{"id":"https://openalex.org/W2149873877","doi":"https://doi.org/10.1186/1471-2105-13-225","title":"Coupled mutation finder: A new entropy-based method quantifying phylogenetic noise for the detection of compensatory mutations","display_name":"Coupled mutation finder: A new entropy-based method quantifying phylogenetic noise for the detection of compensatory mutations","publication_year":2012,"publication_date":"2012-09-11","ids":{"openalex":"https://openalex.org/W2149873877","doi":"https://doi.org/10.1186/1471-2105-13-225","mag":"2149873877","pmid":"https://pubmed.ncbi.nlm.nih.gov/22963049"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-13-225","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-225","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-225","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-225","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085199270","display_name":"Mehmet G\u00fclta\u015f","orcid":"https://orcid.org/0000-0003-3297-3192"},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mehmet G\u00fcltas","raw_affiliation_strings":["Institute of Computer Science, University of G\u00f6ttingen, Goldschmidtstr. 7, G\u00f6ttingen, 37077, Germany. gueltas@cs.uni-goettingen.de","Institute of Computer Science, University of G\u00f6ttingen, Goldschmidtstr. 7, G\u00f6ttingen, 37077, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Computer Science, University of G\u00f6ttingen, Goldschmidtstr. 7, G\u00f6ttingen, 37077, Germany. gueltas@cs.uni-goettingen.de","institution_ids":["https://openalex.org/I74656192"]},{"raw_affiliation_string":"Institute of Computer Science, University of G\u00f6ttingen, Goldschmidtstr. 7, G\u00f6ttingen, 37077, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074217468","display_name":"Martin Haubrock","orcid":"https://orcid.org/0000-0001-5292-4561"},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Haubrock","raw_affiliation_strings":["Department of Bioinformatics, University of G ttingen, Goldschmidtstr. 1, 37077 G ttingen, Germany","Department of Bioinformatics, University of G\u00f6ttingen, Goldschmidtstr. 1, 37077, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, University of G ttingen, Goldschmidtstr. 1, 37077 G ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]},{"raw_affiliation_string":"Department of Bioinformatics, University of G\u00f6ttingen, Goldschmidtstr. 1, 37077, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070759447","display_name":"Nesrin T\u00fcys\u00fcz","orcid":null},"institutions":[{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nesrin T\u00fcys\u00fcz","raw_affiliation_strings":["Erasmus MC Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasmus MC Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I4210149908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113553795","display_name":"Stephan Waack","orcid":null},"institutions":[{"id":"https://openalex.org/I143910747","display_name":"TH Bingen University of Applied Sciences","ror":"https://ror.org/01pxkj057","country_code":"DE","type":"education","lineage":["https://openalex.org/I143910747"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Waack","raw_affiliation_strings":["Institute of Computer Science, University of G ttingen, Goldschmidtstr. 7, 37077, G ttingen, Germany","Institute of Computer Science, University of G\u00f6ttingen, Goldschmidtstr. 7, G\u00f6ttingen, 37077, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Computer Science, University of G ttingen, Goldschmidtstr. 7, 37077, G ttingen, Germany","institution_ids":["https://openalex.org/I143910747"]},{"raw_affiliation_string":"Institute of Computer Science, University of G\u00f6ttingen, Goldschmidtstr. 7, G\u00f6ttingen, 37077, Germany","institution_ids":["https://openalex.org/I74656192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1456,"currency":"EUR","value_usd":1570},"fwci":1.404,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83136711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"225","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.669700026512146,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.669700026512146,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.09430000185966492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6687543392181396},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.650041937828064},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5697360038757324},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5677282810211182},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5609031319618225},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.5552157163619995},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.43459299206733704},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.23044368624687195},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.13859766721725464}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6687543392181396},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.650041937828064},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5697360038757324},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5677282810211182},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5609031319618225},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.5552157163619995},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.43459299206733704},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23044368624687195},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.13859766721725464}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1186/1471-2105-13-225","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-225","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-225","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22963049","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22963049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:eur:oai:repub.eur.nl:71708","is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/71708","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Bioinformatics, 13(1)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:d5a1561626ed46e9875d1cff1155d779","is_oa":false,"landing_page_url":"https://doaj.org/article/d5a1561626ed46e9875d1cff1155d779","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 13, Iss 1, p 225 