{"id":"https://openalex.org/W2012241850","doi":"https://doi.org/10.1186/1471-2105-15-149","title":"FIGG: Simulating populations of whole genome sequences for heterogeneous data analyses","display_name":"FIGG: Simulating populations of whole genome sequences for heterogeneous data analyses","publication_year":2014,"publication_date":"2014-05-19","ids":{"openalex":"https://openalex.org/W2012241850","doi":"https://doi.org/10.1186/1471-2105-15-149","mag":"2012241850","pmid":"https://pubmed.ncbi.nlm.nih.gov/24885193"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-149","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-149","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-149","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-149","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005430904","display_name":"Sarah Killcoyne","orcid":"https://orcid.org/0000-0003-3686-6167"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Sarah Killcoyne","raw_affiliation_strings":["Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, 7, avenue des Hauts fourneaux, Esch/Alzette L-4362, Luxembourg","Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, 7, avenue des Hauts fourneaux, Esch/Alzette L-4362, Luxembourg","institution_ids":["https://openalex.org/I186903577"]},{"raw_affiliation_string":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075664103","display_name":"Antonio del Sol","orcid":"https://orcid.org/0000-0002-9926-617X"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":true,"raw_author_name":"Antonio del Sol","raw_affiliation_strings":["Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, 7, avenue des Hauts fourneaux, Esch/Alzette L-4362, Luxembourg. antonio.delsol@uni.lu","Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Campus Belval, 7, avenue des Hauts fourneaux, Esch/Alzette L-4362, Luxembourg. antonio.delsol@uni.lu","institution_ids":["https://openalex.org/I186903577"]},{"raw_affiliation_string":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075664103"],"corresponding_institution_ids":["https://openalex.org/I186903577"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.4262,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.67964029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"149","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.37599998712539673,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.37599998712539673,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.32429999113082886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.08709999918937683,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.7090153694152832},{"id":"https://openalex.org/keywords/reference-genome","display_name":"Reference genome","score":0.5839486718177795},{"id":"https://openalex.org/keywords/matching","display_name":"Matching (statistics)","score":0.5048933625221252},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5029959082603455},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.4908231198787689},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.4798421561717987},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47535011172294617},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4479847550392151},{"id":"https://openalex.org/keywords/structural-variation","display_name":"Structural variation","score":0.4216215908527374},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.42017993330955505},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3904256820678711},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3525393605232239},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3259308934211731},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1350601613521576},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12289556860923767},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10443156957626343}],"concepts":[{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7090153694152832},{"id":"https://openalex.org/C192953774","wikidata":"https://www.wikidata.org/wiki/Q7307127","display_name":"Reference genome","level":4,"score":0.5839486718177795},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.5048933625221252},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5029959082603455},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.4908231198787689},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4798421561717987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47535011172294617},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4479847550392151},{"id":"https://openalex.org/C151020129","wikidata":"https://www.wikidata.org/wiki/Q7625067","display_name":"Structural variation","level":4,"score":0.4216215908527374},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.42017993330955505},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3904256820678711},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3525393605232239},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3259308934211731},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1350601613521576},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12289556860923767},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10443156957626343},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-15-149","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-149","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-149","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24885193","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24885193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:3011388","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4039316","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:orbilu.uni.lu:10993/16942","is_oa":true,"landing_page_url":"http://orbilu.uni.lu/handle/10993/16942","pdf_url":null,"source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 