{"id":"https://openalex.org/W2133125835","doi":"https://doi.org/10.1186/1471-2105-13-296","title":"Quantitative fluorescence loss in photobleaching for analysis of protein transport and aggregation","display_name":"Quantitative fluorescence loss in photobleaching for analysis of protein transport and aggregation","publication_year":2012,"publication_date":"2012-11-13","ids":{"openalex":"https://openalex.org/W2133125835","doi":"https://doi.org/10.1186/1471-2105-13-296","mag":"2133125835","pmid":"https://pubmed.ncbi.nlm.nih.gov/23148417"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-13-296","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-296","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-296","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-296","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090901298","display_name":"Daniel W\u00fcstner","orcid":"https://orcid.org/0000-0003-4995-9709"},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Daniel W\u00fcstner","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M, DK-5230, Denmark. wuestner@bmb.sdu.dk","Department of Biochemistry and Molecular Biology University of Southern Denmark Odense M Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M, DK-5230, Denmark. wuestner@bmb.sdu.dk","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology University of Southern Denmark Odense M Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007674259","display_name":"Lukasz M. Solanko","orcid":null},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lukasz M Solanko","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M, DK-5230, Denmark","Department of Biochemistry and Molecular Biology University of Southern Denmark Odense M Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M, DK-5230, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology University of Southern Denmark Odense M Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024117382","display_name":"Frederik W. Lund","orcid":"https://orcid.org/0000-0002-8261-0309"},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Frederik W Lund","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M, DK-5230, Denmark","Department of Biochemistry and Molecular Biology University of Southern Denmark Odense M Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M, DK-5230, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology University of Southern Denmark Odense M Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019987836","display_name":"Daniel Sage","orcid":"https://orcid.org/0000-0002-1150-1623"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel Sage","raw_affiliation_strings":["Biomedical Imaging Group, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland","Biomedical Imaging Group, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Group, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Biomedical Imaging Group, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027317343","display_name":"Hans Joachim Schroll","orcid":"https://orcid.org/0000-0002-5301-2916"},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hans J Schroll","raw_affiliation_strings":["Institute for Mathematics and Computer Science (IMADA), University of Southern Denmark, Odense M, DK-5230, Denmark","Institute for Mathematics and Computer Science (IMADA), University of Southern Denmark, Odense M, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Mathematics and Computer Science (IMADA), University of Southern Denmark, Odense M, DK-5230, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Institute for Mathematics and Computer Science (IMADA), University of Southern Denmark, Odense M, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071803297","display_name":"Michael A. Lomholt","orcid":"https://orcid.org/0000-0002-3698-0958"},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Michael A Lomholt","raw_affiliation_strings":["Department of Physics, Chemistry and Pharmacy, MEMPHYS Center for Biomembrane Physics, University of Southern Denmark, Odense M, DK-5230, Denmark","Department of Physics, Chemistry and Pharmacy, MEMPHYS Center for Biomembrane Physics, University of Southern Denmark, Odense M, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Chemistry and Pharmacy, MEMPHYS Center for Biomembrane Physics, University of Southern Denmark, Odense M, DK-5230, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Physics, Chemistry and Pharmacy, MEMPHYS Center for Biomembrane Physics, University of Southern Denmark, Odense M, Denmark","institution_ids":["https://openalex.org/I177969490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090901298"],"corresponding_institution_ids":["https://openalex.org/I177969490"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":3.2365,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.92878539,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"296","last_page":"296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.42170000076293945,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.42170000076293945,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.09300000220537186,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.05820000171661377,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photobleaching","display_name":"Photobleaching","score":0.7875176668167114},{"id":"https://openalex.org/keywords/fluorescence-recovery-after-photobleaching","display_name":"Fluorescence recovery after photobleaching","score":0.7773020267486572},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5799773335456848},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5662253499031067},{"id":"https://openalex.org/keywords/kinetics","display_name":"Kinetics","score":0.5633087754249573},{"id":"https://openalex.org/keywords/green-fluorescent-protein","display_name":"Green