{"id":"https://openalex.org/W2161339256","doi":"https://doi.org/10.1186/1471-2105-15-75","title":"Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis","display_name":"Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis","publication_year":2014,"publication_date":"2014-03-19","ids":{"openalex":"https://openalex.org/W2161339256","doi":"https://doi.org/10.1186/1471-2105-15-75","mag":"2161339256","pmid":"https://pubmed.ncbi.nlm.nih.gov/24646163"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-75","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-75","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-75","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-75","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103261223","display_name":"Debanu Das","orcid":null},"institutions":[{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]},{"id":"https://openalex.org/I4210120900","display_name":"Stanford Synchrotron Radiation Lightsource","ror":"https://ror.org/02vzbm991","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I4210120900","https://openalex.org/I97018004","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I2801935854","display_name":"SLAC National Accelerator Laboratory","ror":"https://ror.org/05gzmn429","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Debanu Das","raw_affiliation_strings":["Joint Center for Structural Genomics, La Jolla, CA, USA. debanu@slac.stanford.edu","Joint Center for Structural Genomics, La Jolla, USA","Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, USA"],"affiliations":[{"raw_affiliation_string":"Joint Center for Structural Genomics, La Jolla, CA, USA. debanu@slac.stanford.edu","institution_ids":[]},{"raw_affiliation_string":"Joint Center for Structural Genomics, La Jolla, USA","institution_ids":["https://openalex.org/I4210091204"]},{"raw_affiliation_string":"Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, USA","institution_ids":["https://openalex.org/I2801935854","https://openalex.org/I4210120900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025834882","display_name":"Alexey G. Murzin","orcid":null},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexey G Murzin","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, CB2 0QH, UK","MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051168121","display_name":"Neil D. Rawlings","orcid":"https://orcid.org/0000-0001-5557-7665"},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil D Rawlings","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK","European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK","Wellcome Trust Sanger Institute, Hinxton, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK","institution_ids":["https://openalex.org/I1303153112"]},{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104045098","display_name":"ROBERT FINN","orcid":"https://orcid.org/0000-0001-8626-2148"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210163239","display_name":"Helix (United States)","ror":"https://ror.org/056jgxp12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163239"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D Finn","raw_affiliation_strings":["Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700, Helix Drive, Ashburn, VA, USA","Howard Hughes Medical Institute, Helix Drive, Ashburn, USA"],"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700, Helix Drive, Ashburn, VA, USA","institution_ids":["https://openalex.org/I195573530"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Helix Drive, Ashburn, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210163239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064117037","display_name":"Penelope Coggill","orcid":null},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Penelope Coggill","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK","Wellcome Trust Sanger Institute, Hinxton, UK","European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059430118","display_name":"Alex Bateman","orcid":null},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex Bateman","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010671148","display_name":"Adam Godzik","orcid":"https://orcid.org/0000-0002-2425-852X"},"institutions":[{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]},{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Godzik","raw_affiliation_strings":["Joint Center for Structural Genomics, La Jolla, CA, USA","Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA","Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, USA","Joint Center for Structural Genomics, La Jolla, USA"],"affiliations":[{"raw_affiliation_string":"Joint Center for Structural Genomics, La Jolla, CA, USA","institution_ids":["https://openalex.org/I4210091204"]},{"raw_affiliation_string":"Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Joint Center for Structural Genomics, La Jolla, USA","institution_ids":["https://openalex.org/I4210091204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026932356","display_name":"L. Aravind","orcid":"https://orcid.org/0000-0003-0771-253X"},"institutions":[{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L Aravind","raw_affiliation_strings":["National Center for Biotechnology Information, National Library of Medicine, Building 38A, Bethesda, MD, USA","National Center for Biotechnology Information, National Library of Medicine, Bethesda, USA"],"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology Information, National Library of Medicine, Building 