{"id":"https://openalex.org/W2168339751","doi":"https://doi.org/10.1186/1471-2105-15-s10-p3","title":"Genome wide analysis of sex difference in gene expression profiles of bone formations","display_name":"Genome wide analysis of sex difference in gene expression profiles of bone formations","publication_year":2014,"publication_date":"2014-09-29","ids":{"openalex":"https://openalex.org/W2168339751","doi":"https://doi.org/10.1186/1471-2105-15-s10-p3","mag":"2168339751"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-s10-p3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-s10-p3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S10-P3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S10-P3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101457872","display_name":"Yue Huang","orcid":"https://orcid.org/0000-0002-6057-0190"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yue Huang","raw_affiliation_strings":["Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN, 38163, USA"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN, 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101408712","display_name":"Xiaodong Zhu","orcid":"https://orcid.org/0000-0002-9221-7674"},"institutions":[{"id":"https://openalex.org/I4210093324","display_name":"Mudanjiang Medical University","ror":"https://ror.org/00mc5wj35","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210093324"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Zhu","raw_affiliation_strings":["Mudanjiang Medical College, Mudanjiang, 157001, China"],"affiliations":[{"raw_affiliation_string":"Mudanjiang Medical College, Mudanjiang, 157001, China","institution_ids":["https://openalex.org/I4210093324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022448458","display_name":"Lishi Wang","orcid":"https://orcid.org/0000-0003-2991-0211"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lishi Wang","raw_affiliation_strings":["Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN, 38163, USA"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN, 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100776309","display_name":"Xiaoyun Liu","orcid":"https://orcid.org/0000-0001-7083-5263"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyun Liu","raw_affiliation_strings":["Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN, 38163, USA"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN, 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000103692","display_name":"Robert W. Williams","orcid":"https://orcid.org/0000-0001-8924-4447"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W Williams","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100596158","display_name":"Lu Lu","orcid":"https://orcid.org/0000-0001-5840-5340"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Lu","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065649509","display_name":"Yan Jiao","orcid":"https://orcid.org/0000-0001-6914-7949"},"institutions":[{"id":"https://openalex.org/I4210093324","display_name":"Mudanjiang Medical University","ror":"https://ror.org/00mc5wj35","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210093324"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Jiao","raw_affiliation_strings":["Mudanjiang Medical College, Mudanjiang, 157001, China"],"affiliations":[{"raw_affiliation_string":"Mudanjiang Medical College, Mudanjiang, 157001, China","institution_ids":["https://openalex.org/I4210093324"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009729295","display_name":"Weikuan Gu","orcid":"https://orcid.org/0000-0003-1112-8088"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weikuan Gu","raw_affiliation_strings":["Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN, 38163, USA"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN, 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5101457872"],"corresponding_institution_ids":["https://openalex.org/I160606119"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15013964,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"S10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9761999845504761,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9577999711036682,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ascorbic-acid","display_name":"Ascorbic acid","score":0.6942583322525024},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6776840090751648},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6503282785415649},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5314461588859558},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4743351340293884},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4529803991317749},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4371640086174011},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.3566477298736572},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3305138349533081},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15546447038650513}],"concepts":[{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.6942583322525024},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6776840090751648},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6503282785415649},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5314461588859558},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4743351340293884},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4529803991317749},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4371640086174011},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3566477298736572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3305138349533081},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15546447038650513},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/1471-2105-15-s10-p3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-s10-p3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S10-P3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4196079","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4196079","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-s10-p3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-s10-p3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-S10-P3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168339751.pdf","grobid_xml":"https://content.openalex.org/works/W2168339751.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W1900028828","https://openalex.org/W1966354230","https://openalex.org/W2018194674","https://openalex.org/W2035873416"],"related_works":["https://openalex.org/W2987420353","https://openalex.org/W1491897707","https://openalex.org/W106077234","https://openalex.org/W2041374557","https://openalex.org/W3032874291","https://openalex.org/W2005057264","https://openalex.org/W2081929287","https://openalex.org/W2363156284","https://openalex.org/W2132561013","https://openalex.org/W2415025170"],"abstract_inverted_index":{"Background":[0],"Geber":[1],"and":[2,9,19,104,112,134],"Murphy":[3],"[1]":[4],"found":[5],"that":[6],"a":[7,44,56,68,83],"sex":[8,57,124],"stature":[10],"bias":[11],"is":[12,121],"evident":[13],"among":[14],"adults":[15],"in":[16,50,86,128],"which":[17,75],"males":[18],"taller":[20],"individuals":[21],"displayed":[22],"statistically":[23],"significantly":[24],"higher":[25],"levels":[26],"of":[27,46,118],"scorbutic":[28],"lesions.":[29],"Thus":[30],"the":[31,40,77,87,98,108,131],"study":[32,120],"provided":[33],"evidence":[34],"to":[35,122],"support":[36],"an":[37,53],"investigation":[38],"on":[39],"gender":[41],"difference":[42,58],"with":[43],"lack":[45],"vitamin":[47],"C":[48],"(VC)":[49],"humans.":[51],"In":[52,93],"animal":[54],"study,":[55,95],"has":[59],"also":[60],"been":[61],"evidenced":[62],"[2,3].":[63],"Previously,":[64],"we":[65,96],"have":[66],"studied":[67],"spontaneous":[69],"bone":[70,129],"fracture":[71],"(sfx)":[72],"mouse":[73,110],"[4]":[74],"lacks":[76],"gene":[78,99],"for":[79],"Lgulonolactone":[80],"oxidase":[81],"(Gulo),":[82],"key":[84],"enzyme":[85],"ascorbic":[88],"acid":[89],"(AA)":[90],"synthesis":[91],"pathway.":[92],"this":[94,119],"investigated":[97],"expression":[100],"profiles":[101],"between":[102],"female":[103],"male":[105],"mice":[106],"using":[107,130],"sfx":[109,132],"model":[111,133],"BXD":[113,135],"RI":[114,136],"strains.":[115,137],"The":[116],"objective":[117],"identify":[123],"differentially":[125],"expressed":[126],"genes":[127]},"counts_by_year":[],"updated_date":"2026-03-18T14:38:29.013473","created_date":"2025-10-10T00:00:00"}
