{"id":"https://openalex.org/W2141063866","doi":"https://doi.org/10.1186/1471-2105-5-49","title":"An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene Interactions on risk of myocardial infarction: The importance of model validation","display_name":"An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene Interactions on risk of myocardial infarction: The importance of model validation","publication_year":2004,"publication_date":"2004-04-30","ids":{"openalex":"https://openalex.org/W2141063866","doi":"https://doi.org/10.1186/1471-2105-5-49","mag":"2141063866","pmid":"https://pubmed.ncbi.nlm.nih.gov/15119966"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-5-49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-5-49","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-5-49","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-5-49","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101963138","display_name":"Christopher S. Coffey","orcid":"https://orcid.org/0000-0002-8130-5484"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher S Coffey","raw_affiliation_strings":["Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA. ccoffey@uab.edu","Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 35294-0022, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA. ccoffey@uab.edu","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 35294-0022, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111750708","display_name":"Patricia R. Hebert","orcid":null},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia R Hebert","raw_affiliation_strings":["Section of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081769614","display_name":"Marylyn D. Ritchie","orcid":"https://orcid.org/0000-0002-1208-1720"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210105714","display_name":"Center for Human Genetics","ror":"https://ror.org/01gcrbc43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marylyn D Ritchie","raw_affiliation_strings":["Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN, 37232-0700, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN, 37232-0700, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210105714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088028306","display_name":"Harlan M. Krumholz","orcid":"https://orcid.org/0000-0003-2046-127X"},"institutions":[{"id":"https://openalex.org/I1323778983","display_name":"Yale New Haven Hospital","ror":"https://ror.org/05tszed37","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1323778983","https://openalex.org/I4210117499"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I46968129","display_name":"Robert Wood Johnson Foundation","ror":"https://ror.org/02ymmdj85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I46968129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harlan M Krumholz","raw_affiliation_strings":["Section of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, 06510, USA","Section of Health Policy and Administration, Department of Epidemiology and Public Health and Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, New Haven, CT, 06510, USA","Yale-New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, CT, 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, 06510, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Section of Health Policy and Administration, Department of Epidemiology and Public Health and Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, New Haven, CT, 06510, USA","institution_ids":["https://openalex.org/I46968129"]},{"raw_affiliation_string":"Yale-New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, CT, 06510, USA","institution_ids":["https://openalex.org/I1323778983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012460833","display_name":"J. Michael Gaziano","orcid":"https://orcid.org/0000-0002-5384-9767"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Michael Gaziano","raw_affiliation_strings":["Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091595592","display_name":"Paul M. Ridker","orcid":"https://orcid.org/0000-0003-1249-4522"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M Ridker","raw_affiliation_strings":["Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055618165","display_name":"Nancy J. Brown","orcid":"https://orcid.org/0000-0001-7109-3142"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy J Brown","raw_affiliation_strings":["Departments of Medicine and Pharmacology, Vanderbilt University Medical School, Nashville, TN, 37232-0700, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pharmacology, Vanderbilt University Medical School, Nashville, TN, 37232-0700, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039275729","display_name":"Douglas E. Vaughan","orcid":"https://orcid.org/0000-0002-8407-6613"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas E Vaughan","raw_affiliation_strings":["Departments of Medicine and Pharmacology, Vanderbilt University Medical School, Nashville, TN, 37232-0700, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pharmacology, Vanderbilt University Medical School, Nashville, TN, 37232-0700, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032971510","display_name":"Jason H. Moore","orcid":"https://orcid.org/0000-0002-5015-1099"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210105714","display_name":"Center for Human Genetics","ror":"https://ror.org/01gcrbc43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason H Moore","raw_affiliation_strings":["Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN, 37232-0700, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN, 37232-0700, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210105714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5101963138"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":7.7047,"has_fulltext":true,"cited_by_count":132,"citation_normalized_percentile":{"value":0.97933678,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"49","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7179999947547913,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7179999947547913,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.13050000369548798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multifactor-dimensionality-reduction","display_name":"Multifactor