{"id":"https://openalex.org/W1817457239","doi":"https://doi.org/10.1186/1471-2105-15-s17-s4","title":"Improving protein order-disorder classification using charge-hydropathy plots","display_name":"Improving protein order-disorder classification using charge-hydropathy plots","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W1817457239","doi":"https://doi.org/10.1186/1471-2105-15-s17-s4","mag":"1817457239","pmid":"https://pubmed.ncbi.nlm.nih.gov/25559583"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-s17-s4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-s17-s4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S17-S4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S17-S4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062094994","display_name":"Fei Huang","orcid":"https://orcid.org/0000-0003-3263-0675"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fei Huang","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091785779","display_name":"Christopher J. Oldfield","orcid":"https://orcid.org/0000-0002-3362-2047"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J Oldfield","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011869206","display_name":"Bin Xue","orcid":"https://orcid.org/0000-0002-6344-0623"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Xue","raw_affiliation_strings":["Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, USA","Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112535441","display_name":"Wei Lun Hsu","orcid":null},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-Lun Hsu","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008253090","display_name":"Jingwei Meng","orcid":"https://orcid.org/0000-0003-1550-2719"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingwei Meng","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437902","display_name":"Xiaowen Liu","orcid":"https://orcid.org/0000-0003-4139-1127"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowen Liu","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333320","display_name":"Li Shen","orcid":"https://orcid.org/0000-0002-5443-0503"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Shen","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102760837","display_name":"Pedro Romero","orcid":"https://orcid.org/0000-0002-6995-5193"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro Romero","raw_affiliation_strings":["Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA","Chemical and Biological Engineering, University of Wisconsin\u2014Madison, Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Chemical and Biological Engineering, University of Wisconsin\u2014Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083199032","display_name":"Vladimir N. Uversky","orcid":"https://orcid.org/0000-0002-4037-5857"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210112128","display_name":"Institute for Biological Instrumentation","ror":"https://ror.org/01tyr1g37","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210112128","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210140006","display_name":"USF Health Byrd Alzheimer's Institute","ror":"https://ror.org/048768v87","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210140006"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Vladimir N Uversky","raw_affiliation_strings":["Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA","Institute for Biological Instrumentation, Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia","USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA","Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Russia","USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Institute for Biological Instrumentation, Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia","institution_ids":["https://openalex.org/I4210112128"]},{"raw_affiliation_string":"USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I4210140006"]},{"raw_affiliation_string":"Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Russia","institution_ids":["https://openalex.org/I4210112128"]},{"raw_affiliation_string":"USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, USA","institution_ids":["https://openalex.org/I4210140006","https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017746551","display_name":"A. Keith Dunker","orcid":"https://orcid.org/0000-0002-0744-5243"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Keith Dunker","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5062094994"],"corresponding_institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.4228,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.80192291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"15","issue":"S17","first_page":"S4","last_page":"S4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.49129998683929443,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.49129998683929443,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.211899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"Intrinsically disordered proteins","score":0.5777713060379028},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.5156256556510925},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.5005965232849121},{"id":"https://openalex.org/keywords/plot","display_name":"Plot (graphics)","score":0.4692874848842621},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.37918734550476074},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2649398446083069},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13591906428337097},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10775494575500488},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.09333637356758118}],"concepts":[{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.5777713060379028},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5156256556510925},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.5005965232849121},{"id":"https://openalex.org/C167651023","wikidata":"https://www.wikidata.org/wiki/Q1474611","display_name":"Plot (graphics)","level":2,"score":0.4692874848842621},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37918734550476074},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2649398446083069},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13591906428337097},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10775494575500488},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.09333637356758118},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-15-s17-s4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-s17-s4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S17-S4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25559583","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25559583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:digitalcommons.usf.edu:mme_facpub-1407","is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/mme_facpub/405","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Medicine Faculty Publications","raw_type":"text"},{"id":"pmh:oai:europepmc.org:3287954","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4304195","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/9666","is_oa":true,"landing_page_url":"http://hdl.handle.net/1805/9666","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Conference proceedings"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-s17-s4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-s17-s4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S17-S4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1817457239.pdf","grobid_xml":"https://content.openalex.org/works/W1817457239.