{"id":"https://openalex.org/W2024362135","doi":"https://doi.org/10.1186/1471-2105-15-312","title":"Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) Study","display_name":"Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) Study","publication_year":2014,"publication_date":"2014-09-19","ids":{"openalex":"https://openalex.org/W2024362135","doi":"https://doi.org/10.1186/1471-2105-15-312","mag":"2024362135","pmid":"https://pubmed.ncbi.nlm.nih.gov/25239148"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-312","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-312","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-312","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-312","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083751989","display_name":"Maitreyee Bose","orcid":null},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maitreyee Bose","raw_affiliation_strings":["Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA","University of\u00a0Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of\u00a0Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011295368","display_name":"Chong Wu","orcid":"https://orcid.org/0000-0002-8400-1785"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chong Wu","raw_affiliation_strings":["Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA","University of\u00a0Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of\u00a0Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022683360","display_name":"James S. Pankow","orcid":"https://orcid.org/0000-0001-7076-483X"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James S Pankow","raw_affiliation_strings":["Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA","University of\u00a0Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of\u00a0Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075195377","display_name":"Ellen W. Demerath","orcid":"https://orcid.org/0000-0002-4585-4064"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen W Demerath","raw_affiliation_strings":["Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA","University of\u00a0Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of\u00a0Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001471706","display_name":"Jan Bressler","orcid":"https://orcid.org/0000-0001-6578-4772"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Bressler","raw_affiliation_strings":["Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100672057","display_name":"Myriam Fornage","orcid":"https://orcid.org/0000-0003-0677-8158"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myriam Fornage","raw_affiliation_strings":["Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046703707","display_name":"Megan L. Grove","orcid":"https://orcid.org/0000-0001-6764-2508"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan L Grove","raw_affiliation_strings":["Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075741409","display_name":"Thomas H. Mosley","orcid":"https://orcid.org/0000-0003-3343-1352"},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas H Mosley","raw_affiliation_strings":["Department of Neurology and Department of Medicine, University of Mississippi, Jackson, MS, 39216, USA","University of Mississippi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Department of Medicine, University of Mississippi, Jackson, MS, 39216, USA","institution_ids":["https://openalex.org/I368840534"]},{"raw_affiliation_string":"University of Mississippi","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023610125","display_name":"Chindo Hicks","orcid":"https://orcid.org/0000-0002-1876-299X"},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chindo Hicks","raw_affiliation_strings":["Department of Neurology and Department of Medicine, University of Mississippi, Jackson, MS, 39216, USA","University of Mississippi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Department of Medicine, University of Mississippi, Jackson, MS, 39216, USA","institution_ids":["https://openalex.org/I368840534"]},{"raw_affiliation_string":"University of Mississippi","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062296084","display_name":"Kari E. North","orcid":"https://orcid.org/0000-0002-8903-0366"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kari North","raw_affiliation_strings":["Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, 27516, USA","University of North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, 27516, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110003068","display_name":"Wen Hong Linda Kao","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen Hong Kao","raw_affiliation_strings":["Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA","\u00b6Dept of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"\u00b6Dept of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100433374","display_name":"Yu Zhang","orcid":"https://orcid.org/0000-0001-5757-293X"},"institutions":[{"id":"https://openalex.org/I142823887","display_name":"St. John's University","ror":"https://ror.org/00bgtad15","country_code":"US","type":"education","lineage":["https://openalex.org/I142823887"]},{"id":"https://openalex.org/I84360360","display_name":"College of Saint Benedict and Saint John's University","ror":"https://ror.org/00watgv28","country_code":"US","type":"education","lineage":["https://openalex.org/I84360360"]},{"id":"https://openalex.org/I4210149082","display_name":"Saint John's University","ror":"https://ror.org/04ec26n40","country_code":"TH","type":"education","lineage":["https://openalex.org/I4210149082"]}],"countries":["TH","US"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["Department of Computer Science, Saint John\u2019s University, Collegeville, MN, 56321, USA","Department of Computer Science, Saint John\u2019s