{"id":"https://openalex.org/W2015735909","doi":"https://doi.org/10.1186/1471-2105-14-35","title":"An integrated pharmacokinetics ontology and corpus for text mining","display_name":"An integrated pharmacokinetics ontology and corpus for text mining","publication_year":2013,"publication_date":"2013-02-01","ids":{"openalex":"https://openalex.org/W2015735909","doi":"https://doi.org/10.1186/1471-2105-14-35","mag":"2015735909","pmid":"https://pubmed.ncbi.nlm.nih.gov/23374886"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-14-35","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-35","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-35","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-35","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100552223","display_name":"Heng\u2010Yi Wu","orcid":"https://orcid.org/0009-0000-5415-8186"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Heng-Yi Wu","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113636391","display_name":"Shreyas Karnik","orcid":null},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shreyas Karnik","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113813259","display_name":"Abhinita Subhadarshini","orcid":null},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhinita Subhadarshini","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387995","display_name":"Zhiping Wang","orcid":"https://orcid.org/0000-0002-6438-1418"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiping Wang","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076547223","display_name":"Santosh Philips","orcid":"https://orcid.org/0000-0003-2420-0819"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santosh Philips","raw_affiliation_strings":["Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101616231","display_name":"Xu Han","orcid":"https://orcid.org/0000-0001-9278-767X"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xu Han","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA","Division of Clinical Pharmacology, School of Medicine, Indiana University, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102101965","display_name":"Chien\u2010Wei Chiang","orcid":"https://orcid.org/0000-0002-0988-8478"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chienwei Chiang","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001388944","display_name":"Lei Liu","orcid":"https://orcid.org/0000-0002-3710-7042"},"institutions":[{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Liu","raw_affiliation_strings":["Shanghai Center for Bioinformation and Technology, Shanghai, 200235, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Center for Bioinformation and Technology, Shanghai, 200235, China","institution_ids":["https://openalex.org/I4210162648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046402446","display_name":"Malaz Boustani","orcid":null},"institutions":[{"id":"https://openalex.org/I1324682000","display_name":"Regenstrief Institute","ror":"https://ror.org/05f2ywb48","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1324682000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malaz Boustani","raw_affiliation_strings":["Regenstrief Institute, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regenstrief Institute, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I1324682000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065682719","display_name":"Lu\u00eds M. Rocha","orcid":"https://orcid.org/0000-0001-9402-887X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis M Rocha","raw_affiliation_strings":["Informatics and Cognitive Science Center for Complex Networks and Systems Research, School of Informatics & Computing, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Informatics and Cognitive Science Center for Complex Networks and Systems Research, School of Informatics & Computing, Indianapolis, IN, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061341188","display_name":"Sara K. Quinney","orcid":"https://orcid.org/0000-0002-6554-0695"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara K Quinney","raw_affiliation_strings":["Department of Obstetrics and Gynecology, School of Medicine, Indiana University, Indianapolis, IN, USA","Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109078846","display_name":"David A. Flockhart","orcid":null},"institutions":[{"id":"https://openalex.org/I4210163547","display_name":"Institute of Predictive and Personalized Medicine of Cancer","ror":"https://ror.org/05hxqvt36","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210163547"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"David Flockhart","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, USA","Department of Obstetrics and Gynecology, School of Medicine, Indiana University, Indianapolis, IN, USA","Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA","Division of Clinical Pharmacology, School of Medicine, Indiana University, Indianapolis, IN, USA","Indiana Institute of Personalized Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Indiana Institute of Personalized Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4210163547"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100383618","display_name":"Lang Li","orcid":"https://orcid.org/0000-0002-5334-8719"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lang Li","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, USA","Division of Clinical Pharmacology, School of Medicine, Indiana University, Indianapolis, IN, USA","Informatics and Cognitive Science Center for Complex Networks and Systems Research, School of Informatics & Computing, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Informatics and Cognitive Science Center for Complex Networks and Systems Research, School of Informatics & Computing, Indianapolis, IN, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5100552223"],"corresponding_institution_ids":["https://openalex.org/I55769427"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.1412,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.91951418,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"35","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10215","display_name":"Semantic Web and Ontologies","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6067448854446411},{"id":"https://openalex.org/keywords/ontology","display_name":"Ontology","score":0.5460030436515808},{"id":"https://openalex.org/keywords/text-mining","display_name":"Text