38A, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210109390"]},{"raw_affiliation_string":"National Center for Biotechnology Information, National Library of Medicine, Bethesda, USA","institution_ids":["https://openalex.org/I4210109390"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5026932356","https://openalex.org/A5103261223"],"corresponding_institution_ids":["https://openalex.org/I2801935854","https://openalex.org/I4210091204","https://openalex.org/I4210109390","https://openalex.org/I4210120900"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.1494,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5579181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"15","issue":"1","first_page":"75","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.9836000204086304,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.5826953649520874},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.5789013504981995},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5096421241760254},{"id":"https://openalex.org/keywords/multiple-sequence-alignment","display_name":"Multiple sequence alignment","score":0.5021934509277344},{"id":"https://openalex.org/keywords/helix","display_name":"Helix (gastropod)","score":0.49845004081726074},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4888750910758972},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.48746490478515625},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46796542406082153},{"id":"https://openalex.org/keywords/helix-turn-helix","display_name":"Helix-turn-helix","score":0.4337003827095032},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.41139376163482666},{"id":"https://openalex.org/keywords/structural-genomics","display_name":"Structural genomics","score":0.4100729823112488},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.33273208141326904},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.31544822454452515},{"id":"https://openalex.org/keywords/repressor","display_name":"Repressor","score":0.1152498722076416},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.06883716583251953}],"concepts":[{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.5826953649520874},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.5789013504981995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5096421241760254},{"id":"https://openalex.org/C88031987","wikidata":"https://www.wikidata.org/wiki/Q1377767","display_name":"Multiple sequence alignment","level":5,"score":0.5021934509277344},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.49845004081726074},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4888750910758972},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.48746490478515625},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46796542406082153},{"id":"https://openalex.org/C199487717","wikidata":"https://www.wikidata.org/wiki/Q24786260","display_name":"Helix-turn-helix","level":5,"score":0.4337003827095032},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.41139376163482666},{"id":"https://openalex.org/C192772702","wikidata":"https://www.wikidata.org/wiki/Q2583975","display_name":"Structural genomics","level":3,"score":0.4100729823112488},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33273208141326904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31544822454452515},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.1152498722076416},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.06883716583251953},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046969","descriptor_name":"Clostridium acetobutylicum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D046969","descriptor_name":"Clostridium acetobutylicum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D046969","descriptor_name":"Clostridium acetobutylicum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D046969","descriptor_name":"Clostridium acetobutylicum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046969","descriptor_name":"Clostridium acetobutylicum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046969","descriptor_name":"Clostridium acetobutylicum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-15-75","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-75","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-75","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24646163","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24646163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:ark:/13030/qt4107q93s","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:escholarship.org/ark:/13030/qt4107q93s","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/4107q93s","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics, vol 15, iss 1","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2977337","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4000134","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-75","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-75","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-75","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1556023774","display_name":null,"funder_award_id":"P41GM1033","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1804828992","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G2393997808","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3295375304","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3611247453","display_name":null,"funder_award_id":"R01GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3629260272","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3817829172","display_name":null,"funder_award_id":"GM101457","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4047395780","display_name":null,"funder_award_id":"GM094586","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4219948241","display_name":null,"funder_award_id":"U54 