{"id":"https://openalex.org/W1956634061","doi":"https://doi.org/10.1186/1471-2105-15-s17-s6","title":"Mining hidden knowledge for drug safety assessment: topic modeling of LiverTox as a case study","display_name":"Mining hidden knowledge for drug safety assessment: topic modeling of LiverTox as a case study","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W1956634061","doi":"https://doi.org/10.1186/1471-2105-15-s17-s6","mag":"1956634061","pmid":"https://pubmed.ncbi.nlm.nih.gov/25559675"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-s17-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-s17-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S17-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S17-S6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068979281","display_name":"Ke Yu","orcid":"https://orcid.org/0000-0001-9882-5729"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ke Yu","raw_affiliation_strings":["Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436791","display_name":"Jie Zhang","orcid":"https://orcid.org/0000-0002-6944-2021"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035030398","display_name":"Minjun Chen","orcid":"https://orcid.org/0000-0002-6453-2351"},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minjun Chen","raw_affiliation_strings":["Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086347026","display_name":"Xiaowei Xu","orcid":"https://orcid.org/0000-0003-2836-5944"},"institutions":[{"id":"https://openalex.org/I102401767","display_name":"University of Arkansas at Little Rock","ror":"https://ror.org/04fttyv97","country_code":"US","type":"education","lineage":["https://openalex.org/I102401767"]},{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowei Xu","raw_affiliation_strings":["Department of Information Science, University of Arkansas at Little Rock, 2801 S. University Ave., Little Rock, AR, 72204, USA","Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, USA","Department of Information Science, University of Arkansas at Little Rock, Little Rock, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Science, University of Arkansas at Little Rock, 2801 S. University Ave., Little Rock, AR, 72204, USA","institution_ids":["https://openalex.org/I102401767"]},{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"raw_affiliation_string":"Department of Information Science, University of Arkansas at Little Rock, Little Rock, USA","institution_ids":["https://openalex.org/I102401767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047141065","display_name":"Ayako Suzuki","orcid":"https://orcid.org/0000-0003-1824-1067"},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayako Suzuki","raw_affiliation_strings":["Division of Gastroenterology, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR, 72205, USA","Division of Gastroenterology, University of Arkansas for Medical Sciences, Little Rock, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR, 72205, USA","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Division of Gastroenterology, University of Arkansas for Medical Sciences, Little Rock, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085814385","display_name":"Katarina Ili\u0107","orcid":"https://orcid.org/0000-0003-4915-8602"},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Katarina Ilic","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, 450 Vojvode Stepe, Belgrade, 11221, Serbia","Department of Pharmacology, Faculty of Pharmacy; University of Belgrade; Belgrade Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, 450 Vojvode Stepe, Belgrade, 11221, Serbia","institution_ids":["https://openalex.org/I4068193"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy; University of Belgrade; Belgrade Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068886380","display_name":"Weida Tong","orcid":"https://orcid.org/0000-0003-3488-6148"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weida Tong","raw_affiliation_strings":["Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA","Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5068979281"],"corresponding_institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.8989,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.88929283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"15","issue":"S17","first_page":"S6","last_page":"S6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.4997999966144562,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.4997999966144562,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.34279999136924744,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.6364727020263672},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5662378072738647},{"id":"https://openalex.org/keywords/topic-model","display_name":"Topic model","score":0.4970753490924835},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45706430077552795},{"id":"https://openalex.org/keywords/public-health","display_name":"Public health","score":0.4567162096500397},{"id":"https://openalex.org/keywords/public-domain","display_name":"Public domain","score":0.4253842234611511},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4090566635131836},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.40399596095085144},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.2646281123161316},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.24676796793937683},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.14392757415771484},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.13019853830337524}],"concepts":[{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.6364727020263672},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5662378072738647},{"id":"https://openalex.org/C171686336","wikidata":"https://www.wikidata.org/wiki/Q3532085","display_name":"Topic model","level":2,"score":0.4970753490924835},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45706430077552795},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.4567162096500397},{"id":"https://openalex.org/C512654426","wikidata":"https://www.wikidata.org/wiki/Q19652","display_name":"Public