{"id":"https://openalex.org/W2143873179","doi":"https://doi.org/10.1186/1471-2105-6-s2-s6","title":"Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling","display_name":"Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2143873179","doi":"https://doi.org/10.1186/1471-2105-6-s2-s6","mag":"2143873179","pmid":"https://pubmed.ncbi.nlm.nih.gov/16026603"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-6-s2-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-6-s2-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-S2-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-S2-S6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100624061","display_name":"Hong Fang","orcid":"https://orcid.org/0000-0003-4504-2741"},"institutions":[{"id":"https://openalex.org/I4210147108","display_name":"Hi-Z Technology (United States)","ror":"https://ror.org/03x8f0b85","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Fang","raw_affiliation_strings":["Division of Bioinformatics, Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR 72079, USA. hfang@nctr.fda.gov","Division of Bioinformatics, Z-Tech Corporation, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics, Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR 72079, USA. hfang@nctr.fda.gov","institution_ids":["https://openalex.org/I4210147108"]},{"raw_affiliation_string":"Division of Bioinformatics, Z-Tech Corporation, Jefferson, USA","institution_ids":["https://openalex.org/I4210147108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068886380","display_name":"Weida Tong","orcid":"https://orcid.org/0000-0003-3488-6148"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W Tong","raw_affiliation_strings":["Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061"]},{"raw_affiliation_string":"Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, Jefferson, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048655816","display_name":"Roger Perkins","orcid":null},"institutions":[{"id":"https://openalex.org/I4210147108","display_name":"Hi-Z Technology (United States)","ror":"https://ror.org/03x8f0b85","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Perkins","raw_affiliation_strings":["Division of Bioinformatics, Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Bioinformatics, Z-Tech Corporation, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics, Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I4210147108"]},{"raw_affiliation_string":"Division of Bioinformatics, Z-Tech Corporation, Jefferson, USA","institution_ids":["https://openalex.org/I4210147108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103270054","display_name":"Liyu Shi","orcid":"https://orcid.org/0000-0002-0143-8544"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Shi","raw_affiliation_strings":["Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061"]},{"raw_affiliation_string":"Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, Jefferson, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100742819","display_name":"Huixiao Hong","orcid":"https://orcid.org/0000-0001-8087-3968"},"institutions":[{"id":"https://openalex.org/I4210147108","display_name":"Hi-Z Technology (United States)","ror":"https://ror.org/03x8f0b85","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Hong","raw_affiliation_strings":["Division of Bioinformatics, Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Bioinformatics, Z-Tech Corporation, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics, Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I4210147108"]},{"raw_affiliation_string":"Division of Bioinformatics, Z-Tech Corporation, Jefferson, USA","institution_ids":["https://openalex.org/I4210147108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031909133","display_name":"Xiaoxi Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210147108","display_name":"Hi-Z Technology (United States)","ror":"https://ror.org/03x8f0b85","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X Cao","raw_affiliation_strings":["Division of Bioinformatics, Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Bioinformatics, Z-Tech Corporation, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics, Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I4210147108"]},{"raw_affiliation_string":"Division of Bioinformatics, Z-Tech Corporation, Jefferson, USA","institution_ids":["https://openalex.org/I4210147108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101466012","display_name":"Qian Xie","orcid":"https://orcid.org/0009-0003-3547-0264"},"institutions":[{"id":"https://openalex.org/I4210147108","display_name":"Hi-Z Technology (United States)","ror":"https://ror.org/03x8f0b85","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Q Xie","raw_affiliation_strings":["Division of Bioinformatics, Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Bioinformatics, Z-Tech Corporation, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics, Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I4210147108"]},{"raw_affiliation_string":"Division of Bioinformatics, Z-Tech Corporation, Jefferson, USA","institution_ids":["https://openalex.org/I4210147108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109238183","display_name":"SH