{"id":"https://openalex.org/W2101019241","doi":"https://doi.org/10.1186/1471-2105-13-s4-s11","title":"Characterization of an inducible promoter in different DNA copy number conditions","display_name":"Characterization of an inducible promoter in different DNA copy number conditions","publication_year":2012,"publication_date":"2012-03-28","ids":{"openalex":"https://openalex.org/W2101019241","doi":"https://doi.org/10.1186/1471-2105-13-s4-s11","mag":"2101019241","pmid":"https://pubmed.ncbi.nlm.nih.gov/22536957"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-13-s4-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s4-s11","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S4-S11","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S4-S11","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062705104","display_name":"Susanna Zucca","orcid":"https://orcid.org/0000-0001-8465-632X"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Susanna Zucca","raw_affiliation_strings":["Dipartimento di Informatica e Sistemistica, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100 Pavia, Italy","Dipartimento di Informatica e Sistemistica, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Informatica e Sistemistica, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100 Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Dipartimento di Informatica e Sistemistica, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080904375","display_name":"Lorenzo Pasotti","orcid":"https://orcid.org/0000-0002-5431-3083"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Pasotti","raw_affiliation_strings":["Centro di Ingegneria Tissutale, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy","Dipartimento di Informatica e Sistemistica, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro di Ingegneria Tissutale, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Dipartimento di Informatica e Sistemistica, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111735796","display_name":"Giuliano Mazzini","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129724","display_name":"Istituto di Genetica Molecolare","ror":"https://ror.org/03qpd8w66","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210129724","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuliano Mazzini","raw_affiliation_strings":["Istituto di Genetica Molecolare - Consiglio Nazionale delle Ricerche, Via Ferrata 9, I-27100, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Genetica Molecolare - Consiglio Nazionale delle Ricerche, Via Ferrata 9, I-27100, Pavia, Italy","institution_ids":["https://openalex.org/I4210129724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063579573","display_name":"Maria Gabriella Cusella De Angelis","orcid":"https://orcid.org/0000-0003-2642-3346"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Gabriella Cusella De Angelis","raw_affiliation_strings":["Centro di Ingegneria Tissutale, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro di Ingegneria Tissutale, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081448028","display_name":"Paolo Magni","orcid":"https://orcid.org/0000-0002-8931-4676"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Magni","raw_affiliation_strings":["Centro di Ingegneria Tissutale, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy","Dipartimento di Informatica e Sistemistica, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro di Ingegneria Tissutale, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Dipartimento di Informatica e Sistemistica, Universit\u00e0 degli Studi di Pavia, Via Ferrata 1, I-27100, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5062705104"],"corresponding_institution_ids":["https://openalex.org/I25217355"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.6869,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.90583125,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"S4","first_page":"S11","last_page":"S11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.4056999981403351,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.4056999981403351,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.30809998512268066,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmid","display_name":"Plasmid","score":0.618116557598114},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5841831564903259},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5654346346855164},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.5612582564353943},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5340774059295654},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5270431637763977},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"Copy-number variation","score":0.4945027530193329},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4825696051120758},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4285568594932556},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.42378613352775574},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4177766442298889},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.23889440298080444}],"concepts":[{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.618116557598114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5841831564903259},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5654346346855164},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5612582564353943},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5340774059295654},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5270431637763977},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.4945027530193329},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4825696051120758},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4285568594932556},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.42378613352775574},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4177766442298889},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23889440298080444}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2105-13-s4-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s4-s11","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S4-S11","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22536957","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22536957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3314568","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3314568","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-13-s4-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s4-s11","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S4-S11","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320331528","display_name":"Ministero dell'Universit\u00e0 e della Ricerca","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2101019241.pdf","grobid_xml":"https://content.openalex.org/works/W2101019241.