{"id":"https://openalex.org/W2127342293","doi":"https://doi.org/10.1186/1471-2105-14-336","title":"A novel phenotypic dissimilarity method for image-based high-throughput screens","display_name":"A novel phenotypic dissimilarity method for image-based high-throughput screens","publication_year":2013,"publication_date":"2013-11-20","ids":{"openalex":"https://openalex.org/W2127342293","doi":"https://doi.org/10.1186/1471-2105-14-336","mag":"2127342293","pmid":"https://pubmed.ncbi.nlm.nih.gov/24256072"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-14-336","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-336","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-336","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-336","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100678094","display_name":"Xian Zhang","orcid":"https://orcid.org/0000-0002-7337-747X"},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH","DE"],"is_corresponding":true,"raw_author_name":"Xian Zhang","raw_affiliation_strings":["German Cancer Research Center (DKFZ), Div, Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany. xianzhang@gmail.com","German Cancer Research Center (DKFZ), Div. Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg, Germany","Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Research Center (DKFZ), Div, Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany. xianzhang@gmail.com","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Cancer Research Center (DKFZ), Div. Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066882189","display_name":"Michael Boutros","orcid":"https://orcid.org/0000-0002-9458-817X"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michael Boutros","raw_affiliation_strings":["German Cancer Research Center (DKFZ), Div. Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany","German Cancer Research Center (DKFZ), Div. Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Research Center (DKFZ), Div. Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Cancer Research Center (DKFZ), Div. Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066882189","https://openalex.org/A5100678094"],"corresponding_institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4400600974"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.4907,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.86297677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"336","last_page":"336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.09960000216960907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6489385962486267},{"id":"https://openalex.org/keywords/high-content-screening","display_name":"High-content screening","score":0.6061697602272034},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.5733397006988525},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5323097705841064},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5065981149673462},{"id":"https://openalex.org/keywords/replicate","display_name":"Replicate","score":0.49051135778427124},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.4898702800273895},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4778273105621338},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.4560028314590454},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.45529675483703613},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.44375720620155334},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.43765872716903687},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.41360944509506226},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.39667102694511414},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2936154901981354},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2458268702030182},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.19888964295387268},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14904344081878662},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09730055928230286},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09551414847373962}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6489385962486267},{"id":"https://openalex.org/C157044486","wikidata":"https://www.wikidata.org/wiki/Q5754482","display_name":"High-content screening","level":3,"score":0.6061697602272034},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5733397006988525},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5323097705841064},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5065981149673462},{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.49051135778427124},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.4898702800273895},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4778273105621338},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.4560028314590454},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.45529675483703613},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.44375720620155334},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.43765872716903687},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41360944509506226},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.39667102694511414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2936154901981354},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2458268702030182},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.19888964295387268},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14904344081878662},