{"id":"https://openalex.org/W2137316294","doi":"https://doi.org/10.1186/1471-2105-13-s7-s7","title":"Exploring drug combinations in genetic interaction network","display_name":"Exploring drug combinations in genetic interaction network","publication_year":2012,"publication_date":"2012-05-08","ids":{"openalex":"https://openalex.org/W2137316294","doi":"https://doi.org/10.1186/1471-2105-13-s7-s7","mag":"2137316294","pmid":"https://pubmed.ncbi.nlm.nih.gov/22595004"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-13-s7-s7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s7-s7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S7-S7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S7-S7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076665826","display_name":"Yin\u2010Ying Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin-Ying Wang","raw_affiliation_strings":["Institute of Systems Biology, Shanghai University, Shanghai 200444, China","Institute of Systems Biology, Shanghai University, Shanghai, 200444, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai 200444, China","institution_ids":["https://openalex.org/I113940042"]},{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064726881","display_name":"Kejia Xu","orcid":"https://orcid.org/0009-0001-1659-4363"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke-Jia Xu","raw_affiliation_strings":["Department of Mathematics, Shanghai University, Shanghai, 200444, China","Institute of Systems Biology, Shanghai University, Shanghai, 200444, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Shanghai University, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042"]},{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012709797","display_name":"Jiangning Song","orcid":"https://orcid.org/0000-0001-8031-9086"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210139473","display_name":"Tianjin Institute of Industrial Biotechnology","ror":"https://ror.org/042pyga86","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210139473"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Jiangning Song","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia","Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210139473"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049435754","display_name":"Xing\u2010Ming Zhao","orcid":"https://orcid.org/0000-0002-4531-3970"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xing-Ming Zhao","raw_affiliation_strings":["Institute of Systems Biology, Shanghai University, Shanghai, 200444, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049435754"],"corresponding_institution_ids":["https://openalex.org/I113940042"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.7182,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.84230806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"S7","first_page":"S7","last_page":"S7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5264999866485596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5264999866485596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.42410001158714294,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.698074996471405},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.6907538771629333},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6650881767272949},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.656202495098114},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5318920612335205},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5141237378120422},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.49838972091674805},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4860120713710785},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.4686065912246704},{"id":"https://openalex.org/keywords/perspective","display_name":"Perspective (graphical)","score":0.44226551055908203},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4399203062057495},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34078294038772583},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34030768275260925},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.23429149389266968},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.19439512491226196},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16171813011169434},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1523255705833435}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.698074996471405},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.6907538771629333},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6650881767272949},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.656202495098114},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5318920612335205},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5141237378120422},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.49838972091674805},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4860120713710785},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.4686065912246704},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.44226551055908203},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4399203062057495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34078294038772583},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34030768275260925},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23429149389266968},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.19439512491226196},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16171813011169434},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1523255705833435},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-13-s7-s7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s7-s7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S7-S7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22595004","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22595004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:monash.edu:publications/b07132ac-d1ee-44d7-90f4-58b30b9f6137","is_oa":true,"landing_page_url":"https://research.monash.edu/en/publications/b07132ac-d1ee-44d7-90f4-58b30b9f6137","pdf_url":null,"source":{"id":"https://openalex.org/S4306402625","display_name":"Monash