{"id":"https://openalex.org/W2027515689","doi":"https://doi.org/10.1186/1471-2105-13-s10-s13","title":"Horizontal gene transfer dynamics and distribution of fitness effects during microbial in silico evolution","display_name":"Horizontal gene transfer dynamics and distribution of fitness effects during microbial in silico evolution","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2027515689","doi":"https://doi.org/10.1186/1471-2105-13-s10-s13","mag":"2027515689","pmid":"https://pubmed.ncbi.nlm.nih.gov/22759418"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-13-s10-s13","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s10-s13","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S10-S13","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S10-S13","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064103619","display_name":"Vadim Mozhayskiy","orcid":null},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vadim Mozhayskiy","raw_affiliation_strings":["Department of Computer Science and UC Davis Genome Center, University of California Davis, Davis, California 95616, USA","Department of Computer Science and UC Davis Genome Center, University of California Davis, Davis, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and UC Davis Genome Center, University of California Davis, Davis, California 95616, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Computer Science and UC Davis Genome Center, University of California Davis, Davis, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004351739","display_name":"Ilias Tagkopoulos","orcid":"https://orcid.org/0000-0003-1104-7616"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilias Tagkopoulos","raw_affiliation_strings":["Department of Computer Science and UC Davis Genome Center, University of California Davis, Davis, California, 95616, USA","Department of Computer Science and UC Davis Genome Center, University of California Davis, Davis, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and UC Davis Genome Center, University of California Davis, Davis, California, 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Computer Science and UC Davis Genome Center, University of California Davis, Davis, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064103619"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.4845,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.8921889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"S10","first_page":"S13","last_page":"S13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/horizontal-gene-transfer","display_name":"Horizontal gene transfer","score":0.8160962462425232},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7669069170951843},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.6625372171401978},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.6619386672973633},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6394568681716919},{"id":"https://openalex.org/keywords/evolutionary-dynamics","display_name":"Evolutionary dynamics","score":0.584244966506958},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5638142228126526},{"id":"https://openalex.org/keywords/tree-of-life","display_name":"Tree of life (biology)","score":0.5566712021827698},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4739401638507843},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.47162389755249023},{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"Experimental evolution","score":0.4653651714324951},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.44791942834854126},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.43970951437950134},{"id":"https://openalex.org/keywords/molecular-evolution","display_name":"Molecular evolution","score":0.4291791319847107},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3337358236312866},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.12758496403694153}],"concepts":[{"id":"https://openalex.org/C92938381","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Horizontal gene transfer","level":4,"score":0.8160962462425232},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7669069170951843},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.6625372171401978},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.6619386672973633},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6394568681716919},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.584244966506958},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5638142228126526},{"id":"https://openalex.org/C124388736","wikidata":"https://www.wikidata.org/wiki/Q3247497","display_name":"Tree of life (biology)","level":4,"score":0.5566712021827698},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4739401638507843},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.47162389755249023},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.4653651714324951},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44791942834854126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43970951437950134},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.4291791319847107},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3337358236312866},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.12758496403694153},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019020","descriptor_name":"Directed Molecular Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019020","descriptor_name":"Directed Molecular Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019020","descriptor_name":"Directed Molecular Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022761","descriptor_name":"Gene Transfer, Horizontal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022761","descriptor_name":"Gene Transfer, Horizontal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022761","descriptor_name":"Gene Transfer, Horizontal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-13-s10-s13","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s10-s13","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S10-S13","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22759418","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22759418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:5c39653de37b462e87e3b7a0d24e5c5f","is_oa":true,"landing_page_url":"https://doaj.org/article/5c39653de37b462e87e3b7a0d24e5c5f","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 