15 (1) (2014)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-149","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-149","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-149","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310598","display_name":"Amazon Web Services","ror":"https://ror.org/04mv4n011"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012241850.pdf","grobid_xml":"https://content.openalex.org/works/W2012241850.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1981420413","https://openalex.org/W1990073900","https://openalex.org/W2015885891","https://openalex.org/W2019851585","https://openalex.org/W2025183726","https://openalex.org/W2034078054","https://openalex.org/W2046601740","https://openalex.org/W2046956642","https://openalex.org/W2048818637","https://openalex.org/W2058401000","https://openalex.org/W2100874222","https://openalex.org/W2103441770","https://openalex.org/W2108234281","https://openalex.org/W2108698786","https://openalex.org/W2121762798","https://openalex.org/W2130381967","https://openalex.org/W2137297899","https://openalex.org/W2141431050","https://openalex.org/W2145336165","https://openalex.org/W2148981095","https://openalex.org/W2151773637","https://openalex.org/W2153010521","https://openalex.org/W2157259743","https://openalex.org/W2157539385","https://openalex.org/W2158023121","https://openalex.org/W2168023521","https://openalex.org/W2171777347","https://openalex.org/W2172260290","https://openalex.org/W2173213060","https://openalex.org/W2187636357","https://openalex.org/W2518697824","https://openalex.org/W2796223938","https://openalex.org/W2885727518","https://openalex.org/W2911561283"],"related_works":["https://openalex.org/W2949103014","https://openalex.org/W2155537421","https://openalex.org/W2032247293","https://openalex.org/W2153994884","https://openalex.org/W2509648056","https://openalex.org/W2380556100","https://openalex.org/W4361984506","https://openalex.org/W2949865853","https://openalex.org/W2529001379","https://openalex.org/W1966520799"],"abstract_inverted_index":{"BACKGROUND:":[0],"High-throughput":[1],"sequencing":[2,22,73],"has":[3],"become":[4],"one":[5],"of":[6,12,16,21,49,59,70,86,103,114,132,176,185,188],"the":[7,13,44,64,130,137,183],"primary":[8],"tools":[9,40,77],"for":[10,234],"investigation":[11],"molecular":[14],"basis":[15],"disease.":[17],"The":[18,68,162,204],"increasing":[19],"use":[20],"in":[23,52],"investigations":[24],"that":[25,41,54,78,214],"aim":[26],"to":[27,37,128,147,181,219],"understand":[28],"both":[29],"individuals":[30],"and":[31,81,198,227],"populations":[32],"is":[33,48,206],"challenging":[34],"our":[35],"ability":[36],"develop":[38],"analysis":[39,76,236],"scale":[42,72],"with":[43,106,155,211],"data.":[45,88],"This":[46],"issue":[47],"particular":[50],"concern":[51],"studies":[53,74],"exhibit":[55],"a":[56,92,145,152,172,230],"wide":[57],"degree":[58],"heterogeneity":[60],"or":[61,117,171,238],"deviation":[62],"from":[63,151,194],"standard":[65,231],"reference":[66,222],"genome.":[67,138],"advent":[69],"population":[71],"requires":[75],"are":[79],"developed":[80,91],"tested":[82],"against":[83],"matching":[84,156],"quantities":[85],"heterogeneous":[87,225],"RESULTS:":[89],"We":[90],"large-scale":[93],"whole":[94,104,208],"genome":[95,202,209],"simulation":[96],"tool,":[97],"FIGG,":[98],"which":[99],"generates":[100,191],"large":[101,186],"numbers":[102,187],"genomes":[105],"known":[107,116,168,195],"sequence":[108,154],"characteristics":[109],"based":[110],"on":[111],"direct":[112],"sampling":[113],"experimentally":[115],"theorized":[118],"variations.":[119,177],"For":[120],"normal":[121,166],"variations":[122,213],"we":[123],"used":[124,218],"publicly":[125],"available":[126],"data":[127],"determine":[129],"frequency":[131,174],"different":[133,159,221],"mutation":[134],"classes":[135],"across":[136],"FIGG":[139,190],"then":[140],"uses":[141],"this":[142],"information":[143],"as":[144],"background":[146,163],"generate":[148],"new":[149,235],"sequences":[150,193,210],"parent":[153],"frequencies,":[157],"but":[158],"actual":[160],"mutations.":[161],"can":[164,215,228],"be":[165,217],"variations,":[167,170],"disease":[169],"theoretical":[173],"distribution":[175],"CONCLUSION:":[178],"In":[179],"order":[180],"enable":[182],"creation":[184],"genomes,":[189,223],"simulated":[192],"genomic":[196],"variation":[197],"iteratively":[199],"mutates":[200],"each":[201],"separately.":[203],"result":[205],"multiple":[207],"unique":[212],"primarily":[216],"provide":[220],"model":[224],"populations,":[226],"offer":[229],"test":[232],"environment":[233],"algorithms":[237],"bioinformatics":[239],"tools.":[240]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}