{"id":"https://openalex.org/W1969272330","doi":"https://doi.org/10.1186/1471-2105-14-41","title":"Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling","display_name":"Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling","publication_year":2013,"publication_date":"2013-02-06","ids":{"openalex":"https://openalex.org/W1969272330","doi":"https://doi.org/10.1186/1471-2105-14-41","mag":"1969272330","pmid":"https://pubmed.ncbi.nlm.nih.gov/23384097"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-14-41","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-41","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-41","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-41","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101398997","display_name":"Yunfeng Qi","orcid":"https://orcid.org/0000-0002-2704-6792"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun-feng Qi","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020070866","display_name":"Yanxin Huang","orcid":"https://orcid.org/0000-0002-4913-8161"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan-xin Huang","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359667","display_name":"Hongyan Wang","orcid":"https://orcid.org/0000-0002-5781-3745"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-yan Wang","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100433539","display_name":"Yu Zhang","orcid":"https://orcid.org/0000-0002-3702-6541"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008609733","display_name":"Yongli Bao","orcid":"https://orcid.org/0000-0002-5972-1983"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong-li Bao","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113529432","display_name":"Luguo Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu-guo Sun","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101076058","display_name":"Yin Wu","orcid":"https://orcid.org/0000-0001-7369-8612"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin Wu","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106467070","display_name":"Chunlei Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-lei Yu","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102396886","display_name":"Zhenbo Song","orcid":null},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen-bo Song","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087757321","display_name":"Lihua Zheng","orcid":"https://orcid.org/0000-0001-5380-2021"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-hua Zheng","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100355568","display_name":"Ying Sun","orcid":"https://orcid.org/0000-0003-2440-4125"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Sun","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106468289","display_name":"Guan\u2010Nan Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guan-nan Wang","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106468504","display_name":"Yuxin Li","orcid":"https://orcid.org/0000-0002-6889-4050"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu-xin Li","raw_affiliation_strings":["Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, 130024, ChangChun, China","Research Center of Agriculture and Medicine gene Engineering of Ministry of Education, Northeast Normal University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, 130024, ChangChun, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"Research Center of Agriculture and Medicine gene Engineering of Ministry of Education, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5020070866","https://openalex.org/A5106468504"],"corresponding_institution_ids":["https://openalex.org/I184983240"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.475,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.65493892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"41","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.7833602428436279},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.5544094443321228},{"id":"https://openalex.org/keywords/stat-protein","display_name":"STAT protein","score":0.5356838703155518},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.5210223197937012},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.49830055236816406},{"id":"https://openalex.org/keywords/socs3","display_name":"SOCS3","score":0.4910404682159424},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48086172342300415},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4531181752681732},{"id":"https://openalex.org/keywords/cytokine","display_name":"Cytokine","score":0.4471934139728546},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.41698628664016724},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2373473048210144},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.21896100044250488}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.7833602428436279},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5544094443321228},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.5356838703155518},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.5210223197937012},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49830055236816406},{"id":"https://openalex.org/C126042315","wikidata":"https://www.wikidata.org/wiki/Q18033763","display_name":"SOCS3","level":4,"score":0.4910404682159424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48086172342300415},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4531181752681732},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4471934139728546},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41698628664016724},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2373473048210144},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.21896100044250488},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053612","descriptor_name":"Janus Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053612","descriptor_name":"Janus Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053612","descriptor_name":"Janus Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2105-14-41","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-41","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-41","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23384097","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23384097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:2603554","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3599299","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-14-41","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-41","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-41","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1893054079","display_name":null,"funder_award_id":"20110711","funder_id":"https://openalex.org/F4320322174","funder_display_name":"People's Government of Jilin Province"},{"id":"https://openalex.org/G3917996438","display_name":null,"funder_award_id":"11QNJJ021","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G4378717432","display_name":null,"funder_award_id":"2012AA02A407","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5252224160","display_name":"\u7ec6\u80de\u51cb\u4ea1\u4fe1\u53f7\u8f6c\u5bfc\u7f51\u7edc\u591a\u5c3a\u5ea6\u5efa\u6a21\u53ca\u5176\u5728\u65b0\u6297\u80bf\u7624\u836f\u7269\u9776\u6807\u8bc6\u522b\u65b9\u9762\u7684\u5e94\u7528\u7814\u7a76","funder_award_id":"61172183","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320310121","display_name":"Natural Science Foundation of Jilin Province","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1969272330.pdf","grobid_xml":"https://content.openalex.org/works/W1969272330.