{"id":"https://openalex.org/W2023106695","doi":"https://doi.org/10.1186/1471-2105-15-136","title":"MEIGO: an open-source software suite based on metaheuristics for global optimization in systems biology and bioinformatics","display_name":"MEIGO: an open-source software suite based on metaheuristics for global optimization in systems biology and bioinformatics","publication_year":2014,"publication_date":"2014-05-10","ids":{"openalex":"https://openalex.org/W2023106695","doi":"https://doi.org/10.1186/1471-2105-15-136","mag":"2023106695","pmid":"https://pubmed.ncbi.nlm.nih.gov/24885957"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-136","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-136","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-136","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-136","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019217140","display_name":"Jos\u00e9 A. Egea","orcid":"https://orcid.org/0000-0002-7821-1604"},"institutions":[{"id":"https://openalex.org/I3123212020","display_name":"Universidad Polit\u00e9cnica de Cartagena","ror":"https://ror.org/02k5kx966","country_code":"ES","type":"education","lineage":["https://openalex.org/I3123212020"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jose A Egea","raw_affiliation_strings":["Department of Applied Mathematics and Statistics, Universidad Polit\u00e9cnica de Cartagena, 30202, Cartagena, Spain","[Department of Applied Mathematics and Statistics, Universidad Polit\u00e9cnica de Cartagena, Cartagena, SPAIN]"],"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Statistics, Universidad Polit\u00e9cnica de Cartagena, 30202, Cartagena, Spain","institution_ids":["https://openalex.org/I3123212020"]},{"raw_affiliation_string":"[Department of Applied Mathematics and Statistics, Universidad Polit\u00e9cnica de Cartagena, Cartagena, SPAIN]","institution_ids":["https://openalex.org/I3123212020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051590122","display_name":"David Henriques","orcid":"https://orcid.org/0000-0002-9477-292X"},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"David Henriques","raw_affiliation_strings":["(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, 36208, Vigo, Spain","European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK","European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK","(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, Vigo, Spain"],"affiliations":[{"raw_affiliation_string":"(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, 36208, Vigo, Spain","institution_ids":["https://openalex.org/I134820265"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, Vigo, Spain","institution_ids":["https://openalex.org/I134820265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026372984","display_name":"Thomas Cokelaer","orcid":"https://orcid.org/0000-0001-6286-1138"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Cokelaer","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK","European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032919554","display_name":"Alejandro F. Villaverde","orcid":"https://orcid.org/0000-0001-7401-7380"},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro F Villaverde","raw_affiliation_strings":["(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, 36208, Vigo, Spain","(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, Vigo, Spain"],"affiliations":[{"raw_affiliation_string":"(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, 36208, Vigo, Spain","institution_ids":["https://openalex.org/I134820265"]},{"raw_affiliation_string":"(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, Vigo, Spain","institution_ids":["https://openalex.org/I134820265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064631396","display_name":"Aidan MacNamara","orcid":"https://orcid.org/0000-0001-5958-2429"},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aidan MacNamara","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK","European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030479704","display_name":"Diana-Patricia Danciu","orcid":"https://orcid.org/0000-0002-8683-3956"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Diana-Patricia Danciu","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK","European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090264675","display_name":"Julio R. Banga","orcid":"https://orcid.org/0000-0002-4245-0320"},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julio R Banga","raw_affiliation_strings":["(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, 36208 Vigo, Spain. julio@iim.csic.es","(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, Vigo, Spain"],"affiliations":[{"raw_affiliation_string":"(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, 36208 Vigo, Spain. julio@iim.csic.es","institution_ids":[]},{"raw_affiliation_string":"(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, Vigo, Spain","institution_ids":["https://openalex.org/I134820265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005499510","display_name":"Julio S\u00e1ez-Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-8552-8976"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julio Saez-Rodriguez","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK","European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5019217140"],"corresponding_institution_ids":["https://openalex.org/I3123212020"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":5.1336,"has_fulltext":true,"cited_by_count":184,"citation_normalized_percentile":{"value":0.96308958,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"136","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metaheuristic","display_name":"Metaheuristic","score":0.8063369989395142},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6996634006500244},{"id":"https://openalex.org/keywords/python","display_name":"Python (programming language)","score":0.6408527493476868},{"id":"https://openalex.org/keywords/toolbox","display_name":"Toolbox","score":0.46814945340156555},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.46602603793144226},{"id":"https://openalex.org/keywords/global-optimization","display_name":"Global