Yim","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SH Yim","raw_affiliation_strings":["Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, 20892, USA","Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111954340","display_name":"JM Ward","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JM Ward","raw_affiliation_strings":["Verterinary and Tumor Pathology Section, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702, USA","Verterinary and Tumor Pathology Section, Center for Cancer Research, National Cancer Institute, Frederick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Verterinary and Tumor Pathology Section, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Verterinary and Tumor Pathology Section, Center for Cancer Research, National Cancer Institute, Frederick, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111954339","display_name":"HC Pitot","orcid":null},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HC Pitot","raw_affiliation_strings":["McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, 53706, USA","McArdle Laboratory for Cancer Research, Univ. of Wisconsin, Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"McArdle Laboratory for Cancer Research, Univ. of Wisconsin, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113685073","display_name":"YP Dragan","orcid":null},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YP Dragan","raw_affiliation_strings":["Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061"]},{"raw_affiliation_string":"Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, Jefferson, USA","institution_ids":["https://openalex.org/I1304557061"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068886380"],"corresponding_institution_ids":["https://openalex.org/I1304557061"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.4237,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.80205821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"S2","first_page":"S6","last_page":"S6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7185999751091003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7185999751091003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.06129999831318855,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8327235579490662},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6688306331634521},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.5918123722076416},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.567924439907074},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.559205174446106},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.5364364385604858},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5107648372650146},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.47728481888771057},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46436449885368347},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4569563865661621},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.42323848605155945},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"Liver cancer","score":0.4152531027793884},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.33223530650138855}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8327235579490662},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6688306331634521},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5918123722076416},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.567924439907074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.559205174446106},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5364364385604858},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5107648372650146},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.47728481888771057},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46436449885368347},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4569563865661621},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.42323848605155945},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4152531027793884},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33223530650138855}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-6-s2-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-6-s2-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-S2-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16026603","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16026603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:5efaddc9158d47c6a4abdaa609535e41","is_oa":true,"landing_page_url":"https://doaj.org/article/5efaddc9158d47c6a4abdaa609535e41","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 6, Iss Suppl 2, p S6 (2005)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:367598","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1637037","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1637037","is_oa":true,"landing_page_url":"http://doi.org/10.1186/1471-2105-6-S2-S6","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-6-s2-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-6-s2-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-S2-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.5799999833106995,"display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2143873179.pdf","grobid_xml":"https://content.openalex.org/works/W2143873179.