{"id":"https://openalex.org/W2010497636","doi":"https://doi.org/10.1186/1471-2105-15-112","title":"Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase","display_name":"Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase","publication_year":2014,"publication_date":"2014-04-17","ids":{"openalex":"https://openalex.org/W2010497636","doi":"https://doi.org/10.1186/1471-2105-15-112","mag":"2010497636","pmid":"https://pubmed.ncbi.nlm.nih.gov/24742328"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-15-112","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-112","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-112","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-112","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078711654","display_name":"Anna Sheydina","orcid":null},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anna Sheydina","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA","Joint Center for Structural Genomics, 10550 North Torrey Pines Road, BCC-206, La Jolla, California, 92037, USA","Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Joint Center for Structural Genomics, 10550 North Torrey Pines Road, BCC-206, La Jolla, California, 92037, USA","institution_ids":["https://openalex.org/I4210091204"]},{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040135675","display_name":"Ruth Y. Eberhardt","orcid":"https://orcid.org/0000-0001-6152-1369"},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruth Y Eberhardt","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK","European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK","Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009636964","display_name":"Daniel J. Rigden","orcid":"https://orcid.org/0000-0002-7565-8937"},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel J Rigden","raw_affiliation_strings":["Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK","[Institute of Integrative Biology, University of Liverpool, Liverpool, UK]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"[Institute of Integrative Biology, University of Liverpool, Liverpool, UK]","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030348326","display_name":"Yuanyuan Chang","orcid":"https://orcid.org/0000-0001-8562-3781"},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanyuan Chang","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA","Joint Center for Structural Genomics, 10550 North Torrey Pines Road, BCC-206, La Jolla, California, 92037, USA","Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Joint Center for Structural Genomics, 10550 North Torrey Pines Road, BCC-206, La Jolla, California, 92037, USA","institution_ids":["https://openalex.org/I4210091204"]},{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072166385","display_name":"Zhanwen Li","orcid":null},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhanwen Li","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA","Bioinformatics and Systems Biology Program, Sanford Burnham Medical Research Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, Sanford Burnham Medical Research Institute, La Jolla, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023385216","display_name":"Christian C Zmasek","orcid":null},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian C Zmasek","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA","Bioinformatics and Systems Biology Program, Sanford Burnham Medical Research Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, Sanford Burnham Medical Research Institute, La Jolla, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035358093","display_name":"Herbert L. Axelrod","orcid":null},"institutions":[{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4210120900","display_name":"Stanford Synchrotron Radiation Lightsource","ror":"https://ror.org/02vzbm991","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I4210120900","https://openalex.org/I97018004","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert L Axelrod","raw_affiliation_strings":["Joint Center for Structural Genomics, 10550 North Torrey Pines Road, BCC-206, La Jolla, California, 92037, USA","Stanford Synchrotron Radiation Lightsource, Menlo Park, CA, 94025, USA","Stanford Synchrotron Radiation Lightsource, , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center for Structural Genomics, 10550 North Torrey Pines Road, BCC-206, La Jolla, California, 92037, USA","institution_ids":["https://openalex.org/I4210091204"]},{"raw_affiliation_string":"Stanford Synchrotron Radiation Lightsource, Menlo Park, CA, 94025, USA","institution_ids":["https://openalex.org/I4210120900"]},{"raw_affiliation_string":"Stanford Synchrotron Radiation Lightsource, , USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010671148","display_name":"Adam Godzik","orcid":"https://orcid.org/0000-0002-2425-852X"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Godzik","raw_affiliation_strings":["Joint Center for Structural Genomics, 10550 North Torrey Pines Road, BCC-206, La Jolla, California 92037, USA. adam@sanfordburnham.org","Center for Research in Biological Systems, University of California, La Jolla, USA","Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center for Structural Genomics, 10550 North Torrey Pines Road, BCC-206, La Jolla, California 92037, USA. adam@sanfordburnham.org","institution_ids":[]},{"raw_affiliation_string":"Center for Research in Biological Systems, University of California, La