{"id":"https://openalex.org/W1855537617","doi":"https://doi.org/10.1186/1471-2105-5-109","title":"The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases","display_name":"The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases","publication_year":2004,"publication_date":"2004-08-12","ids":{"openalex":"https://openalex.org/W1855537617","doi":"https://doi.org/10.1186/1471-2105-5-109","mag":"1855537617","pmid":"https://pubmed.ncbi.nlm.nih.gov/15307895"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-5-109","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-5-109","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-5-109","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-5-109","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080331226","display_name":"Shane C. Dillon","orcid":null},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Shane C Dillon","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK. scd@sanger.ac.uk","The Wellcome Trust Sanger Institute, Wellcome Trust, Genome Campus, Hinxton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK. scd@sanger.ac.uk","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"The Wellcome Trust Sanger Institute, Wellcome Trust, Genome Campus, Hinxton, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059430118","display_name":"Alex Bateman","orcid":"https://orcid.org/0000-0002-6982-4660"},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex Bateman","raw_affiliation_strings":["The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK","The Wellcome Trust Sanger Institute, Wellcome Trust, Genome Campus, Hinxton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"The Wellcome Trust Sanger Institute, Wellcome Trust, Genome Campus, Hinxton, UK","institution_ids":["https://openalex.org/I2802476451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080331226"],"corresponding_institution_ids":["https://openalex.org/I2802476451"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":4.2643,"has_fulltext":true,"cited_by_count":188,"citation_normalized_percentile":{"value":0.94804391,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"5","issue":"1","first_page":"109","last_page":"109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8551999926567078,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8551999926567078,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0406000018119812,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superfamily","display_name":"SUPERFAMILY","score":0.7535744905471802},{"id":"https://openalex.org/keywords/fold","display_name":"Fold (higher-order function)","score":0.4660687744617462},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.43536531925201416},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42516207695007324},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38131090998649597},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.365494966506958},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3116263151168823},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20261278748512268},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1403881311416626},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12231564521789551}],"concepts":[{"id":"https://openalex.org/C92028520","wikidata":"https://www.wikidata.org/wiki/Q7395025","display_name":"SUPERFAMILY","level":3,"score":0.7535744905471802},{"id":"https://openalex.org/C53942344","wikidata":"https://www.wikidata.org/wiki/Q951651","display_name":"Fold (higher-order function)","level":2,"score":0.4660687744617462},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.43536531925201416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42516207695007324},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38131090998649597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.365494966506958},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3116263151168823},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20261278748512268},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1403881311416626},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12231564521789551},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013869","descriptor_name":"Thiolester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013869","descriptor_name":"Thiolester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013869","descriptor_name":"Thiolester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013869","descriptor_name":"Thiolester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-5-109","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-5-109","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-5-109","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15307895","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15307895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:7ace468f99bd4b499ea90a9aa7b58559","is_oa":true,"landing_page_url":"https://doaj.org/article/7ace468f99bd4b499ea90a9aa7b58559","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 5, Iss 1, p 109 (2004)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:103058","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC516016","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:516016","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/516016","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-5-109","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-5-109","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-5-109","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1855537617.pdf","grobid_xml":"https://content.openalex.org/works/W1855537617.