{"id":"https://openalex.org/W2087819700","doi":"https://doi.org/10.1186/1471-2105-14-79","title":"Comparative analysis of microbiome measurement platforms using latent variable structural equation modeling","display_name":"Comparative analysis of microbiome measurement platforms using latent variable structural equation modeling","publication_year":2013,"publication_date":"2013-03-05","ids":{"openalex":"https://openalex.org/W2087819700","doi":"https://doi.org/10.1186/1471-2105-14-79","mag":"2087819700","pmid":"https://pubmed.ncbi.nlm.nih.gov/23497007"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-14-79","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-79","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-79","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-79","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103525813","display_name":"Xiao Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiao Wu","raw_affiliation_strings":["Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA. xiaowu1@ic.sunysb.edu","Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA. xiaowu1@ic.sunysb.edu","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028311173","display_name":"Kathryn S. Berkow","orcid":null},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Berkow","raw_affiliation_strings":["Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA","Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065375575","display_name":"Daniel N. Frank","orcid":"https://orcid.org/0000-0001-6669-228X"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel N Frank","raw_affiliation_strings":["Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA","Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011733054","display_name":"Ellen Li","orcid":"https://orcid.org/0000-0002-1141-0406"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Li","raw_affiliation_strings":["Department of Medicine, Stony Brook University, Stony Brook, NY, USA","Department of Medicine, Washington University, St. Louis, MO, USA","Department of Medicine, Stony Brook University, Stony Brook, USA","Department of Medicine, Washington University, St. Louis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, Stony Brook, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Washington University, St. Louis, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036399239","display_name":"Ajay Gulati","orcid":"https://orcid.org/0000-0002-7612-6369"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajay S Gulati","raw_affiliation_strings":["Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA","Department of Pediatrics, University of North Carolina, Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pediatrics, University of North Carolina, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057328085","display_name":"Wei Zhu","orcid":"https://orcid.org/0000-0003-3218-8573"},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhu","raw_affiliation_strings":["Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA","Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, USA","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103525813"],"corresponding_institution_ids":["https://openalex.org/I59553526"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.6948,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68213503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":"1","first_page":"79","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.3977999985218048,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.3977999985218048,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.38359999656677246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/latent-variable","display_name":"Latent variable","score":0.7762390375137329},{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.6556116938591003},{"id":"https://openalex.org/keywords/structural-equation-modeling","display_name":"Structural equation modeling","score":0.6469748616218567},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5757396817207336},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5277904868125916},{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.4769372344017029},{"id":"https://openalex.org/keywords/statistical-model","display_name":"Statistical model","score":0.4267967939376831},{"id":"https://openalex.org/keywords/sanger-sequencing","display_name":"Sanger sequencing","score":0.41928917169570923},{"id":"https://openalex.org/keywords/variable","display_name":"Variable (mathematics)","score":0.41752171516418457},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4150375425815582},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39428409934043884},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.37912988662719727},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33430904150009155},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.33334827423095703},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.30684521794319153},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3044391870498657},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2902970314025879},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.20044440031051636},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17267102003097534},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13606169819831848}],"concepts":[{"id":"https://openalex.org/C51167844","wikidata":"https://www.wikidata.org/wiki/Q4422623","display_name":"Latent variable","level":2,"score":0.7762390375137329},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6556116938591003},{"id":"https://openalex.org/C71104824","wikidata":"https://www.wikidata.org/wiki/Q1476639","display_name":"Structural equation modeling","level":2,"score":0.6469748616218567},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5757396817207336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5277904868125916},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.4769372344017029},{"id":"https://openalex.org/C114289077","wikidata":"https://www.wikidata.org/wiki/Q3284399","display_name":"Statistical model","level":2,"score":0.4267967939376831},{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.41928917169570923},{"id":"https://openalex.org/C182365436","wikidata":"https://www.wikidata.org/wiki/Q50701","display_name":"Variable (mathematics)","level":2,"score":0.41752171516418457},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4150375425815582},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39428409934043884},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.37912988662719727},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33430904150009155},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.33334827423095703},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.30684521794319153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3044391870498657},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2902970314025879},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.20044440031051636},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17267102003097534},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13606169819831848},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-14-79","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-79","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-79","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23497007","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23497007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:cdr.lib.unc.edu:uuid:9b6dcd29-5799-4176-be04-e0a0f93d7e1b","is_oa":true,"landing_page_url":"https://cdr.lib.unc.edu/record/uuid:9b6dcd29-5799-4176-be04-e0a0f93d7e1b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2613658","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3608994","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3608994","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3608994","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-14-79","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-79","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-79","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1110470793","display_name":null,"funder_award_id":"MH090134","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1625195244","display_name":null,"funder_award_id":"P30 DK-52574","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2204166352","display_name":null,"funder_award_id":"UH2DK083994","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4847597066","display_name":null,"funder_award_id":"HL091939","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5460141302","display_name":null,"funder_award_id":"HG005964","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G559218600","display_name":"BIOBANK Core","funder_award_id":"5p30dk052574-24","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6338960616","display_name":"High Performance Validation and Classification of Metagenomic Ribosomal-RNA Seque","funder_award_id":"7r21hg005964-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6413003373","display_name":null,"funder_award_id":"K08 DK095917","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7636173400","display_name":null,"funder_award_id":"EB007530","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G908263762","display_name":"Genetic dissection of the platelet thrombohemorrhagic phenotype","funder_award_id":"5r01hl091939-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320306301","display_name":"Crohn's and Colitis Foundation of America","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087819700.pdf","grobid_xml":"https://content.openalex.org/works/W2087819700.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1586414640","https://openalex.org/W1665332082","https://openalex.org/W1997861202","https://openalex.org/W1998601670","https://openalex.org/W1999295494","https://openalex.org/W2006457441","https://openalex.org/W2022111659","https://openalex.org/W2025986883","https://openalex.org/W2026074634","https://openalex.org/W2028520715","https://openalex.org/W2030030445","https://openalex.org/W2034833171","https://openalex.org/W2059334100","https://openalex.org/W2071666535","https://openalex.org/W2072812562","https://openalex.org/W2078325900","https://openalex.org/W2091031656","https://openalex.org/W2092784580","https://openalex.org/W2097875133","https://openalex.org/W2106005988","https://openalex.org/W2120529603","https://openalex.org/W2122007620","https://openalex.org/W2124181495","https://openalex.org/W2128114769","https://openalex.org/W2141125135","https://openalex.org/W2146503791","https://openalex.org/W2154401636","https://openalex.org/W2169891354","https://openalex.org/W2171571559","https://openalex.org/W2319405466","https://openalex.org/W2320788982","https://openalex.org/W3026721701","https://openalex.org/W4298091299"],"related_works":["https://openalex.org/W1828158523","https://openalex.org/W2047547195","https://openalex.org/W204175656","https://openalex.org/W2322817607","https://openalex.org/W1993992974","https://openalex.org/W1512294453","https://openalex.org/W2738234280","https://openalex.org/W2546271652","https://openalex.org/W2563724974","https://openalex.org/W4296822203"],"abstract_inverted_index":{"BACKGROUND:":[0],"Culture-independent":[1],"phylogenetic":[2],"analysis":[3,120,168,207],"of":[4,17,33,95,121,135,169,215,226],"16S":[5],"ribosomal":[6],"RNA":[7],"(rRNA)":[8],"gene":[9],"sequences":[10],"has":[11],"emerged":[12],"as":[13,112,143,189,193,209],"an":[14],"incisive":[15],"method":[16,248],"profiling":[18],"bacteria":[19],"present":[20,104],"in":[21,36,66,140],"a":[22,99,113,136,141,166,194,212],"specimen.":[23],"Currently,":[24],"multiple":[25],"techniques":[26],"are":[27,237],"available":[28],"to":[29,74,83,91,239,242,252],"enumerate":[30],"the":[31,39,42,50,70,76,85,105,118,130,144,150,170,178,183,186,216,223,229,244,259],"abundance":[32],"bacterial":[34,138],"taxa":[35],"specimens,":[37],"including":[38],"Sanger":[40],"sequencing,":[41,55],"'next":[43],"generation'":[44],"pyrosequencing,":[45],"microarrays,":[46],"quantitative":[47],"PCR,":[48],"and":[49,56,89,148,153,159,185,197,204,234,241],"rapidly":[51],"emerging,":[52],"third":[53],"generation":[54,58],"fourth":[57],"sequencing":[59],"methods.":[60],"An":[61],"efficient":[62],"statistical":[63,115],"tool":[64],"is":[65,249],"urgent":[67],"need":[68],"for":[69,98,117,165],"followings":[71],"tasks:":[72],"(1)":[73],"compare":[75],"agreement":[77],"between":[78],"these":[79],"measurement":[80,122,157,230],"platforms,":[81,158],"(2)":[82],"select":[84],"most":[86],"reliable":[87,206],"platform(s),":[88],"(3)":[90],"combine":[92],"different":[93,156],"platforms":[94],"complementary":[96],"strengths,":[97],"unified":[100,167],"analysis.":[101],"RESULTS:":[102],"We":[103],"latent":[106,125,145,174,245],"variable":[107,126,147,175,246],"structural":[108],"equation":[109],"modeling":[110,199],"(SEM)":[111],"novel":[114],"application":[116],"comparative":[119],"platforms.":[123],"The":[124,173],"SEM":[127,176,247],"model":[128],"treats":[129],"true":[131],"(unknown)":[132],"relative":[133],"frequency":[134],"given":[137],"taxon":[139],"specimen":[142],"(unobserved)":[146],"estimates":[149],"reliabilities":[151],"of,":[152],"similarities":[154],"between,":[155],"subsequently":[160],"weighs":[161],"those":[162],"measurements":[163],"optimally":[164],"microbiome":[171,213,260],"composition.":[172],"contains":[177],"repeated":[179],"measures":[180],"ANOVA":[181],"(both":[182],"univariate":[184],"multivariate":[187],"models)":[188],"special":[190],"cases":[191],"and,":[192],"more":[195,205],"general":[196],"realistic":[198],"approach,":[200],"yields":[201],"superior":[202],"goodness-of-fit":[203],"results,":[208],"demonstrated":[210],"by":[211],"study":[214,261],"human":[217],"inflammatory":[218],"bowel":[219],"diseases.":[220],"CONCLUSIONS:":[221],"Given":[222],"rapid":[224],"evolution":[225],"modern":[227],"biotechnologies,":[228],"platform":[231],"comparison,":[232],"selection":[233],"combination":[235],"tasks":[236],"here":[238],"stay":[240],"grow--and":[243],"readily":[250],"applicable":[251],"any":[253],"other":[254],"biological":[255],"settings,":[256],"aside":[257],"from":[258],"presented":[262],"here.":[263]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}