{"id":"https://openalex.org/W1651886044","doi":"https://doi.org/10.1186/1471-2105-7-167","title":"Prediction of indirect interactions in proteins","display_name":"Prediction of indirect interactions in proteins","publication_year":2006,"publication_date":"2006-03-22","ids":{"openalex":"https://openalex.org/W1651886044","doi":"https://doi.org/10.1186/1471-2105-7-167","mag":"1651886044","pmid":"https://pubmed.ncbi.nlm.nih.gov/16553946"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-167","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-167","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-167","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-167","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020443976","display_name":"Peteris Pr\u016bsis","orcid":null},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Peteris Prusis","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. peteris.prusis@farmbio.uu.se","Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. peteris.prusis@farmbio.uu.se","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000367311","display_name":"Staffan Uhl\u00e9n","orcid":null},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO","SE"],"is_corresponding":false,"raw_author_name":"Staffan Uhl\u00e9n","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","Section for Pharmacology, The University of Bergen, Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Section for Pharmacology, The University of Bergen, Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005902170","display_name":"Ramona Petrovska","orcid":"https://orcid.org/0000-0003-0875-8943"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ramona Petrovska","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064016167","display_name":"Maris Lapins","orcid":"https://orcid.org/0000-0002-0122-6680"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Maris Lapinsh","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081984122","display_name":"Jarl E. S. Wikberg","orcid":"https://orcid.org/0000-0003-1916-3013"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Jarl ES Wikberg","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081984122"],"corresponding_institution_ids":["https://openalex.org/I123387679"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.9076,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.83950645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"167","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.14339999854564667,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.14339999854564667,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.1256999969482422,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.10189999639987946,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.636340320110321},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.6315348148345947},{"id":"https://openalex.org/keywords/molecular-recognition","display_name":"Molecular recognition","score":0.6046333312988281},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.5334981083869934},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4642556309700012},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"Mutagenesis","score":0.4548202157020569},{"id":"https://openalex.org/keywords/protein-ligand","display_name":"Protein ligand","score":0.447339802980423},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4195294976234436},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.37885376811027527},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3586985170841217},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.35452669858932495},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.3378673791885376},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.27555614709854126},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.2405475378036499},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.12765759229660034},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11437904834747314}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.636340320110321},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6315348148345947},{"id":"https://openalex.org/C179303850","wikidata":"https://www.wikidata.org/wiki/Q4300362","display_name":"Molecular recognition","level":3,"score":0.6046333312988281},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5334981083869934},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4642556309700012},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4548202157020569},{"id":"https://openalex.org/C109095088","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Protein