{"id":"https://openalex.org/W2147951581","doi":"https://doi.org/10.1186/1471-2105-13-325","title":"A novel approach for biomarker selection and the integration of repeated measures experiments from two assays","display_name":"A novel approach for biomarker selection and the integration of repeated measures experiments from two assays","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2147951581","doi":"https://doi.org/10.1186/1471-2105-13-325","mag":"2147951581","pmid":"https://pubmed.ncbi.nlm.nih.gov/23216942"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-13-325","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-325","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-325","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-325","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040962966","display_name":"Beno\u00eet Liquet","orcid":"https://orcid.org/0000-0002-8136-2294"},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210106115","display_name":"Bordeaux Population Health","ror":"https://ror.org/00xzzba89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benoit Liquet","raw_affiliation_strings":["Univ, Bordeaux, ISPED, centre INSERM U-897-Epid\u00e9miologie-Biostatistique, Bordeaux, F-33000, France. benoit.liquet@isped.u-bordeaux2.fr","Univ. Bordeaux, ISPED, centre INSERM U-897-Epid\u00e9miologie-Biostatistique, Bordeaux, F-33000, FRANCE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ, Bordeaux, ISPED, centre INSERM U-897-Epid\u00e9miologie-Biostatistique, Bordeaux, F-33000, France. benoit.liquet@isped.u-bordeaux2.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210106115"]},{"raw_affiliation_string":"Univ. Bordeaux, ISPED, centre INSERM U-897-Epid\u00e9miologie-Biostatistique, Bordeaux, F-33000, FRANCE","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I15057530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091163780","display_name":"Kim\u2010Anh L\u00ea Cao","orcid":"https://orcid.org/0000-0003-3923-1116"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kim-Anh L\u00ea Cao","raw_affiliation_strings":["Queensland Facility for Advanced Bioinformatics and the institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland Facility for Advanced Bioinformatics and the institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005751696","display_name":"Hakim Hocini","orcid":"https://orcid.org/0000-0002-4972-3547"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013"]},{"id":"https://openalex.org/I4210119150","display_name":"Institut de Recherche Vaccinale","ror":"https://ror.org/02f9r3321","country_code":"FR","type":"facility","lineage":["https://openalex.org/I197681013","https://openalex.org/I4210116296","https://openalex.org/I4210119150"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hakim Hocini","raw_affiliation_strings":["INSERM U955 Eq 16, UPEC Universit\u00e9, Cr\u00e9teil, FRANCE","Vaccine Research Institute ANRS, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U955 Eq 16, UPEC Universit\u00e9, Cr\u00e9teil, FRANCE","institution_ids":["https://openalex.org/I197681013","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Vaccine Research Institute ANRS, Paris, France","institution_ids":["https://openalex.org/I4210119150"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022077216","display_name":"Rodolphe Thi\u00e9baut","orcid":"https://orcid.org/0000-0002-5235-3962"},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119150","display_name":"Institut de Recherche Vaccinale","ror":"https://ror.org/02f9r3321","country_code":"FR","type":"facility","lineage":["https://openalex.org/I197681013","https://openalex.org/I4210116296","https://openalex.org/I4210119150"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rodolphe Thi\u00e9baut","raw_affiliation_strings":["INSERM, ISPED, centre INSERM U-897-Epid\u00e9miologie-Biostatistique, Bordeaux, F-33000, FRANCE","Univ. Bordeaux, ISPED, centre INSERM U-897-Epid\u00e9miologie-Biostatistique, Bordeaux, F-33000, FRANCE","Vaccine Research Institute ANRS, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, ISPED, centre INSERM U-897-Epid\u00e9miologie-Biostatistique, Bordeaux, F-33000, FRANCE","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Univ. Bordeaux, ISPED, centre INSERM U-897-Epid\u00e9miologie-Biostatistique, Bordeaux, F-33000, FRANCE","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I15057530"]},{"raw_affiliation_string":"Vaccine Research Institute ANRS, Paris, France","institution_ids":["https://openalex.org/I4210119150"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.1501,"has_fulltext":true,"cited_by_count":120,"citation_normalized_percentile":{"value":0.87677723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"325","last_page":"325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.3343999981880188,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.3343999981880188,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.3107999861240387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.07360000163316727,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.8253970146179199},{"id":"https://openalex.org/keywords/multivariate-analysis","display_name":"Multivariate analysis","score":0.6364190578460693},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5524182915687561},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5515590906143188},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.4729713499546051},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41388219594955444},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38261398673057556},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.356204092502594},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.342265784740448},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.227460116147995}],"concepts":[{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.8253970146179199},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.6364190578460693},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5524182915687561},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5515590906143188},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.4729713499546051},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41388219594955444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38261398673057556},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.356204092502594},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.342265784740448},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.227460116147995}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-13-325","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-325","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-325","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23216942","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23216942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:eprints.qut.edu.au:128023","is_oa":true,"landing_page_url":null,"pdf_url":"https://eprints.qut.edu.au/128023/1/document.pdf","source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Contribution