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W620420907","https://openalex.org/W1511098027","https://openalex.org/W1512424569","https://openalex.org/W1601146943","https://openalex.org/W1648226743","https://openalex.org/W1973577260","https://openalex.org/W1979159575","https://openalex.org/W1982228455","https://openalex.org/W1986663500","https://openalex.org/W1988327779","https://openalex.org/W1991439176","https://openalex.org/W2023525048","https://openalex.org/W2025399691","https://openalex.org/W2027576577","https://openalex.org/W2028343312","https://openalex.org/W2031462867","https://openalex.org/W2040092713","https://openalex.org/W2047360542","https://openalex.org/W2047882868","https://openalex.org/W2049432343","https://openalex.org/W2080233018","https://openalex.org/W2091731123","https://openalex.org/W2098355653","https://openalex.org/W2099090468","https://openalex.org/W2104098849","https://openalex.org/W2106259383","https://openalex.org/W2109389103","https://openalex.org/W2113000430","https://openalex.org/W2113983551","https://openalex.org/W2114228460","https://openalex.org/W2116137883","https://openalex.org/W2121360410","https://openalex.org/W2124977728","https://openalex.org/W2128018926","https://openalex.org/W2130912501","https://openalex.org/W2132086259","https://openalex.org/W2134759932","https://openalex.org/W2137325336","https://openalex.org/W2141749341","https://openalex.org/W2144588155","https://openalex.org/W2148641266","https://openalex.org/W2149202606","https://openalex.org/W2153874589","https://openalex.org/W2155264370","https://openalex.org/W2159230317","https://openalex.org/W2161006911","https://openalex.org/W2161251399","https://openalex.org/W2164957727","https://openalex.org/W2165784284","https://openalex.org/W2172162088","https://openalex.org/W2804007336","https://openalex.org/W3215043601","https://openalex.org/W4211125927"],"related_works":["https://openalex.org/W1571771606","https://openalex.org/W2524850911","https://openalex.org/W2620737981","https://openalex.org/W2187207551","https://openalex.org/W2069184423","https://openalex.org/W2058336589","https://openalex.org/W1603543036","https://openalex.org/W2071271062","https://openalex.org/W2090745153","https://openalex.org/W2053073046"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,99,133,298],"bottom-up":[2],"programming":[3],"of":[4,15,19,30,39,56,62,89,101,163,169,178,253,268,301,325,335],"living":[5,48],"organisms":[6],"to":[7,69,74,83,128,175,220,237,242,293,308,330,349],"implement":[8],"novel":[9],"user-defined":[10],"biological":[11,34,91,326],"capabilities":[12],"is":[13,36,81,135,153,202,249,291],"one":[14,177],"the":[16,28,37,40,57,63,85,126,149,156,176,187,198,223,229,239,243,250,261,265,309,312,318],"main":[17],"goals":[18],"synthetic":[20,33,313],"biology.":[21],"Currently,":[22],"a":[23,138,144,167,179,231,258,279,331],"predominant":[24],"problem":[25],"connected":[26],"with":[27,95],"construction":[29],"even":[31],"simple":[32,280],"systems":[35,92,303],"unpredictability":[38],"genetic":[41],"circuitry":[42],"when":[43,93],"assembled":[44],"and":[45,54,72,143,206,264,271,287,322],"incorporated":[46],"in":[47,110,113,125,161,182,197,204,278,311],"cells.":[49],"Copy":[50],"number,":[51],"transcriptional/translational":[52],"demand":[53],"toxicity":[55],"DNA-encoded":[58],"functions":[59],"are":[60,285],"some":[61],"major":[64],"factors":[65],"which":[66,152,201,248],"may":[67],"lead":[68,329],"cell":[70,123],"overburdening":[71],"thus":[73],"nonlinear":[75,283],"effects":[76,194,284],"on":[77],"system":[78,134],"output.":[79],"It":[80],"important":[82],"disclose":[84],"linearity":[86,321],"working":[87,323],"boundaries":[88,324],"engineered":[90],"dealing":[94],"such":[96],"phenomena.":[97],"RESULTS:":[98],"output":[100],"an":[102],"N-3-oxohexanoyl-L-homoserine":[103],"lactone":[104],"(HSL)-inducible":[105],"RFP-expressing":[106],"device":[107],"was":[108,172,235,274],"studied":[109],"Escherichia":[111],"coli":[112],"different":[114],"copy":[115,121,208,215,262],"number":[116,216,263],"contexts,":[117],"ranging":[118],"from":[119],"1":[120],"per":[122],"(integrated":[124],"genome)":[127],"hundreds":[129],"(via":[130],"multicopy":[131],"plasmids).":[132],"composed":[136],"by":[137,148,155,185],"luxR":[139],"constitutive":[140],"expression":[141],"cassette":[142],"RFP":[145],"gene":[146],"regulated":[147],"luxI":[150,224,272],"promoter,":[151],"activated":[154],"HSL-LuxR":[157,245,269],"complex.":[158],"System":[159],"output,":[160],"terms":[162],"promoter":[164,181,225,240,273],"activity":[165,241],"as":[166],"function":[168],"HSL":[170],"concentration,":[171,247],"assessed":[173],"relative":[174],"reference":[180],"identical":[183,203],"conditions":[184],"using":[186],"Relative":[188],"Promoter":[189],"Units":[190],"(RPU)":[191],"approach.":[192],"Nonlinear":[193],"were":[195],"observed":[196,286],"maximum":[199],"activity,":[200],"single":[205],"low":[207],"conditions,":[209,230],"while":[210],"it":[211],"decreases":[212],"for":[213,343],"higher":[214],"conditions.":[217],"In":[218],"order":[219],"properly":[221],"compare":[222],"strength":[226],"among":[227],"all":[228],"mathematical":[232,340],"modeling":[233],"approach":[234],"used":[236,347],"relate":[238],"estimated":[244],"complex":[246,270],"actual":[251],"activator":[252],"transcription.":[254],"During":[255],"model":[256,302],"fitting,":[257],"correlation":[259],"between":[260],"dissociation":[266],"constant":[267],"observed.":[275],"CONCLUSIONS:":[276],"Even":[277],"inducible":[281],"system,":[282],"non-trivial":[288],"data":[289],"processing":[290],"necessary":[292],"fully":[294],"characterize":[295],"its":[296],"operation.":[297],"in-depth":[299],"analysis":[300],"like":[304],"this":[305],"can":[306],"contribute":[307],"advances":[310],"biology":[314],"field,":[315],"since":[316],"increasing":[317],"knowledge":[319],"about":[320],"phenomena":[327],"could":[328],"more":[332],"rational":[333],"design":[334],"artificial":[336],"systems,":[337],"also":[338],"through":[339],"models,":[341],"which,":[342],"example,":[344],"have":[345],"been":[346],"here":[348],"study":[350],"hard-to-predict":[351],"interactions.":[352]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