domain","level":2,"score":0.4253842234611511},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4090566635131836},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40399596095085144},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.2646281123161316},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24676796793937683},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14392757415771484},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13019853830337524},{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017751","descriptor_name":"Safety Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017751","descriptor_name":"Safety Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017751","descriptor_name":"Safety Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2105-15-s17-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-s17-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S17-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25559675","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25559675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:3287945","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4304199","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-s17-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-s17-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S17-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","score":0.6100000143051147,"id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320332382","display_name":"Oak Ridge Institute for Science and Education","ror":"https://ror.org/0526p1y61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1956634061.pdf","grobid_xml":"https://content.openalex.org/works/W1956634061.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W125892352","https://openalex.org/W1528875781","https://openalex.org/W1758032857","https://openalex.org/W1772740936","https://openalex.org/W1880262756","https://openalex.org/W1970401253","https://openalex.org/W1975440270","https://openalex.org/W2000660841","https://openalex.org/W2001082470","https://openalex.org/W2003673908","https://openalex.org/W2030920368","https://openalex.org/W2036392083","https://openalex.org/W2046905690","https://openalex.org/W2059383818","https://openalex.org/W2089707005","https://openalex.org/W2094771193","https://openalex.org/W2107743791","https://openalex.org/W2118809428","https://openalex.org/W2120831232","https://openalex.org/W2129974743","https://openalex.org/W2142572836","https://openalex.org/W2154896031","https://openalex.org/W2161109243","https://openalex.org/W2742227015","https://openalex.org/W4233135949"],"related_works":["https://openalex.org/W2345282316","https://openalex.org/W3200230513","https://openalex.org/W147115947","https://openalex.org/W2787993192","https://openalex.org/W2769501189","https://openalex.org/W2070248261","https://openalex.org/W4206379684","https://openalex.org/W2220789231","https://openalex.org/W3125837273","https://openalex.org/W2037605929"],"abstract_inverted_index":{"BACKGROUND:":[0],"Given":[1],"the":[2,51,55,70,78,104,154,178,182,232,238,241,265,269,288,299,314,332],"significant":[3],"impact":[4],"on":[5,103,128,156],"public":[6,52,87,258],"health":[7],"and":[8,18,34,39,54,84,234,302,309],"drug":[9,11,32,46,82,120,186,324,338],"development,":[10],"safety":[12,47,83,325],"has":[13,41],"been":[14],"a":[15,37,164,190,199,215],"focal":[16],"point":[17],"research":[19],"emphasis":[20],"across":[21,184],"multiple":[22,123],"disciplines":[23],"in":[24,50,210,231,268,331],"addition":[25],"to":[26,68,147,194,287,319,336],"scientific":[27],"investigation,":[28],"including":[29],"consumer":[30],"advocates,":[31],"developers":[33],"regulators.":[35],"Such":[36],"concern":[38],"effort":[40],"led":[42],"numerous":[43],"databases":[44],"with":[45,169,204,278,298],"information":[48,127,321],"available":[49],"domain":[53],"majority":[56],"of":[57,81,111,167,177,181,207,217,224,237,243,249,276,280,296,304,316],"them":[58,305],"contain":[59,139],"substantial":[60],"textual":[61,75,141,270,323],"data.":[62],"Text":[63],"mining":[64,99],"offers":[65],"an":[66,96],"opportunity":[67],"leverage":[69,320],"hidden":[71,191],"knowledge":[72,266,292],"within":[73,322],"these":[74,136],"data":[76,271,334],"for":[77,253,274],"enhanced":[79],"understanding":[80],"thus":[85],"improving":[86],"health.":[88],"METHODS:":[89],"In":[90,261],"this":[91,213,262],"proof-of-concept":[92],"study,":[93,264],"topic":[94,175,192,285,317],"modeling,":[95],"unsupervised":[97],"text":[98],"approach,":[100],"was":[101,163,198,251,272],"performed":[102],"LiverTox":[105,115,183,289],"database":[106],"developed":[107],"by":[108,283],"National":[109],"Institutes":[110],"Health":[112],"(NIH).":[113],"The":[114,291],"structured":[116],"one":[117],"document":[118],"per":[119],"that":[121,135,143,197],"contains":[122],"sections":[124,180,236],"summarizing":[125],"clinical":[126],"drug-induced":[129,157],"liver":[130,159],"injury":[131],"(DILI).":[132],"We":[133,152],"hypothesized":[134],"documents":[137],"might":[138],"specific":[140],"patterns":[142],"could":[144,306],"be":[145,307],"used":[146],"address":[148],"key":[149],"DILI":[150,168],"issues.":[151],"placed":[153],"study":[155,312],"acute":[158],"failure":[160],"(ALF)":[161],"which":[162,225,327],"severe":[165],"form":[166],"limited":[170],"treatment":[171],"options.":[172],"RESULTS:":[173],"After":[174],"modeling":[176,286,318],"\"Hepatotoxicity\"":[179],"478":[185],"documents,":[187],"we":[188],"identified":[189],"relevant":[193,229],"Hy's":[195],"law":[196],"widely-accepted":[200],"rule":[201],"incriminating":[202],"drugs":[203,219,255,277,297],"high":[205],"risk":[206,248],"causing":[208,281],"ALF":[209,228,250,282],"humans.":[211],"Using":[212],"topic,":[214],"total":[216],"127":[218],"were":[220],"further":[221,293],"implicated,":[222],"77":[223],"had":[226],"clear":[227],"terms":[230],"\"Outcome":[233],"management\"":[235],"LiverTox.":[239],"For":[240],"rest":[242],"50":[244],"drugs,":[245],"evidence":[246],"supporting":[247],"found":[252],"42":[254],"from":[256],"other":[257],"databases.":[259],"CONCLUSION:":[260],"case":[263],"buried":[267],"extracted":[273],"identification":[275,295],"potential":[279,301],"applying":[284],"database.":[290],"guided":[294],"similar":[300],"most":[303],"verified":[308],"confirmed.":[310],"This":[311],"highlights":[313],"utility":[315],"databases,":[326],"provides":[328],"new":[329],"opportunities":[330],"big":[333],"era":[335],"assess":[337],"safety.":[339]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}