{"id":"https://openalex.org/W1806973358","doi":"https://doi.org/10.1186/1471-2105-7-132","title":"Network-level analysis of metabolic regulation in the human red blood cell using random sampling and singular value decomposition","display_name":"Network-level analysis of metabolic regulation in the human red blood cell using random sampling and singular value decomposition","publication_year":2006,"publication_date":"2006-03-13","ids":{"openalex":"https://openalex.org/W1806973358","doi":"https://doi.org/10.1186/1471-2105-7-132","mag":"1806973358","pmid":"https://pubmed.ncbi.nlm.nih.gov/16533395"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-7-132","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-132","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-132","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-132","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082405466","display_name":"Christian Barrett","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christian L Barrett","raw_affiliation_strings":["Bioengineering Department, University of California--San Diego, 9500 Gilman Drive, La Jolla, California, 92093-0412, USA. cbarrett@bioeng.ucsd.edu","Bioengineering Department, University of California San Diego, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Department, University of California--San Diego, 9500 Gilman Drive, La Jolla, California, 92093-0412, USA. cbarrett@bioeng.ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Bioengineering Department, University of California San Diego, La Jolla, USA","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034589050","display_name":"Nathan D. Price","orcid":"https://orcid.org/0000-0002-4157-0267"},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I58610484","display_name":"Seattle University","ror":"https://ror.org/02jqc0m91","country_code":"US","type":"education","lineage":["https://openalex.org/I58610484"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan D Price","raw_affiliation_strings":["Institute for Systems Biology, 1441 North 34th Street, Seattle, WA, 98103, USA","Institute for Systems Biology, Seattle, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, 1441 North 34th Street, Seattle, WA, 98103, USA","institution_ids":["https://openalex.org/I3148997608"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle, USA#TAB#","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I58610484"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051097609","display_name":"Bernhard \u00d8. Palsson","orcid":"https://orcid.org/0000-0003-2357-6785"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernhard O Palsson","raw_affiliation_strings":["Bioengineering Department, University of California \u2013 San Diego, 9500, Gilman Drive, La Jolla, California, 92093-0412, USA","Bioengineering Department, University of California San Diego, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Department, University of California \u2013 San Diego, 9500, Gilman Drive, La Jolla, California, 92093-0412, USA","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Bioengineering Department, University of California San Diego, La Jolla, USA","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082405466"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210133661"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.0446,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.85088197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"132","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.4449999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.4449999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.20419999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/singular-value-decomposition","display_name":"Singular value decomposition","score":0.8052654266357422},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.6863121390342712},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5047570466995239},{"id":"https://openalex.org/keywords/sampling","display_name":"Sampling (signal processing)","score":0.5014567375183105},{"id":"https://openalex.org/keywords/singular-value","display_name":"Singular value","score":0.4358738660812378},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.41080406308174133},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3522176742553711},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3475189507007599},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3085588216781616},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.24345585703849792},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20578989386558533},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.16980412602424622}],"concepts":[{"id":"https://openalex.org/C22789450","wikidata":"https://www.wikidata.org/wiki/Q420904","display_name":"Singular value decomposition","level":2,"score":0.8052654266357422},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.6863121390342712},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5047570466995239},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.5014567375183105},{"id":"https://openalex.org/C109282560","wikidata":"https://www.wikidata.org/wiki/Q4166054","display_name":"Singular