{"id":"https://openalex.org/W1537494447","doi":"https://doi.org/10.1186/1471-2105-4-24","title":"A data review and re-assessment of ovarian cancer serum proteomic profiling","display_name":"A data review and re-assessment of ovarian cancer serum proteomic profiling","publication_year":2003,"publication_date":"2003-06-09","ids":{"openalex":"https://openalex.org/W1537494447","doi":"https://doi.org/10.1186/1471-2105-4-24","mag":"1537494447","pmid":"https://pubmed.ncbi.nlm.nih.gov/12795817"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-4-24","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-4-24","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-4-24","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-4-24","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091682436","display_name":"James Sorace","orcid":null},"institutions":[{"id":"https://openalex.org/I4210163125","display_name":"VA Maryland Health Care System","ror":"https://ror.org/05ax3zh38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210163125"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James M Sorace","raw_affiliation_strings":["Department of Pathology and Laboratory Services, Veterans Administration Maryland Health Care System, Baltimore 21201, USA. jmsorace@ix.netcom.com","Department of Pathology and Laboratory Services, Veterans Administration Maryland Health Care System, Baltimore, 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Services, Veterans Administration Maryland Health Care System, Baltimore 21201, USA. jmsorace@ix.netcom.com","institution_ids":["https://openalex.org/I4210163125"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Services, Veterans Administration Maryland Health Care System, Baltimore, 21201, USA","institution_ids":["https://openalex.org/I4210163125"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002903482","display_name":"Min Zhan","orcid":"https://orcid.org/0000-0002-6650-0337"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Zhan","raw_affiliation_strings":["Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091682436"],"corresponding_institution_ids":["https://openalex.org/I4210163125"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":24.7712,"has_fulltext":true,"cited_by_count":335,"citation_normalized_percentile":{"value":0.99836297,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"4","issue":"1","first_page":"24","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9632999897003174,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9632999897003174,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14364","display_name":"Clusterin in disease pathology","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonparametric-statistics","display_name":"Nonparametric statistics","score":0.6798499226570129},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"Ovarian cancer","score":0.6565765142440796},{"id":"https://openalex.org/keywords/wilcoxon-signed-rank-test","display_name":"Wilcoxon signed-rank test","score":0.5866819620132446},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.4496515095233917},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4262201488018036},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.41114896535873413},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.4049249291419983},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3963020145893097},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3949664235115051},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3526729941368103},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3422294855117798},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32227808237075806},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25973138213157654},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24478167295455933},{"id":"https://openalex.org/keywords/mann\u2013whitney-u-test","display_name":"Mann\u2013Whitney U test","score":0.10536181926727295},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10007637739181519}],"concepts":[{"id":"https://openalex.org/C102366305","wikidata":"https://www.wikidata.org/wiki/Q1097688","display_name":"Nonparametric statistics","level":2,"score":0.6798499226570129},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6565765142440796},{"id":"https://openalex.org/C206041023","wikidata":"https://www.wikidata.org/wiki/Q1751970","display_name":"Wilcoxon signed-rank test","level":3,"score":0.5866819620132446},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4496515095233917},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4262201488018036},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41114896535873413},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4049249291419983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3963020145893097},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3949664235115051},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3526729941368103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3422294855117798},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32227808237075806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25973138213157654},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24478167295455933},{"id":"https://openalex.org/C12868164","wikidata":"https://www.wikidata.org/wiki/Q1424533","display_name":"Mann\u2013Whitney U test","level":2,"score":0.10536181926727295},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10007637739181519},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D003944","descriptor_name":"Diagnostic Techniques, Obstetrical and Gynecological","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D003944","descriptor_name":"Diagnostic Techniques, Obstetrical and Gynecological","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D003944","descriptor_name":"Diagnostic