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W17916349","https://openalex.org/W283578788","https://openalex.org/W1490574368","https://openalex.org/W1578104218","https://openalex.org/W1956912477","https://openalex.org/W1971965421","https://openalex.org/W1980022529","https://openalex.org/W1983017536","https://openalex.org/W1990453950","https://openalex.org/W1991251859","https://openalex.org/W2011912935","https://openalex.org/W2027962951","https://openalex.org/W2037479635","https://openalex.org/W2040316588","https://openalex.org/W2056107570","https://openalex.org/W2059550141","https://openalex.org/W2061206375","https://openalex.org/W2083986341","https://openalex.org/W2091512192","https://openalex.org/W2097040991","https://openalex.org/W2100132991","https://openalex.org/W2102956442","https://openalex.org/W2107427637","https://openalex.org/W2122051016","https://openalex.org/W2129441189","https://openalex.org/W2131658210","https://openalex.org/W2136835420","https://openalex.org/W2139148987","https://openalex.org/W2139703939","https://openalex.org/W2147955536","https://openalex.org/W2151464048","https://openalex.org/W2154361640","https://openalex.org/W2154867943","https://openalex.org/W2155606054","https://openalex.org/W2163806225","https://openalex.org/W2164942212","https://openalex.org/W2168909179","https://openalex.org/W2177441133","https://openalex.org/W2196239460","https://openalex.org/W4255576518"],"related_works":["https://openalex.org/W2041540252","https://openalex.org/W2796636403","https://openalex.org/W2415545834","https://openalex.org/W1547158732","https://openalex.org/W3203113381","https://openalex.org/W170658859","https://openalex.org/W1483316219","https://openalex.org/W4310366902","https://openalex.org/W3023720143","https://openalex.org/W2107563406"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,268,299],"completion":[2],"of":[3,6,14,20,29,39,194,209,236,249,314],"the":[4,32,128,136,140,146,172,181,232,237,247,272,278],"sequencing":[5],"human,":[7],"mouse":[8,182,197],"and":[9,12,84,115,155,177,179,186,196,229,259,264,286,292,312,319],"rat":[10,129,161,167,233,281],"genomes":[11],"knowledge":[13],"cross-species":[15],"gene":[16,22,107,274],"homologies":[17],"enables":[18],"studies":[19,30,193],"differential":[21],"expression":[23,68,108,275],"in":[24,45,75,153,160,166,192,212,246,295,303],"animal":[25],"models.":[26],"These":[27,122],"types":[28],"have":[31,56,60,189,240],"potential":[33,210],"to":[34,55,65,79,127,149,171,180,220,243],"greatly":[35],"enhance":[36],"our":[37],"understanding":[38],"diseases":[40],"such":[41],"as":[42],"liver":[43,71,92,168,198,251,297],"cancer":[44,169],"humans.":[46],"Genes":[47],"co-expressed":[48],"across":[49],"multiple":[50],"species":[51,310],"are":[52,164,306],"most":[53],"likely":[54],"conserved":[57],"functions.":[58],"We":[59],"used":[61],"various":[62],"bioinformatics":[63,300],"approaches":[64],"examine":[66],"microarray":[67,315],"profiles":[69,109,276],"from":[70,231,277],"neoplasms":[72],"that":[73,86,163,271],"arise":[74],"albumin-SV40":[76,279],"transgenic":[77,280],"rats":[78],"elucidate":[80],"genes,":[81,284],"chromosome":[82,287],"aberrations":[83,211],"pathways":[85,224,239,285],"might":[87],"be":[88,244],"associated":[89],"with":[90,290],"human":[91,154,173,195,223,250,296],"cancer.":[93,199,298],"RESULTS:":[94],"In":[95],"this":[96,304],"study,":[97],"we":[98,143,206],"first":[99],"identified":[100,207,238],"2223":[101],"differentially":[102],"expressed":[103,159],"genes":[104,123,148,158],"by":[105],"comparing":[106],"for":[110,308],"two":[111,113,116],"control,":[112,256],"adenoma":[114],"carcinoma":[117],"samples":[118],"using":[119,131],"an":[120],"F-test.":[121],"were":[124],"subsequently":[125],"mapped":[126,145],"chromosomes":[130,174,183],"a":[132,215],"novel":[133],"visualization":[134],"tool,":[135],"Chromosome":[137],"Plot.":[138],"Using":[139,200],"same":[141],"plot,":[142],"further":[144],"significant":[147],"orthologous":[150],"chromosomal":[151],"locations":[152],"mouse.":[156],"Many":[157],"1q":[162],"amplified":[165],"map":[170],"10,":[175],"11":[176],"19":[178],"7,":[184],"17":[185],"19,":[187],"which":[188],"been":[190,241],"implicated":[191],"Comparative":[201],"Genomics":[202],"Microarray":[203],"Analysis":[204],"(CGMA),":[205],"regions":[208],"human.":[213],"Lastly,":[214],"pathway":[216],"analysis":[217,228,318],"was":[218],"conducted":[219],"predict":[221],"altered":[222],"based":[225],"on":[226],"statistical":[227],"extrapolation":[230,311],"data.":[234],"All":[235],"known":[242],"important":[245],"etiology":[248],"cancer,":[252],"including":[253],"cell":[254,257],"cycle":[255],"growth":[258],"differentiation,":[260],"apoptosis,":[261],"transcriptional":[262],"regulation,":[263],"protein":[265],"metabolism.":[266],"CONCLUSION:":[267],"study":[269],"demonstrates":[270],"hepatic":[273],"model":[282],"revealed":[283],"alterations":[288],"consistent":[289],"experimental":[291],"clinical":[293],"research":[294],"tools":[301],"presented":[302],"paper":[305],"essential":[307],"cross":[309],"mapping":[313],"data,":[316],"its":[317],"interpretation.":[320]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}