{"id":"https://openalex.org/W1858351564","doi":"https://doi.org/10.1186/1471-2105-6-210","title":"Variation in structural location and amino acid conservation of functional sites in protein domain families","display_name":"Variation in structural location and amino acid conservation of functional sites in protein domain families","publication_year":2005,"publication_date":"2005-08-25","ids":{"openalex":"https://openalex.org/W1858351564","doi":"https://doi.org/10.1186/1471-2105-6-210","mag":"1858351564","pmid":"https://pubmed.ncbi.nlm.nih.gov/16122386"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-6-210","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-6-210","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-210","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-210","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036982836","display_name":"Birgit Pils","orcid":null},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Birgit Pils","raw_affiliation_strings":["Department of Bioinformatics, University of W\u00fcrzburg, Biocenter, Am Hubland, 97074 W\u00fcrzburg, Germany. birgit.pils@biozentrum.uni-wuerzburg.de","Department of Bioinformatics University of W\u00fcrzburg Biocenter W\u00fcrzburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, University of W\u00fcrzburg, Biocenter, Am Hubland, 97074 W\u00fcrzburg, Germany. birgit.pils@biozentrum.uni-wuerzburg.de","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Department of Bioinformatics University of W\u00fcrzburg Biocenter W\u00fcrzburg Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057740801","display_name":"Richard R. Copley","orcid":"https://orcid.org/0000-0001-7846-4954"},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard R Copley","raw_affiliation_strings":["Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, OX3 7BN, Oxford, UK","Wellcome Trust Centre for Human Genetics; University of Oxford; Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, OX3 7BN, Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Wellcome Trust Centre for Human Genetics; University of Oxford; Oxford, UK","institution_ids":["https://openalex.org/I1336263701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108354950","display_name":"J\u00f6rg Schultz","orcid":"https://orcid.org/0000-0002-0838-7700"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J\u00f6rg Schultz","raw_affiliation_strings":["Department of Bioinformatics, University of W\u00fcrzburg, Biocenter, Am Hubland, 97074, W\u00fcrzburg, Germany","Department of Bioinformatics University of W\u00fcrzburg Biocenter W\u00fcrzburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, University of W\u00fcrzburg, Biocenter, Am Hubland, 97074, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Department of Bioinformatics University of W\u00fcrzburg Biocenter W\u00fcrzburg Germany","institution_ids":["https://openalex.org/I25974101"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108354950"],"corresponding_institution_ids":["https://openalex.org/I25974101"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.717,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.6605802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"210","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.8463000059127808,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.8463000059127808,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.7234258651733398},{"id":"https://openalex.org/keywords/protein-superfamily","display_name":"Protein superfamily","score":0.6066122651100159},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6063076853752136},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5609343647956848},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.55258709192276},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.512990415096283},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.5030056834220886},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.43129763007164},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4236880838871002},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.42053335905075073},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.41741040349006653},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.3875393569469452},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18489250540733337},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13270354270935059}],"concepts":[{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.7234258651733398},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.6066122651100159},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6063076853752136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5609343647956848},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.55258709192276},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.512990415096283},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.5030056834220886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43129763007164},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4236880838871002},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.42053335905075073},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.41741040349006653},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3875393569469452},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18489250540733337},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13270354270935059}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039301","descriptor_name":"Computers, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039301","descriptor_name":"Computers, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039301","descriptor_name":"Computers, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2105-6-210","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-6-210","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-210","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16122386","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16122386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:ed0a1189-d699-4839-b227-c49308b43385","is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:ed0a1189-d699-4839-b227-c49308b43385","pdf_url":"https://ora.ox.ac.uk/objects/uuid:ed0a1189-d699-4839-b227-c49308b43385","source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1215474","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1215474","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:df1e948566d44f74a43087739d45dcfb","is_oa":false,"landing_page_url":"https://doaj.org/article/df1e948566d44f74a43087739d45dcfb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 