{"id":"https://openalex.org/W2033713602","doi":"https://doi.org/10.1186/1471-2105-15-240","title":"MCA: Multiresolution Correlation Analysis, a graphical tool for subpopulation identification in single-cell gene expression data","display_name":"MCA: Multiresolution Correlation Analysis, a graphical tool for subpopulation identification in single-cell gene expression data","publication_year":2014,"publication_date":"2014-07-11","ids":{"openalex":"https://openalex.org/W2033713602","doi":"https://doi.org/10.1186/1471-2105-15-240","mag":"2033713602","pmid":"https://pubmed.ncbi.nlm.nih.gov/25015590"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-240","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-240","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-240","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-240","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044515651","display_name":"Justin Feigelman","orcid":"https://orcid.org/0000-0002-6296-7087"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Justin Feigelman","raw_affiliation_strings":["Department of Mathematics, Technische Universit\u00e4t M\u00fcnchen, Boltzmannstrasse, 3, 85747, Garching, Germany","Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Technische Universit\u00e4t M\u00fcnchen, Boltzmannstrasse, 3, 85747, Garching, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083128670","display_name":"Fabian J. Theis","orcid":"https://orcid.org/0000-0002-2419-1943"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian J Theis","raw_affiliation_strings":["Department of Mathematics, Technische Universit\u00e4t M\u00fcnchen, Boltzmannstrasse, 3, 85747, Garching, Germany","Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Technische Universit\u00e4t M\u00fcnchen, Boltzmannstrasse, 3, 85747, Garching, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046721596","display_name":"Carsten Marr","orcid":"https://orcid.org/0000-0003-2154-4552"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Carsten Marr","raw_affiliation_strings":["Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764 Neuherberg, Germany. carsten.marr@helmholtz-muenchen.de","Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764 Neuherberg, Germany. carsten.marr@helmholtz-muenchen.de","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046721596"],"corresponding_institution_ids":["https://openalex.org/I3018134672"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.1696,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76990621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"240","last_page":"240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.8425999879837036,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.8425999879837036,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.6841577291488647},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.6579576730728149},{"id":"https://openalex.org/keywords/covariate","display_name":"Covariate","score":0.6573418974876404},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6324628591537476},{"id":"https://openalex.org/keywords/outlier","display_name":"Outlier","score":0.6298357248306274},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6190057992935181},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5603682398796082},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5242512226104736},{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.49067747592926025},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.47410494089126587},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.43718820810317993},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.42930975556373596},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.36287128925323486},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.34767770767211914},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3285660743713379},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32054397463798523},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2004852294921875},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.17149734497070312},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.10781678557395935}],"concepts":[{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.6841577291488647},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.6579576730728149},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.6573418974876404},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6324628591537476},{"id":"https://openalex.org/C79337645","wikidata":"https://www.wikidata.org/wiki/Q779824","display_name":"Outlier","level":2,"score":0.6298357248306274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6190057992935181},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5603682398796082},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5242512226104736},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.49067747592926025},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.47410494089126587},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.43718820810317993},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.42930975556373596},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.36287128925323486},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34767770767211914},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3285660743713379},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32054397463798523},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2004852294921875},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17149734497070312},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.10781678557395935},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-15-240","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-240","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-240","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25015590","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25015590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:3197065","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4227291","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:31757","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=31757","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics 