{"id":"https://openalex.org/W2000314525","doi":"https://doi.org/10.1186/1471-2105-13-s12-a10","title":"Identifying indispensable proteins of the type III secretion systems of Salmonella enterica serovar Typhimurium strain LT2","display_name":"Identifying indispensable proteins of the type III secretion systems of Salmonella enterica serovar Typhimurium strain LT2","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2000314525","doi":"https://doi.org/10.1186/1471-2105-13-s12-a10","mag":"2000314525"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-13-s12-a10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s12-a10","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S12-A10","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S12-A10","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059498160","display_name":"Chandrajit Lahiri","orcid":"https://orcid.org/0000-0002-9783-7741"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]},{"id":"https://openalex.org/I119668213","display_name":"Karunya University","ror":"https://ror.org/03k23nv15","country_code":"IN","type":"education","lineage":["https://openalex.org/I119668213"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Chandrajit Lahiri","raw_affiliation_strings":["Center for Infectious Diseases Research, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India","Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, 641114, India","Center for Infectious Diseases Research, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India","Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, India"],"affiliations":[{"raw_affiliation_string":"Center for Infectious Diseases Research, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, 641114, India","institution_ids":["https://openalex.org/I119668213"]},{"raw_affiliation_string":"Center for Infectious Diseases Research, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, India","institution_ids":["https://openalex.org/I119668213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103425333","display_name":"Pawar Shrikant","orcid":null},"institutions":[{"id":"https://openalex.org/I94339441","display_name":"Western Kentucky University","ror":"https://ror.org/0446vnd56","country_code":"US","type":"education","lineage":["https://openalex.org/I94339441"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pawar Shrikant","raw_affiliation_strings":["Department of Biology, Western Kentucky University, Bowling Green, Kentucky, 42101, USA","Department of Cell and Developmental Biology, Cornell University, Weill Cornell Medical College, Manhattan, NY, 10065, USA","Department of Biology, Western Kentucky University, Kentucky, USA","Department of Cell and Developmental Biology, Cornell University, Weill Cornell Medical College, Manhattan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biology, Western Kentucky University, Bowling Green, Kentucky, 42101, USA","institution_ids":["https://openalex.org/I94339441"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, Cornell University, Weill Cornell Medical College, Manhattan, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Biology, Western Kentucky University, Kentucky, USA","institution_ids":["https://openalex.org/I94339441"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, Cornell University, Weill Cornell Medical College, Manhattan, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024231765","display_name":"Radhakrishnan Sabarinathan","orcid":"https://orcid.org/0000-0001-8916-3954"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Radhakrishnan Sabarinathan","raw_affiliation_strings":["Bioinformatics Center, Indian Institute of Science, Bangalore, 560012, India","Bioinformatics Center, Indian Institute of Science, Bangalore, India"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Center, Indian Institute of Science, Bangalore, 560012, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Bioinformatics Center, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112337955","display_name":"Md. Izhar Ashraf","orcid":null},"institutions":[{"id":"https://openalex.org/I59611059","display_name":"Institute of Mathematical Sciences","ror":"https://ror.org/05078rg59","country_code":"IN","type":"facility","lineage":["https://openalex.org/I59611059"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M Izhar Ashraf","raw_affiliation_strings":["Theoretical Physics, The Institute of Mathematical Sciences, Chennai, 600113, India","Theoretical Physics, The Institute of Mathematical Sciences, Chennai, India"],"affiliations":[{"raw_affiliation_string":"Theoretical Physics, The Institute of Mathematical Sciences, Chennai, 600113, India","institution_ids":["https://openalex.org/I59611059"]},{"raw_affiliation_string":"Theoretical Physics, The