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W135486017","https://openalex.org/W1486156642","https://openalex.org/W1499095623","https://openalex.org/W1743711678","https://openalex.org/W1821858011","https://openalex.org/W1939561089","https://openalex.org/W1953156122","https://openalex.org/W1954030774","https://openalex.org/W1965366240","https://openalex.org/W1970308473","https://openalex.org/W1981299945","https://openalex.org/W1983974405","https://openalex.org/W1983989619","https://openalex.org/W1998149586","https://openalex.org/W2000583211","https://openalex.org/W2001158436","https://openalex.org/W2002117801","https://openalex.org/W2004593694","https://openalex.org/W2007199665","https://openalex.org/W2008295144","https://openalex.org/W2012438019","https://openalex.org/W2019050142","https://openalex.org/W2021164055","https://openalex.org/W2021469201","https://openalex.org/W2030624761","https://openalex.org/W2036263889","https://openalex.org/W2039793587","https://openalex.org/W2044532151","https://openalex.org/W2046447629","https://openalex.org/W2048051867","https://openalex.org/W2050661504","https://openalex.org/W2052982889","https://openalex.org/W2054132395","https://openalex.org/W2060339708","https://openalex.org/W2065601509","https://openalex.org/W2067476313","https://openalex.org/W2071825914","https://openalex.org/W2075325752","https://openalex.org/W2085935547","https://openalex.org/W2086840459","https://openalex.org/W2088001545","https://openalex.org/W2099171741","https://openalex.org/W2102653059","https://openalex.org/W2106219094","https://openalex.org/W2114990619","https://openalex.org/W2115653742","https://openalex.org/W2120019133","https://openalex.org/W2120474497","https://openalex.org/W2129556256","https://openalex.org/W2130840648","https://openalex.org/W2133064649","https://openalex.org/W2137695731","https://openalex.org/W2144322759","https://openalex.org/W2147495692","https://openalex.org/W2147511779","https://openalex.org/W2149895449","https://openalex.org/W2156116283","https://openalex.org/W2164967233","https://openalex.org/W2165798482","https://openalex.org/W2167017590","https://openalex.org/W2170456918","https://openalex.org/W2361484863","https://openalex.org/W2419090891","https://openalex.org/W2799941631"],"related_works":["https://openalex.org/W1980817114","https://openalex.org/W1993520606","https://openalex.org/W1964215388","https://openalex.org/W2886181943","https://openalex.org/W2079870321","https://openalex.org/W2069683822","https://openalex.org/W3087149089","https://openalex.org/W2365509284","https://openalex.org/W2917410143","https://openalex.org/W2017417748"],"abstract_inverted_index":{"BACKGROUND:":[0],"Interferon-gamma":[1],"(IFN-gamma)":[2],"and":[3,15,18,39,56,63,73,84,94,114,128,130,171,188,219,223,231,265],"interleukin-6":[4],"(IL-6)":[5],"are":[6,32],"multifunctional":[7],"cytokines":[8,31],"that":[9,103,268],"regulate":[10],"immune":[11],"responses,":[12],"cell":[13],"proliferation,":[14],"tumour":[16],"development":[17],"progression,":[19],"which":[20],"frequently":[21],"have":[22,67],"functionally":[23],"opposing":[24],"roles.":[25],"The":[26,158,197,255],"cellular":[27],"responses":[28],"to":[29,148,191,226,273],"both":[30],"activated":[33,253],"via":[34],"the":[35,46,50,54,71,89,92,110,122,132,137,150,155,164,169,174,186,201,204,209,214,235,238,252,262,279,283],"Janus":[36],"kinase/signal":[37],"transducer":[38],"activator":[40],"of":[41,88,136,139,144,152,173,185,203,229,240,251,261,278],"transcription":[42],"(JAK/STAT)":[43],"pathway.":[44],"During":[45],"past":[47],"10":[48],"years,":[49],"crosstalk":[51,75,90,101,107,183,206],"mechanism":[52,76,281],"between":[53,91,112,126,154,208,217,282],"IFN-gamma":[55,93,187,230],"IL-6":[57,95,189],"pathways":[58,190],"has":[59],"been":[60,68],"studied":[61],"widely":[62],"several":[64],"biological":[65],"hypotheses":[66],"proposed,":[69],"but":[70],"kinetics":[72],"detailed":[74],"remain":[77],"unclear.":[78],"RESULTS:":[79],"Using":[80],"established":[81],"mathematical":[82],"models":[83],"new":[85,100],"experimental":[86,165,263],"observations":[87,264],"pathways,":[96],"we":[97,180],"constructed":[98],"a":[99,182,249,258,275],"model":[102,184,256],"considers":[104],"three":[105,205],"possible":[106],"levels:":[108],"(1)":[109],"competition":[111,216],"STAT1":[113,218],"STAT3":[115,220],"for":[116,221],"common":[117],"receptor":[118],"docking":[119],"sites;":[120],"(2)":[121],"mutual":[123],"negative":[124,133],"regulation":[125],"SOCS1":[127],"SOCS3;":[129],"(3)":[131],"regulatory":[134],"effects":[135],"formation":[138,239],"STAT1/3":[140,241],"heterodimers.":[141],"A":[142],"number":[143],"simulations":[145],"were":[146],"tested":[147],"explore":[149],"consequences":[151],"cross-regulation":[153,195,280],"two":[156,210,284],"pathways.":[157,211,285],"simulation":[159,198],"results":[160],"agreed":[161],"well":[162],"with":[163],"data,":[166],"thereby":[167],"demonstrating":[168],"effectiveness":[170],"correctness":[172],"model.":[175],"CONCLUSION:":[176],"In":[177,212],"this":[178],"study,":[179],"developed":[181],"theoretically":[192],"investigate":[193],"their":[194],"mechanism.":[196],"experiments":[199],"showed":[200],"importance":[202],"levels":[207],"particular,":[213],"unbalanced":[215],"IFNR":[222],"gp130":[224],"led":[225],"preferential":[227,244],"activation":[228],"IL-6,":[232],"while":[233],"at":[234],"same":[236],"time":[237],"heterodimers":[242],"enhanced":[243],"signal":[245],"transduction":[246],"by":[247],"sequestering":[248],"fraction":[250],"STATs.":[254],"provided":[257,266],"good":[259],"explanation":[260],"insights":[267],"may":[269],"inform":[270],"further":[271],"research":[272],"facilitate":[274],"better":[276],"understanding":[277]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}
