{"id":"https://openalex.org/W2166975926","doi":"https://doi.org/10.1186/1471-2105-15-199","title":"Non-specific filtering of beta-distributed data","display_name":"Non-specific filtering of beta-distributed data","publication_year":2014,"publication_date":"2014-06-19","ids":{"openalex":"https://openalex.org/W2166975926","doi":"https://doi.org/10.1186/1471-2105-15-199","mag":"2166975926","pmid":"https://pubmed.ncbi.nlm.nih.gov/24943962"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-199","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-199","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-199","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-199","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100370835","display_name":"Xinhui Wang","orcid":"https://orcid.org/0000-0003-0472-413X"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xinhui Wang","raw_affiliation_strings":["Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 2001 N Soto Street, Suite 202W, Los Angeles, 90089-9239, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 2001 N Soto Street, Suite 202W, Los Angeles, 90089-9239, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025761663","display_name":"Peter W. Laird","orcid":"https://orcid.org/0000-0001-9117-3641"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W Laird","raw_affiliation_strings":["Epigenome Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenome Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026537645","display_name":"Toshinori Hinoue","orcid":"https://orcid.org/0000-0002-5078-5016"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshinori Hinoue","raw_affiliation_strings":["Epigenome Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenome Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067387322","display_name":"Susan Groshen","orcid":"https://orcid.org/0000-0001-9705-1012"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Groshen","raw_affiliation_strings":["Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 2001 N Soto Street, Suite 202W, Los Angeles, 90089-9239, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 2001 N Soto Street, Suite 202W, Los Angeles, 90089-9239, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023411724","display_name":"Kimberly D. Siegmund","orcid":"https://orcid.org/0000-0001-7599-9726"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly D Siegmund","raw_affiliation_strings":["Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 2001 N Soto Street, Suite 202W, Los Angeles 90089-9239 California, USA. kims@usc.edu","Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 2001 N Soto Street, Suite 202W, Los Angeles, 90089-9239, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 2001 N Soto Street, Suite 202W, Los Angeles 90089-9239 California, USA. kims@usc.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 2001 N Soto Street, Suite 202W, Los Angeles, 90089-9239, California, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100370835"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.5691,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.68216579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"199","last_page":"199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.1615999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11901","display_name":"Bayesian Methods and Mixture Models","score":0.06419999897480011,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/filter","display_name":"Filter (signal processing)","score":0.6452606916427612},{"id":"https://openalex.org/keywords/standard-deviation","display_name":"Standard deviation","score":0.6274943351745605},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5107824802398682},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.45944440364837646},{"id":"https://openalex.org/keywords/statistic","display_name":"Statistic","score":0.4553854465484619},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.45473816990852356},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.4538191854953766},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.45189806818962097},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4399198293685913},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.41404321789741516},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3993682265281677},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35966479778289795},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3325366675853729},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.32671058177948},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3198149502277374},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1932257115840912},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09451478719711304}],"concepts":[{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.6452606916427612},{"id":"https://openalex.org/C22679943","wikidata":"https://www.wikidata.org/wiki/Q159375","display_name":"Standard deviation","level":2,"score":0.6274943351745605},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5107824802398682},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.45944440364837646},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.4553854465484619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45473816990852356},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.4538191854953766},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.45189806818962097},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4399198293685913},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.41404321789741516},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3993682265281677},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35966479778289795},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3325366675853729},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.32671058177948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3198149502277374},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1932257115840912},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09451478719711304},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016008","descriptor_name":"Statistical Distributions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016008","descriptor_name":"Statistical Distributions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016008","descriptor_name":"Statistical