{"id":"https://openalex.org/W2088297042","doi":"https://doi.org/10.1186/1471-2105-15-196","title":"Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of Glycoside Hydrolase","display_name":"Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of Glycoside Hydrolase","publication_year":2014,"publication_date":"2014-06-17","ids":{"openalex":"https://openalex.org/W2088297042","doi":"https://doi.org/10.1186/1471-2105-15-196","mag":"2088297042","pmid":"https://pubmed.ncbi.nlm.nih.gov/24938123"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-196","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-196","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-196","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-196","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009636964","display_name":"Daniel J. Rigden","orcid":"https://orcid.org/0000-0002-7565-8937"},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel J Rigden","raw_affiliation_strings":["Institute of Integrative Biology, University of Liverpool, Liverpool, UK. drigden@liv.ac.uk","[Institute of Integrative Biology, University of Liverpool, Liverpool, UK]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, University of Liverpool, Liverpool, UK. drigden@liv.ac.uk","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"[Institute of Integrative Biology, University of Liverpool, Liverpool, UK]","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040135675","display_name":"Ruth Y. Eberhardt","orcid":"https://orcid.org/0000-0001-6152-1369"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruth Y Eberhardt","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridgeshire, CB10 1SD, UK","Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK","European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK","Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112"]},{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK","institution_ids":["https://openalex.org/I1303153112"]},{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059560909","display_name":"Harry J. Gilbert","orcid":"https://orcid.org/0000-0003-3597-2347"},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Harry J Gilbert","raw_affiliation_strings":["Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK","Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100854728","display_name":"Qingping Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I2801935854","display_name":"SLAC National Accelerator Laboratory","ror":"https://ror.org/05gzmn429","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]},{"id":"https://openalex.org/I4210120900","display_name":"Stanford Synchrotron Radiation Lightsource","ror":"https://ror.org/02vzbm991","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I4210120900","https://openalex.org/I97018004","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingping Xu","raw_affiliation_strings":["Joint Center for Structural Genomics, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA","Joint Center for Structural Genomics, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center for Structural Genomics, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA","institution_ids":["https://openalex.org/I2801935854"]},{"raw_affiliation_string":"Joint Center for Structural Genomics, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, USA","institution_ids":["https://openalex.org/I4210120900","https://openalex.org/I4210091204","https://openalex.org/I2801935854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030348326","display_name":"Yuanyuan Chang","orcid":"https://orcid.org/0000-0001-8562-3781"},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanyuan Chang","raw_affiliation_strings":["Joint Center for Structural Genomics, Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA","Joint Center for Structural Genomics, Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center for Structural Genomics, Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I4210091204","https://openalex.org/I188891513"]},{"raw_affiliation_string":"Joint Center for Structural Genomics, Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, USA","institution_ids":["https://openalex.org/I4210091204","https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010671148","display_name":"Adam Godzik","orcid":"https://orcid.org/0000-0002-2425-852X"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Godzik","raw_affiliation_strings":["Joint Center for Structural Genomics, Center for Research in Biological Systems, University of California, San Diego, La Jolla CA, 92093, USA","Joint Center for Structural Genomics, Center for Research in Biological Systems, University of California, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center for Structural Genomics, Center for Research in Biological Systems, University of California, San Diego, La Jolla CA, 92093, USA","institution_ids":["https://openalex.org/I4210091204"]},{"raw_affiliation_string":"Joint Center for Structural Genomics, Center for Research in Biological Systems, University of California, San Diego, USA","institution_ids":["https://openalex.org/I4210091204","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.2868,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79405358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"196","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.19300000369548798,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.19300000369548798,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.10639999806880951,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.0997999981045723,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7553824186325073},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6560796499252319},{"id":"https://openalex.org/keywords/horizontal-gene-transfer","display_name":"Horizontal