{"id":"https://openalex.org/W2115580179","doi":"https://doi.org/10.1186/1471-2105-6-58","title":"Towards precise classification of cancers based on robust gene functional expression profiles","display_name":"Towards precise classification of cancers based on robust gene functional expression profiles","publication_year":2005,"publication_date":"2005-03-17","ids":{"openalex":"https://openalex.org/W2115580179","doi":"https://doi.org/10.1186/1471-2105-6-58","mag":"2115580179","pmid":"https://pubmed.ncbi.nlm.nih.gov/15774002"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-6-58","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-6-58","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-58","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-58","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087055335","display_name":"Zheng Guo","orcid":"https://orcid.org/0000-0003-4466-6026"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zheng Guo","raw_affiliation_strings":["Department of Computer Science, Harbin Institute of Technology, Harbin 150001, China. guoz@ems.hrbmu.edu.cn","School of Biological Science and Technology, Tongji University, Shanghai, China","Department of Computer Science, Harbin Institute of Technology, Harbin, China","Department of Bioinformatics, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin 150001, China. guoz@ems.hrbmu.edu.cn","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Biological Science and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101963061","display_name":"Tianwen Zhang","orcid":"https://orcid.org/0000-0003-0269-0773"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianwen Zhang","raw_affiliation_strings":["Department of Computer Science, Harbin Institute of Technology, Harbin, 150001, China","Department of Computer Science, Harbin Institute of Technology, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, 150001, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445596","display_name":"Xia Li","orcid":"https://orcid.org/0000-0002-9794-2648"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Li","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","Department of Computer Science, Harbin Institute of Technology, Harbin, 150001, China","School of Biological Science and Technology, Tongji University, Shanghai, 200092, China","Department of Computer Science, Harbin Institute of Technology, Harbin, China","Department of Bioinformatics, Harbin Medical University, Harbin, China","School of Biological Science and Technology, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, 150001, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Biological Science and Technology, Tongji University, Shanghai, 200092, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"Department of Computer Science, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"School of Biological Science and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100341255","display_name":"Qi Wang","orcid":"https://orcid.org/0000-0002-0634-9882"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Qi Wang","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","Department of Bioinformatics, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070236474","display_name":"Jianzhen Xu","orcid":"https://orcid.org/0000-0002-0697-9075"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianzhen Xu","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","Department of Bioinformatics, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004341112","display_name":"Hui Yu","orcid":"https://orcid.org/0000-0002-4617-7640"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Yu","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","Department of Bioinformatics, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101811772","display_name":"Jing Zhu","orcid":"https://orcid.org/0000-0002-9039-6533"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhu","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","Department of Bioinformatics, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100601473","display_name":"Haiyun Wang","orcid":"https://orcid.org/0000-0001-8364-8328"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyun Wang","raw_affiliation_strings":["School of Biological Science and Technology, Tongji University, Shanghai, 200092, China","School of Biological Science and Technology, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science and Technology, Tongji University, Shanghai, 200092, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"School of Biological Science and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100329694","display_name":"Chenguang Wang","orcid":"https://orcid.org/0000-0002-9082-2117"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenguang Wang","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","Department of Bioinformatics, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084515381","display_name":"Eric J. Topol","orcid":"https://orcid.org/0000-0002-1478-4729"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric J Topol","raw_affiliation_strings":["Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, Cleveland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010515168","display_name":"Qing K. Wang","orcid":"https://orcid.org/0000-0002-5639-8519"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Qing Wang","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, Cleveland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089580482","display_name":"Shaoqi Rao","orcid":"https://orcid.org/0000-0001-7809-3700"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Shaoqi Rao","raw_affiliation_strings":["Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","Department of Bioinformatics, Harbin Medical University, Harbin, China","Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, Cleveland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Bioinformatics, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Department of Molecular Cardiology and Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087055335","https://openalex.org/A5089580482"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I1316902750","https://openalex.org/I156144747","https://openalex.org/I204983213"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.0141,"has_fulltext":true,"cited_by_count":164,"citation_normalized_percentile":{"value":0.9153368,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"6","issue":"1","first_page":"58","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9758999943733215,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9758999943733215,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6924590468406677},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6121869683265686},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.6056903600692749},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.5381153225898743},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4885188341140747},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4606682062149048},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.44824159145355225},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4117143154144287},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.37052541971206665},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32987180352211},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.07928267121315002}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6924590468406677},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6121869683265686},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6056903600692749},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5381153225898743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4885188341140747},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4606682062149048},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44824159145355225},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4117143154144287},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37052541971206665},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32987180352211},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.07928267121315002}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-6-58","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-6-58","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-58","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15774002","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15774002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:944c37e91f6a4142ad34e97f85e69da4","is_oa":true,"landing_page_url":"https://doaj.org/article/944c37e91f6a4142ad34e97f85e69da4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 