{"id":"https://openalex.org/W2042856624","doi":"https://doi.org/10.1186/1471-2105-14-32","title":"Mechanistic analysis of multi-omics datasets to generate kinetic parameters for constraint-based metabolic models","display_name":"Mechanistic analysis of multi-omics datasets to generate kinetic parameters for constraint-based metabolic models","publication_year":2013,"publication_date":"2013-01-30","ids":{"openalex":"https://openalex.org/W2042856624","doi":"https://doi.org/10.1186/1471-2105-14-32","mag":"2042856624","pmid":"https://pubmed.ncbi.nlm.nih.gov/23360254"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-14-32","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-32","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-32","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-32","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088594229","display_name":"Cameron Cotten","orcid":null},"institutions":[{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cameron Cotten","raw_affiliation_strings":["Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Dr, Madison, WI 53706, USA","Department of Chemical and Biological Engineering, University of Wisconsin\u2013Madison, Madison, USA","DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Dr, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Wisconsin\u2013Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, USA","institution_ids":["https://openalex.org/I2801044051","https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059438505","display_name":"Jennifer L. Reed","orcid":"https://orcid.org/0000-0001-7854-6220"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L Reed","raw_affiliation_strings":["DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, 1415 Engineering Dr, Madison, WI, 53706, USA","Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Dr, Madison, WI, 53706, USA","DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, USA","Department of Chemical and Biological Engineering, University of Wisconsin\u2013Madison, Madison, USA"],"affiliations":[{"raw_affiliation_string":"DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, 1415 Engineering Dr, Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I2801044051"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Dr, Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, USA","institution_ids":["https://openalex.org/I2801044051","https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Wisconsin\u2013Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088594229"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.5935,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.93460076,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"32","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinetic-energy","display_name":"Kinetic energy","score":0.7045535445213318},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.6202611327171326},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5876348614692688},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.5537447333335876},{"id":"https://openalex.org/keywords/metabolic-flux-analysis","display_name":"Metabolic flux analysis","score":0.5031408667564392},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.4875785708427429},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.43873119354248047},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.4220884144306183},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3308652639389038},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.27846407890319824},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2308996021747589},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.2074805498123169},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.16794010996818542},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15890410542488098},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1261235773563385}],"concepts":[{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.7045535445213318},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.6202611327171326},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5876348614692688},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5537447333335876},{"id":"https://openalex.org/C160941953","wikidata":"https://www.wikidata.org/wiki/Q6822342","display_name":"Metabolic flux analysis","level":3,"score":0.5031408667564392},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.4875785708427429},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.43873119354248047},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4220884144306183},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3308652639389038},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.27846407890319824},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2308996021747589},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2074805498123169},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.16794010996818542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15890410542488098},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1261235773563385},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-14-32","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-32","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-32","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23360254","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23360254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a3e1882c53ce4240b8d0f62607c39275","is_oa":true,"landing_page_url":"https://doaj.org/article/a3e1882c53ce4240b8d0f62607c39275","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 14, Iss 1, p 32 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2575093","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3571921","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-14-32","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-14-32","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-14-32","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.7400000095367432}],"awards":[{"id":"https://openalex.org/G1052503337","display_name":null,"funder_award_id":"FC02-07ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G222180108","display_name":null,"funder_award_id":"07ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G23300722","display_name":null,"funder_award_id":"DE-FC02-07ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4063130707","display_name":null,"funder_award_id":"DE-FC02-07ER64494","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G4385836085","display_name":null,"funder_award_id":"FC02-07ER64494","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G4406015036","display_name":null,"funder_award_id":"DOE BER Office of Science DE-FC02-07ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4553821525","display_name":null,"funder_award_id":"DOE BER Office of Science DE-FC02-07ER64494","funder_id":"https://openalex.org/F4320333880","funder_display_name":"Great Lakes Bioenergy Research Center"},{"id":"https://openalex.org/G6299481046","display_name":null,"funder_award_id":"DE-FC02-07ER64494","funder_id":"https://openalex.org/F4320333880","funder_display_name":"Great Lakes Bioenergy Research Center"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320333880","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2042856624.pdf","grobid_xml":"https://content.openalex.org/works/W2042856624.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1529898704","https://openalex.org/W1966497610","https://openalex.org/W1982309495","https://openalex.org/W1985687822","https://openalex.org/W1996529795","https://openalex.org/W1998633945","https://openalex.org/W2014294355","https://openalex.org/W2048596643","https://openalex.org/W2053339983","https://openalex.org/W2057685234","https://openalex.org/W2078355959","https://openalex.org/W2092493462","https://openalex.org/W2100262190","https://openalex.org/W2103795997","https://openalex.org/W2107409961","https://openalex.org/W2110585845","https://openalex.org/W2111421616","https://openalex.org/W2111905282","https://openalex.org/W2112258048","https://openalex.org/W2112933558","https://openalex.org/W2124737787","https://openalex.org/W2131187223","https://openalex.org/W2141776893","https://openalex.org/W2154126596","https://openalex.org/W2157457604","https://openalex.org/W2160541874","https://openalex.org/W2161227644","https://openalex.org/W2161304688","https://openalex.org/W2171560951","https://openalex.org/W4256259619"],"related_works":["https://openalex.org/W2521903434","https://openalex.org/W1753739957","https://openalex.org/W2085913165","https://openalex.org/W2011282322","https://openalex.org/W2024044986","https://openalex.org/W2005550771","https://openalex.org/W323632276","https://openalex.org/W2418404479","https://openalex.org/W2078089453","https://openalex.org/W2016858531"],"abstract_inverted_index":{"This":[0],"study":[1],"has":[2],"produced":[3],"a":[4],"method":[5],"for":[6,36],"in":[7],"vivo":[8],"kinetic":[9,18,26],"parameter":[10],"estimation":[11],"and":[12,15,39,42],"identified":[13],"strategies":[14],"outcomes":[16],"of":[17,51],"model":[19,34],"simplification.":[20],"We":[21],"also":[22],"have":[23],"illustrated":[24],"how":[25],"constraints":[27],"can":[28],"be":[29],"used":[30],"to":[31],"improve":[32],"constraint-based":[33],"predictions":[35],"intracellular":[37],"fluxes":[38],"biomass":[40],"yield":[41],"identify":[43],"potential":[44],"metabolic":[45],"limitations":[46],"through":[47],"the":[48],"integrated":[49],"analysis":[50],"multi-omics":[52],"datasets.":[53]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}