gene transfer","score":0.6252821683883667},{"id":"https://openalex.org/keywords/metagenomics","display_name":"Metagenomics","score":0.6178549528121948},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6048628687858582},{"id":"https://openalex.org/keywords/glycoside-hydrolase","display_name":"Glycoside hydrolase","score":0.5305531024932861},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"Homology modeling","score":0.5266485214233398},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.4990522861480713},{"id":"https://openalex.org/keywords/homology","display_name":"Homology (biology)","score":0.4835476875305176},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4314459264278412},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.41422972083091736},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.40660586953163147},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.33536532521247864},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.13691791892051697}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7553824186325073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6560796499252319},{"id":"https://openalex.org/C92938381","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Horizontal gene transfer","level":4,"score":0.6252821683883667},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.6178549528121948},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6048628687858582},{"id":"https://openalex.org/C196032511","wikidata":"https://www.wikidata.org/wiki/Q375795","display_name":"Glycoside hydrolase","level":3,"score":0.5305531024932861},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.5266485214233398},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4990522861480713},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.4835476875305176},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4314459264278412},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.41422972083091736},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40660586953163147},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33536532521247864},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13691791892051697},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-15-196","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-196","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-196","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24938123","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24938123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:eprint.ncl.ac.uk:204770","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:escholarship.org/ark:/13030/qt5j98r7hw","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/5j98r7hw","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics, vol 15, iss 1","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3043612","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4071793","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-196","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-196","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-196","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7300000190734863,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1804828992","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G2393997808","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3295375304","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3629260272","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4047395780","display_name":null,"funder_award_id":"GM094586","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4219948241","display_name":null,"funder_award_id":"U54 GM094586","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4280418065","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320338381","funder_display_name":"SLAC National Accelerator Laboratory"},{"id":"https://openalex.org/G4947820509","display_name":"EAGER: An Exploration in Enabling Community-Driven Collaboration","funder_award_id":"1153617","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5950577451","display_name":null,"funder_award_id":"NIH U54","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6785210703","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G7026415125","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8284605592","display_name":"An Annual Workshop on Automated Function Prediction","funder_award_id":"0646708","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8684857560","display_name":null,"funder_award_id":"U54 GM094586","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G903384155","display_name":null,"funder_award_id":"GM094586","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"},{"id":"https://openalex.org/F4320338381","display_name":"SLAC National Accelerator Laboratory","ror":"https://ror.org/05gzmn429"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2088297042.pdf","grobid_xml":"https://content.openalex.org/works/W2088297042.