{"id":"https://openalex.org/W1988728360","doi":"https://doi.org/10.1186/1471-2105-15-51","title":"Statistical hypothesis testing of factor loading in principal component analysis and its application to metabolite set enrichment analysis","display_name":"Statistical hypothesis testing of factor loading in principal component analysis and its application to metabolite set enrichment analysis","publication_year":2014,"publication_date":"2014-02-21","ids":{"openalex":"https://openalex.org/W1988728360","doi":"https://doi.org/10.1186/1471-2105-15-51","mag":"1988728360","pmid":"https://pubmed.ncbi.nlm.nih.gov/24555693"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-51","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-51","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-51","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042088140","display_name":"Hiroyuki Yamamoto","orcid":"https://orcid.org/0000-0002-1344-6525"},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Yamamoto","raw_affiliation_strings":["Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata 997-0052, Japan. h.yama2396@gmail.com","Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata 997-0052, Japan. h.yama2396@gmail.com","institution_ids":["https://openalex.org/I112524849"]},{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029741188","display_name":"Tamaki Fujimori","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamaki Fujimori","raw_affiliation_strings":["Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan","Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan","institution_ids":[]},{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022750117","display_name":"Hajime Sato","orcid":"https://orcid.org/0000-0001-5185-096X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hajime Sato","raw_affiliation_strings":["Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan","Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan","institution_ids":[]},{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110824421","display_name":"Gen Ishikawa","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gen Ishikawa","raw_affiliation_strings":["Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan","Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan","institution_ids":[]},{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083033918","display_name":"Kenjiro Kami","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenjiro Kami","raw_affiliation_strings":["Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan","Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan","institution_ids":[]},{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034807411","display_name":"Yoshiaki Ohashi","orcid":"https://orcid.org/0000-0003-2093-5519"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshiaki Ohashi","raw_affiliation_strings":["Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan","Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan","institution_ids":[]},{"raw_affiliation_string":"Human Metabolome Technologies, Inc, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.9889,"has_fulltext":true,"cited_by_count":160,"citation_normalized_percentile":{"value":0.91555279,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"51","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9254999756813049,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9254999756813049,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.8419891595840454},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5361464023590088},{"id":"https://openalex.org/keywords/statistical-analysis","display_name":"Statistical analysis","score":0.527727484703064},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.5226399898529053},{"id":"https://openalex.org/keywords/factor","display_name":"Factor (programming language)","score":0.5113264918327332},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48945558071136475},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47942107915878296},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.4376676380634308},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.4153820872306824},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3609929084777832},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33719587326049805},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2829488515853882},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.07622545957565308}],"concepts":[{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.8419891595840454},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5361464023590088},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.527727484703064},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.5226399898529053},{"id":"https://openalex.org/C2781039887","wikidata":"https://www.wikidata.org/wiki/Q1391724","display_name":"Factor (programming