13, Iss Suppl 10, p S13 (2012)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt3fz9z22t","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3fz9z22t","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, vol 13, iss Suppl 10","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2388110","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3382434","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:qt3fz9z22t","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/3fz9z22t","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mozhayskiy, Vadim; &amp; Tagkopoulos, Ilias. (2012). Horizontal gene transfer dynamics and distribution of fitness effects during microbial in silico evolution. BMC Bioinformatics, 13(Suppl 10), S13. doi: http://dx.doi.org/10.1186/1471-2105-13-S10-S13. Retrieved from: http://www.escholarship.org/uc/item/3fz9z22t","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-13-s10-s13","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-s10-s13","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-S10-S13","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.47999998927116394,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G6961881350","display_name":null,"funder_award_id":"941360","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G736847297","display_name":"Petascale simulations of Complex Biological Behavior in Fluctuating Environments","funder_award_id":"0941360","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320312143","display_name":"National Centre for Supercomputing Applications","ror":"https://ror.org/03r10zj06"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2027515689.pdf","grobid_xml":"https://content.openalex.org/works/W2027515689.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1578556740","https://openalex.org/W1583066216","https://openalex.org/W1963732026","https://openalex.org/W1972740086","https://openalex.org/W1993351732","https://openalex.org/W2000175834","https://openalex.org/W2005100412","https://openalex.org/W2006716355","https://openalex.org/W2012766690","https://openalex.org/W2019196452","https://openalex.org/W2020048892","https://openalex.org/W2044775606","https://openalex.org/W2045815467","https://openalex.org/W2053822186","https://openalex.org/W2056772522","https://openalex.org/W2062210712","https://openalex.org/W2084887718","https://openalex.org/W2085909456","https://openalex.org/W2087895317","https://openalex.org/W2088160202","https://openalex.org/W2088297366","https://openalex.org/W2107495006","https://openalex.org/W2108923274","https://openalex.org/W2109970745","https://openalex.org/W2110105435","https://openalex.org/W2111403860","https://openalex.org/W2115590956","https://openalex.org/W2121166240","https://openalex.org/W2124788609","https://openalex.org/W2125088626","https://openalex.org/W2137296148","https://openalex.org/W2138728248","https://openalex.org/W2142391696","https://openalex.org/W2142879643","https://openalex.org/W2144386534","https://openalex.org/W2145406188","https://openalex.org/W2153685804","https://openalex.org/W2164321064","https://openalex.org/W2165479490","https://openalex.org/W2166074460","https://openalex.org/W2168912452","https://openalex.org/W2169947310","https://openalex.org/W2174626282","https://openalex.org/W2180177760","https://openalex.org/W2275615274","https://openalex.org/W2800394774","https://openalex.org/W2912478709","https://openalex.org/W3017143921","https://openalex.org/W3098632781","https://openalex.org/W4236670782","https://openalex.org/W4239648059","https://openalex.org/W4256068768","https://openalex.org/W4295837538"],"related_works":["https://openalex.org/W2058766820","https://openalex.org/W2029133099","https://openalex.org/W2130436157","https://openalex.org/W2070620318","https://openalex.org/W2001721767","https://openalex.org/W3191711189","https://openalex.org/W2017754509","https://openalex.org/W12279734","https://openalex.org/W2106136091","https://openalex.org/W2074675159"],"abstract_inverted_index":{"Large-scale":[0],"simulations":[1],"reveal":[2],"a":[3,31,48,74],"distinct":[4],"signature":[5],"of":[6,9,51,65,72,138],"the":[7,70,89,101,117],"Distribution":[8],"Fitness":[10],"Effect":[11],"(DFE)":[12],"for":[13,149],"HGT":[14,27,81,109],"events:":[15],"during":[16,43],"evolution,":[17],"while":[18,88,141],"mutation":[19],"fitness":[20],"effects":[21],"become":[22],"more":[23],"negative":[24],"and":[25,130],"neutral,":[26],"events":[28,39],"result":[29],"in":[30,69,100,111,124],"balanced":[32],"effect":[33],"distribution.":[34],"In":[35],"either":[36],"case,":[37],"lethal":[38],"are":[40],"significantly":[41],"decreased":[42],"evolution":[44,55],"(33.0%":[45],"to":[46,62,85,96,135,152],"3.2%),":[47],"clear":[49],"indication":[50],"mutational":[52],"robustness.":[53],"Interestingly,":[54],"was":[56,94,147],"accelerated":[57],"when":[58],"populations":[59],"were":[60,83,133],"exposed":[61],"correlated":[63],"environments":[64],"increasing":[66],"complexity,":[67],"especially":[68],"presence":[71],"HGT,":[73],"phenomenon":[75],"that":[76,108],"warrants":[77],"further":[78],"investigation.":[79],"High":[80],"rates":[82],"found":[84],"be":[86],"disruptive,":[87],"average":[90],"transferred":[91],"fragment":[92,145],"size":[93,99],"linked":[95],"functional":[97],"module":[98],"underlying":[102],"biological":[103],"network.":[104],"Network":[105],"analysis":[106],"reveals":[107],"results":[110],"larger":[112],"regulatory":[113],"networks,":[114],"but":[115],"with":[116],"same":[118],"sparsity":[119],"level":[120],"as":[121],"those":[122],"evolved":[123],"its":[125],"absence.":[126],"Observed":[127],"phenotypic":[128],"variability":[129],"co-existing":[131],"solutions":[132],"traced":[134],"individual":[136],"gain/loss":[137],"function":[139],"events,":[140],"subsequent":[142],"re-wiring":[143],"after":[144],"integration":[146],"necessary":[148],"complex":[150],"traits":[151],"emerge.":[153]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