fluorescent protein","score":0.5192484855651855},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.4859972894191742},{"id":"https://openalex.org/keywords/cellular-compartment","display_name":"Cellular compartment","score":0.4210691452026367},{"id":"https://openalex.org/keywords/confocal-microscopy","display_name":"Confocal microscopy","score":0.4207674264907837},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.39964941143989563},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2766628861427307},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23167362809181213},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.19522613286972046},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.1376657783985138},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.1267872452735901},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11119860410690308}],"concepts":[{"id":"https://openalex.org/C31332276","wikidata":"https://www.wikidata.org/wiki/Q899750","display_name":"Photobleaching","level":3,"score":0.7875176668167114},{"id":"https://openalex.org/C26659971","wikidata":"https://www.wikidata.org/wiki/Q729923","display_name":"Fluorescence recovery after photobleaching","level":3,"score":0.7773020267486572},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5799773335456848},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5662253499031067},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.5633087754249573},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.5192484855651855},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4859972894191742},{"id":"https://openalex.org/C78885561","wikidata":"https://www.wikidata.org/wiki/Q189055","display_name":"Cellular compartment","level":3,"score":0.4210691452026367},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.4207674264907837},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39964941143989563},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2766628861427307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23167362809181213},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19522613286972046},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1376657783985138},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.1267872452735901},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11119860410690308},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036681","descriptor_name":"Fluorescence Recovery After Photobleaching","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D036681","descriptor_name":"Fluorescence Recovery After Photobleaching","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D036681","descriptor_name":"Fluorescence Recovery After Photobleaching","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D038761","descriptor_name":"Photobleaching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D038761","descriptor_name":"Photobleaching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D038761","descriptor_name":"Photobleaching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-13-296","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-296","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-296","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23148417","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23148417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:sdu.dk:publications/f9ce2455-4f16-4763-bce4-9e0bc3e48af3","is_oa":false,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/f9ce2455-4f16-4763-bce4-9e0bc3e48af3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"W\u00fcstner, D, Solanko, L M, Lund, F W, Sage, D, Schroll, A & Lomholt, M A 2012, 'Quantitative fluorescence loss in photobleaching for analysis of protein transport and aggregation', BMC Bioinformatics, vol. 13, pp. 296. https://doi.org/10.1186/1471-2105-13-296","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:2562188","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3557157","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:072b8ef9f4d14f818e500a6b94c6f397","is_oa":true,"landing_page_url":"https://doaj.org/article/072b8ef9f4d14f818e500a6b94c6f397","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 13, Iss 1, p 296 (2012)","raw_type":"article"},{"id":"pmh:oai:infoscience.epfl.ch:185734","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/185734","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-13-296","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-296","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-296","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.5199999809265137}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2133125835.pdf","grobid_xml":"https://content.openalex.org/works/W2133125835.