{"id":"https://openalex.org/W2069716529","doi":"https://doi.org/10.1186/1471-2105-14-s16-s6","title":"Random forests on Hadoop for genome-wide association studies of multivariate neuroimaging phenotypes","display_name":"Random forests on Hadoop for genome-wide association studies of multivariate neuroimaging phenotypes","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2069716529","doi":"https://doi.org/10.1186/1471-2105-14-s16-s6","mag":"2069716529","pmid":"https://pubmed.ncbi.nlm.nih.gov/24564704"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-14-s16-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-s16-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-S16-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-S16-S6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100372002","display_name":"Yue Wang","orcid":"https://orcid.org/0000-0002-1788-1102"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["Department of Mathematics, Imperial College London, UK","Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054040512","display_name":"Wilson Wen Bin Goh","orcid":"https://orcid.org/0000-0003-3863-7501"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Wilson Goh","raw_affiliation_strings":["Department of Computing, Imperial College London, UK","School of Computing, National University of Singapore, Singapore","School of Computing, National University of Singapore, , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computing, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"School of Computing, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"School of Computing, National University of Singapore, , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012381970","display_name":"Limsoon Wong","orcid":"https://orcid.org/0000-0003-1241-5441"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Limsoon Wong","raw_affiliation_strings":["School of Computing, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010581004","display_name":"Giovanni Montana","orcid":"https://orcid.org/0000-0003-3942-3900"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Giovanni Montana","raw_affiliation_strings":["Department of Mathematics, Imperial College London, UK","Department of Mathematics, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Mathematics, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":null,"display_name":"the Alzheimer's Disease Neuroimaging Initiative","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the Alzheimer's Disease Neuroimaging Initiative","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010581004"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.2082,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.91820462,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"14","issue":"S16","first_page":"S6","last_page":"S6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.7109770774841309},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.6934996843338013},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5989024639129639},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5098499655723572},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.48626792430877686},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.47280779480934143},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4691174328327179},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"Genetic architecture","score":0.4505905210971832},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.44189995527267456},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.4240923821926117},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.41377830505371094},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3696170151233673},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.34065568447113037},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3155165910720825},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.23445168137550354},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19578304886817932},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11688223481178284},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.10798177123069763}],"concepts":[{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.7109770774841309},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.6934996843338013},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5989024639129639},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5098499655723572},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.48626792430877686},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.47280779480934143},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4691174328327179},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.4505905210971832},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.44189995527267456},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.4240923821926117},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41377830505371094},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3696170151233673},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34065568447113037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3155165910720825},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.23445168137550354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19578304886817932},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11688223481178284},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10798177123069763},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-14-s16-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-s16-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-S16-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24564704","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24564704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/77908","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/77908","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:2847337","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3853073","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-14-s16-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-s16-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-S16-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.6800000071525574}],"awards":[{"id":"https://openalex.org/G1082030533","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G1131972899","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1336222015","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1593117279","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320309470","funder_display_name":"Meso