{"id":"https://openalex.org/W2280599546","doi":"https://doi.org/10.1186/1471-2105-16-s15-p1","title":"Synaptic plasticity in infralimbic cortex mediates socially-acquired nicotine self-administration","display_name":"Synaptic plasticity in infralimbic cortex mediates socially-acquired nicotine self-administration","publication_year":2015,"publication_date":"2015-10-23","ids":{"openalex":"https://openalex.org/W2280599546","doi":"https://doi.org/10.1186/1471-2105-16-s15-p1","mag":"2280599546"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-16-s15-p1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-16-s15-p1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-16-S15-P1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-16-S15-P1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100353673","display_name":"Hao Chen","orcid":"https://orcid.org/0009-0001-6480-7976"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hao Chen","raw_affiliation_strings":["Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416148","display_name":"Tengfei Wang","orcid":"https://orcid.org/0000-0002-1585-4143"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tengfei Wang","raw_affiliation_strings":["Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037493083","display_name":"Wenyan Han","orcid":"https://orcid.org/0000-0003-0886-1430"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenyan Han","raw_affiliation_strings":["Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN38163, USA","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100353673"],"corresponding_institution_ids":["https://openalex.org/I160606119"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.1604,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.4761174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"16","issue":"S15","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infralimbic-cortex","display_name":"Infralimbic cortex","score":0.745885968208313},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7133721113204956},{"id":"https://openalex.org/keywords/nicotine","display_name":"Nicotine","score":0.5766765475273132},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"Synaptic plasticity","score":0.5751802325248718},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"Neuroplasticity","score":0.5049481987953186},{"id":"https://openalex.org/keywords/plasticity","display_name":"Plasticity","score":0.4303953945636749},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3388512134552002},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.33693844079971313},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"Prefrontal cortex","score":0.32060837745666504},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.17164862155914307},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09659183025360107},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0960245430469513}],"concepts":[{"id":"https://openalex.org/C2779934784","wikidata":"https://www.wikidata.org/wiki/Q16259058","display_name":"Infralimbic cortex","level":4,"score":0.745885968208313},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7133721113204956},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.5766765475273132},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5751802325248718},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.5049481987953186},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.4303953945636749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3388512134552002},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33693844079971313},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.32060837745666504},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.17164862155914307},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09659183025360107},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0960245430469513},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/1471-2105-16-s15-p1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-16-s15-p1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-16-S15-P1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3597122","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4625416","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-16-s15-p1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-16-s15-p1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-16-S15-P1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2280599546.pdf","grobid_xml":"https://content.openalex.org/works/W2280599546.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2511528658","https://openalex.org/W1986328929","https://openalex.org/W1978631167","https://openalex.org/W2910702611","https://openalex.org/W2231648340","https://openalex.org/W4288078006","https://openalex.org/W2003968300","https://openalex.org/W2157852221","https://openalex.org/W2345112163","https://openalex.org/W2943803214"],"abstract_inverted_index":{"Background":[0],"Social":[1],"environment":[2],"plays":[3],"a":[4,81],"critical":[5,82],"role":[6],"in":[7,91,106],"the":[8,21,38,86],"initiation":[9],"of":[10,25,51,88,112],"cigarette":[11],"smoking":[12],"among":[13],"adolescents.":[14],"It":[15],"has":[16,28],"been":[17],"established":[18],"that":[19,48,77,98],"nicotine,":[20],"principal":[22],"psychoactive":[23],"ingredient":[24],"tobacco":[26],"products,":[27],"both":[29],"aversive":[30],"and":[31,64],"rewarding":[32],"properties.":[33],"Using":[34],"olfactogustatory":[35],"stimuli":[36],"as":[37],"sensory":[39],"cue":[40,55],"for":[41,85],"intravenous":[42],"nicotine":[43,52,71,93],"self-administration,":[44],"we":[45],"have":[46,75],"shown":[47,76],"social":[49,89,113],"learning":[50,90],"contingent":[53],"odor":[54],"prevented":[56],"rats":[57],"from":[58],"developing":[59],"conditioned":[60,94],"taste":[61],"aversion":[62],"(CTA)":[63],"allowed":[65],"them":[66],"to":[67,103],"instead":[68],"establish":[69],"stable":[70],"self-administration.":[72],"We":[73,96],"also":[74],"infralimbic":[78,107],"cortex":[79,108],"is":[80],"brain":[83],"region":[84],"effect":[87,111],"reversing":[92],"aversion.":[95],"hypothesized":[97],"gene":[99],"expression":[100],"changes":[101],"related":[102],"synaptic":[104],"plasticity":[105],"underlies":[109],"this":[110],"learning.":[114]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}
