{"id":"https://openalex.org/W2123668032","doi":"https://doi.org/10.1186/1471-2105-16-s4-s2","title":"Problems with the nested granularity of feature domains in bioinformatics: the eXtasy case","display_name":"Problems with the nested granularity of feature domains in bioinformatics: the eXtasy case","publication_year":2015,"publication_date":"2015-02-23","ids":{"openalex":"https://openalex.org/W2123668032","doi":"https://doi.org/10.1186/1471-2105-16-s4-s2","mag":"2123668032","pmid":"https://pubmed.ncbi.nlm.nih.gov/25734591"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-16-s4-s2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-16-s4-s2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-16-S4-S2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-16-S4-S2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085611600","display_name":"Du\u0161an Popovi\u0107","orcid":"https://orcid.org/0000-0002-5912-0360"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Dusan Popovic","raw_affiliation_strings":["KU Leuven, Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium","iMinds Medical IT, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"iMinds Medical IT, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045411063","display_name":"Alejandro Sifrim","orcid":"https://orcid.org/0000-0001-8247-4020"},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alejandro Sifrim","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton Cambridge, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029479248","display_name":"Jesse Davis","orcid":"https://orcid.org/0000-0002-3748-9263"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jesse Davis","raw_affiliation_strings":["KU Leuven, Department of Computer Science, Celestijnenlaan 200A, B-3001, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Department of Computer Science, Celestijnenlaan 200A, B-3001, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041984163","display_name":"Yves Moreau","orcid":"https://orcid.org/0000-0002-4647-6560"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Yves Moreau","raw_affiliation_strings":["KU Leuven, Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium","iMinds Medical IT, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"iMinds Medical IT, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018814006","display_name":"Bart De Moor","orcid":"https://orcid.org/0000-0002-1154-5028"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bart De Moor","raw_affiliation_strings":["KU Leuven, Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium","iMinds Medical IT, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"iMinds Medical IT, Kasteelpark Arenberg 10, box 2446, B-3001, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085611600"],"corresponding_institution_ids":["https://openalex.org/I39327780","https://openalex.org/I99464096"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.6886,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.69572686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"16","issue":"S4","first_page":"S2","last_page":"S2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.629800021648407,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.629800021648407,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.1014999970793724,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.060499999672174454,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granularity","display_name":"Granularity","score":0.7167383432388306},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6318119764328003},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5847670435905457},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5421926975250244},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.5312297940254211},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.47773048281669617},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33451002836227417},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2746419906616211},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15752968192100525},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.13830304145812988},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07009387016296387},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.054080307483673096}],"concepts":[{"id":"https://openalex.org/C177774035","wikidata":"https://www.wikidata.org/wiki/Q1246948","display_name":"Granularity","level":2,"score":0.7167383432388306},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6318119764328003},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5847670435905457},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5421926975250244},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.5312297940254211},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.47773048281669617},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33451002836227417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2746419906616211},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15752968192100525},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.13830304145812988},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07009387016296387},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.054080307483673096},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-16-s4-s2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-16-s4-s2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-16-S4-S2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25734591","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25734591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/463446","is_oa":true,"landing_page_url":"http://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-16-S4-S2","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, vol. 