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1534406401","https://openalex.org/W1791999417","https://openalex.org/W1964640688","https://openalex.org/W1966379061","https://openalex.org/W1970695165","https://openalex.org/W1971147414","https://openalex.org/W1978444265","https://openalex.org/W1985629904","https://openalex.org/W1986154009","https://openalex.org/W1986347357","https://openalex.org/W1992124716","https://openalex.org/W1997793435","https://openalex.org/W2001117460","https://openalex.org/W2003441269","https://openalex.org/W2012490955","https://openalex.org/W2014694459","https://openalex.org/W2015392436","https://openalex.org/W2020350008","https://openalex.org/W2022058405","https://openalex.org/W2024993723","https://openalex.org/W2029824071","https://openalex.org/W2030966943","https://openalex.org/W2033829415","https://openalex.org/W2037708392","https://openalex.org/W2037958927","https://openalex.org/W2038048096","https://openalex.org/W2050802287","https://openalex.org/W2057342848","https://openalex.org/W2062359859","https://openalex.org/W2069458148","https://openalex.org/W2076048958","https://openalex.org/W2082667898","https://openalex.org/W2084512022","https://openalex.org/W2084931423","https://openalex.org/W2085205436","https://openalex.org/W2087646013","https://openalex.org/W2088986290","https://openalex.org/W2092122285","https://openalex.org/W2094652061","https://openalex.org/W2096343837","https://openalex.org/W2097706568","https://openalex.org/W2099010819","https://openalex.org/W2100494857","https://openalex.org/W2101092030","https://openalex.org/W2101429346","https://openalex.org/W2101572186","https://openalex.org/W2101973479","https://openalex.org/W2102918226","https://openalex.org/W2105902442","https://openalex.org/W2107319829","https://openalex.org/W2107644675","https://openalex.org/W2108929776","https://openalex.org/W2109715166","https://openalex.org/W2112200653","https://openalex.org/W2116398954","https://openalex.org/W2116609117","https://openalex.org/W2116900051","https://openalex.org/W2120772351","https://openalex.org/W2125826054","https://openalex.org/W2127297026","https://openalex.org/W2127950208","https://openalex.org/W2128653811","https://openalex.org/W2129553461","https://openalex.org/W2130381741","https://openalex.org/W2131350133","https://openalex.org/W2132632499","https://openalex.org/W2137597742","https://openalex.org/W2138070240","https://openalex.org/W2141885858","https://openalex.org/W2142270082","https://openalex.org/W2144998676","https://openalex.org/W2145268834","https://openalex.org/W2150444353","https://openalex.org/W2154264360","https://openalex.org/W2154714625","https://openalex.org/W2159407190","https://openalex.org/W2160378127","https://openalex.org/W2165335121","https://openalex.org/W2168621448","https://openalex.org/W2168708922","https://openalex.org/W2171866976","https://openalex.org/W2786774014","https://openalex.org/W4233334497","https://openalex.org/W4248872320","https://openalex.org/W4254275792","https://openalex.org/W4320301318"],"related_works":["https://openalex.org/W638577851","https://openalex.org/W2968354375","https://openalex.org/W2359440920","https://openalex.org/W2889550857","https://openalex.org/W3013372948","https://openalex.org/W3135997498","https://openalex.org/W4242417330","https://openalex.org/W3198631238","https://openalex.org/W2028334780","https://openalex.org/W3130075881"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gut":[1],"microbiome":[2],"metagenomics":[3],"has":[4],"revealed":[5],"many":[6],"protein":[7,93],"families":[8],"and":[9,29,62,155,168],"domains":[10,142],"found":[11,31],"largely":[12],"or":[13],"exclusively":[14],"in":[15,25,32,36,45,73,78],"that":[16,173],"environment.":[17],"Proteins":[18],"containing":[19],"the":[20,26,37,54,70,81,90,96,103,118,140],"GxGYxYP":[21,71,91],"domain":[22,63,72],"are":[23,30,80],"over-represented":[24],"gut":[27,38],"microbiota,":[28],"Polysaccharide":[33],"Utilization":[34],"Loci":[35],"symbiont":[39],"Bacteroides":[40],"thetaiotaomicron,":[41],"suggesting":[42],"their":[43],"involvement":[44],"polysaccharide":[46],"metabolism,":[47],"but":[48],"little":[49],"else":[50],"is":[51],"known":[52],"of":[53,56,83,89,106,143,165,182],"function":[55],"this":[57],"domain.":[58],"RESULTS:":[59],"Genomic":[60],"context":[61],"architecture":[64],"analyses":[65,127,157],"support":[66],"a":[67,120,132,137,147,152,160,177],"role":[68],"for":[69],"carbohydrate":[74],"metabolism.":[75],"Sparse":[76],"occurrences":[77],"eukaryotes":[79],"result":[82],"lateral":[84],"gene":[85],"transfer.":[86],"The":[87],"structure":[88],"domain-containing":[92],"encoded":[94],"by":[95],"BT2193":[97],"locus":[98],"reveals":[99],"two":[100,141],"structural":[101],"domains,":[102],"first":[104],"composed":[105,164],"three":[107],"divergent":[108],"repeats":[109],"with":[110],"no":[111],"recognisable":[112],"homology":[113],"to":[114,136,146,159],"previously":[115],"solved":[116],"structures,":[117],"second":[119],"more":[121],"familiar":[122],"seven-stranded":[123],"\u03b2/\u03b1":[124],"barrel.":[125],"Structure-based":[126],"including":[128],"conservation":[129],"mapping":[130],"localise":[131],"presumed":[133],"functional":[134],"site":[135,149],"cleft":[138],"between":[139],"BT2193.":[144],"Matching":[145],"catalytic":[148,162],"template":[150],"from":[151],"GH9":[153],"cellulase":[154],"other":[156],"point":[158],"putative":[161],"triad":[163],"Glu272,":[166],"Asp331":[167],"Asp333.":[169],"CONCLUSIONS:":[170],"We":[171],"suggest":[172],"GxGYxYP-containing":[174],"proteins":[175],"constitute":[176],"novel":[178],"glycoside":[179],"hydrolase":[180],"family":[181],"as":[183],"yet":[184],"unknown":[185],"specificity.":[186]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