Scale Diagnostics"},{"id":"https://openalex.org/G2152643862","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320311551","funder_display_name":"Northern California Institute for Research and Education"},{"id":"https://openalex.org/G2409989180","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320309546","funder_display_name":"Synarc"},{"id":"https://openalex.org/G29951154","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G3131374986","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307115","funder_display_name":"Bristol-Myers Squibb"},{"id":"https://openalex.org/G3553156159","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307115","funder_display_name":"Bristol-Myers Squibb"},{"id":"https://openalex.org/G3710456697","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307758","funder_display_name":"Eli Lilly and Company"},{"id":"https://openalex.org/G3752451908","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320327235","funder_display_name":"Servier"},{"id":"https://openalex.org/G3870774570","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320332193","funder_display_name":"Genentech"},{"id":"https://openalex.org/G3908963977","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G3966393351","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320309432","funder_display_name":"F. Hoffmann-La Roche"},{"id":"https://openalex.org/G4401988282","display_name":null,"funder_award_id":"Grant U01 AG024904","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G4558216502","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5209990037","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G5581794527","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5740349702","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320309470","funder_display_name":"Meso Scale Diagnostics"},{"id":"https://openalex.org/G613619302","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320310388","funder_display_name":"Novartis Pharmaceuticals Corporation"},{"id":"https://openalex.org/G6210868510","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320308604","funder_display_name":"Biogen"},{"id":"https://openalex.org/G6371410416","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320308604","funder_display_name":"Biogen"},{"id":"https://openalex.org/G6412110892","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320332193","funder_display_name":"Genentech"},{"id":"https://openalex.org/G6789252168","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6812249457","display_name":null,"funder_award_id":"Grant U01 AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6948409098","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320309432","funder_display_name":"F. Hoffmann-La Roche"},{"id":"https://openalex.org/G7414321945","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G7463692367","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G7799614282","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G781725486","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307758","funder_display_name":"Eli Lilly and Company"},{"id":"https://openalex.org/G839208290","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320310388","funder_display_name":"Novartis Pharmaceuticals Corporation"},{"id":"https://openalex.org/G8636843673","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320309466","funder_display_name":"Medpace"},{"id":"https://openalex.org/G8852128998","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320327235","funder_display_name":"Servier"},{"id":"https://openalex.org/G8940068167","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307132","display_name":"Alzheimer's Drug Discovery Foundation","ror":"https://ror.org/0185drb55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320309432","display_name":"F. Hoffmann-La Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320309466","display_name":"Medpace","ror":"https://ror.org/05mgcmd27"},{"id":"https://openalex.org/F4320309470","display_name":"Meso Scale Diagnostics","ror":"https://ror.org/05jgy0m16"},{"id":"https://openalex.org/F4320309546","display_name":"Synarc","ror":"https://ror.org/03t95yr58"},{"id":"https://openalex.org/F4320309697","display_name":"Alzheimer's Disease Neuroimaging Initiative","ror":"https://ror.org/01j20wc74"},{"id":"https://openalex.org/F4320309934","display_name":"Amorfix Life Sciences","ror":"https://ror.org/045rtab03"},{"id":"https://openalex.org/F4320310388","display_name":"Novartis Pharmaceuticals Corporation","ror":"https://ror.org/028fhxy95"},{"id":"https://openalex.org/F4320311551","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320320303","display_name":"Bayer HealthCare","ror":"https://ror.org/04hmn8g73"},{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320332502","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2069716529.pdf","grobid_xml":"https://content.openalex.org/works/W2069716529.