ligand","level":2,"score":0.447339802980423},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4195294976234436},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37885376811027527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3586985170841217},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.35452669858932495},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3378673791885376},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27555614709854126},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2405475378036499},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.12765759229660034},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11437904834747314},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-7-167","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-167","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-167","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16553946","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16553946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:197167","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1435945","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:bora.uib.no:1956/1921","is_oa":true,"landing_page_url":"https://hdl.handle.net/1956/1921","pdf_url":null,"source":{"id":"https://openalex.org/S4306401716","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:c142ccd7ad9d4c3ca9bf6509be965b9a","is_oa":true,"landing_page_url":"https://doaj.org/article/c142ccd7ad9d4c3ca9bf6509be965b9a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 167 (2006)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-167","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-167","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-167","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6126399274","display_name":null,"funder_award_id":"04X-05957","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1651886044.pdf","grobid_xml":"https://content.openalex.org/works/W1651886044.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W587662218","https://openalex.org/W623454765","https://openalex.org/W1480531921","https://openalex.org/W1549372716","https://openalex.org/W1566308385","https://openalex.org/W1584367161","https://openalex.org/W1964209583","https://openalex.org/W1968731886","https://openalex.org/W1973772334","https://openalex.org/W1992220387","https://openalex.org/W1996630442","https://openalex.org/W2005051528","https://openalex.org/W2010810795","https://openalex.org/W2013238066","https://openalex.org/W2015451996","https://openalex.org/W2016605869","https://openalex.org/W2024213882","https://openalex.org/W2024356898","https://openalex.org/W2060913542","https://openalex.org/W2073110681","https://openalex.org/W2075904044","https://openalex.org/W2084547258","https://openalex.org/W2101001127","https://openalex.org/W2106440817","https://openalex.org/W2126624551","https://openalex.org/W2126728600","https://openalex.org/W2144969564","https://openalex.org/W2149963584","https://openalex.org/W2158863190","https://openalex.org/W2322193123","https://openalex.org/W4233523656","https://openalex.org/W4252684946"],"related_works":["https://openalex.org/W1576852562","https://openalex.org/W3141735581","https://openalex.org/W191244194","https://openalex.org/W2386140904","https://openalex.org/W1827023575","https://openalex.org/W4388384997","https://openalex.org/W2411516357","https://openalex.org/W2106106031","https://openalex.org/W2164210098","https://openalex.org/W2058311929"],"abstract_inverted_index":{"BACKGROUND:":[0],"Both":[1],"direct":[2,38,149,165,229],"and":[3,35,49,113,135,142,150,230],"indirect":[4,151,190,231],"interactions":[5,14,39,166],"determine":[6],"molecular":[7,95],"recognition":[8,21,53,96,105,194],"of":[9,44,75,94,106,175,189,226,228],"ligands":[10,107],"by":[11,30,72,108,159,236],"proteins.":[12,237],"Indirect":[13],"can":[15,216],"be":[16,217],"defined":[17],"as":[18],"effects":[19,70,101,191,232],"on":[20,123,192,233],"controlled":[22],"from":[23,81,196],"distant":[24,197],"sites":[25,198],"in":[26,32,41,103,148,168,179,199],"the":[27,45,50,69,82,92,99,104,181,187,200,224],"proteins,":[28],"e.g.":[29],"changes":[31,74],"protein":[33,127],"conformation":[34],"mobility,":[36],"whereas":[37],"occur":[40],"close":[42],"proximity":[43],"protein's":[46],"amino":[47,76,140],"acids":[48,77,141],"ligand.":[51],"Molecular":[52],"is":[54,65],"traditionally":[55],"studied":[56],"using":[57,110],"three-dimensional":[58,173,204],"methods,":[59],"but":[60],"with":[61,132,171,219],"such":[62],"techniques":[63],"it":[64],"difficult":[66],"to":[67,91,137,222],"predict":[68,138,186,223],"caused":[71],"mutational":[73],"located":[78],"far":[79],"away":[80],"ligand-binding":[83],"site.":[84],"We":[85,210],"recently":[86],"developed":[87],"an":[88],"approach,":[89],"proteochemometrics,":[90],"study":[93],"that":[97,145,203,213],"models":[98],"chemical":[100],"involved":[102,147],"proteins":[109],"statistical":[111],"sampling":[112],"mathematical":[114],"modelling.":[115],"RESULTS:":[116],"A":[117],"proteochemometric":[118,214],"model":[119,155,182],"was":[120],"built,":[121],"based":[122],"a":[124],"statistically":[125],"designed":[126],"library's":[128],"(melanocortin":[129],"receptors')":[130],"interaction":[131],"three":[133],"peptides":[134],"used":[136,218],"which":[139],"sequence":[143],"fragments":[144],"are":[146],"ligand":[152,176,193,234],"interactions.":[153],"The":[154,162],"predictions":[156],"were":[157,167],"confirmed":[158],"directed":[160],"mutagenesis.":[161],"predicted":[163],"presumed":[164],"good":[169],"agreement":[170],"previous":[172],"studies":[174],"recognition.":[177],"However,":[178],"addition":[180],"could":[183,206],"also":[184],"correctly":[185],"location":[188],"arising":[195],"receptors,":[201],"something":[202],"modelling":[205,215],"not":[207],"afford.":[208],"CONCLUSION:":[209],"demonstrate":[211],"experimentally":[212],"high":[220],"accuracy":[221],"site":[225],"origin":[227],"recognitions":[235]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}