W2079365725","https://openalex.org/W2079789016","https://openalex.org/W2084619201","https://openalex.org/W2087158203","https://openalex.org/W2088367672","https://openalex.org/W2096194986","https://openalex.org/W2096245011","https://openalex.org/W2097706568","https://openalex.org/W2103148270","https://openalex.org/W2106391842","https://openalex.org/W2107717979","https://openalex.org/W2109715166","https://openalex.org/W2111031006","https://openalex.org/W2112460093","https://openalex.org/W2119043225","https://openalex.org/W2124491835","https://openalex.org/W2126991359","https://openalex.org/W2128572161","https://openalex.org/W2128817214","https://openalex.org/W2128923603","https://openalex.org/W2145010684","https://openalex.org/W2146264532","https://openalex.org/W2146312020","https://openalex.org/W2149310258","https://openalex.org/W2158246396","https://openalex.org/W2162422091","https://openalex.org/W2166558964","https://openalex.org/W2168020168","https://openalex.org/W2169929748","https://openalex.org/W2171088586","https://openalex.org/W2171430493","https://openalex.org/W3097169496","https://openalex.org/W4252706339","https://openalex.org/W6631530885"],"related_works":["https://openalex.org/W2063475537","https://openalex.org/W2341681417","https://openalex.org/W1961707331","https://openalex.org/W2012938657","https://openalex.org/W1578136679","https://openalex.org/W2096004952","https://openalex.org/W2087715585","https://openalex.org/W2147962989","https://openalex.org/W4309835295","https://openalex.org/W4223538309"],"abstract_inverted_index":{"We":[0],"illustrate":[1],"that":[2],"a":[3],"combination":[4],"of":[5],"genome":[6],"context":[7],"and":[8,34],"other":[9],"functional":[10],"association":[11],"evidence":[12],"is":[13],"effective":[14],"in":[15,38],"predicting":[16],"genes":[17],"encoding":[18],"metabolic":[19,43,55],"enzymes.":[20],"Our":[21],"approach":[22],"does":[23],"not":[24],"rely":[25],"on":[26],"direct":[27],"sequence":[28],"homology":[29],"to":[30,52],"known":[31],"enzyme-encoding":[32],"genes,":[33],"can":[35,48],"be":[36,50],"used":[37,51],"conjunction":[39],"with":[40],"traditional":[41],"homology-based":[42],"reconstruction":[44],"methods.":[45],"The":[46],"method":[47],"also":[49],"target":[53],"orphan":[54],"activities.":[56]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