Institute of Mathematical Sciences, Chennai, India","institution_ids":["https://openalex.org/I59611059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030416693","display_name":"Dipshikha Chakravortty","orcid":"https://orcid.org/0000-0002-7838-5145"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dipshikha Chakravortty","raw_affiliation_strings":["Center for Infectious Diseases Research, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India","Center for Infectious Diseases Research, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India"],"affiliations":[{"raw_affiliation_string":"Center for Infectious Diseases Research, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Center for Infectious Diseases Research, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5059498160"],"corresponding_institution_ids":["https://openalex.org/I119668213","https://openalex.org/I59270414"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.16984174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"S12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salmonella-enterica","display_name":"Salmonella enterica","score":0.8580366969108582},{"id":"https://openalex.org/keywords/serotype","display_name":"Serotype","score":0.7876622676849365},{"id":"https://openalex.org/keywords/salmonella","display_name":"Salmonella","score":0.7471522688865662},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.6912586688995361},{"id":"https://openalex.org/keywords/strain","display_name":"Strain (injury)","score":0.585259735584259},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5842088460922241},{"id":"https://openalex.org/keywords/secretion","display_name":"Secretion","score":0.5178406834602356},{"id":"https://openalex.org/keywords/type-three-secretion-system","display_name":"Type three secretion system","score":0.5134447813034058},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.466456800699234},{"id":"https://openalex.org/keywords/enterobacteriaceae","display_name":"Enterobacteriaceae","score":0.412127822637558},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.34433430433273315},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.26022565364837646},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.23915857076644897},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.2362191379070282},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16135817766189575},{"id":"https://openalex.org/keywords/virulence","display_name":"Virulence","score":0.13214027881622314},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08870628476142883},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06148117780685425}],"concepts":[{"id":"https://openalex.org/C2779607309","wikidata":"https://www.wikidata.org/wiki/Q2264864","display_name":"Salmonella enterica","level":4,"score":0.8580366969108582},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.7876622676849365},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.7471522688865662},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6912586688995361},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.585259735584259},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5842088460922241},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5178406834602356},{"id":"https://openalex.org/C130211564","wikidata":"https://www.wikidata.org/wiki/Q21199165","display_name":"Type three secretion system","level":4,"score":0.5134447813034058},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.466456800699234},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.412127822637558},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34433430433273315},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26022565364837646},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.23915857076644897},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2362191379070282},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16135817766189575},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.13214027881622314},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08870628476142883},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06148117780685425},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/1471-2105-13-s12-a10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s12-a10","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S12-A10","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2418946","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3409079","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-13-s12-a10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s12-a10","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S12-A10","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","score":0.8700000047683716,"display_name":"Life below water"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000314525.pdf","grobid_xml":"https://content.openalex.org/works/W2000314525.