6, Iss 1, p 58 (2005)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1456164","is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC1274255","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1274255","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1274255","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-6-58","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-6-58","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-58","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6700000166893005,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G4243412236","display_name":null,"funder_award_id":"863 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5464014682","display_name":null,"funder_award_id":"R01 HL066251","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G807070257","display_name":null,"funder_award_id":"211 Project","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8774128957","display_name":null,"funder_award_id":"30370798","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320312270","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335773","display_name":"National High-tech Research and Development Program","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115580179.pdf","grobid_xml":"https://content.openalex.org/works/W2115580179.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1504694836","https://openalex.org/W1519001562","https://openalex.org/W1535641839","https://openalex.org/W1575640329","https://openalex.org/W1592785605","https://openalex.org/W1644749979","https://openalex.org/W1964599014","https://openalex.org/W1968758858","https://openalex.org/W1987687771","https://openalex.org/W1989076816","https://openalex.org/W1992242907","https://openalex.org/W1998902445","https://openalex.org/W2017337590","https://openalex.org/W2020502894","https://openalex.org/W2024487262","https://openalex.org/W2030923426","https://openalex.org/W2040411864","https://openalex.org/W2053269411","https://openalex.org/W2059313996","https://openalex.org/W2064237923","https://openalex.org/W2070448217","https://openalex.org/W2071936413","https://openalex.org/W2077617582","https://openalex.org/W2081931663","https://openalex.org/W2085096251","https://openalex.org/W2098509901","https://openalex.org/W2102794349","https://openalex.org/W2103017472","https://openalex.org/W2108043112","https://openalex.org/W2116665656","https://openalex.org/W2117822166","https://openalex.org/W2119668204","https://openalex.org/W2124388496","https://openalex.org/W2125055259","https://openalex.org/W2127163275","https://openalex.org/W2128936012","https://openalex.org/W2137088684","https://openalex.org/W2139703939","https://openalex.org/W2147246240","https://openalex.org/W2150630892","https://openalex.org/W2152393933","https://openalex.org/W2159917467","https://openalex.org/W2163296727","https://openalex.org/W2163480486","https://openalex.org/W2171280873","https://openalex.org/W2171674404","https://openalex.org/W2171936986","https://openalex.org/W3015789953","https://openalex.org/W4241034460"],"related_works":["https://openalex.org/W2069695727","https://openalex.org/W1996185163","https://openalex.org/W106077234","https://openalex.org/W2084813257","https://openalex.org/W2043690326","https://openalex.org/W2052655934","https://openalex.org/W2041374557","https://openalex.org/W2045929470","https://openalex.org/W2081929287","https://openalex.org/W2144348650"],"abstract_inverted_index":{"BACKGROUND:":[0],"Development":[1],"of":[2,51,67,158,168,194,202,226,285],"robust":[3,60,261],"and":[4,9,34,54,229,259,266],"efficient":[5,275],"methods":[6],"for":[7,49,103,153,290],"analyzing":[8,254],"interpreting":[10],"high":[11,255,263],"dimension":[12,99,256],"gene":[13,110,118,178,213],"expression":[14,62,101,156,208,214,239],"profiles":[15,63,209,215],"continues":[16],"to":[17,86,111,162,189,247,253,262],"be":[18,233,248],"a":[19,84,89,97,116,149,181,249],"focus":[20],"in":[21,38,41,115,127,271],"computational":[22,56],"biology.":[23],"The":[24],"accumulated":[25],"experiment":[26],"evidence":[27],"supports":[28],"the":[29,52,72,78,154,159,164,169,177,191,199,211,236,283,286,295],"assumption":[30],"that":[31,58,80,223],"genes":[32,81,161],"express":[33],"perform":[35],"their":[36],"functions":[37],"modular":[39,73,243,296],"fashions":[40],"cells.":[42],"Therefore,":[43],"there":[44],"is":[45,245,260],"an":[46,185],"open":[47],"space":[48],"development":[50],"timely":[53],"relevant":[55],"algorithms":[57],"use":[59],"functional":[61,100,112,133,142,145,182,207,238],"towards":[64],"precise":[65,224],"classification":[66,120,200,225],"complex":[68,291],"human":[69,292],"diseases":[70,293],"at":[71,294],"level.":[74,297],"RESULTS:":[75],"Inspired":[76],"by":[77],"insight":[79],"act":[82],"as":[83,123,184],"module":[85,183],"carry":[87],"out":[88],"highly":[90],"integrated":[91],"cellular":[92],"function,":[93],"we":[94,130,147,174],"thus":[95],"define":[96],"low":[98],"profile":[102],"data":[104,187,258],"reduction.":[105],"After":[106],"annotating":[107],"each":[108,141],"individual":[109,195],"categories":[113,134],"defined":[114],"proper":[117],"function":[119],"system":[121],"such":[122],"Gene":[124],"Ontology":[125],"applied":[126],"this":[128,172],"study,":[129],"identify":[131],"those":[132],"enriched":[135],"with":[136,210,235,277],"differentially":[137],"expressed":[138],"genes.":[139,196],"For":[140],"category":[143],"or":[144],"module,":[146],"compute":[148],"summary":[150],"measure":[151],"(s)":[152],"raw":[155],"values":[157,193],"annotated":[160],"capture":[163],"overall":[165],"activity":[166],"level":[167],"module.":[170],"In":[171],"way,":[173],"can":[175,232],"treat":[176],"expressions":[179],"within":[180],"integrative":[186],"point":[188],"replace":[190],"multiple":[192],"We":[197],"compare":[198],"performance":[201],"decision":[203],"trees":[204],"based":[205],"on":[206],"conventional":[212],"using":[216],"four":[217],"publicly":[218],"available":[219],"datasets,":[220],"which":[221],"indicates":[222],"tumour":[227],"types":[228],"improved":[230],"interpretation":[231,284],"achieved":[234],"reduced":[237],"profiles.":[240],"CONCLUSION:":[241],"This":[242],"approach":[244,252],"demonstrated":[246],"powerful":[250],"alternative":[251],"microarray":[257,272],"measurement":[264],"noise":[265],"intrinsic":[267],"biological":[268,279],"variance":[269],"inherent":[270],"data.":[273],"Furthermore,":[274],"integration":[276],"current":[278],"knowledge":[280],"has":[281],"facilitated":[282],"underlying":[287],"molecular":[288],"mechanisms":[289]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":14}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}