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W41743907","https://openalex.org/W85002878","https://openalex.org/W595896130","https://openalex.org/W1512281481","https://openalex.org/W1519786321","https://openalex.org/W1664619999","https://openalex.org/W1806395945","https://openalex.org/W1968060296","https://openalex.org/W1970580210","https://openalex.org/W1974956983","https://openalex.org/W1975826430","https://openalex.org/W1980893888","https://openalex.org/W1982138681","https://openalex.org/W1985243580","https://openalex.org/W1986846248","https://openalex.org/W1989174525","https://openalex.org/W1992755218","https://openalex.org/W1994624166","https://openalex.org/W1995029094","https://openalex.org/W1996419188","https://openalex.org/W1998193097","https://openalex.org/W2000235766","https://openalex.org/W2000744765","https://openalex.org/W2010181298","https://openalex.org/W2024324386","https://openalex.org/W2027717396","https://openalex.org/W2031313854","https://openalex.org/W2031395392","https://openalex.org/W2032161274","https://openalex.org/W2035556394","https://openalex.org/W2035664621","https://openalex.org/W2039070119","https://openalex.org/W2045881750","https://openalex.org/W2053642248","https://openalex.org/W2056062902","https://openalex.org/W2060391279","https://openalex.org/W2061334464","https://openalex.org/W2066703502","https://openalex.org/W2068786839","https://openalex.org/W2069520354","https://openalex.org/W2080394935","https://openalex.org/W2082210254","https://openalex.org/W2083773088","https://openalex.org/W2086356224","https://openalex.org/W2086461023","https://openalex.org/W2092072282","https://openalex.org/W2097624735","https://openalex.org/W2099183701","https://openalex.org/W2110427436","https://openalex.org/W2113413121","https://openalex.org/W2121378814","https://openalex.org/W2128691473","https://openalex.org/W2129570611","https://openalex.org/W2130741221","https://openalex.org/W2131938193","https://openalex.org/W2136180087","https://openalex.org/W2137567288","https://openalex.org/W2141829222","https://openalex.org/W2143623375","https://openalex.org/W2155274044","https://openalex.org/W2157831747","https://openalex.org/W2162093412","https://openalex.org/W2166155213","https://openalex.org/W2172177962","https://openalex.org/W2188232828","https://openalex.org/W4250448744"],"related_works":["https://openalex.org/W1518240974","https://openalex.org/W2410074698","https://openalex.org/W1997452518","https://openalex.org/W113297786","https://openalex.org/W4392913268","https://openalex.org/W2140320154","https://openalex.org/W2143611296","https://openalex.org/W2789311093","https://openalex.org/W1964678604","https://openalex.org/W1976055993"],"abstract_inverted_index":{"BACKGROUND:":[0],"Fluorescence":[1],"loss":[2,122],"in":[3,18,102,164,176,182,197,234,294],"photobleaching":[4],"(FLIP)":[5],"is":[6,28,75,118,253],"a":[7,24,45,113,165],"widely":[8],"used":[9],"imaging":[10],"technique,":[11],"which":[12,74,169],"provides":[13],"information":[14],"about":[15],"protein":[16,98,160,244],"dynamics":[17,303],"various":[19],"cellular":[20,26,170],"regions.":[21,265],"In":[22,109],"FLIP,":[23],"small":[25],"region":[27],"repeatedly":[29],"illuminated":[30],"by":[31,132],"an":[32],"intense":[33],"laser":[34,42],"pulse,":[35],"while":[36],"images":[37],"are":[38,55],"taken":[39],"with":[40,44,228],"reduced":[41],"power":[43],"time":[46],"lag":[47],"between":[48,246,277],"the":[49,64,110,127,136,177,183,187,198,249,258,263],"bleaches.":[50],"Despite":[51],"its":[52],"popularity,":[53],"tools":[54],"lacking":[56],"for":[57,71,81,191,195,288,323],"quantitative":[58,289,324],"analysis":[59,73,290],"of":[60,68,150,156,202,231,241,275,291,301,308,320,326],"FLIP":[61,106,292],"experiments.":[62,281],"Typically,":[63],"user":[65],"defines":[66],"regions":[67,171],"interest":[69],"(ROIs)":[70],"further":[72],"subjective":[76],"and":[77,85,96,100,125,143,200,248,261,280,304],"does":[78],"not":[79],"allow":[80,190],"comparing":[82],"different":[83,278],"cells":[84,104,279],"experimental":[86],"settings.":[87],"RESULTS:":[88],"We":[89,130,283],"present":[90,284],"two":[91,285],"complementary":[92,286],"methods":[93,287,317],"to":[94,120,153,237,271,311],"detect":[95],"quantify":[97],"transport":[99],"aggregation":[101],"living":[103,203,295],"from":[105,168,186],"image":[107],"series.":[108],"first":[111],"approach,":[112],"stretched":[114],"exponential":[115],"(StrExp)":[116],"function":[117,138,152,189],"fitted":[119],"fluorescence":[121],"(FL)":[123],"inside":[124,260],"outside":[126,262],"bleached":[128,178,264],"region.":[129],"show":[131],"reaction-diffusion":[133],"simulations,":[134],"that":[135,151],"StrExp":[137,188],"can":[139,173,213],"describe":[140],"both,":[141],"binding/barrier-limited":[142],"diffusion-limited":[144],"FL":[145,154,232,259],"kinetics.":[146],"By":[147],"pixel-wise":[148],"regression":[149],"kinetics":[155,233,274],"enhanced":[157],"green":[158],"fluorescent":[159,309],"(eGFP),":[161],"we":[162],"determined":[163],"user-unbiased":[166],"manner":[167],"eGFP":[172,196],"be":[174,319],"replenished":[175],"area.":[179],"Spatial":[180],"variation":[181],"parameters":[184,307],"calculated":[185],"detecting":[192],"diffusion":[193],"barriers":[194],"nucleus":[199],"cytoplasm":[201],"cells.":[204,296],"Polyglutamine":[205],"(polyQ)":[206],"disease":[207],"proteins":[208],"like":[209],"mutant":[210],"huntingtin":[211],"(mtHtt)":[212],"form":[214],"large":[215],"aggregates":[216,247],"called":[217],"inclusion":[218],"bodies":[219],"(IB's).":[220],"The":[221],"second":[222],"method":[223,252],"combines":[224],"single":[225],"particle":[226],"tracking":[227],"multi-compartment":[229],"modelling":[230],"moving":[235,312],"IB's":[236],"determine":[238],"exchange":[239,302],"rates":[240],"eGFP-tagged":[242],"mtHtt":[243],"(eGFP-mtHtt)":[245],"cytoplasm.":[250],"This":[251],"self-calibrating":[254],"since":[255],"it":[256,268],"relates":[257],"It":[266],"makes":[267],"therefore":[269],"possible":[270],"compare":[272],"release":[273],"eGFP-mtHtt":[276],"CONCLUSIONS:":[282],"experiments":[293],"They":[297],"provide":[298],"spatial":[299],"maps":[300],"absolute":[305],"binding":[306],"molecules":[310],"intracellular":[313,327],"entities,":[314],"respectively.":[315],"Our":[316],"should":[318],"great":[321],"value":[322],"studies":[325],"transport.":[328]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}