GM094586","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4280418065","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320338381","funder_display_name":"SLAC National Accelerator Laboratory"},{"id":"https://openalex.org/G4359693134","display_name":null,"funder_award_id":"NIGMS","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G473593538","display_name":null,"funder_award_id":"Molecular","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4947820509","display_name":"EAGER: An Exploration in Enabling Community-Driven Collaboration","funder_award_id":"1153617","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G501232126","display_name":null,"funder_award_id":"GM103393","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6101595067","display_name":null,"funder_award_id":"intramura","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G671616930","display_name":null,"funder_award_id":"GM103393","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6785210703","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G7026415125","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7340972926","display_name":null,"funder_award_id":"other","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7908228807","display_name":null,"funder_award_id":"Molecular","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8284605592","display_name":"An Annual Workshop on Automated Function Prediction","funder_award_id":"0646708","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8684857560","display_name":null,"funder_award_id":"U54 GM094586","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G903384155","display_name":null,"funder_award_id":"GM094586","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"},{"id":"https://openalex.org/F4320338381","display_name":"SLAC National Accelerator Laboratory","ror":"https://ror.org/05gzmn429"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2161339256.pdf","grobid_xml":"https://content.openalex.org/works/W2161339256.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W60711875","https://openalex.org/W255996521","https://openalex.org/W1506664007","https://openalex.org/W1567730256","https://openalex.org/W1966379061","https://openalex.org/W1969672293","https://openalex.org/W1975284044","https://openalex.org/W1978096114","https://openalex.org/W1978811317","https://openalex.org/W1980315021","https://openalex.org/W1982118354","https://openalex.org/W1989668259","https://openalex.org/W1997644819","https://openalex.org/W2001641653","https://openalex.org/W2006724716","https://openalex.org/W2009393104","https://openalex.org/W2012072946","https://openalex.org/W2020429677","https://openalex.org/W2032293502","https://openalex.org/W2032675744","https://openalex.org/W2035503835","https://openalex.org/W2046372352","https://openalex.org/W2064165347","https://openalex.org/W2073954040","https://openalex.org/W2085785716","https://openalex.org/W2088422782","https://openalex.org/W2089999388","https://openalex.org/W2094201044","https://openalex.org/W2107717979","https://openalex.org/W2109191660","https://openalex.org/W2110035145","https://openalex.org/W2112097237","https://openalex.org/W2113952988","https://openalex.org/W2114034054","https://openalex.org/W2117239890","https://openalex.org/W2124088653","https://openalex.org/W2125850770","https://openalex.org/W2128653811","https://openalex.org/W2131350133","https://openalex.org/W2135621733","https://openalex.org/W2137587451","https://openalex.org/W2139621307","https://openalex.org/W2144081223","https://openalex.org/W2144998676","https://openalex.org/W2147526198","https://openalex.org/W2158714788","https://openalex.org/W2162220273","https://openalex.org/W2162407342","https://openalex.org/W2168621448","https://openalex.org/W2412963709","https://openalex.org/W2786774014","https://openalex.org/W3021859301","https://openalex.org/W3023724238","https://openalex.org/W4246643264"],"related_works":["https://openalex.org/W2051969447","https://openalex.org/W2111937814","https://openalex.org/W2162923930","https://openalex.org/W1482324242","https://openalex.org/W2133116680","https://openalex.org/W2091678889","https://openalex.org/W2029514038","https://openalex.org/W2028741573","https://openalex.org/W2134646385","https://openalex.org/W3164623151"],"abstract_inverted_index":{"Based":[0],"on":[1],"our":[2],"sequence":[3],"and":[4,39],"structural":[5],"analyses":[6],"using":[7],"the":[8,18,22,62,65,69],"crystal":[9],"structure":[10],"of":[11,21,48,68],"CA_C2195":[12,38],"we":[13,30],"provide":[14,61],"a":[15,36,44,49],"view":[16],"into":[17],"possible":[19],"functions":[20],"protein.":[23],"From":[24],"contextual":[25],"information":[26],"from":[27],"gene-neighborhood":[28],"analysis,":[29],"propose":[31],"that":[32],"rather":[33],"than":[34],"being":[35],"peptidase,":[37],"its":[40],"homologs":[41],"might":[42],"play":[43],"role":[45],"in":[46,53],"biosynthesis":[47],"modified":[50],"cell-surface":[51],"carbohydrate":[52],"conjunction":[54],"with":[55],"several":[56],"sugar-modification":[57],"enzymes.":[58],"These":[59],"results":[60],"groundwork":[63],"for":[64],"experimental":[66],"verification":[67],"function.":[70]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}