Jolla, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, USA","institution_ids":["https://openalex.org/I188891513"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5078711654"],"corresponding_institution_ids":["https://openalex.org/I188891513","https://openalex.org/I4210091204"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.7147,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.67676071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"112","last_page":"112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.6274999976158142,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.6274999976158142,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.14270000159740448,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacteroides-thetaiotaomicron","display_name":"Bacteroides thetaiotaomicron","score":0.8143149614334106},{"id":"https://openalex.org/keywords/glycoside-hydrolase","display_name":"Glycoside hydrolase","score":0.7844385504722595},{"id":"https://openalex.org/keywords/structural-genomics","display_name":"Structural genomics","score":0.6545674800872803},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6310060620307922},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.5487369894981384},{"id":"https://openalex.org/keywords/bacteroides","display_name":"Bacteroides","score":0.5189623236656189},{"id":"https://openalex.org/keywords/glycosyl","display_name":"Glycosyl","score":0.5054020881652832},{"id":"https://openalex.org/keywords/hydrolase","display_name":"Hydrolase","score":0.5000879764556885},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4712755084037781},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.469840943813324},{"id":"https://openalex.org/keywords/hypothetical-protein","display_name":"Hypothetical protein","score":0.4613149166107178},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.456306129693985},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4517979323863983},{"id":"https://openalex.org/keywords/protein-family","display_name":"Protein family","score":0.4517976939678192},{"id":"https://openalex.org/keywords/structural-similarity","display_name":"Structural similarity","score":0.4484453797340393},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4405907988548279},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.4321485757827759},{"id":"https://openalex.org/keywords/sequence-analysis","display_name":"Sequence analysis","score":0.42245346307754517},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4195529520511627},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.4092821180820465},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2798490524291992},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.25880756974220276},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.24738427996635437}],"concepts":[{"id":"https://openalex.org/C2908934157","wikidata":"https://www.wikidata.org/wiki/Q798597","display_name":"Bacteroides thetaiotaomicron","level":4,"score":0.8143149614334106},{"id":"https://openalex.org/C196032511","wikidata":"https://www.wikidata.org/wiki/Q375795","display_name":"Glycoside hydrolase","level":3,"score":0.7844385504722595},{"id":"https://openalex.org/C192772702","wikidata":"https://www.wikidata.org/wiki/Q2583975","display_name":"Structural genomics","level":3,"score":0.6545674800872803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6310060620307922},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.5487369894981384},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.5189623236656189},{"id":"https://openalex.org/C2780906977","wikidata":"https://www.wikidata.org/wiki/Q2855177","display_name":"Glycosyl","level":2,"score":0.5054020881652832},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.5000879764556885},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4712755084037781},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.469840943813324},{"id":"https://openalex.org/C129075420","wikidata":"https://www.wikidata.org/wiki/Q10855009","display_name":"Hypothetical protein","level":3,"score":0.4613149166107178},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.456306129693985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4517979323863983},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.4517976939678192},{"id":"https://openalex.org/C139489369","wikidata":"https://www.wikidata.org/wiki/Q770846","display_name":"Structural similarity","level":2,"score":0.4484453797340393},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4405907988548279},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.4321485757827759},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.42245346307754517},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4195529520511627},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4092821180820465},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2798490524291992},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25880756974220276},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.24738427996635437}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-15-112","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-112","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-112","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24742328","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24742328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:ark:/13030/qt20c4w1fz","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:escholarship.org/ark:/13030/qt20c4w1fz","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/20c4w1fz","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics, vol 15, iss 1","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3006518","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4032388","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-15-112","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-15-112","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-15-112","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010497636.pdf","grobid_xml":"https://content.openalex.org/works/W2010497636.