Techniques, Obstetrical and Gynecological","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D003944","descriptor_name":"Diagnostic Techniques, Obstetrical and Gynecological","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D003944","descriptor_name":"Diagnostic Techniques, Obstetrical and Gynecological","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D003944","descriptor_name":"Diagnostic Techniques, Obstetrical and Gynecological","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-4-24","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-4-24","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-4-24","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:12795817","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12795817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:d4e8b09443f248a9a50331b40101738f","is_oa":false,"landing_page_url":"https://doaj.org/article/d4e8b09443f248a9a50331b40101738f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 4, Iss 1, p 24 (2003)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:519607","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC165662","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:165662","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/165662","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-4-24","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-4-24","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-4-24","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.4699999988079071}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1537494447.pdf","grobid_xml":"https://content.openalex.org/works/W1537494447.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W186095526","https://openalex.org/W1730869288","https://openalex.org/W2000305974","https://openalex.org/W2006442507","https://openalex.org/W2007477730","https://openalex.org/W2028038006","https://openalex.org/W2041726373","https://openalex.org/W2048202432","https://openalex.org/W2069827953","https://openalex.org/W2090533408","https://openalex.org/W2108060795","https://openalex.org/W2108725536","https://openalex.org/W2109082306","https://openalex.org/W2120501961","https://openalex.org/W2129028825","https://openalex.org/W2130213158","https://openalex.org/W2134389439","https://openalex.org/W2137723853","https://openalex.org/W2172300860","https://openalex.org/W2519438632","https://openalex.org/W4233738236"],"related_works":["https://openalex.org/W1599875686","https://openalex.org/W2611072612","https://openalex.org/W4230051407","https://openalex.org/W4224271975","https://openalex.org/W4205615042","https://openalex.org/W1965291129","https://openalex.org/W1977652979","https://openalex.org/W2068010140","https://openalex.org/W2143170093","https://openalex.org/W3180080"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,90,148,219],"early":[2],"detection":[3,133],"of":[4,17,23,107,117,134,144,154,174,192,233,240,262],"ovarian":[5],"cancer":[6,97,127,159,185,205,224],"has":[7,33],"the":[8,15,49,55,82,108,113,118,126,132,151,171,184,230,238],"potential":[9],"to":[10,20,40,68,71,77,121,181,221,255,259],"dramatically":[11],"reduce":[12],"mortality.":[13],"Recently,":[14],"use":[16,106,256],"mass":[18,91,120,272],"spectrometry":[19,92,273],"develop":[21,69],"profiles":[22,94],"patient":[24],"serum":[25,93],"proteins,":[26],"combined":[27],"with":[28,213,284],"advanced":[29],"data":[30,83,275],"mining":[31,276],"algorithms":[32,277],"been":[34],"reported":[35],"as":[36,74,76],"a":[37,142,198,210,241],"promising":[38],"method":[39],"achieve":[41],"this":[42,45,257],"goal.":[43],"In":[44],"report,":[46],"we":[47],"analyze":[48],"Ovarian":[50],"Dataset":[51],"8-7-02":[52],"downloaded":[53],"from":[54,96,186],"Clinical":[56],"Proteomics":[57],"Program":[58],"Databank":[59],"website,":[60],"using":[61,197,271],"nonparametric":[62],"statistics":[63],"and":[64,98,128,160,176,206,216,225,235,274,282],"stepwise":[65],"discriminant":[66],"analysis":[67],"rules":[70],"diagnose":[72],"patients,":[73],"well":[75],"understand":[78],"general":[79],"patterns":[80,261],"in":[81,111,131,209],"that":[84,201],"may":[85,252],"guide":[86],"future":[87],"research.":[88],"RESULTS:":[89],"derived":[95],"controls":[99,161],"exhibited":[100],"numerous":[101],"statistical":[102,156,286],"differences.":[103],"For":[104,169],"example,":[105],"Wilcoxon":[109],"test":[110,211],"comparing":[112],"intensity":[114],"at":[115,163],"each":[116],"15,154":[119],"charge":[122],"(M/Z)":[123],"values":[124,137,153,165,173,194,232],"between":[125,158,204,223,246],"controls,":[129],"resulted":[130],"3,591":[135],"M/Z":[136,152,164,172,193,231],"whose":[138],"intensities":[139],"differed":[140],"by":[141],"p-value":[143],"10-6":[145],"or":[146],"less.":[147],"region":[149],"containing":[150],"greatest":[155],"difference":[157],"occurred":[162],"less":[166],"than":[167],"500.":[168],"example":[170],"2.7921478":[175,234],"245.53704":[177,236],"could":[178,202],"be":[179,279],"used":[180],"significantly":[182],"separate":[183],"control":[187,207,226],"groups.":[188,249],"Three":[189],"other":[190],"sets":[191],"were":[195],"developed":[196],"training":[199],"set":[200,212],"distinguish":[203],"subjects":[208,227],"100%":[214],"sensitivity":[215],"specificity.":[217],"CONCLUSION:":[218],"ability":[220],"discriminate":[222],"based":[228],"on":[229],"reveals":[237],"existence":[239],"significant":[242],"non-biologic":[243],"experimental":[244],"bias":[245,251],"these":[247],"two":[248],"This":[250],"invalidate":[253],"attempts":[254],"dataset":[258],"find":[260],"reproducible":[263],"diagnostic":[264],"value.":[265],"To":[266],"minimize":[267],"false":[268],"discovery,":[269],"results":[270],"should":[278],"carefully":[280],"reviewed":[281],"benchmarked":[283],"routine":[285],"methods.":[287]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