University, Collegeville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Saint John\u2019s University, Collegeville, MN, 56321, USA","institution_ids":["https://openalex.org/I4210149082","https://openalex.org/I84360360"]},{"raw_affiliation_string":"Department of Computer Science, Saint John\u2019s University, Collegeville, USA","institution_ids":["https://openalex.org/I142823887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044048476","display_name":"Eric Boerwinkle","orcid":"https://orcid.org/0000-0001-8813-0544"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Boerwinkle","raw_affiliation_strings":["Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101877549","display_name":"Weihua Guan","orcid":"https://orcid.org/0000-0002-0956-9821"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weihua Guan","raw_affiliation_strings":["Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA. wguan@umn.edu","University of\u00a0Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA. wguan@umn.edu","institution_ids":[]},{"raw_affiliation_string":"University of\u00a0Minnesota","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5083751989"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.4228,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.80714785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"312","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.8057987689971924},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7521741986274719},{"id":"https://openalex.org/keywords/intraclass-correlation","display_name":"Intraclass correlation","score":0.6668846011161804},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.655363142490387},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.6421938538551331},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5667914152145386},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5103346705436707},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.4169939458370209},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3972097635269165},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3262806534767151},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.29192423820495605},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.23584458231925964},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19019263982772827},{"id":"https://openalex.org/keywords/clinical-psychology","display_name":"Clinical psychology","score":0.14891499280929565},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08046746253967285},{"id":"https://openalex.org/keywords/psychometrics","display_name":"Psychometrics","score":0.07328379154205322}],"concepts":[{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.8057987689971924},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7521741986274719},{"id":"https://openalex.org/C104709138","wikidata":"https://www.wikidata.org/wiki/Q1671540","display_name":"Intraclass correlation","level":3,"score":0.6668846011161804},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.655363142490387},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6421938538551331},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5667914152145386},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5103346705436707},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4169939458370209},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3972097635269165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3262806534767151},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29192423820495605},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.23584458231925964},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19019263982772827},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.14891499280929565},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08046746253967285},{"id":"https://openalex.org/C171606756","wikidata":"https://www.wikidata.org/wiki/Q506132","display_name":"Psychometrics","level":2,"score":0.07328379154205322}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012111","descriptor_name":"Residence Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012111","descriptor_name":"Residence Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012111","descriptor_name":"Residence Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-15-312","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-312","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-312","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25239148","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25239148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4180315","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4180315","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:cdr.lib.unc.edu:uuid:ee264ba5-bad0-4516-9da2-9ade48f70905","is_oa":true,"landing_page_url":"https://cdr.lib.unc.edu/record/uuid:ee264ba5-bad0-4516-9da2-9ade48f70905","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-312","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-312","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-312","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1243299691","display_name":null,"funder_award_id":"HHSN268201100007C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1420454791","display_name":null,"funder_award_id":"HHSN268201100009C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1460387277","display_name":null,"funder_award_id":"HHSN268201100012C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G173303992","display_name":null,"funder_award_id":"HHSN268201100011C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1878914780","display_name":null,"funder_award_id":"5RC2HL102419","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2204534856","display_name":null,"funder_award_id":"HHSN268201100008C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2548373799","