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W771846863","https://openalex.org/W1974702731","https://openalex.org/W2108559568"],"related_works":["https://openalex.org/W1977144460","https://openalex.org/W4295414647","https://openalex.org/W2911973517","https://openalex.org/W2604851483","https://openalex.org/W1974842464","https://openalex.org/W1970386319","https://openalex.org/W2171269550","https://openalex.org/W2170772601","https://openalex.org/W2132644071","https://openalex.org/W2097248465"],"abstract_inverted_index":{"Background\r\nAn":[0],"estimated":[1],"1.3":[2],"billion":[3],"cases":[4],"of":[5,43,47,53,69,79,104,132,142,181,234,248,286,301,329],"salmonellosis":[6],"occur":[7],"worldwide":[8],"every":[9],"year":[10],"[1].":[11],"The":[12,280],"causative":[13],"organism":[14],"Salmonella":[15,54],"enterica":[16],"serovar":[17],"Typhimurium":[18],"strain":[19],"LT2":[20],"uses":[21],"different":[22],"proteins":[23,46,111,143,195,236],"to":[24,30,100,121,128,212,251],"inject":[25],"into":[26,176,316],"the":[27,39,48,76,130,133,140,179,190,193,214,235,239,246,296,304,327],"host":[28],"cells":[29],"cause":[31],"such":[32],"systemic":[33],"infection.":[34],"Several":[35],"reports":[36],"exist":[37],"on":[38],"role":[40,66,84],"and":[41,81,92,106,112,118,172,183,185,222,271,310],"importance":[42],"these":[44,105,308],"individual":[45],"Type":[49],"III":[50],"secretion":[51],"system":[52,62],"pathogenicity":[55],"islands":[56],"(SPI).":[57],"Two":[58],"component":[59],"signal":[60,109],"transduction":[61,110],"plays":[63],"a":[64,96,102,232,283,299],"major":[65],"in":[67,90,178,238,303,335],"regulation":[68],"those":[70],"virulent":[71,311],"SPI":[72,261],"genes":[73,268,287,312],"[2].":[74],"However,":[75],"most":[77,215],"indispensable":[78,188,216],"them":[80],"their":[82],"hierarchical":[83],"has":[85],"not":[86],"been":[87],"worked":[88],"out":[89,139,211],"detail.\r\n\r\nMaterials":[91],"methods\r\nWe":[93],"have":[94],"adopted":[95],"graph":[97],"theoretical":[98],"approach":[99,127],"build":[101],"network":[103,119,134],"other":[107],"associated":[108],"utilized":[113],"modules":[114],"like":[115],"centrality":[116,220],"measures":[117,221],"decomposition":[120],"analyze":[122],"our":[123],"result.":[124],"An":[125],"initial":[126],"get":[129],"fingerprint":[131],"via":[135],"k-core":[136],"analyses":[137,226],"listed":[138],"set":[141,285],"InvA,":[144],"InvE,":[145],"InvG,":[146],"InvF,":[147],"PrgK,":[148],"SicA,":[149],"SipA,":[150],"SipB,":[151],"SipC,":[152],"SpaK,":[153],"SpaL,":[154],"SpaO,":[155],"SpaP,":[156],"SpaQ,":[157],"SpaR,":[158],"SpaS,":[159],"SsaJ,":[160],"SsaK,":[161],"SsaL,":[162],"SsaM,":[163],"SsaN,":[164],"SsaO,":[165],"SsaP,":[166],"SsaQ,":[167],"SsaS,":[168],"SsaT,":[169],"SsaU,":[170],"SsaV,":[171],"YscR":[173],"which":[174,292,318,331],"comes":[175],"action":[177],"process":[180],"invasion":[182],"colonization":[184],"thus":[186],"become":[187],"than":[189],"rest.":[191],"All":[192],"significant":[194],"identified":[196,270],"were":[197,269],"confirmed":[198,223],"by":[199,224,260,274,321],"Agilent":[200],"Microarray":[201],"with":[202],"subsequent":[203],"Cytoscape":[204],"analysis.\r\n\r\nResults\r\nThe":[205],"chaperone":[206],"protein":[207],"SicA":[208],"was":[209],"figured":[210],"be":[213],"one":[217],"from":[218],"classical":[219],"microarray":[225,278],"as":[227],"well.":[228],"We":[229],"also":[230],"propose":[231],"hierarchy":[233],"involved":[237],"total":[240],"infection":[241,330],"process.":[242],"Our":[243],"method":[244],"is":[245,282],"first":[247],"its":[249],"kind":[250],"figure":[252],"out,":[253],"albeit":[254],"theoretically,":[255],"potential":[256],"virulence":[257],"determinants":[258],"encoded":[259],"for":[262,265,298,339],"therapeutic":[263],"targets":[264,338],"enteric":[266,324],"infection.\r\n\r\nConclusions\r\nTarget":[267],"then":[272,294],"validated":[273],"using":[275],"independent,":[276],"published":[277],"data.":[279],"result":[281],"targeted":[284],"that":[288],"are":[289,319],"sensitive":[290],"predictors":[291],"could":[293],"form":[295],"basis":[297],"series":[300],"tests":[302],"wet-lab":[305],"background.":[306],"Understanding":[307],"regulatory":[309],"will":[313,332],"provide":[314],"insight":[315],"conditions":[317],"encountered":[320],"this":[322],"intracellular":[323],"pathogen":[325],"during":[326],"course":[328],"further":[333],"contribute":[334],"identifying":[336],"new":[337],"antimicrobial":[340],"agents.":[341]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4}],"updated_date":"2026-03-18T14:38:29.013473","created_date":"2025-10-10T00:00:00"}