{"id":"https://openalex.org/W2129797522","doi":"https://doi.org/10.1186/1471-2105-13-s12-a6","title":"Meta-analysis of genes within QTLs of group A streptococcal sepsis and their expression QTLs reveal pathways modulating host differential response to streptococcal sepsis","display_name":"Meta-analysis of genes within QTLs of group A streptococcal sepsis and their expression QTLs reveal pathways modulating host differential response to streptococcal sepsis","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2129797522","doi":"https://doi.org/10.1186/1471-2105-13-s12-a6","mag":"2129797522"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-13-s12-a6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s12-a6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/1471-2105-13-S12-A6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/1471-2105-13-S12-A6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051085042","display_name":"Nourtan F. Abdeltawab","orcid":"https://orcid.org/0000-0002-1290-2197"},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["EG","US"],"is_corresponding":true,"raw_author_name":"Nourtan Abdeltawab","raw_affiliation_strings":["Department of Molecular Genetics, Microbiology and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA","Faculty of Pharmacy, Cairo University, Cairo, Egypt","Veteran\u2019s Affairs Medical Center, Cincinnati, OH, 45220, USA"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Microbiology and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA","institution_ids":["https://openalex.org/I92156820"]},{"raw_affiliation_string":"Faculty of Pharmacy, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Veteran\u2019s Affairs Medical Center, Cincinnati, OH, 45220, USA","institution_ids":["https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100366032","display_name":"Lu Lu","orcid":"https://orcid.org/0000-0002-6174-3209"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Lu","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000103692","display_name":"Robert W. Williams","orcid":"https://orcid.org/0000-0001-8924-4447"},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Williams","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107841006","display_name":"Malak Kotb","orcid":null},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malak Kotb","raw_affiliation_strings":["Department of Molecular Genetics, Microbiology and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA","Veteran\u2019s Affairs Medical Center, Cincinnati, OH, 45220, USA"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Microbiology and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA","institution_ids":["https://openalex.org/I92156820"]},{"raw_affiliation_string":"Veteran\u2019s Affairs Medical Center, Cincinnati, OH, 45220, USA","institution_ids":["https://openalex.org/I2799886695"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051085042"],"corresponding_institution_ids":["https://openalex.org/I145487455","https://openalex.org/I2799886695","https://openalex.org/I92156820"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18956335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"S12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9847000241279602,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11578","display_name":"Plant Pathogenic Bacteria Studies","score":0.9650999903678894,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"Sepsis","score":0.7181341648101807},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.616703450679779},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5928565263748169},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.55712890625},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.444038987159729},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.42584237456321716},{"id":"https://openalex.org/keywords/host-response","display_name":"Host response","score":0.4198282063007355},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.3981431722640991},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.29069745540618896},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.09877580404281616}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7181341648101807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.616703450679779},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5928565263748169},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.55712890625},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.444038987159729},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42584237456321716},{"id":"https://openalex.org/C2994443828","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Host response","level":3,"score":0.4198282063007355},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3981431722640991},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29069745540618896},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.09877580404281616}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2105-13-s12-a6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s12-a6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/1471-2105-13-S12-A6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:8753a746458740a1bdd6d8ca75cb9a1a","is_oa":true,"landing_page_url":"https://doaj.org/article/8753a746458740a1bdd6d8ca75cb9a1a","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 13, Iss Suppl 12, p A6 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2418934","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3409053","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-13-s12-a6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s12-a6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/1471-2105-13-S12-A6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129797522.pdf","grobid_xml":"https://content.openalex.org/works/W2129797522.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2018134587","https://openalex.org/W2070144977","https://openalex.org/W2104305294","https://openalex.org/W2128414133","https://openalex.org/W2220414859","https://openalex.org/W4238302500"],"related_works":["https://openalex.org/W66091777","https://openalex.org/W2922419521","https://openalex.org/W2806642408","https://openalex.org/W1914860920","https://openalex.org/W2411508033","https://openalex.org/W2363116951","https://openalex.org/W106077234","https://openalex.org/W4214719377","https://openalex.org/W3032309784","https://openalex.org/W4248937386"],"abstract_inverted_index":{"Complex":[0],"host\u2013pathogen":[1],"interactions":[2],"modulate":[3,173],"differential":[4,26,84,112,174],"responses":[5,54],"to":[6,28,48,87,91,104,176],"group":[7],"A":[8],"streptococcal":[9],"(GAS)":[10],"sepsis":[11,31,40,90,156,165],"systemic":[12],"disease":[13,49,65,157],"[1,2].":[14],"We":[15,56,76,137],"previously":[16],"found":[17,42],"that":[18,172],"host":[19,44,85],"HLA-II":[20],"allelic":[21],"variations":[22,63],"are":[23],"associated":[24,82,110],"with":[25,83,111,167],"response":[27,86],"severe":[29,88,177,186],"GAS":[30,39,89,113,155,178,187],"[3].":[32],"In":[33],"addition,":[34],"using":[35,68,130],"mouse":[36,92],"models":[37],"of":[38,99,125,134,161,164,183,207],"we":[41,118],"other":[43],"genetic":[45],"factors":[46],"contribute":[47],"severity":[50,66],"by":[51],"modulating":[52,185,204],"inflammatory":[53],"[4,5].":[55],"applied":[57],"systems":[58],"genetics":[59,198],"approaches":[60],"and":[61,94,123,141],"analyzed":[62],"in":[64,121,147,191],"phenotypes":[67,166],"advance":[69],"recombinant":[70],"inbred":[71],"(ARI)":[72],"BXD":[73],"strain":[74],"panel.":[75],"mapped":[77,128],"quantitative":[78],"trait":[79],"loci":[80],"(QTLs)":[81],"Chr2":[93],"X":[95],"[5].":[96],"The":[97],"focus":[98],"the":[100,181,205],"current":[101],"study":[102,193],"is":[103],"identify":[105],"regulating":[106],"genes":[107,126],"within":[108,127],"QTLs":[109,129,169],"sepsis.":[114,188],"To":[115],"do":[116],"so,":[117],"explored":[119],"differences":[120],"expression":[122,131,143,168],"nsSNPs":[124],"data":[132,144,152],"sets":[133,145,153],"relevant":[135,151],"tissues.":[136],"selected":[138],"spleen,":[139],"leukocytes":[140],"lung":[142],"deposited":[146],"GeneNetwork":[148],"as":[149],"most":[150],"for":[154,200],"severity.":[158],"Collectively,":[159],"integration":[160],"QTL":[162],"mapping":[163],"uncovered":[170],"pathways":[171],"susceptibility":[175],"sepsis,":[179],"underscoring":[180],"complexity":[182],"traits":[184,203],"Approaches":[189],"used":[190],"our":[192],"provide":[194],"a":[195],"powerful,":[196],"unbiased":[197],"approach":[199],"analyzing":[201],"interactive":[202],"outcomes":[206],"infectious":[208],"diseases.":[209]},"counts_by_year":[],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2016-06-24T00:00:00"}