University Research Portal (Monash University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I56590836","host_organization_name":"Monash University","host_organization_lineage":["https://openalex.org/I56590836"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wang, Y-Y, Xu, K-J, Song, J & Zhao, X-M 2012, 'Exploring drug combinations in genetic interaction network', BMC Bioinformatics, vol. 13, no. Suppl 7, S7. https://doi.org/10.1186/1471-2105-13-S7-S7","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:monash.edu:Publications/b07132ac-d1ee-44d7-90f4-58b30b9f6137","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402625","display_name":"Monash University Research Portal (Monash University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I56590836","host_organization_name":"Monash University","host_organization_lineage":["https://openalex.org/I56590836"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:pubmedcentral.nih.gov:3348050","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3348050","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-13-s7-s7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s7-s7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S7-S7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7200000286102295,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3440752333","display_name":null,"funder_award_id":"91130032","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G3491903578","display_name":"\u57fa\u4e8e\u591a\u6e90\u6570\u636e\u6574\u5408\u7684\u836f\u7269\u7ec4\u5408\u9884\u6d4b\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61103075","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G505025389","display_name":null,"funder_award_id":"61103075","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G5368559053","display_name":"\u57fa\u4e8e\u673a\u5668\u5b66\u4e60\u7684\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u4e0e\u529f\u80fd\u9884\u6d4b\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61133010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5682096352","display_name":null,"funder_award_id":"31071168","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5737903045","display_name":null,"funder_award_id":"91130032","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320327803","display_name":"Shanghai Rising-Star Program","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137316294.pdf","grobid_xml":"https://content.openalex.org/works/W2137316294.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1521972501","https://openalex.org/W1916504364","https://openalex.org/W1980482640","https://openalex.org/W2009313526","https://openalex.org/W2010601590","https://openalex.org/W2022192839","https://openalex.org/W2029726120","https://openalex.org/W2044025814","https://openalex.org/W2050343160","https://openalex.org/W2056354857","https://openalex.org/W2063575312","https://openalex.org/W2082032299","https://openalex.org/W2105536900","https://openalex.org/W2107046691","https://openalex.org/W2109322740","https://openalex.org/W2110095004","https://openalex.org/W2113551867","https://openalex.org/W2114469671","https://openalex.org/W2122082921","https://openalex.org/W2138427043","https://openalex.org/W2149754404","https://openalex.org/W2154896031","https://openalex.org/W2155626151","https://openalex.org/W2160261947","https://openalex.org/W2165863045","https://openalex.org/W2171437346"],"related_works":["https://openalex.org/W2553548503","https://openalex.org/W3045995536","https://openalex.org/W2226749982","https://openalex.org/W1967404732","https://openalex.org/W1989543759","https://openalex.org/W4310831746","https://openalex.org/W2509838516","https://openalex.org/W1971106435","https://openalex.org/W2623587811","https://openalex.org/W4379010217"],"abstract_inverted_index":{"BACKGROUND:":[0],"Drug":[1],"combination":[2,147],"that":[3,119,155,170,195],"consists":[4],"of":[5,29,44,95,112,144,189,203,207],"distinctive":[6],"agents":[7],"is":[8,135],"an":[9,52,136],"attractive":[10],"strategy":[11],"to":[12,40,84,106,123,139,161],"combat":[13],"complex":[14],"diseases":[15],"and":[16,36,88,99],"has":[17],"been":[18],"widely":[19],"used":[20],"clinically":[21],"with":[22],"improved":[23],"therapeutic":[24,142],"effects.":[25],"However,":[26],"the":[27,41,48,55,69,93,100,109,130,141,149,171,186,201,204],"identification":[28],"efficacious":[30],"drug":[31,72,86,114,146,156,175,191,209],"combinations":[32,46,87,157,176],"remains":[33],"a":[34,80,125,145],"non-trivial":[35],"challenging":[37],"task":[38],"due":[39],"huge":[42],"number":[43],"possible":[45],"among":[47],"candidate":[49],"drugs.":[50],"As":[51],"important":[53,137,183],"factor,":[54],"molecular":[56,172],"context":[57,94],"in":[58,92,104,129],"which":[59,134],"drugs":[60,121],"exert":[61,177],"their":[62,89,178],"functions":[63,179],"can":[64,180,198],"provide":[65,182],"crucial":[66],"insights":[67,184],"into":[68,185],"mechanism":[70],"underlying":[71,110,187],"combinations.":[73,115,192,210],"RESULTS:":[74],"In":[75],"this":[76],"work,":[77],"we":[78],"present":[79],"network":[81,150],"biology":[82],"approach":[83],"investigate":[85],"target":[90],"proteins":[91],"genetic":[96,131],"interaction":[97,132],"networks":[98,173],"related":[101,164],"human":[102],"pathways,":[103],"order":[105],"better":[107],"understand":[108],"rules":[111,188],"effective":[113,190],"Our":[116],"results":[117],"indicate":[118],"combinatorial":[120],"tend":[122],"have":[124],"smaller":[126],"effect":[127,143],"radius":[128],"networks,":[133],"parameter":[138],"describe":[140],"from":[148],"perspective.":[151],"We":[152,193],"also":[153],"find":[154],"are":[158],"more":[159],"likely":[160],"modulate":[162],"functionally":[163],"pathways.":[165],"CONCLUSIONS:":[166],"This":[167],"study":[168],"confirms":[169],"where":[174],"indeed":[181],"hope":[194],"our":[196],"findings":[197],"help":[199],"shortcut":[200],"expedition":[202],"future":[205],"discovery":[206],"novel":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}