display_name":null,"funder_award_id":"HHSN268201100006C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G301743239","display_name":null,"funder_award_id":"HHSN268201100008C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3114902838","display_name":null,"funder_award_id":"HHSN268201100005C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3152385821","display_name":null,"funder_award_id":"HHSN268201100006C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G339263803","display_name":null,"funder_award_id":"5RC2HL102419","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3462919067","display_name":null,"funder_award_id":"HHSN268201100010C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4200864717","display_name":null,"funder_award_id":"HHSN268201100007C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5053595415","display_name":null,"funder_award_id":"HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5074086979","display_name":null,"funder_award_id":"HHSN268201100011C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6195637971","display_name":null,"funder_award_id":"HHSN268201100010C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6552090923","display_name":null,"funder_award_id":"HHSN268201100009C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6865635144","display_name":null,"funder_award_id":"HHSN268201100005C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8258276203","display_name":null,"funder_award_id":"HHSN268201100012C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024362135.pdf","grobid_xml":"https://content.openalex.org/works/W2024362135.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1967778641","https://openalex.org/W1975528145","https://openalex.org/W1986849266","https://openalex.org/W1994777946","https://openalex.org/W1997824331","https://openalex.org/W1998453757","https://openalex.org/W2004078197","https://openalex.org/W2011052948","https://openalex.org/W2018800004","https://openalex.org/W2021459974","https://openalex.org/W2022484411","https://openalex.org/W2049633694","https://openalex.org/W2050112556","https://openalex.org/W2074746593","https://openalex.org/W2078028724","https://openalex.org/W2081502106","https://openalex.org/W2096192437","https://openalex.org/W2099437253","https://openalex.org/W2107665951","https://openalex.org/W2107776519","https://openalex.org/W2108176813","https://openalex.org/W2108947463","https://openalex.org/W2116711987","https://openalex.org/W2125180026","https://openalex.org/W2130523009","https://openalex.org/W2141105144","https://openalex.org/W2144640466","https://openalex.org/W2144998962","https://openalex.org/W2161922342","https://openalex.org/W2163125553","https://openalex.org/W2169353806","https://openalex.org/W2329888282","https://openalex.org/W2731507867","https://openalex.org/W4242416368"],"related_works":["https://openalex.org/W2214376880","https://openalex.org/W3212149434","https://openalex.org/W2073893804","https://openalex.org/W2291484187","https://openalex.org/W2902329290","https://openalex.org/W2169344098","https://openalex.org/W2139872319","https://openalex.org/W2052355316","https://openalex.org/W2046964473","https://openalex.org/W2107880877"],"abstract_inverted_index":{"BACKGROUND:":[0],"DNA":[1,40],"methylation":[2,11,41,98,162],"is":[3],"a":[4,116,157],"widely":[5],"studied":[6],"epigenetic":[7],"phenomenon;":[8],"alterations":[9],"in":[10,26,42,79,186],"patterns":[12],"influence":[13],"human":[14],"phenotypes":[15],"and":[16,101,107,123,137,164],"risk":[17],"of":[18,22,68,97,113,118,151,159,167],"disease.":[19],"As":[20],"part":[21],"the":[23,30,61,66,80,89,111,142,149,170,187],"Atherosclerosis":[24],"Risk":[25],"Communities":[27],"(ARIC)":[28],"study,":[29],"Illumina":[31],"Infinium":[32],"HumanMethylation450":[33],"(HM450)":[34],"BeadChip":[35],"was":[36],"used":[37],"to":[38,94,141,156,211],"measure":[39],"peripheral":[43],"blood":[44],"obtained":[45],"from":[46,74,184,203],"~3000":[47],"African":[48],"American":[49],"study":[50,158],"participants.":[51],"Over":[52],"480,000":[53],"cytosine-guanine":[54],"(CpG)":[55],"dinucleotide":[56],"sites":[57,132,172,185,196],"were":[58,77,133,182],"surveyed":[59],"on":[60],"HM450":[62],"BeadChip.":[63],"To":[64],"evaluate":[65],"impact":[67],"technical":[69,72],"variation,":[70],"265":[71],"replicates":[73],"130":[75],"participants":[76],"included":[78],"study.":[81],"RESULTS:":[82],"For":[83,169],"each":[84],"CpG":[85,131,171,195],"site,":[86],"we":[87],"calculated":[88,143],"intraclass":[90],"correlation":[91],"coefficient":[92],"(ICC)":[93],"compare":[95],"variation":[96],"levels":[99,163],"within-":[100],"between-replicate":[102],"pairs,":[103],"ranging":[104],"between":[105,161],"0":[106],"1.":[108],"We":[109,146,192],"modeled":[110],"distribution":[112],"ICC":[114,199],"as":[115],"mixture":[117],"censored":[119],"or":[120,207],"truncated":[121],"normal":[122,124],"distributions":[125],"using":[126],"an":[127],"EM":[128],"algorithm.":[129],"The":[130],"clustered":[134],"into":[135],"low-":[136],"high-reliability":[138],"groups,":[139],"according":[140],"posterior":[144],"probabilities.":[145],"also":[147],"demonstrated":[148],"performance":[150],"this":[152],"clustering":[153],"when":[154],"applied":[155],"association":[160,176,205],"smoking":[165,178],"status":[166],"individuals.":[168],"showing":[173],"genome-wide":[174],"significant":[175],"with":[177,197],"status,":[179],"most":[180],"(~96%)":[181],"seen":[183],"high":[188],"reliability":[189],"cluster.":[190],"CONCLUSIONS:":[191],"suggest":[193],"that":[194],"low":[198],"may":[200],"be":[201,212],"excluded":[202],"subsequent":[204],"analyses,":[206],"extra":[208],"caution":[209],"needs":[210],"taken":[213],"for":[214],"associations":[215],"at":[216],"such":[217],"sites.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