15:240 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-240","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-240","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-240","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2304404308","display_name":null,"funder_award_id":"SPP 1356","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2033713602.pdf","grobid_xml":"https://content.openalex.org/works/W2033713602.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W74439177","https://openalex.org/W155837971","https://openalex.org/W230980609","https://openalex.org/W1966758700","https://openalex.org/W1967948152","https://openalex.org/W1968121660","https://openalex.org/W1971445167","https://openalex.org/W1973332790","https://openalex.org/W1981600092","https://openalex.org/W1986746875","https://openalex.org/W1988146848","https://openalex.org/W1990512452","https://openalex.org/W1999541949","https://openalex.org/W2009563919","https://openalex.org/W2010173857","https://openalex.org/W2025897582","https://openalex.org/W2038254572","https://openalex.org/W2040188417","https://openalex.org/W2042035594","https://openalex.org/W2043399100","https://openalex.org/W2060929285","https://openalex.org/W2072806829","https://openalex.org/W2080081864","https://openalex.org/W2092033222","https://openalex.org/W2093100781","https://openalex.org/W2099236226","https://openalex.org/W2104893769","https://openalex.org/W2111607395","https://openalex.org/W2114870653","https://openalex.org/W2115875363","https://openalex.org/W2116163594","https://openalex.org/W2124379907","https://openalex.org/W2128728535","https://openalex.org/W2129905934","https://openalex.org/W2134229566","https://openalex.org/W2145274698","https://openalex.org/W2146007026","https://openalex.org/W2157140345","https://openalex.org/W2168221215","https://openalex.org/W2168945089","https://openalex.org/W2325963232","https://openalex.org/W2611591252","https://openalex.org/W3099514962","https://openalex.org/W4248949446"],"related_works":["https://openalex.org/W2162899405","https://openalex.org/W3113091479","https://openalex.org/W941090075","https://openalex.org/W2044987316","https://openalex.org/W3134374554","https://openalex.org/W2237480245","https://openalex.org/W2519167559","https://openalex.org/W2075065631","https://openalex.org/W4288358396","https://openalex.org/W4311248832"],"abstract_inverted_index":{"BACKGROUND:":[0],"Biological":[1],"data":[2,78,93],"often":[3],"originate":[4],"from":[5,79,94,142],"samples":[6],"containing":[7],"mixtures":[8],"of":[9,19,72,134,156,174,183,188],"subpopulations,":[10,106,161],"corresponding":[11],"e.g.":[12],"to":[13,58,88,152,169],"distinct":[14,20],"cellular":[15],"phenotypes.":[16],"However,":[17],"identification":[18,71,133],"subpopulations":[21,47,75,135],"may":[22],"be":[23],"difficult":[24],"if":[25],"biological":[26,191],"measurements":[27],"yield":[28],"distributions":[29],"that":[30,67,101],"are":[31],"not":[32],"easily":[33],"separable.":[34],"RESULTS:":[35],"We":[36,65,99],"present":[37],"Multiresolution":[38],"Correlation":[39],"Analysis":[40],"(MCA),":[41],"a":[42,61,80,128,179],"method":[43,130],"for":[44,131,181,186],"visually":[45],"identifying":[46],"based":[48],"on":[49],"the":[50,70,111,132,154],"local":[51],"pairwise":[52],"correlation":[53,113],"between":[54,172],"covariates,":[55],"without":[56],"needing":[57],"define":[59],"an":[60],"priori":[62],"interaction":[63],"scale.":[64],"demonstrate":[66],"MCA":[68,102,126,148,176],"facilitates":[69],"differentially":[73],"regulated":[74],"in":[76,136],"simulated":[77],"small":[81],"gene":[82],"regulatory":[83],"network,":[84],"followed":[85],"by":[86],"application":[87],"previously":[89,104],"published":[90],"single-cell":[91],"qPCR":[92,143],"mouse":[95],"embryonic":[96],"stem":[97],"cells.":[98],"show":[100],"recovers":[103],"identified":[105],"provides":[107,120,178],"additional":[108],"insight":[109,121],"into":[110,122],"underlying":[112],"structure,":[114],"reveals":[115],"potentially":[116],"spurious":[117],"compartmentalizations,":[118],"and":[119,165,190],"novel":[123],"subpopulations.":[124],"CONCLUSIONS:":[125],"is":[127,150],"useful":[129],"low-dimensional":[137],"expression":[138,184],"data,":[139],"as":[140],"emerging":[141],"or":[144],"FACS":[145],"measurements.":[146],"With":[147],"it":[149],"possible":[151],"investigate":[153],"robustness":[155],"covariate":[157],"correlations":[158,185],"with":[159],"respect":[160],"graphically":[162],"identify":[163,166],"outliers,":[164],"factors":[167],"contributing":[168],"differential":[170],"regulation":[171],"pairs":[173],"covariates.":[175],"thus":[177],"framework":[180],"investigation":[182],"genes":[187],"interests":[189],"hypothesis":[192],"generation.":[193]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}