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1506664007","https://openalex.org/W1546639740","https://openalex.org/W1563050043","https://openalex.org/W1567157571","https://openalex.org/W1602620867","https://openalex.org/W1965186869","https://openalex.org/W1966379061","https://openalex.org/W1969672293","https://openalex.org/W1978096114","https://openalex.org/W1979234848","https://openalex.org/W1985629904","https://openalex.org/W1988966516","https://openalex.org/W2000075248","https://openalex.org/W2001641653","https://openalex.org/W2003852785","https://openalex.org/W2017727500","https://openalex.org/W2020429677","https://openalex.org/W2024708232","https://openalex.org/W2042045767","https://openalex.org/W2046372352","https://openalex.org/W2063865878","https://openalex.org/W2064165347","https://openalex.org/W2070457843","https://openalex.org/W2092471412","https://openalex.org/W2102502076","https://openalex.org/W2103539617","https://openalex.org/W2108929776","https://openalex.org/W2110035145","https://openalex.org/W2116398954","https://openalex.org/W2120819924","https://openalex.org/W2123993442","https://openalex.org/W2126103104","https://openalex.org/W2131350133","https://openalex.org/W2132247062","https://openalex.org/W2141885858","https://openalex.org/W2144081223","https://openalex.org/W2147847105","https://openalex.org/W2147949826","https://openalex.org/W2154714625","https://openalex.org/W2165335121","https://openalex.org/W2168964504","https://openalex.org/W2170996473","https://openalex.org/W2412963709","https://openalex.org/W2786774014","https://openalex.org/W3199943451","https://openalex.org/W4242740445","https://openalex.org/W4246328533","https://openalex.org/W4320301318"],"related_works":["https://openalex.org/W2976630437","https://openalex.org/W2978458780","https://openalex.org/W2960017850","https://openalex.org/W4389022011","https://openalex.org/W2077847478","https://openalex.org/W2125494000","https://openalex.org/W1967097205","https://openalex.org/W2096002674","https://openalex.org/W1986155816","https://openalex.org/W1854805360"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bacteroides":[1,26,47,216],"spp.":[2,217],"form":[3],"a":[4,34,51,57,60,135,150,201],"significant":[5,140],"part":[6],"of":[7,18,23,37,53,59,66,104,113,124,158,175,194,209],"our":[8],"gut":[9],"microbiome":[10],"and":[11,33,56,83,96,121,179,184,191,237,243],"are":[12,165],"well":[13],"known":[14,143],"for":[15],"optimized":[16],"metabolism":[17,214],"diverse":[19],"polysaccharides.":[20],"Initial":[21,69],"analysis":[22,71,123],"the":[24,81,86,105,114,146,173,176,195,224,228,233],"archetypal":[25],"thetaiotaomicron":[27,48],"genome":[28],"identified":[29],"172":[30],"glycosyl":[31,160,202],"hydrolases":[32],"large":[35,61],"number":[36],"uncharacterized":[38,67],"proteins":[39],"associated":[40],"with":[41,139],"polysaccharide":[42,213],"metabolism.":[43],"RESULTS:":[44],"BT_1012":[45,115,177,196,234],"from":[46],"VPI-5482":[49],"is":[50,134],"protein":[52,62,75,116,178,197],"unknown":[54],"function":[55],"member":[58],"family":[63],"consisting":[64,102],"entirely":[65],"proteins.":[68],"sequence":[70,192],"predicted":[72],"that":[73],"this":[74,220],"has":[76,149],"two":[77,229],"domains,":[78],"one":[79,84],"on":[80,85,219],"N-":[82],"C-terminal.":[87],"A":[88],"PSI-BLAST":[89],"search":[90],"found":[91,154,231],"over":[92,97],"150":[93],"full":[94],"length":[95],"90":[98],"half":[99],"size":[100],"homologs":[101],"only":[103],"N-terminal":[106,132],"domain.":[107],"The":[108,131],"experimentally":[109],"determined":[110],"three-dimensional":[111],"structure":[112,174],"confirms":[117],"its":[118,181],"two-domain":[119],"architecture":[120],"structural":[122],"both":[125],"domains":[126,157,164,230],"suggests":[127],"their":[128,185],"specific":[129],"functions.":[130],"domain":[133,138,148,247],"putative":[136,240],"catalytic":[137],"similarity":[141],"to":[142],"glycoside":[144,241,244],"hydrolases,":[145,161],"C-terminal":[147,156,246],"beta-sandwich":[151],"fold":[152],"typically":[153,166],"in":[155,168,212,215,232],"other":[159],"however":[162],"these":[163],"involved":[167,211],"substrate":[169],"binding.":[170],"We":[171],"describe":[172],"discuss":[180],"sequence-structure":[182],"relationship":[183],"possible":[186],"functional":[187],"implications.":[188],"CONCLUSIONS:":[189],"Structural":[190],"analyses":[193],"identifies":[198],"it":[199],"as":[200,239],"hydrolase,":[203],"expanding":[204],"an":[205],"already":[206],"impressive":[207],"catalog":[208],"enzymes":[210],"Based":[218],"we":[221],"have":[222],"renamed":[223],"Pfam":[225],"families":[226],"representing":[227],"protein,":[235],"PF13204":[236],"PF12904,":[238],"hydrolase":[242],"hydrolase-associated":[245],"respectively.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