dimensionality reduction","score":0.9185240268707275},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"Logistic regression","score":0.6881236433982849},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5270165205001831},{"id":"https://openalex.org/keywords/type-i-and-type-ii-errors","display_name":"Type I and type II errors","score":0.5156984925270081},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.49762776494026184},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"Myocardial infarction","score":0.4844822585582733},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.45977649092674255},{"id":"https://openalex.org/keywords/regression-analysis","display_name":"Regression analysis","score":0.4491533637046814},{"id":"https://openalex.org/keywords/plasminogen-activator","display_name":"Plasminogen activator","score":0.425339937210083},{"id":"https://openalex.org/keywords/boosting","display_name":"Boosting (machine learning)","score":0.41382133960723877},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3684210181236267},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.35163629055023193},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.35074275732040405},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3305729031562805},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3146997094154358},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2626796364784241},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.25711899995803833},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2417779266834259},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.22820857167243958},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22689801454544067},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16568908095359802},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15719658136367798},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.11848652362823486},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.08881253004074097}],"concepts":[{"id":"https://openalex.org/C25249476","wikidata":"https://www.wikidata.org/wiki/Q6934678","display_name":"Multifactor dimensionality reduction","level":5,"score":0.9185240268707275},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6881236433982849},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5270165205001831},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.5156984925270081},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.49762776494026184},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4844822585582733},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.45977649092674255},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.4491533637046814},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.425339937210083},{"id":"https://openalex.org/C46686674","wikidata":"https://www.wikidata.org/wiki/Q466303","display_name":"Boosting (machine learning)","level":2,"score":0.41382133960723877},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3684210181236267},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35163629055023193},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.35074275732040405},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3305729031562805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3146997094154358},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2626796364784241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25711899995803833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2417779266834259},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.22820857167243958},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22689801454544067},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16568908095359802},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15719658136367798},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.11848652362823486},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.08881253004074097}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-5-49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-5-49","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-5-49","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15119966","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15119966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:dash.harvard.edu:1/4889518","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:4889518","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7d9f34a45a2f4495b055552eedb278da","is_oa":true,"landing_page_url":"https://doaj.org/article/7d9f34a45a2f4495b055552eedb278da","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 5, Iss 1, p 49 (2004)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:419697","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/419697","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-5-49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-5-49","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-5-49","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.41999998688697815}],"awards":[{"id":"https://openalex.org/G1021031087","display_name":null,"funder_award_id":"R44 HL099015","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1041122237","display_name":null,"funder_award_id":"AG20135","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1124536103","display_name":null,"funder_award_id":"HL-65962","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G120018185","display_name":null,"funder_award_id":"GM31304","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1612602199","display_name":null,"funder_award_id":"T15 LM007450","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G1684704463","display_name":null,"funder_award_id":"HL67466","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1880103910","display_name":null,"funder_award_id":"HL-65962","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2385477758","display_name":null,"funder_award_id":"LM-007450","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G25420283","display_name":null,"funder_award_id":"U19 