6, Iss 1, p 210 (2005)","raw_type":"article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:bd1699a4-a771-4b88-b956-19550403824c","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:bd1699a4-a771-4b88-b956-19550403824c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"},{"id":"pmh:uuid:ed0a1189-d699-4839-b227-c49308b43385","is_oa":true,"landing_page_url":"http://www.biomedcentral.com/1471-2105/6/210","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-6-210","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-6-210","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-6-210","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.6800000071525574}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1858351564.pdf","grobid_xml":"https://content.openalex.org/works/W1858351564.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1518889327","https://openalex.org/W1935774199","https://openalex.org/W1967408543","https://openalex.org/W1977922844","https://openalex.org/W1994261741","https://openalex.org/W1995245717","https://openalex.org/W1999032243","https://openalex.org/W2005153862","https://openalex.org/W2012796753","https://openalex.org/W2027036222","https://openalex.org/W2030860488","https://openalex.org/W2037122000","https://openalex.org/W2039063819","https://openalex.org/W2041673942","https://openalex.org/W2043543538","https://openalex.org/W2058527555","https://openalex.org/W2070871842","https://openalex.org/W2075770210","https://openalex.org/W2077847478","https://openalex.org/W2078866107","https://openalex.org/W2086193113","https://openalex.org/W2094148990","https://openalex.org/W2097818324","https://openalex.org/W2115156437","https://openalex.org/W2117923629","https://openalex.org/W2119498937","https://openalex.org/W2122854841","https://openalex.org/W2123858481","https://openalex.org/W2128402268","https://openalex.org/W2137991504","https://openalex.org/W2139919097","https://openalex.org/W2140455347","https://openalex.org/W2142757818","https://openalex.org/W2147862296","https://openalex.org/W2163352757","https://openalex.org/W2163493367","https://openalex.org/W2165181282","https://openalex.org/W2166458835","https://openalex.org/W2582743722","https://openalex.org/W3199943451","https://openalex.org/W4302414012"],"related_works":["https://openalex.org/W1973727281","https://openalex.org/W2514476306","https://openalex.org/W2121560377","https://openalex.org/W2786092929","https://openalex.org/W2030041169","https://openalex.org/W2792119560","https://openalex.org/W2888081294","https://openalex.org/W2133420109","https://openalex.org/W4229858997","https://openalex.org/W2516488001"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,152,200],"functional":[2,28,53,79,86,118,142,193,212],"sites":[3,29,54,87,94,121,143,186,194],"of":[4,27,31,42,71,75,85,135,149,154,161,211,219],"a":[5,40,108,146],"protein":[6,90,110,163,221],"present":[7,145],"important":[8],"information":[9],"for":[10,24],"determining":[11],"its":[12],"cellular":[13],"function":[14,160],"and":[15,45,50,73,81,165,172,215],"are":[16,30,37,55,128],"fundamental":[17],"in":[18,132,170],"drug":[19],"design.":[20],"Accordingly,":[21],"accurate":[22],"methods":[23,36],"the":[25,59,62,69,83,103,113,159,162,209,217],"prediction":[26,214],"immense":[32],"value.":[33],"Most":[34],"available":[35],"based":[38],"on":[39,158],"set":[41],"homologous":[43],"sequences":[44],"structural":[46,100],"or":[47,197],"evolutionary":[48],"information,":[49],"assume":[51],"that":[52,183],"more":[56,125,130,190],"conserved":[57,109,127,131,141,169,191],"than":[58,192],"average.":[60],"In":[61,116],"analysis":[63,205],"presented":[64],"here,":[65],"we":[66],"have":[67],"investigated":[68],"conservation":[70,155],"location":[72,123,171],"type":[74,134],"amino":[76,136,150,173],"acids":[77],"at":[78],"sites,":[80],"compared":[82],"behaviour":[84],"between":[88],"different":[89],"domains.":[91],"RESULTS:":[92],"Functional":[93],"were":[95],"extracted":[96],"from":[97,102,112,167],"experimentally":[98],"determined":[99],"complexes":[101],"Protein":[104],"Data":[105],"Bank":[106],"harbouring":[107],"domain":[111,164],"SMART":[114],"database.":[115],"general,":[117],"(i.e.":[119],"interacting)":[120],"whose":[122],"is":[124],"highly":[126,140,168],"also":[129],"their":[133],"acid.":[137],"However,":[138],"even":[139],"can":[144],"wide":[147],"spectrum":[148],"acids.":[151],"degree":[153],"strongly":[156],"depends":[157],"ranges":[166],"acid":[174],"to":[175,188],"very":[176],"variable.":[177],"Differentiation":[178],"by":[179,203],"binding":[180,185,195],"partner":[181],"shows":[182],"ion":[184],"tend":[187],"be":[189],"peptides":[196],"nucleotides.":[198],"CONCLUSION:":[199],"results":[201],"gained":[202],"this":[204],"will":[206],"help":[207],"improve":[208],"accuracy":[210],"site":[213],"facilitate":[216],"characterization":[218],"unknown":[220],"sequences.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}