language)","level":2,"score":0.5113264918327332},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48945558071136475},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47942107915878296},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4376676380634308},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4153820872306824},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3609929084777832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33719587326049805},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2829488515853882},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07622545957565308},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2105-15-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-51","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-51","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24555693","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24555693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:3005798","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4015128","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-51","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-51","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1988728360.pdf","grobid_xml":"https://content.openalex.org/works/W1988728360.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W642635438","https://openalex.org/W1535641839","https://openalex.org/W1922999930","https://openalex.org/W1968486566","https://openalex.org/W1971817110","https://openalex.org/W1978626190","https://openalex.org/W1995888001","https://openalex.org/W1997195198","https://openalex.org/W2018507034","https://openalex.org/W2025701648","https://openalex.org/W2034400748","https://openalex.org/W2077109639","https://openalex.org/W2080897135","https://openalex.org/W2081463586","https://openalex.org/W2086840831","https://openalex.org/W2090046776","https://openalex.org/W2098562143","https://openalex.org/W2099790516","https://openalex.org/W2110065044","https://openalex.org/W2113664327","https://openalex.org/W2118069309","https://openalex.org/W2124911115","https://openalex.org/W2128557965","https://openalex.org/W2130410032","https://openalex.org/W2134582937","https://openalex.org/W2145265944","https://openalex.org/W2159482845","https://openalex.org/W2164583936","https://openalex.org/W2282948130","https://openalex.org/W2582743722","https://openalex.org/W3099514962","https://openalex.org/W4206739449","https://openalex.org/W4211009599","https://openalex.org/W4250857377","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2521903434","https://openalex.org/W1753739957","https://openalex.org/W2085913165","https://openalex.org/W2011282322","https://openalex.org/W2024044986","https://openalex.org/W2005550771","https://openalex.org/W323632276","https://openalex.org/W4256652904","https://openalex.org/W1598178850","https://openalex.org/W2356483589"],"abstract_inverted_index":{"BACKGROUND:":[0],"Principal":[1],"component":[2],"analysis":[3,98,176],"(PCA)":[4],"has":[5],"been":[6,30],"widely":[7],"used":[8,193],"to":[9,52,116,132,168,224,228,247,261,278],"visualize":[10],"high-dimensional":[11],"metabolomic":[12,136,234],"data":[13,113,137,235],"in":[14,37,83,109,146,156,186,194,214,240,258],"a":[15,69,94,244],"two-":[16],"or":[17],"three-dimensional":[18],"subspace.":[19],"In":[20],"metabolomics,":[21],"some":[22],"metabolites":[23,58,74,92,145,155,173,184,203,226,249,268],"(e.g.,":[24],"the":[25,80,104,107,117,121,147,157,170,175,180,255,289],"top":[26],"10":[27],"metabolites)":[28],"have":[29,272],"subjectively":[31],"selected":[32,62],"when":[33,189,197,236],"using":[34,237],"factor":[35,81,190,238,256],"loading":[36,82,191,239,257],"PCA,":[38,259],"and":[39,85,124,151,260],"biological":[40,54,87,218,231,263],"inferences":[41,55,88,232,264],"are":[42,59],"made":[43],"for":[44,111],"these":[45,57,90,201,266],"metabolites.":[46],"However,":[47],"this":[48,130,280],"approach":[49,131],"may":[50],"lead":[51],"biased":[53],"because":[56,179],"not":[60],"objectively":[61],"with":[63,75,93,250,269],"statistical":[64,70,76,245,251],"criteria.":[65],"RESULTS:":[66],"We":[67,128,242,271],"propose":[68,243],"procedure":[71,101,246],"that":[72,106,167],"selects":[73],"hypothesis":[77,252],"testing":[78,253],"of":[79,135,143,153,172,182,200,216,254],"PCA":[84,110],"makes":[86],"about":[89,265],"significant":[91,183,202,206,267],"metabolite":[95,126],"set":[96,169],"enrichment":[97],"(MSEA).":[99],"This":[100,164],"depends":[102],"on":[103],"fact":[105],"eigenvector":[108],"autoscaled":[112],"is":[114,177,192,222,285],"proportional":[115],"correlation":[118],"coefficient":[119],"between":[120],"PC":[122],"score":[123],"each":[125,187],"level.":[127],"applied":[129],"two":[133],"sets":[134],"from":[138,233],"mouse":[139],"liver":[140],"samples:":[141],"136":[142],"282":[144],"first":[148],"case":[149,159],"study":[150,160,188],"66":[152],"275":[154],"second":[158],"were":[161,209,212],"statistically":[162,227],"significant.":[163],"result":[165],"suggests":[166],"number":[171,181],"before":[174],"inappropriate":[178],"differs":[185],"PCA.":[195,241],"Moreover,":[196],"an":[198,274],"MSEA":[199],"was":[204],"performed,":[205],"metabolic":[207],"pathways":[208],"detected,":[210],"which":[211],"acceptable":[213],"terms":[215],"previous":[217],"knowledge.":[219],"CONCLUSIONS:":[220],"It":[221],"essential":[223],"select":[225,248],"make":[229],"unbiased":[230],"draw":[262],"MSEA.":[270],"developed":[273],"R":[275],"package":[276,284],"\"mseapca\"":[277,283],"facilitate":[279],"approach.":[281],"The":[282],"publicly":[286],"available":[287],"at":[288],"CRAN":[290],"website.":[291]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-13T07:54:00.901334","created_date":"2025-10-10T00:00:00"}