to Journal"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/259607","is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/259607","pdf_url":"http://hdl.handle.net/11343/259607","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:inserm-00814235v1","is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00814235","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 2012, 13 (1), pp.325. ⟨10.1186/1471-2105-13-325⟩","raw_type":"Journal articles"},{"id":"pmh:oai:europepmc.org:2627550","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3627901","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-13-325","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-325","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-325","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.7200000286102295}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320333684","display_name":"Sanofi Pasteur","ror":null},{"id":"https://openalex.org/F4320336914","display_name":"Wound Management Innovation Cooperative Research Centre","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147951581.pdf","grobid_xml":"https://content.openalex.org/works/W2147951581.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1587094587","https://openalex.org/W1880834807","https://openalex.org/W1965138864","https://openalex.org/W1967827763","https://openalex.org/W1968206427","https://openalex.org/W1969435618","https://openalex.org/W1981747359","https://openalex.org/W1984311170","https://openalex.org/W1992549770","https://openalex.org/W1993572741","https://openalex.org/W2003913885","https://openalex.org/W2022960516","https://openalex.org/W2036010272","https://openalex.org/W2046173425","https://openalex.org/W2054324592","https://openalex.org/W2071527134","https://openalex.org/W2082253757","https://openalex.org/W2097057782","https://openalex.org/W2098290597","https://openalex.org/W2107397182","https://openalex.org/W2107956883","https://openalex.org/W2110065044","https://openalex.org/W2130648981","https://openalex.org/W2138389055","https://openalex.org/W2143784594","https://openalex.org/W2149566602","https://openalex.org/W2150168309","https://openalex.org/W2164583936","https://openalex.org/W2169281074","https://openalex.org/W2170917242","https://openalex.org/W2617515964","https://openalex.org/W4206439534"],"related_works":["https://openalex.org/W2406638334","https://openalex.org/W40745829","https://openalex.org/W1978357124","https://openalex.org/W1578824628","https://openalex.org/W2032728545","https://openalex.org/W1570805059","https://openalex.org/W4250754046","https://openalex.org/W4318262572","https://openalex.org/W2036849593","https://openalex.org/W1978174651"],"abstract_inverted_index":{"BACKGROUND:":[0],"High":[1],"throughput":[2],"'omics'":[3],"experiments":[4],"are":[5,40],"usually":[6],"designed":[7],"to":[8,18,60,79,83,96,100,113,124,140,155,244,262],"compare":[9],"changes":[10],"observed":[11],"between":[12,73],"different":[13,35,38],"conditions":[14,39,66],"(or":[15],"interventions)":[16],"and":[17,56,82,145,165,187,210],"identify":[19],"biomarkers":[20],"capable":[21],"of":[22,31,65,86,118,148,176,185,207,216,228],"characterizing":[23],"each":[24],"condition.":[25],"We":[26,47],"consider":[27],"the":[28,43,63,70,84,102,115,119,134,141,146,160,179,194,221,254,264],"complex":[29],"structure":[30],"repeated":[32],"measurements":[33],"from":[34,69],"assays":[36],"where":[37],"applied":[41,154],"on":[42],"same":[44],"subjects.":[45,74,107],"RESULTS:":[46],"propose":[48],"a":[49,53,57,125,173,213],"two-step":[50],"analysis":[51,171,182,225],"combining":[52],"multilevel":[54,120,130,170,181,199],"approach":[55,59,76,122,132,137,152,201,250],"multivariate":[58,121,127,131,136,200],"reveal":[61],"separately":[62],"effects":[64],"within":[67,106],"subjects":[68],"biological":[71],"variation":[72],"The":[75,129,151,168,223,249],"is":[77,251],"extended":[78],"two-factor":[80],"designs":[81],"integration":[85],"two":[87],"matched":[88],"data":[89],"sets.":[90],"It":[91],"allows":[92,211],"internal":[93],"variable":[94],"selection":[95,147],"highlight":[97],"genes":[98,177,186],"able":[99],"discriminate":[101],"net":[103],"condition":[104],"effect":[105,209],"A":[108],"simulation":[109],"study":[110],"was":[111,153],"performed":[112],"demonstrate":[114],"good":[116],"performance":[117],"compared":[123],"classical":[126,135],"method.":[128],"outperformed":[133],"with":[138,162,233,259],"respect":[139],"classification":[142],"error":[143],"rate":[144],"relevant":[149,174],"genes.":[150],"an":[156],"HIV-vaccine":[157],"trial":[158],"evaluating":[159],"response":[161],"gene":[163,242],"expression":[164],"cytokine":[166,234,247],"secretion.":[167,235],"discriminant":[169],"selected":[172],"subset":[175],"while":[178],"integrative":[180,224],"highlighted":[183],"clusters":[184,227,237],"cytokines":[188],"that":[189,230],"were":[190,231],"highly":[191],"correlated":[192],"across":[193],"samples.":[195],"CONCLUSIONS:":[196],"Our":[197],"combined":[198],"may":[202],"help":[203],"in":[204,253],"finding":[205],"signatures":[206,243],"vaccine":[208],"for":[212],"better":[214],"understanding":[215],"immunological":[217],"mechanisms":[218],"activated":[219],"by":[220],"intervention.":[222],"revealed":[226],"genes,":[229],"associated":[232,260],"These":[236],"can":[238],"be":[239],"seen":[240],"as":[241],"predict":[245],"future":[246],"response.":[248],"implemented":[252],"R":[255],"package":[256],"mixOmics":[257],"(http://cran.r-project.org/)":[258],"tutorials":[261],"perform":[263],"analysis(a).":[265]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}