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W158815068","https://openalex.org/W165316051","https://openalex.org/W1572699787","https://openalex.org/W1643603004","https://openalex.org/W1839417013","https://openalex.org/W1878596711","https://openalex.org/W1935793071","https://openalex.org/W1966363074","https://openalex.org/W1973010815","https://openalex.org/W1974870493","https://openalex.org/W1977867903","https://openalex.org/W1980737963","https://openalex.org/W1986103520","https://openalex.org/W1998485639","https://openalex.org/W2000596554","https://openalex.org/W2003788979","https://openalex.org/W2004829400","https://openalex.org/W2008867070","https://openalex.org/W2009363979","https://openalex.org/W2020848561","https://openalex.org/W2026975864","https://openalex.org/W2028231353","https://openalex.org/W2030465592","https://openalex.org/W2031407071","https://openalex.org/W2031723388","https://openalex.org/W2036912440","https://openalex.org/W2046431918","https://openalex.org/W2047637160","https://openalex.org/W2056082229","https://openalex.org/W2056883894","https://openalex.org/W2075184035","https://openalex.org/W2076533036","https://openalex.org/W2080528351","https://openalex.org/W2087901202","https://openalex.org/W2099637744","https://openalex.org/W2101295502","https://openalex.org/W2102938999","https://openalex.org/W2104587248","https://openalex.org/W2105663539","https://openalex.org/W2107214348","https://openalex.org/W2109715166","https://openalex.org/W2110293199","https://openalex.org/W2114115565","https://openalex.org/W2116302357","https://openalex.org/W2116382358","https://openalex.org/W2120399525","https://openalex.org/W2122550809","https://openalex.org/W2123854432","https://openalex.org/W2125725297","https://openalex.org/W2126975650","https://openalex.org/W2127774996","https://openalex.org/W2130185698","https://openalex.org/W2132169354","https://openalex.org/W2132200710","https://openalex.org/W2139582206","https://openalex.org/W2141885858","https://openalex.org/W2143486069","https://openalex.org/W2144794307","https://openalex.org/W2145299726","https://openalex.org/W2146312020","https://openalex.org/W2147781917","https://openalex.org/W2148853951","https://openalex.org/W2150781124","https://openalex.org/W2156243227","https://openalex.org/W2158714788","https://openalex.org/W2166278492","https://openalex.org/W2166714586","https://openalex.org/W2167895990","https://openalex.org/W2171772190","https://openalex.org/W2184138225","https://openalex.org/W4210400672"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W1181095405","https://openalex.org/W3014426369","https://openalex.org/W4240318783","https://openalex.org/W4236854317","https://openalex.org/W2311285072","https://openalex.org/W1573293794","https://openalex.org/W783636722","https://openalex.org/W573590566","https://openalex.org/W4239797724"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,92,186],"Hotdog":[2,41],"fold":[3],"was":[4],"initially":[5],"identified":[6],"in":[7,16,64,78,104,181,199],"the":[8,40,88,176,200],"structure":[9],"of":[10,33,52,84,107,178,203],"Escherichia":[11],"coli":[12],"FabA":[13],"and":[14,60,87,193],"subsequently":[15],"4-hydroxybenzoyl-CoA":[17],"thioesterase":[18],"from":[19,71,164],"Pseudomonas":[20],"sp.":[21],"strain":[22],"CBS.":[23],"Since":[24],"that":[25,101],"time":[26],"structural":[27],"determinations":[28],"have":[29,112,140,157],"shown":[30],"a":[31,49,97,149,159,172],"number":[32],"other":[34],"apparently":[35],"unrelated":[36],"proteins":[37,62,126],"also":[38,94],"share":[39],"fold.":[42],"RESULTS:":[43],"Using":[44],"sequence":[45],"analysis":[46,120],"we":[47,156],"unify":[48],"large":[50],"superfamily":[51,93],"HotDog":[53,124,179,187],"domains.":[54,154],"Membership":[55],"includes":[56,95],"numerous":[57,123],"prokaryotic,":[58],"archaeal":[59],"eukaryotic":[61],"involved":[63,103],"several":[65],"related,":[66],"but":[67,136],"distinct,":[68],"catalytic":[69],"activities,":[70],"metabolic":[72],"roles":[73],"such":[74],"as":[75,171],"thioester":[76],"hydrolysis":[77],"fatty":[79,108],"acid":[80,86,109],"metabolism,":[81],"to":[82,127,147],"degradation":[83],"phenylacetic":[85],"environmental":[89],"pollutant":[90],"4-chlorobenzoate.":[91],"FapR,":[96],"non-catalytic":[98],"bacterial":[99],"homologue":[100],"is":[102,189],"transcriptional":[105],"regulation":[106],"biosynthesis.":[110],"We":[111],"defined":[113],"17":[114],"subfamilies,":[115],"with":[116,151,196],"some":[117],"characterisation.":[118],"Operon":[119],"has":[121],"revealed":[122],"domain-containing":[125],"be":[128,169],"fusion":[129],"proteins,":[130],"where":[131],"two":[132,152],"genes,":[133],"once":[134],"separate":[135],"adjacent":[137],"open-reading":[138,145],"frames,":[139],"been":[141],"fused":[142],"into":[143],"one":[144],"frame":[146],"give":[148],"protein":[150,183],"functional":[153],"Finally":[155],"generated":[158],"Hidden":[160],"Markov":[161],"Model":[162],"library":[163],"our":[165],"analysis,":[166],"which":[167],"can":[168],"used":[170],"tool":[173],"for":[174],"predicting":[175],"occurrence":[177],"domains":[180],"any":[182],"sequence.":[184],"CONCLUSIONS:":[185],"domain":[188],"both":[190],"an":[191],"ancient":[192],"ubiquitous":[194],"motif,":[195],"members":[197],"found":[198],"three":[201],"branches":[202],"life.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":15}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