Distributions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-15-199","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-199","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-199","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24943962","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24943962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:ark:/13030/qt8bh8j41w","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:escholarship.org/ark:/13030/qt8bh8j41w","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8bh8j41w","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics, vol 15, iss 1","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4230495","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4230495","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-199","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-199","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-199","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.5299999713897705}],"awards":[{"id":"https://openalex.org/G1185815368","display_name":null,"funder_award_id":"ES07048","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2025263377","display_name":null,"funder_award_id":"HG006705","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G2132585678","display_name":null,"funder_award_id":"P30 ES07048","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2371646462","display_name":null,"funder_award_id":"CA014089","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4322150400","display_name":null,"funder_award_id":"CA097346","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4929552406","display_name":null,"funder_award_id":"R01 HG006705","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5229191008","display_name":null,"funder_award_id":"P30 ES07048","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6069539874","display_name":null,"funder_award_id":"5P30 CA014089","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2166975926.pdf","grobid_xml":"https://content.openalex.org/works/W2166975926.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1984689638","https://openalex.org/W1997817740","https://openalex.org/W2007139266","https://openalex.org/W2011988545","https://openalex.org/W2017502278","https://openalex.org/W2038608603","https://openalex.org/W2056040742","https://openalex.org/W2058358568","https://openalex.org/W2068523052","https://openalex.org/W2081182312","https://openalex.org/W2096715243","https://openalex.org/W2105528101","https://openalex.org/W2119387367","https://openalex.org/W2121139881","https://openalex.org/W2123696077","https://openalex.org/W2127431419","https://openalex.org/W2131593373","https://openalex.org/W2169556367","https://openalex.org/W2169903102","https://openalex.org/W4230408838"],"related_works":["https://openalex.org/W2359776416","https://openalex.org/W2353788488","https://openalex.org/W118630527","https://openalex.org/W38289631","https://openalex.org/W4252337044","https://openalex.org/W2361916204","https://openalex.org/W2372011046","https://openalex.org/W2592886773","https://openalex.org/W2922142213","https://openalex.org/W2387495973"],"abstract_inverted_index":{"BACKGROUND:":[0],"Non-specific":[1],"feature":[2],"selection":[3,67],"is":[4,44,323],"a":[5,47,56,92,124,136,145,151,161,167,200,314],"dimension":[6],"reduction":[7],"procedure":[8],"performed":[9,209,302],"prior":[10],"to":[11,25,70,122,194,227,295],"cluster":[12,201,321],"analysis":[13,322],"of":[14,58,68,126,139,144,147,153,178,182,216,270,307,340],"high":[15],"dimensional":[16],"molecular":[17],"data.":[18],"Not":[19],"all":[20],"measured":[21,45],"features":[22,229,245,258,297,341],"are":[23,34],"expected":[24],"show":[26],"biological":[27,127],"variation,":[28],"so":[29],"only":[30],"the":[31,59,66,79,154,175,183,196,204,211,235,239,251,272,338],"most":[32],"varying":[33],"selected":[35,121,243,256,342],"for":[36,96,110,132,170,213,234,281,304,324],"analysis.":[37,202],"In":[38],"DNA":[39,42,184],"methylation":[40,43,143,185],"studies,":[41],"as":[46],"proportion,":[48,186],"bounded":[49],"between":[50],"0":[51],"and":[52,85,100,222,250,309,312,343],"1,":[53],"with":[54,72,298],"variance":[55,93],"function":[57],"mean.":[60],"Filtering":[61],"on":[62,83,115,332],"standard":[63,180,205,223,252],"deviation":[64,181,206,224,253],"biases":[65],"probes":[69],"those":[71],"mean":[73],"values":[74],"near":[75],"0.5.":[76],"We":[77,107,129,287],"explore":[78],"effect":[80],"this":[81,104],"has":[82],"clustering,":[84],"develop":[86],"alternate":[87],"filter":[88,163,177,207,221,225,241,254,291],"methods":[89],"that":[90,131,165,279,293],"utilize":[91],"stabilizing":[94],"transformation":[95,169],"Beta":[97,171],"distributed":[98,172],"data":[99,119,133,173,237,284,335],"do":[101],"not":[102],"share":[103],"bias.":[105],"RESULTS:":[106],"compared":[108],"results":[109],"11":[111],"different":[112,231,290,299],"non-specific":[113],"filters":[114,274,331],"eight":[116],"Infinium":[117],"HumanMethylation":[118],"sets,":[120,336],"span":[123],"variety":[125],"conditions.":[128],"found":[130,288],"sets":[134,269],"having":[135],"small":[137],"fraction":[138],"samples":[140],"showing":[141],"abnormal":[142],"subset":[146],"normally":[148],"unmethylated":[149],"CpGs,":[150],"characteristic":[152],"CpG":[155,247,316],"island":[156,248,261,317],"methylator":[157],"phenotype":[158],"in":[159,191,199,230],"cancer,":[160],"novel":[162,220,240],"statistic":[164],"utilized":[166],"variance-stabilizing":[168],"outperformed":[174],"common":[176],"using":[179],"or":[187],"its":[188,192],"log-transformed":[189],"M-value,":[190],"ability":[193],"detect":[195],"cancer":[197,308,315],"subtype":[198],"However,":[203],"always":[208,242,255],"among":[210],"best":[212],"distinguishing":[214],"subgroups":[215],"normal":[217],"tissue.":[218],"The":[219],"tended":[226,294],"favour":[228],"genome":[232],"contexts;":[233],"same":[236],"set,":[238],"more":[244,257],"from":[246,259],"promoters":[249],"non-CpG":[260],"intergenic":[262],"regions.":[263],"Interestingly,":[264],"despite":[265],"selecting":[266],"largely":[267],"non-overlapping":[268],"features,":[271],"two":[273,289],"did":[275],"find":[276],"sample":[277],"subsets":[278],"overlapped":[280],"some":[282],"real":[283],"sets.":[285],"CONCLUSIONS:":[286],"statistics":[292],"prioritize":[296],"characteristics,":[300],"each":[301],"well":[303],"identifying":[305,313],"clusters":[306,344],"non-cancer":[310],"tissue,":[311],"hypermethylation":[318],"phenotype.":[319],"Since":[320],"discovery,":[325],"we":[326],"would":[327],"suggest":[328],"trying":[329],"both":[330],"any":[333],"new":[334],"evaluating":[337],"overlap":[339],"discovered.":[345]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}