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1491098415","https://openalex.org/W1539593569","https://openalex.org/W1973891477","https://openalex.org/W1977171789","https://openalex.org/W1981325283","https://openalex.org/W1986303814","https://openalex.org/W1994029270","https://openalex.org/W2030625859","https://openalex.org/W2036248751","https://openalex.org/W2040320905","https://openalex.org/W2040588881","https://openalex.org/W2044863747","https://openalex.org/W2046247026","https://openalex.org/W2046847841","https://openalex.org/W2047860559","https://openalex.org/W2049738506","https://openalex.org/W2056717962","https://openalex.org/W2060551910","https://openalex.org/W2069552222","https://openalex.org/W2072642421","https://openalex.org/W2080183225","https://openalex.org/W2084714454","https://openalex.org/W2099086736","https://openalex.org/W2101350555","https://openalex.org/W2107199945","https://openalex.org/W2110496823","https://openalex.org/W2112348586","https://openalex.org/W2118136004","https://openalex.org/W2118876341","https://openalex.org/W2118890802","https://openalex.org/W2128207034","https://openalex.org/W2132168166","https://openalex.org/W2141270567","https://openalex.org/W2144327682","https://openalex.org/W2146372044","https://openalex.org/W2149916722","https://openalex.org/W2158416439","https://openalex.org/W2167822639","https://openalex.org/W2167865917","https://openalex.org/W2173213060","https://openalex.org/W2911964244","https://openalex.org/W3106409770"],"related_works":["https://openalex.org/W2030319575","https://openalex.org/W2942336194","https://openalex.org/W2114021229","https://openalex.org/W2289210912","https://openalex.org/W2006250117","https://openalex.org/W4243834755","https://openalex.org/W2401648500","https://openalex.org/W2792070472","https://openalex.org/W2062376031","https://openalex.org/W2148749248"],"abstract_inverted_index":{"MOTIVATION:":[0],"Multivariate":[1],"quantitative":[2,96,238],"traits":[3],"arise":[4],"naturally":[5],"in":[6,11,37,47,79,91,111,134,167,217,235,249],"recent":[7],"neuroimaging":[8,244],"genetics":[9],"studies,":[10],"which":[12,54,140,236],"both":[13],"structural":[14],"and":[15,68,98,119,162,191,264,291,316],"functional":[16],"variability":[17],"of":[18,57,76,107,115,117,126,144,156,186,241,258,268,279,301,308,319],"the":[19,62,74,108,132,142,157,187,218,237,250,299,306],"human":[20,251],"brain":[21,252],"is":[22,34,192],"measured":[23],"non-invasively":[24],"through":[25],"techniques":[26],"such":[27,43],"as":[28],"magnetic":[29],"resonance":[30],"imaging":[31],"(MRI).":[32],"There":[33],"growing":[35],"interest":[36],"detecting":[38],"genetic":[39,77,101,163,170,269],"variants":[40,78,285],"associated":[41,260],"with":[42,94],"multivariate":[44,95,174],"traits,":[45,97,121,175],"especially":[46],"genome-wide":[48,228],"studies.":[49,81],"Random":[50,179],"forests":[51],"(RFs)":[52],"classifiers,":[53],"are":[55,60,105,207,326],"ensembles":[56],"decision":[58],"trees,":[59],"amongst":[61],"best":[63],"performing":[64],"machine":[65],"learning":[66,165],"algorithms":[67,146],"have":[69,151,286],"been":[70,224,287],"successfully":[71],"employed":[72],"for":[73,160,214],"prioritisation":[75],"case-control":[80],"RFs":[82],"can":[83,272],"also":[84,294],"be":[85,129,273],"applied":[86,225],"to":[87,99,136,226,261,276],"produce":[88],"gene":[89],"rankings":[90],"association":[92,171,229],"studies":[93,112,172],"estimate":[100],"similarities":[102],"measures":[103,267,278],"that":[104,200,271],"predictive":[106],"trait.":[109],"However,":[110],"involving":[113,173],"hundreds":[114],"thousands":[116],"SNPs":[118,259],"high-dimensional":[120,243],"a":[122,153,211,227,242,256,302],"very":[123],"large":[124],"ensemble":[125],"trees":[127],"must":[128],"inferred":[130],"from":[131],"data":[133],"order":[135],"obtain":[137],"reliable":[138],"rankings,":[139],"makes":[141],"application":[143],"these":[145],"computationally":[147],"prohibitive.":[148],"RESULTS:":[149],"We":[150,293],"developed":[152],"parallel":[154],"version":[155],"RF":[158],"algorithm":[159],"regression":[161],"similarity":[164],"tasks":[166],"large-scale":[168],"population":[169],"called":[176],"PaRFR":[177,222,254],"(Parallel":[178],"Forest":[180],"Regression).":[181],"Our":[182],"implementation":[183],"takes":[184],"advantage":[185],"MapReduce":[188],"programming":[189],"model":[190],"deployed":[193],"on":[194,231],"Hadoop,":[195],"an":[196,317],"open-source":[197],"software":[198],"framework":[199],"supports":[201],"data-intensive":[202],"distributed":[203],"applications.":[204],"Notable":[205],"speed-ups":[206],"obtained":[208],"by":[209],"introducing":[210],"distance-based":[212],"criterion":[213],"node":[215],"splitting":[216],"tree":[219],"estimation":[220],"process.":[221],"has":[223],"study":[230],"Alzheimer's":[232],"disease":[233,320],"(AD)":[234],"trait":[239],"consists":[240],"phenotype":[245],"describing":[246],"longitudinal":[247],"changes":[248],"structure.":[253],"provides":[255],"ranking":[257],"this":[262],"trait,":[263],"produces":[265],"pair-wise":[266,277],"proximity":[270],"directly":[274],"compared":[275],"phenotypic":[280],"proximity.":[281],"Several":[282],"known":[283],"AD-related":[284],"identified,":[288],"including":[289],"APOE4":[290],"TOMM40.":[292],"present":[295],"experimental":[296],"evidence":[297],"supporting":[298],"hypothesis":[300],"linear":[303],"relationship":[304],"between":[305],"number":[307],"top-ranked":[309],"mutated":[310],"states,":[311],"or":[312],"frequent":[313],"mutation":[314],"patterns,":[315],"indicator":[318],"severity.":[321],"AVAILABILITY:":[322],"The":[323],"Java":[324],"codes":[325],"freely":[327],"available":[328],"at":[329],"http://www2.imperial.ac.uk/~gmontana.":[330]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6}],"updated_date":"2026-06-19T17:40:00.097472","created_date":"2025-10-10T00:00:00"}
