{"id":"https://openalex.org/W2022338213","doi":"https://doi.org/10.1186/1471-2105-13-150","title":"A statistical approach to selecting and confirming validation targets in -omics experiments","display_name":"A statistical approach to selecting and confirming validation targets in -omics experiments","publication_year":2012,"publication_date":"2012-06-27","ids":{"openalex":"https://openalex.org/W2022338213","doi":"https://doi.org/10.1186/1471-2105-13-150","mag":"2022338213","pmid":"https://pubmed.ncbi.nlm.nih.gov/22738145"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-13-150","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-150","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-150","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-150","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020868614","display_name":"Jeffrey T. Leek","orcid":"https://orcid.org/0000-0002-2873-2671"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey T Leek","raw_affiliation_strings":["Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205-2179, USA. jleek@jhsph.edu","Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA "],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205-2179, USA. jleek@jhsph.edu","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006226110","display_name":"Margaret A. Taub","orcid":"https://orcid.org/0000-0001-8008-618X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A Taub","raw_affiliation_strings":["Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205-2179, USA","Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA "],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205-2179, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA ","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048916159","display_name":"Jason L. Rasgon","orcid":"https://orcid.org/0000-0002-4050-8429"},"institutions":[{"id":"https://openalex.org/I1338678786","display_name":"Center for Disease Dynamics, Economics & Policy","ror":"https://ror.org/01skhd946","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338678786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason L Rasgon","raw_affiliation_strings":["Department of Entomology, The Center for Infectious Disease Dynamics, and the Huck Institutes of Life Sciences, University Park, PA, 16802, USA","Department of Entomology, The Center for Infectious Disease Dynamics, and the Huck Institutes of Life Sciences, University Park, USA"],"affiliations":[{"raw_affiliation_string":"Department of Entomology, The Center for Infectious Disease Dynamics, and the Huck Institutes of Life Sciences, University Park, PA, 16802, USA","institution_ids":["https://openalex.org/I1338678786"]},{"raw_affiliation_string":"Department of Entomology, The Center for Infectious Disease Dynamics, and the Huck Institutes of Life Sciences, University Park, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020868614"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.6704,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.67979971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"13","issue":"1","first_page":"150","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5759134292602539},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5192625522613525},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5144055485725403},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5018601417541504},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.4650883078575134},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.42401760816574097},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.4148520827293396},{"id":"https://openalex.org/keywords/statistical-model","display_name":"Statistical model","score":0.41448289155960083},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4073559641838074},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.3789765238761902},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34028691053390503},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30091187357902527},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.25032997131347656},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2067013680934906},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19640469551086426},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.192869633436203},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1440695822238922}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5759134292602539},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5192625522613525},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5144055485725403},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5018601417541504},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.4650883078575134},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.42401760816574097},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.4148520827293396},{"id":"https://openalex.org/C114289077","wikidata":"https://www.wikidata.org/wiki/Q3284399","display_name":"Statistical model","level":2,"score":0.41448289155960083},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4073559641838074},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3789765238761902},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34028691053390503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30091187357902527},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.25032997131347656},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2067013680934906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19640469551086426},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.192869633436203},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1440695822238922},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-13-150","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-150","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-150","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22738145","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22738145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:c506f206ec724ee79162beb5c68c825a","is_oa":true,"landing_page_url":"https://doaj.org/article/c506f206ec724ee79162beb5c68c825a","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 13, Iss 1, p 150 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2570020","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3568710","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3568710","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3568710","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-13-150","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-150","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-150","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Decent work and economic growth","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/8"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022338213.pdf","grobid_xml":"https://content.openalex.org/works/W2022338213.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1964895626","https://openalex.org/W1970156673","https://openalex.org/W1971698866","https://openalex.org/W1995859491","https://openalex.org/W1995945562","https://openalex.org/W2011411346","https://openalex.org/W2015795623","https://openalex.org/W2024103316","https://openalex.org/W2025604635","https://openalex.org/W2036583346","https://openalex.org/W2045656233","https://openalex.org/W2051019743","https://openalex.org/W2061680337","https://openalex.org/W2096192437","https://openalex.org/W2101095322","https://openalex.org/W2107665951","https://openalex.org/W2110265246","https://openalex.org/W2130410032","https://openalex.org/W2130530904","https://openalex.org/W2133984660","https://openalex.org/W2137409194","https://openalex.org/W2137499573","https://openalex.org/W2144707864","https://openalex.org/W2156631105","https://openalex.org/W2171324524","https://openalex.org/W2465692541","https://openalex.org/W3106889297","https://openalex.org/W4232383088"],"related_works":["https://openalex.org/W1986765826","https://openalex.org/W154531455","https://openalex.org/W2088387197","https://openalex.org/W1976797354","https://openalex.org/W3174861742","https://openalex.org/W1995992573","https://openalex.org/W3008469829","https://openalex.org/W3172121640","https://openalex.org/W3000705684","https://openalex.org/W2278145554"],"abstract_inverted_index":{"For":[0],"high-throughput":[1],"-omics":[2],"studies,":[3],"statistical":[4],"validation":[5],"is":[6],"a":[7],"cost-effective":[8],"and":[9],"statistically":[10],"valid":[11],"approach":[12],"to":[13],"confirming":[14],"lists":[15],"of":[16],"significant":[17],"results.":[18]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-03-18T14:38:29.013473","created_date":"2025-10-10T00:00:00"}