value","level":3,"score":0.4358738660812378},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.41080406308174133},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3522176742553711},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3475189507007599},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3085588216781616},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.24345585703849792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20578989386558533},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16980412602424622},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-7-132","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-132","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-132","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16533395","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16533395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:81fabfcf067c4d19851971042b037ee2","is_oa":true,"landing_page_url":"https://doaj.org/article/81fabfcf067c4d19851971042b037ee2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 7, Iss 1, p 132 (2006)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1421444","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1421444","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-7-132","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-7-132","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-7-132","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1806973358.pdf","grobid_xml":"https://content.openalex.org/works/W1806973358.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1543292456","https://openalex.org/W1758395617","https://openalex.org/W1963948396","https://openalex.org/W1964491374","https://openalex.org/W1965518203","https://openalex.org/W1968286256","https://openalex.org/W1980717706","https://openalex.org/W1987198680","https://openalex.org/W1994134392","https://openalex.org/W1994656497","https://openalex.org/W2003501808","https://openalex.org/W2005423095","https://openalex.org/W2008818443","https://openalex.org/W2009940763","https://openalex.org/W2009990638","https://openalex.org/W2012459591","https://openalex.org/W2013685063","https://openalex.org/W2015519162","https://openalex.org/W2022440628","https://openalex.org/W2037614307","https://openalex.org/W2042605932","https://openalex.org/W2043016160","https://openalex.org/W2046760236","https://openalex.org/W2056281205","https://openalex.org/W2063475537","https://openalex.org/W2086196945","https://openalex.org/W2089449076","https://openalex.org/W2094399313","https://openalex.org/W2097588479","https://openalex.org/W2098709515","https://openalex.org/W2099039198","https://openalex.org/W2101591109","https://openalex.org/W2117486132","https://openalex.org/W2119642783","https://openalex.org/W2166927282","https://openalex.org/W2170997652","https://openalex.org/W3015962962","https://openalex.org/W4205902690","https://openalex.org/W4210598977","https://openalex.org/W4245245123","https://openalex.org/W4255087327","https://openalex.org/W4301891957"],"related_works":["https://openalex.org/W4319586039","https://openalex.org/W4382583540","https://openalex.org/W2147072251","https://openalex.org/W2148568324","https://openalex.org/W1607100495","https://openalex.org/W4386721910","https://openalex.org/W4378770618","https://openalex.org/W2164147222","https://openalex.org/W2038393145","https://openalex.org/W2594811212"],"abstract_inverted_index":{"BACKGROUND:":[0],"Extreme":[1],"pathways":[2,172],"(ExPas)":[3],"have":[4],"been":[5,41],"shown":[6],"to":[7,43,76,85,181,207],"be":[8,77,179,191],"valuable":[9],"for":[10,67],"studying":[11],"the":[12,22,26,35,45,50,70,102,113,118,126,130,154,157,162,170,175,209,213,221],"functions":[13],"and":[14,66,173],"capabilities":[15],"of":[16,21,25,34,62,72,89,94,104,109,117,129,137,153,156,165,169,186,212,223],"metabolic":[17,46,120,158,218],"networks":[18,69,219],"through":[19,220],"characterization":[20],"null":[23],"space":[24,116,160],"stoichiometric":[27,96],"matrix":[28,37,106],"(S).":[29],"Singular":[30],"value":[31],"decomposition":[32],"(SVD)":[33],"ExPa":[36],"P":[38],"has":[39,74,142],"previously":[40],"used":[42],"characterize":[44],"regulatory":[47,87,127,214],"problem":[48,215],"in":[49,204,216],"human":[51],"red":[52],"blood":[53],"cell":[54],"(hRBC)":[55],"from":[56,112,193],"a":[57,105,150,166,182,205],"network":[58,121,131,210],"perspective.":[59],"The":[60],"calculation":[61],"ExPas":[63,73],"is":[64,83],"NP-hard,":[65],"genome-scale":[68,95,194,217],"computation":[71],"proven":[75],"infeasible.":[78],"Therefore":[79],"an":[80],"alternative":[81],"approach":[82,141],"needed":[84],"reveal":[86],"properties":[88,128],"steady":[90],"state":[91],"solution":[92,115,159],"spaces":[93],"matrices.":[97],"RESULTS:":[98],"We":[99],"show":[100,199],"that":[101,200],"SVD":[103,136,176],"(W)":[107],"formed":[108],"random":[110,224],"samples":[111],"steady-state":[114],"hRBC":[119],"gives":[122],"similar":[123],"insights":[124],"into":[125],"as":[132,189],"was":[133],"obtained":[134],"with":[135,149],"P.":[138],"This":[139],"new":[140],"two":[143],"main":[144],"advantages.":[145],"First,":[146],"it":[147],"works":[148],"direct":[151],"representation":[152],"shape":[155],"without":[161],"confounding":[163],"factor":[164],"non-uniform":[167],"distribution":[168],"extreme":[171],"second,":[174],"procedure":[177],"can":[178],"applied":[180],"very":[183],"large":[184],"number":[185],"samples,":[187],"such":[188],"will":[190],"produced":[192],"networks.":[195],"CONCLUSION:":[196],"These":[197],"results":[198],"we":[201],"are":[202],"now":[203],"position":[206],"study":[208],"aspects":[211],"use":[222],"sampling.":[225]},"counts_by_year":[{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-05-21T09:19:25.381259","created_date":"2025-10-10T00:00:00"}