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W45157614","https://openalex.org/W113475142","https://openalex.org/W166169566","https://openalex.org/W1481607975","https://openalex.org/W1501347866","https://openalex.org/W1536886974","https://openalex.org/W1574715085","https://openalex.org/W1588000118","https://openalex.org/W1792685479","https://openalex.org/W1963523582","https://openalex.org/W1966041739","https://openalex.org/W1972434016","https://openalex.org/W1975017420","https://openalex.org/W1975304761","https://openalex.org/W1981316712","https://openalex.org/W1982250822","https://openalex.org/W1984501109","https://openalex.org/W1984547849","https://openalex.org/W1985204165","https://openalex.org/W1985544830","https://openalex.org/W1988937679","https://openalex.org/W1993689973","https://openalex.org/W1997870466","https://openalex.org/W2003540678","https://openalex.org/W2005825070","https://openalex.org/W2006192061","https://openalex.org/W2009815491","https://openalex.org/W2014731953","https://openalex.org/W2016170088","https://openalex.org/W2019853549","https://openalex.org/W2022523929","https://openalex.org/W2023400093","https://openalex.org/W2023639956","https://openalex.org/W2026582002","https://openalex.org/W2027035874","https://openalex.org/W2030776726","https://openalex.org/W2043338013","https://openalex.org/W2047094503","https://openalex.org/W2048962498","https://openalex.org/W2049476357","https://openalex.org/W2052606462","https://openalex.org/W2053411993","https://openalex.org/W2053418558","https://openalex.org/W2053820259","https://openalex.org/W2055043387","https://openalex.org/W2056530947","https://openalex.org/W2068997255","https://openalex.org/W2070126374","https://openalex.org/W2070496155","https://openalex.org/W2073745520","https://openalex.org/W2077676861","https://openalex.org/W2085126881","https://openalex.org/W2085306757","https://openalex.org/W2094108392","https://openalex.org/W2103743266","https://openalex.org/W2104960492","https://openalex.org/W2107432340","https://openalex.org/W2110128290","https://openalex.org/W2110790611","https://openalex.org/W2114823344","https://openalex.org/W2117640066","https://openalex.org/W2118585731","https://openalex.org/W2118978333","https://openalex.org/W2119821739","https://openalex.org/W2120167569","https://openalex.org/W2120881407","https://openalex.org/W2125022522","https://openalex.org/W2126064524","https://openalex.org/W2126303237","https://openalex.org/W2131322954","https://openalex.org/W2131965976","https://openalex.org/W2132791018","https://openalex.org/W2134327751","https://openalex.org/W2137029138","https://openalex.org/W2144252381","https://openalex.org/W2147533449","https://openalex.org/W2148143831","https://openalex.org/W2149653886","https://openalex.org/W2152282874","https://openalex.org/W2152896929","https://openalex.org/W2153635508","https://openalex.org/W2156407548","https://openalex.org/W2159938554","https://openalex.org/W2161199282","https://openalex.org/W2163610346","https://openalex.org/W2164260969","https://openalex.org/W2165436430","https://openalex.org/W2168970921","https://openalex.org/W2254809871","https://openalex.org/W2312227688","https://openalex.org/W2314111724","https://openalex.org/W2322304557","https://openalex.org/W2394659075","https://openalex.org/W2938524560","https://openalex.org/W3182520187","https://openalex.org/W4210968583","https://openalex.org/W4213345021"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W2527526854","https://openalex.org/W2062208111","https://openalex.org/W1976181487","https://openalex.org/W1986764834","https://openalex.org/W2145225004"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"earliest":[2],"whole":[3],"protein":[4,239],"order/disorder":[5],"predictor":[6],"(Uversky":[7],"et":[8],"al.,":[9],"Proteins,":[10],"41:":[11],"415-427":[12],"(2000)),":[13],"herein":[14],"called":[15],"the":[16,24,38,44,47,67,70,73,82,85,95,98,114,128,136,151,156,162,226],"charge-hydropathy":[17],"(C-H)":[18],"plot,":[19],"was":[20,94],"originally":[21],"developed":[22,119,236],"using":[23,60,185],"Kyte-Doolittle":[25,152],"(1982)":[26,153],"hydropathy":[27,63,79,88,100,154,159,187,200],"scale":[28,89,164,228],"(Kyte":[29],"&":[30],"Doolittle.,":[31],"J.":[32],"Mol.":[33],"Biol,":[34],"157:":[35],"105-132(1982)).":[36],"Here":[37],"goal":[39],"is":[40,182,195],"to":[41,139,229,237],"determine":[42],"whether":[43],"performance":[45,68],"of":[46,69,97,170,234],"C-H":[48,115,137],"plot":[49,138],"in":[50],"separating":[51,103],"structured":[52,106,131,149],"and":[53,108,133,145,161,173],"disordered":[54,110],"proteins":[55,107,111,132],"can":[56],"be":[57,225],"improved":[58],"by":[59,184],"an":[61],"alternative":[62,78],"scale.":[64],"RESULTS:":[65],"Using":[66],"CH-plot":[71],"as":[72],"metric,":[74],"we":[75,118],"compared":[76],"19":[77],"scales,":[80,201],"with":[81,198],"finding":[83],"that":[84,193,204,221],"Guy":[86,157],"(1985)":[87,158],"(Guy,":[90],"Biophys.":[91],"J,":[92],"47:61-70(1985))":[93],"best":[96,227],"tested":[99],"scales":[101],"for":[102,231],"large":[104],"collections":[105],"intrinsically":[109],"(IDPs)":[112],"on":[113],"plot.":[116],"Next,":[117],"a":[120,140,177],"new":[121],"scale,":[122,155,160],"named":[123],"IDP-Hydropathy,":[124],"which":[125],"further":[126],"improves":[127],"discrimination":[129],"between":[130],"IDPs.":[134],"Applying":[135],"dataset":[141],"containing":[142],"109":[143],"IDPs":[144],"563":[146],"non-homologous":[147],"fully":[148],"proteins,":[150],"IDP-Hydropathy":[163,194,205,222],"gave":[165],"balanced":[166],"two-state":[167],"classification":[168],"accuracies":[169],"79%,":[171],"84%,":[172],"90%,":[174],"respectively,":[175],"indicating":[176],"very":[178],"substantial":[179],"overall":[180],"improvement":[181],"obtained":[183],"different":[186],"scales.":[188],"A":[189],"correlation":[190],"study":[191],"shows":[192],"strongly":[196],"correlated":[197],"other":[199,215],"thus":[202],"suggesting":[203],"probably":[206],"has":[207],"only":[208],"minor":[209],"contributions":[210],"from":[211],"amino":[212],"acid":[213],"properties":[214],"than":[216],"hydropathy.":[217],"CONCLUSION:":[218],"We":[219],"suggest":[220],"would":[223],"likely":[224],"use":[230],"any":[232],"type":[233],"algorithm":[235],"predict":[238],"disorder.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-05-01T08:36:08.643496","created_date":"2025-10-10T00:00:00"}