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09730055928230286},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09551414847373962},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2105-14-336","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-336","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-336","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24256072","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24256072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:3196982","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4225524","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-14-336","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-336","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-336","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G553495057","display_name":null,"funder_award_id":"SFB873","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127342293.pdf","grobid_xml":"https://content.openalex.org/works/W2127342293.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W160641220","https://openalex.org/W1836834096","https://openalex.org/W1963666499","https://openalex.org/W1967660686","https://openalex.org/W1972748508","https://openalex.org/W1974482866","https://openalex.org/W1974683325","https://openalex.org/W1978014529","https://openalex.org/W1978522292","https://openalex.org/W1991001144","https://openalex.org/W1991379208","https://openalex.org/W1993669821","https://openalex.org/W1998202992","https://openalex.org/W1998559419","https://openalex.org/W2007599495","https://openalex.org/W2019621874","https://openalex.org/W2038863154","https://openalex.org/W2051000382","https://openalex.org/W2056022845","https://openalex.org/W2056344676","https://openalex.org/W2056559696","https://openalex.org/W2057257265","https://openalex.org/W2065455422","https://openalex.org/W2067937471","https://openalex.org/W2069236757","https://openalex.org/W2075258506","https://openalex.org/W2094769038","https://openalex.org/W2103017472","https://openalex.org/W2107554012","https://openalex.org/W2108303909","https://openalex.org/W2113613985","https://openalex.org/W2130561514","https://openalex.org/W2137315132","https://openalex.org/W2138255346","https://openalex.org/W2144654038","https://openalex.org/W2150091347","https://openalex.org/W2156732033","https://openalex.org/W2160468101","https://openalex.org/W2160697532","https://openalex.org/W2163906048","https://openalex.org/W2164765928","https://openalex.org/W4292820908"],"related_works":["https://openalex.org/W2360935227","https://openalex.org/W2364993072","https://openalex.org/W2115576822","https://openalex.org/W2356429006","https://openalex.org/W2155595079","https://openalex.org/W2380568150","https://openalex.org/W2385787406","https://openalex.org/W2411510900","https://openalex.org/W2263355832","https://openalex.org/W284518807"],"abstract_inverted_index":{"BACKGROUND:":[0],"Discovering":[1],"functional":[2,15,161],"relationships":[3],"of":[4,43,46,64,145],"genes":[5],"through":[6],"cell-based":[7],"phenotyping":[8],"has":[9],"become":[10],"an":[11,194],"important":[12],"approach":[13],"in":[14,68,88],"genomics.":[16],"High-throughput":[17],"imaging":[18],"offers":[19],"the":[20,41,109,136],"ability":[21],"to":[22,77,83,95,126,154],"quantitatively":[23],"assess":[24],"complex":[25],"phenotypes":[26,157],"after":[27],"perturbation":[28],"by":[29,54,60],"RNA":[30],"interference":[31],"(RNAi).":[32],"Such":[33],"image-based":[34,173],"high-throughput":[35,90,174],"RNAi":[36,129],"screening":[37,130],"studies":[38],"have":[39],"facilitated":[40],"discovery":[42],"novel":[44,169],"components":[45],"gene":[47],"networks":[48],"and":[49,74,82,91,120,147,150,158],"their":[50],"interactions.":[51],"Images":[52],"generated":[53],"automated":[55],"microscopy":[56],"are":[57,152],"typically":[58],"analyzed":[59],"extracting":[61],"quantitative":[62],"features":[63],"individual":[65],"cells,":[66],"resulting":[67],"large":[69],"multidimensional":[70],"data":[71,80,131],"sets.":[72],"Robust":[73],"sensitive":[75],"methods":[76],"interpret":[78],"these":[79],"sets":[81],"derive":[84],"biologically":[85],"relevant":[86],"information":[87],"a":[89,102,127,140,168,186],"unbiased":[92],"manner":[93],"remain":[94],"be":[96,182],"developed.":[97],"RESULTS:":[98],"Here":[99],"we":[100,133,151],"propose":[101],"new":[103],"analysis":[104,170],"method,":[105],"PhenoDissim,":[106],"which":[107,180],"computes":[108],"phenotypic":[110],"dissimilarity":[111],"between":[112,163],"cell":[113],"populations":[114],"via":[115],"Support":[116],"Vector":[117],"Machine":[118],"classification":[119],"cross":[121],"validation.":[122],"Applying":[123],"this":[124],"method":[125,138,171],"kinome":[128],"set,":[132],"demonstrate":[134],"that":[135],"proposed":[137],"shows":[139],"good":[141],"replicate":[142],"reproducibility,":[143],"separation":[144],"controls":[146],"clustering":[148],"quality,":[149],"able":[153],"identify":[155],"siRNA":[156],"discover":[159],"potential":[160],"links":[162],"genes.":[164],"CONCLUSIONS:":[165],"PhenoDissim":[166,189],"is":[167,190],"for":[172],"screen,":[175],"relying":[176],"on":[177],"two":[178],"parameters":[179],"can":[181],"automatically":[183],"optimized":[184],"without":[185],"priori":[187],"knowledge.":[188],"freely":[191],"available":[192],"as":[193],"R":[195],"package.":[196]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2025-10-10T00:00:00"}