mining","score":0.47504308819770813},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.4661152958869934},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44640210270881653},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.4303194284439087},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.41885361075401306},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3936622738838196},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2293153703212738},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07887929677963257}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6067448854446411},{"id":"https://openalex.org/C25810664","wikidata":"https://www.wikidata.org/wiki/Q44325","display_name":"Ontology","level":2,"score":0.5460030436515808},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.47504308819770813},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.4661152958869934},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44640210270881653},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.4303194284439087},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.41885361075401306},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3936622738838196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2293153703212738},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07887929677963257},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008874","descriptor_name":"Midazolam","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008874","descriptor_name":"Midazolam","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008874","descriptor_name":"Midazolam","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008874","descriptor_name":"Midazolam","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-14-35","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-35","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-35","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23374886","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23374886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:c17599111ecf4955a2cb59d4ba1f9e2c","is_oa":false,"landing_page_url":"https://doaj.org/article/c17599111ecf4955a2cb59d4ba1f9e2c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 14, Iss 1, p 35 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2571649","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3571923","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3571923","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3571923","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-14-35","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-35","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-35","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1325993933","display_name":null,"funder_award_id":"R01HS019818-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2043904495","display_name":null,"funder_award_id":"R01HS019818-01","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G5875709954","display_name":null,"funder_award_id":"R01HS019818","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G7763293017","display_name":null,"funder_award_id":"R01 GM74217","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G8804360517","display_name":null,"funder_award_id":"R01 GM74217","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"},{"id":"https://openalex.org/F4320332961","display_name":"School of Medicine, Indiana University","ror":"https://ror.org/05gxnyn08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015735909.pdf","grobid_xml":"https://content.openalex.org/works/W2015735909.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W23768266","https://openalex.org/W1508977358","https://openalex.org/W1516221483","https://openalex.org/W1525055187","https://openalex.org/W1985034927","https://openalex.org/W2004281677","https://openalex.org/W2025142263","https://openalex.org/W2046747418","https://openalex.org/W2052406081","https://openalex.org/W2069002111","https://openalex.org/W2079197876","https://openalex.org/W2082160386","https://openalex.org/W2113524447","https://openalex.org/W2116231552","https://openalex.org/W2137052779","https://openalex.org/W2138275182","https://openalex.org/W2153222072","https://openalex.org/W2163107094","https://openalex.org/W2166111585","https://openalex.org/W2502670554","https://openalex.org/W2683500892","https://openalex.org/W2791114118","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2003333417","https://openalex.org/W2378862226","https://openalex.org/W118236634","https://openalex.org/W2355326633","https://openalex.org/W2804669904","https://openalex.org/W2149777447","https://openalex.org/W2347456287","https://openalex.org/W2121651557","https://openalex.org/W2782969047","https://openalex.org/W1983454176"],"abstract_inverted_index":{"BACKGROUND:":[0],"Drug":[1],"pharmacokinetics":[2,25,31,43,50,59,71,76,88,99,103,146,153,173,179,184,198],"parameters,":[3,6],"drug":[4,81,111,117,135,139,165,201],"interaction":[5,112,118,136,140,166],"and":[7,17,27,49,73,83,114,129,138,155,181,200],"pharmacogenetics":[8],"data":[9,44,51],"have":[10],"been":[11],"unevenly":[12],"collected":[13],"in":[14,20,69,74,101,105,109,115,177,182],"different":[15],"databases":[16],"published":[18],"extensively":[19],"the":[21,47,145,156,159,194],"literature.":[22],"Without":[23],"appropriate":[24],"ontology":[26,60,147,174],"a":[28,90,164,189],"well":[29],"annotated":[30],"corpus,":[32],"it":[33],"will":[34],"be":[35],"difficult":[36],"to":[37,94,131],"develop":[38],"text":[39,168,195],"mining":[40,169,196],"tools":[41],"for":[42,193],"collection":[45],"from":[46,53],"literature":[48],"integration":[52],"multiple":[54],"databases.":[55],"DESCRIPTION:":[56],"A":[57,120],"comprehensive":[58],"was":[61,92,127,148,161],"constructed.":[62],"It":[63,78],"can":[64],"annotate":[65],"all":[66,80],"aspects":[67],"of":[68,98,144,158,197],"vitro":[70,116,178],"experiments":[72,180],"vivo":[75,102,106,110,183],"studies.":[77,119,185],"covers":[79],"metabolism":[82],"transportation":[84],"enzymes.":[85],"Using":[86],"our":[87],"ontology,":[89],"PK-corpus":[91,160,187],"constructed":[93],"present":[95],"four":[96],"classes":[97],"abstracts:":[100],"studies,":[104,108,113],"pharmacogenetic":[107],"novel":[121],"hierarchical":[122],"three":[123,152],"level":[124],"annotation":[125],"scheme":[126],"proposed":[128],"implemented":[130],"tag":[132],"key":[133],"terms,":[134],"sentences,":[137],"pairs.":[141],"The":[142,172,186],"utility":[143,157],"demonstrated":[149,162],"by":[150,163],"annotating":[151],"studies;":[154],"extraction":[167],"analysis.":[170],"CONCLUSIONS:":[171],"annotates":[175],"both":[176],"is":[188],"highly":[190],"valuable":[191],"resource":[192],"parameters":[199],"interactions.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}