optimization","score":0.43613651394844055},{"id":"https://openalex.org/keywords/integer-programming","display_name":"Integer programming","score":0.4278855323791504},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3406252861022949},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.26594096422195435},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2298009693622589},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.1623995006084442},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15904539823532104},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15166780352592468}],"concepts":[{"id":"https://openalex.org/C109718341","wikidata":"https://www.wikidata.org/wiki/Q1385229","display_name":"Metaheuristic","level":2,"score":0.8063369989395142},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6996634006500244},{"id":"https://openalex.org/C519991488","wikidata":"https://www.wikidata.org/wiki/Q28865","display_name":"Python (programming language)","level":2,"score":0.6408527493476868},{"id":"https://openalex.org/C2777655017","wikidata":"https://www.wikidata.org/wiki/Q1501161","display_name":"Toolbox","level":2,"score":0.46814945340156555},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.46602603793144226},{"id":"https://openalex.org/C164752517","wikidata":"https://www.wikidata.org/wiki/Q5570875","display_name":"Global optimization","level":2,"score":0.43613651394844055},{"id":"https://openalex.org/C56086750","wikidata":"https://www.wikidata.org/wiki/Q6042592","display_name":"Integer programming","level":2,"score":0.4278855323791504},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3406252861022949},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.26594096422195435},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2298009693622589},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.1623995006084442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15904539823532104},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15166780352592468}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-15-136","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-136","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-136","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24885957","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24885957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:digital.csic.es:10261/96897","is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/96897","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:europepmc.org:3010970","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4025564","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-136","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-136","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-136","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.4399999976158142}],"awards":[{"id":"https://openalex.org/G2635753817","display_name":null,"funder_award_id":"DPI2011-28112-C04-04","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G4531677044","display_name":null,"funder_award_id":"grant","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G7015208893","display_name":null,"funder_award_id":"C04-04","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G7420919289","display_name":null,"funder_award_id":"FEDER","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320338366","display_name":"FP7 Food, Agriculture and Fisheries, Biotechnology","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2023106695.pdf","grobid_xml":"https://content.openalex.org/works/W2023106695.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1243694217","https://openalex.org/W1509329028","https://openalex.org/W1537544745","https://openalex.org/W1595159159","https://openalex.org/W1807981783","https://openalex.org/W1970686413","https://openalex.org/W1982834739","https://openalex.org/W1986177561","https://openalex.org/W1986254541","https://openalex.org/W1995911707","https://openalex.org/W2004322850","https://openalex.org/W2010334716","https://openalex.org/W2015401980","https://openalex.org/W2019264851","https://openalex.org/W2019877779","https://openalex.org/W2025500642","https://openalex.org/W2033837064","https://openalex.org/W2040558572","https://openalex.org/W2048478820","https://openalex.org/W2063224828","https://openalex.org/W2067419406","https://openalex.org/W2068945449","https://openalex.org/W2070989743","https://openalex.org/W2073903631","https://openalex.org/W2088383307","https://openalex.org/W2090517830","https://openalex.org/W2097375195","https://openalex.org/W2098740506","https://openalex.org/W2107080166","https://openalex.org/W2115343689","https://openalex.org/W2126877057","https://openalex.org/W2127419446","https://openalex.org/W2127808973","https://openalex.org/W2129796710","https://openalex.org/W2129935828","https://openalex.org/W2130364940","https://openalex.org/W2144197118","https://openalex.org/W2152304735","https://openalex.org/W2153446897","https://openalex.org/W2155306598","https://openalex.org/W2156730317","https://openalex.org/W2165603655","https://openalex.org/W2167334954","https://openalex.org/W2177180613","https://openalex.org/W2416677001"],"related_works":["https://openalex.org/W2068663075","https://openalex.org/W4205140848","https://openalex.org/W2978678743","https://openalex.org/W2797837731","https://openalex.org/W2150344375","https://openalex.org/W829257147","https://openalex.org/W3081389670","https://openalex.org/W4390832911","https://openalex.org/W2549786917","https://openalex.org/W2103427527"],"abstract_inverted_index":{"MEIGO":[0],"provides":[1],"a":[2],"free,":[3],"open-source":[4],"platform":[5],"for":[6],"optimization":[7],"that":[8],"can":[9],"be":[10],"applied":[11],"to":[12],"multiple":[13],"domains":[14],"of":[15,24,37],"systems":[16],"biology":[17],"and":[18,28,31],"bioinformatics.":[19],"It":[20],"includes":[21],"efficient":[22],"state":[23],"the":[25,35],"art":[26],"metaheuristics,":[27],"its":[29],"open":[30],"modular":[32],"structure":[33],"allows":[34],"addition":[36],"further":[38],"methods.":[39]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}