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2579017","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3577461","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:goescholar:1/8541","is_oa":true,"landing_page_url":"http://resolver.sub.uni-goettingen.de/purl?gs-1/8541","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journalArticle"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/25431","is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/25431","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3577461","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3577461","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:repub.eur.nl:71708","is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/71708","pdf_url":null,"source":{"id":"https://openalex.org/S4306400997","display_name":"RePub (Erasmus University, Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Bioinformatics vol. 13 no. 1","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-13-225","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-225","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-225","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2149873877.pdf","grobid_xml":"https://content.openalex.org/works/W2149873877.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1500839801","https://openalex.org/W1964895626","https://openalex.org/W1972291833","https://openalex.org/W1976666280","https://openalex.org/W1979965027","https://openalex.org/W1982387777","https://openalex.org/W1984765576","https://openalex.org/W1985499302","https://openalex.org/W2004306990","https://openalex.org/W2019020499","https://openalex.org/W2019947024","https://openalex.org/W2021769301","https://openalex.org/W2032521962","https://openalex.org/W2036926586","https://openalex.org/W2043696829","https://openalex.org/W2051352017","https://openalex.org/W2051872583","https://openalex.org/W2052193304","https://openalex.org/W2053618775","https://openalex.org/W2056637421","https://openalex.org/W2063274819","https://openalex.org/W2066614521","https://openalex.org/W2069327241","https://openalex.org/W2071289226","https://openalex.org/W2087300028","https://openalex.org/W2092006899","https://openalex.org/W2096279929","https://openalex.org/W2099846003","https://openalex.org/W2109372707","https://openalex.org/W2110065044","https://openalex.org/W2111109297","https://openalex.org/W2112040506","https://openalex.org/W2113175552","https://openalex.org/W2116087481","https://openalex.org/W2119026448","https://openalex.org/W2119412782","https://openalex.org/W2120549641","https://openalex.org/W2122732537","https://openalex.org/W2131848438","https://openalex.org/W2134970730","https://openalex.org/W2137284086","https://openalex.org/W2142319534","https://openalex.org/W2143210482","https://openalex.org/W2143238378","https://openalex.org/W2146891463","https://openalex.org/W2159409048","https://openalex.org/W2163352757","https://openalex.org/W2163544308","https://openalex.org/W2164391585","https://openalex.org/W2166935403","https://openalex.org/W2171641243","https://openalex.org/W2187469065","https://openalex.org/W2963508016","https://openalex.org/W4297623296","https://openalex.org/W6806875027"],"related_works":["https://openalex.org/W2146397496","https://openalex.org/W2076383445","https://openalex.org/W2136281516","https://openalex.org/W4281740518","https://openalex.org/W2025340064","https://openalex.org/W4384665577","https://openalex.org/W2592888218","https://openalex.org/W4231831369","https://openalex.org/W2097774084","https://openalex.org/W2606677068"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,146,176,264],"detection":[2,96],"of":[3,27,46,57,63,67,72,97,105,112,149,162,200,229,258,262],"significant":[4,28,134],"compensatory":[5,98,135,150,214,226],"mutation":[6,136,151,227],"signals":[7,29,137],"in":[8,21,198,234],"multiple":[9,190],"sequence":[10],"alignments":[11],"(MSAs)":[12],"is":[13,23,51,130,178,218,252,267],"often":[14],"complicated":[15],"by":[16,154],"noise.":[17],"A":[18],"challenging":[19],"problem":[20],"bioinformatics":[22],"remains":[24],"the":[25,38,55,64,85,91,95,103,128,139,155,195,201,239,259],"separation":[26],"between":[30],"two":[31,113],"or":[32,173,231],"more":[33],"non-conserved":[34,48],"residue":[35,49,75],"sites":[36,50,111,152,161,228],"from":[37,138],"phylogenetic":[39,92,140],"noise":[40,93,141],"and":[41,70,121,142,165,205,224],"unrelated":[42,143],"pair":[43,144],"signals.":[44,145],"Determination":[45],"these":[47],"as":[52,54,244],"important":[53,74],"recognition":[56],"strictly":[58],"conserved":[59],"positions":[60],"for":[61,94,254],"understanding":[62,257],"structural":[65,230,260],"basis":[66,261],"protein":[68,171],"functions":[69],"identification":[71],"functionally":[73],"regions.":[76],"In":[77],"this":[78,106],"study,":[79],"we":[80,108],"developed":[81],"a":[82,179,206,219,245,255],"new":[83,180],"method,":[84,107,181],"Coupled":[86],"Mutation":[87],"Finder":[88],"(CMF)":[89],"quantifying":[90],"mutations.":[99,215],"RESULTS:":[100],"To":[101],"demonstrate":[102],"effectiveness":[104],"analyzed":[109],"essential":[110,160],"human":[114],"proteins:":[115],"epidermal":[116],"growth":[117],"factor":[118],"receptor":[119],"(EGFR)":[120],"glucokinase":[122],"(GCK).":[123],"Our":[124],"results":[125],"suggest":[126,237],"that":[127,193,238,251],"CMF":[129,156,177,240,265],"able":[131],"to":[132,159,169,210,222],"separate":[133],"vast":[147],"majority":[148],"found":[153],"are":[157,167],"related":[158],"both":[163],"proteins":[164],"they":[166],"likely":[168],"affect":[170],"stability":[172],"functionality.":[174],"CONCLUSIONS:":[175],"which":[182],"includes":[183],"an":[184],"MSA-specific":[185],"statistical":[186],"model":[187],"based":[188],"on":[189],"testing":[191],"procedures":[192],"quantify":[194],"error":[196],"made":[197],"terms":[199],"false":[202],"discovery":[203],"rate":[204],"novel":[207,246],"entropy-based":[208],"metric":[209],"upscale":[211],"BLOSUM62":[212],"dissimilar":[213],"Therefore,":[216],"it":[217],"helpful":[220],"tool":[221,250],"predict":[223],"investigate":[225],"functional":[232],"importance":[233],"proteins.":[235,263],"We":[236],"could":[241],"be":[242],"used":[243],"automated":[247],"function":[248],"prediction":[249],"required":[253],"better":[256],"server":[266],"freely":[268],"accessible":[269],"at":[270],"http://cmf.bioinf.med.uni-goettingen.de.":[271]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}