HL065962","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2588376548","display_name":null,"funder_award_id":"GM31304","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3104935743","display_name":null,"funder_award_id":"HL99015","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3388351678","display_name":null,"funder_award_id":"P01 GM031304","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3812657198","display_name":null,"funder_award_id":"U01 HL065962","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G389197921","display_name":null,"funder_award_id":"HL67466","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3983084598","display_name":null,"funder_award_id":"HL99015","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5058144948","display_name":null,"funder_award_id":"HL-58755","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5491415535","display_name":null,"funder_award_id":"R01 HL065192","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6417034626","display_name":null,"funder_award_id":"R01 HL065234","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G657172961","display_name":null,"funder_award_id":"R01 AG020135","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G683448622","display_name":null,"funder_award_id":"AG 19085","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7021269361","display_name":null,"funder_award_id":"R01CA097193","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G725644539","display_name":null,"funder_award_id":"HL 65192","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7579655714","display_name":null,"funder_award_id":"HL65234","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7888515719","display_name":null,"funder_award_id":"R01 HL067466","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G802908390","display_name":null,"funder_award_id":"R01-HL065193","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G902857284","display_name":null,"funder_award_id":"R01 AG019085","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2141063866.pdf","grobid_xml":"https://content.openalex.org/works/W2141063866.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W79766069","https://openalex.org/W1505365469","https://openalex.org/W1603164711","https://openalex.org/W1966360257","https://openalex.org/W1974452968","https://openalex.org/W1976175860","https://openalex.org/W1981723690","https://openalex.org/W2024841768","https://openalex.org/W2030385383","https://openalex.org/W2034888656","https://openalex.org/W2043600435","https://openalex.org/W2046154630","https://openalex.org/W2071862675","https://openalex.org/W2072262664","https://openalex.org/W2083944388","https://openalex.org/W2093435132","https://openalex.org/W2103951118","https://openalex.org/W2104605543","https://openalex.org/W2112208424","https://openalex.org/W2116284648","https://openalex.org/W2126436234","https://openalex.org/W2131878646","https://openalex.org/W2134311390","https://openalex.org/W2143249342","https://openalex.org/W2143662702","https://openalex.org/W2154572047","https://openalex.org/W2161670346","https://openalex.org/W2162050622","https://openalex.org/W2162702582","https://openalex.org/W2329157757","https://openalex.org/W3175417087","https://openalex.org/W4245466284","https://openalex.org/W4297938889"],"related_works":["https://openalex.org/W1991506152","https://openalex.org/W1501108249","https://openalex.org/W4299675763","https://openalex.org/W2144981536","https://openalex.org/W2087510781","https://openalex.org/W4307256136","https://openalex.org/W2418485678","https://openalex.org/W1651398297","https://openalex.org/W4386322349","https://openalex.org/W4380483555"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"examine":[2,158],"interactions":[3],"among":[4],"the":[5,37,43,51,60,90,101,113,118],"angiotensin":[6],"converting":[7],"enzyme":[8],"(ACE)":[9],"insertion/deletion,":[10],"plasminogen":[11,18],"activator":[12,19],"inhibitor-1":[13],"(PAI-1)":[14],"4G/5G,":[15],"and":[16,50,104,140,155],"tissue":[17],"(t-PA)":[20],"insertion/deletion":[21],"gene":[22],"polymorphisms":[23],"on":[24],"risk":[25],"of":[26,59,77],"myocardial":[27],"infarction":[28],"using":[29,45,109],"data":[30,44],"from":[31,36],"343":[32],"matched":[33],"case-control":[34],"pairs":[35],"Physicians":[38],"Health":[39],"Study.":[40],"We":[41,73],"examined":[42],"both":[46,96],"conditional":[47],"logistic":[48],"regression":[49],"multifactor":[52],"dimensionality":[53],"reduction":[54],"(MDR)":[55],"method.":[56],"One":[57],"advantage":[58],"MDR":[61,120],"method":[62],"is":[63],"that":[64,127,175],"it":[65,162],"provides":[66],"an":[67,98],"internal":[68,79],"prediction":[69,80,115],"error":[70,81,116],"for":[71,82,89,117],"validation.":[72,84],"summarize":[74],"our":[75],"use":[76],"this":[78],"model":[83,121,169],"RESULTS:":[85],"The":[86,132],"overall":[87],"results":[88],"two":[91],"methods":[92,150],"were":[93],"consistent,":[94],"with":[95],"suggesting":[97],"interaction":[99,134],"between":[100],"ACE":[102],"I/D":[103],"PAI-1":[105],"4G/5G":[106],"polymorphisms.":[107],"However,":[108],"ten-fold":[110],"cross":[111],"validation,":[112],"46%":[114],"final":[119],"was":[122],"not":[123,138],"significantly":[124],"lower":[125],"than":[126,182],"expected":[128],"by":[129],"chance.":[130],"CONCLUSIONS:":[131],"significant":[133,176],"initially":[135],"observed":[136],"does":[137],"validate":[139],"may":[141],"represent":[142,178],"a":[143],"type":[144],"I":[145],"error.":[146],"As":[147],"data-driven":[148],"analytic":[149],"continue":[151],"to":[152,157,167,173],"be":[153],"developed":[154],"used":[156],"complex":[159],"genetic":[160],"interactions,":[161],"will":[163],"become":[164],"increasingly":[165],"important":[166],"stress":[168],"validation":[170],"in":[171],"order":[172],"ensure":[174],"effects":[177],"true":[179],"relationships":[180],"rather":[181],"chance":[183],"findings.":[184]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