16 (4), Art.No. ARTN S2, (1-11)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4347616","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4347616","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-16-s4-s2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-16-s4-s2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-16-S4-S2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.75,"display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2123668032.pdf","grobid_xml":"https://content.openalex.org/works/W2123668032.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1565746575","https://openalex.org/W1976526581","https://openalex.org/W1978005360","https://openalex.org/W2038132549","https://openalex.org/W2045164090","https://openalex.org/W2059145105","https://openalex.org/W2067315559","https://openalex.org/W2076357933","https://openalex.org/W2081484203","https://openalex.org/W2087588809","https://openalex.org/W2089903000","https://openalex.org/W2109555487","https://openalex.org/W2117897510","https://openalex.org/W2118246164","https://openalex.org/W2129016996","https://openalex.org/W2135445066","https://openalex.org/W2141307855","https://openalex.org/W2143238378","https://openalex.org/W2145187337","https://openalex.org/W2145191876","https://openalex.org/W2146841526","https://openalex.org/W2156868954","https://openalex.org/W2158116492","https://openalex.org/W2158698691","https://openalex.org/W2162974025","https://openalex.org/W2167277498","https://openalex.org/W2167917621","https://openalex.org/W2171777347","https://openalex.org/W2885727518","https://openalex.org/W2911964244","https://openalex.org/W2912934387"],"related_works":["https://openalex.org/W2931688134","https://openalex.org/W2377919138","https://openalex.org/W2378857091","https://openalex.org/W4256502920","https://openalex.org/W103652678","https://openalex.org/W2999756192","https://openalex.org/W4226090359","https://openalex.org/W4382701072","https://openalex.org/W2011624601","https://openalex.org/W2354431794"],"abstract_inverted_index":{"BACKGROUND:":[0],"Data":[1],"from":[2,31,89],"biomedical":[3],"domains":[4,115],"often":[5],"have":[6],"an":[7],"inherit":[8],"hierarchical":[9],"structure.":[10],"As":[11],"this":[12,52,56],"structure":[13],"is":[14],"usually":[15],"implicit,":[16],"its":[17,71,95,175],"existence":[18],"can":[19],"be":[20],"overlooked":[21],"by":[22],"practitioners":[23],"interested":[24],"in":[25,46,58,94,188],"constructing":[26],"and":[27,41,49,60,73,126],"evaluating":[28],"predictive":[29],"models":[30,48],"such":[32],"data.":[33,77],"Ignoring":[34],"these":[35],"constructs":[36],"leads":[37],"to":[38,151],"potentially":[39],"problematic":[40],"the":[42,47,82,91,110,121,136,142,145,152,166,182,189,194,197],"routinely":[43],"unrecognized":[44],"bias":[45,57],"results.":[50],"In":[51],"work,":[53],"we":[54,69,79],"discuss":[55],"detail":[59],"propose":[61],"a":[62,127,156,161],"simple,":[63],"sampling-based":[64],"solution":[65],"for":[66,119],"it.":[67],"Next,":[68],"explore":[70],"sources":[72],"extent":[74],"on":[75,131],"synthetic":[76],"Finally,":[78],"demonstrate":[80],"how":[81],"state-of-the-art":[83],"variant":[84],"prioritization":[85],"framework,":[86],"eXtasy,":[87],"benefits":[88],"using":[90,135,165],"described":[92,146],"approach":[93],"Random":[96,123,162],"forest-based":[97],"core":[98],"classification":[99],"model.":[100],"RESULTS":[101],"AND":[102],"CONCLUSIONS:":[103],"The":[104],"conducted":[105],"simulations":[106],"clearly":[107],"indicate":[108],"that":[109,129,174],"heterogeneous":[111],"granularity":[112],"of":[113,193,199],"feature":[114],"poses":[116],"significant":[117],"problems":[118],"both":[120],"standard":[122,176],"forest":[124,163],"classifier":[125,143],"modification":[128],"relies":[130],"stratified":[132],"bootstrapping.":[133],"Conversely,":[134],"proposed":[137,167],"sampling":[138,168],"scheme":[139,169],"when":[140,149],"training":[141],"mitigates":[144],"bias.":[147],"Furthermore,":[148],"applied":[150],"eXtasy":[153],"data":[154],"under":[155],"realistic":[157],"class":[158],"distribution":[159],"scenario,":[160],"learned":[164],"displays":[170],"much":[171],"better":[172],"precision":[173],"version,":[177],"without":[178],"degrading":[179],"recall.":[180],"Moreover,":[181],"largest":[183],"performance":[184],"gains":[185],"are":[186],"achieved":[187],"most":[190],"important":[191],"part":[192],"operating":[195],"range:":[196],"top":[198],"prioritized":[200],"gene":[201],"list.":[202]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}